Molecular basis for the thiol sensitivity of insulin-degrading enzyme

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 28, 2008, Pages 9582-9587

  Neant Fery, Marie ^a   Garcia Ordoñez, Rubén D ^a   Logan, Todd P ^b   Selkoe, Dennis J ^b   Li, Lin ^a   Reinstatler, Lael ^c   Leissring, Malcolm A ^a,b,c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Alzheimer's disease; Amyloid protein; Insulin; Type 2 diabetes mellitus

Indexed keywords

CYSTEINE; INSULINASE; THIOL; ZINC;

ALKYLATION; ALZHEIMER DISEASE; ARTICLE; ENZYMOLOGY; HYDROLYSIS; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALKYLATING AGENTS; BINDING SITES; CYSTEINE; HUMANS; INSULYSIN; MUTAGENESIS, SITE-DIRECTED; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS;

EID: 47749093555     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801261105     Document Type: Article

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