Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

Journal of Biological Chemistry

Volumn 282, Issue 35, 2007, Pages 25453-25463

  Im, Hookang ^a   Manolopoulou, Marika ^a   Malito, Enrico ^a   Shen, Yuequan ^a   Zhao, Ji ^b   Neant Fery, Marie ^b   Sun, Ching Yu ^c   Meredith, Stephen C ^c   Sisodia, Sangram S ^c   Leissring, Malcolm A ^b   Tang, Wei Jen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CONFORMATIONS; DISEASES; ELECTROPHORETIC MOBILITY; ENZYMES; HYDROLYSIS; MOLECULAR STRUCTURE;

ALZHEIMER DISEASE (AD); ATP ACTIVATION; INSULIN-DEGRADING ENZYME (IDE);

INSULIN;

ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; INSULINASE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; ELECTROPHORETIC MOBILITY; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE;

ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIABETES MELLITUS; HUMANS; INSULIN; INSULYSIN; KINETICS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 34548505012     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701590200     Document Type: Article

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