ATP inhibits insulin-degrading enzyme activity

Experimental Biology and Medicine

Volumn 226, Issue 4, 2001, Pages 334-341

  Velleman, Sandra G ^a,d   Mccormick, Richard J ^b   Ely, Daniel ^c   Jarrold, Bradley B ^a   Patterson, Ruthi A ^a   Scott, Christopher B ^b   Daneshvar, Hamid ^c   Bacon, Wayne L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WYOMING   (United States)

^c UNIVERSITY OF AKRON   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

ATP inhibition; Insulin degradation; Insulin degrading activity

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BETA,GAMMA METHYLENEADENOSINE TRIPHOSPHATE; ENZYME INHIBITOR; GUANOSINE TRIPHOSPHATE; INSULIN; INSULIN ANTIBODY; INSULINASE; POLYACRYLAMIDE GEL; PYROPHOSPHATE; TRICHLOROACETIC ACID;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; INSULIN DEGRADATION; MALE; NONHUMAN; RAT; SKELETAL MUSCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIBODIES; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ENZYME STABILITY; IMMUNOBLOTTING; INSULIN; INSULYSIN; MALE; MUSCLE, SKELETAL; RATS; RATS, WISTAR; TRICHLOROACETIC ACID;

ANIMALIA;

EID: 0034983855     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Degradation of the cleaved leader peptide of thiolase by a peroxisomal proteinase
2. Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme
3. Insulin degradation: Mechanisms, products and significance
4. Inhibition of insulin degradation by hepatoma cells after microinjection of monoclonal antibodies to a specific cytosolic protease
5. Regulation of insulin, epidermal growth factor, and transforming growth factor-α levels by growth factor-degrading enzymes
6. Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver
7. Developmental regulation of an insulin degrading enzyme from Drosophila melanogaster
8. Insulin degradation: Progress and potential
9. IV. Hormone chemistry and metabolism: Insulinase, insulinase inhibitors and diabetes mellitus
10. Natural regulatory mechanism of insulin degradation by insulin-degrading enzyme
11. Diversity in the effects of extracellular ATP and adenosine on the cellular processing and physiologic actions of insulin in rat adipocytes
12. Fluoride and phosphatidylserine induced inhibition of cytosolic insulin-degrading activity
13. A high-molecular weight metalloendo-protease from the cytosol of mammalian cells
14. Purification and characterization of insulin- degrading enzyme from human erythrocytes
15. 125I-insulin of high specific activity
16. Proteolytic degradation of insulin and glucagon
17. Internalization and degradation of fat cell-bound insulin: Separation and partial characterization of subcellular vesicles associated with iodoinsulin
18. Retroendocitosis of insulin in rat adipocytes
19. The rat insulin-degrading enzyme: Molecular cloning and characterization of tissue-specific transcripts
20. Negative cooperativity in regulatory enzymes
21. Kinetics and enzyme-catalyzed reactions
22. Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues
23. Decreased insulin binding and degradation associated with depressed intracellular ATP content
24. Partial purification and characterization of insulin protease and its intracellular inhibitor from rat liver
25. + channels in cultured bovine adrenal chromaffin cells
26. Roles of molecular chaperones in protein degradation
27. The molecular basis for enzyme regulation
28. Insulin degradation: Assays and enzymes
29. Identification of γ-endorphin generating enzyme as insulin-degrading enzyme
30. 125I-insulin with a cytosolic insulin-degrading enzyme: Detection by covalent crosslinking and immunoprecipitation with monoclonal antibody
31. Association of insulin-degrading enzyme with a 70-kDa cytosolic protein in hepatoma cells
32. 125I-monoiodoglucagon by isolated canine hepatocytes
33. Characterization of a glucagon receptor-linked protease from canine hepatic plasma membranes: Partial purification, kinetic analysis and determination of sites for hormone processing
34. Fate of injected glucagon taken up by rat liver in vivo: Degradation of internalized ligand in the endosomal compartment
35. Miniglucagon production from glucagon: An extracellular processing of a hormone used as a prohormone
36. Differences between renal tubular processing of glucagon and insulin