Receptor activation of NADPH oxidases

Antioxidants and Redox Signaling

Volumn 13, Issue 4, 2010, Pages 467-487

  Petry, Andreas ^a   Weitnauer, Michael ^a   Görlach, Agnes ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN; ANGIOTENSIN II; BASIC FIBROBLAST GROWTH FACTOR RECEPTOR; DUAL OXIDASE 1; DUAL OXIDASE 2; G PROTEIN COUPLED RECEPTOR; INSULIN; MEMBRANE RECEPTOR; OXIDOREDUCTASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P22; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; THROMBIN; TUMOR NECROSIS FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN;

CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 77954527981     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.3026     Document Type: Review

References (271)

1. Ambasta R, Schreiber J, Janiszewski M, Busse R, and Brandes R. Noxa1 is a central component of the smooth muscle NADPH oxidase in mice. Free Radic Biol Med 41: 193-201, 2006.
2. Anilkumar N, Weber R, Zhang M, Brewer A, and Shah AM. Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation. Arterioscler Thromb Vasc Biol 28: 1347-1354, 2008.
3. Babior BM. NADPH oxidase: An update. Blood 93: 1464-1476, 1999.
4. Babior BM. NADPH oxidase. Curr Opin Immunol 16: 42-47, 2004.
5. Bae YS, Sung JY, Kim OS, Kim YJ, Hur KC, Kazlauskas A, and Rhee SG. Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphati-dylinositol 3-kinase. J Biol Chem 275: 10527-10531, 2000.
6. Bánfi B, Molnár G, Maturana A, Steger K, Hegedûs B, Demaurex N, and Krause KH. A Ca(2\+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem 276: 37594-37601, 2001.
7. Banfi B, Clark RA, Steger K, and Krause K. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem 278: 3510-3513, 2003.
8. Bánfi B, Tirone F, Durussel I, Knisz J, Moskwa P, Molnár GZ, Krause K, and Cox JA. Mechanism of Ca2\+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem 279: 18583-18591, 2004.
9. Bassus S, Herkert O, Kronemann N, Görlach A, Bremerich D, Kirchmaier CM, Busse R, and Schini-Kerth VB. Thrombin causes vascular endothelial growth factor expression in vascular smooth muscle cells: Role of reactive oxygen species. Arterioscler Thromb Vasc Biol 21: 1550-1555, 2001.
10. Basuroy S, Bhattacharya S, Leffler CW, and Parfenova H. Nox4 NADPH oxidase mediates oxidative stress and apo-ptosis caused by TNF-alpha in cerebral vascular endothe-lial cells. Am J Physiol Cell Physiol 296: C422-432, 2009.
11. Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, and Rosenkranz S. Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem 283: 7864-7876, 2008.
12. Bedard K,and Krause K. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysi-ology. Physiol Rev 87: 245-313, 2007. (Pubitemid 46209993)
13. BelAiba RS, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B, Hess J, Pogrebniak A, Bickel C, and Görlach A. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med 42: 446-459, 2007.
14. Block K, Gorin Y, and Abboud HE. Subcellular localization of Nox4 and regulation in diabetes. Proc Nat Acad Sci USA 106: 14385-14390, 2009.
15. Bockaert J and Pin JP. Molecular tinkering of G protein-coupled receptors: An evolutionary success. EMBO J 18: 1723-1729, 1999.
16. Bokoch GM and Zhao T. Regulation of the phagocyte NADPH oxidase by Rac GTPase. Antioxid Redox Signal 8: 1533-1548, 2006.
17. Boureux A, Furstoss O, Simon V, and Roche S. Abl tyrosine kinase regulates a Rac=JNK and a Rac=Nox pathway for DNA synthesis and Myc expression induced by growth factors. J Cell Sci 118: 3717-3726, 2005.
18. Brandes RP, Miller FJ, Beer S, HaendelerJ,Hoffmann J,Ha T, Holland SM, Görlach A, and Busse R. The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression. Free Radic Biol Med 32: 1116-1122, 2002.
19. Brechard S, Salsmann A, and Tschirhart EJ. OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2\+ entry. J Leukoc Biol 85: 638-647, 2009.
20. Breen EC. VEGF in biological control. J Cell Biochem 102: 1358-1367, 2007.
21. Carnesecchi S, Carpentier J, Foti M, and Szanto I. Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3. Exp Cell Res 312: 3413-3424, 2006.
22. Catarzi S, Biagioni C, Giannoni E, Favilli F, Marcucci T, Iantomasi T, and Vincenzini MT. Redox regulation of platelet-derived-growth-factor-receptor: Role of NADPH-oxidase and c-Src tyrosine kinase. Biochim Biophys Acta 1745: 166-175, 2005.
23. Catarzi S, Giannoni E, Favilli F, Meacci E, Iantomasi T, and Vincenzini MT. Sphingosine 1-phosphate stimulation of NADPH oxidase activity: Relationship with platelet-derived growth factor receptor and c-Src kinase. Biochim Biophys Acta 1770: 872-883, 2007.
24. Chen G and Goeddel DV. TNF-R1 signaling: A beautiful pathway. Science 296: 1634-1635, 2002.
25. Chen J, He R, Minshall RD, Dinauer MC, and Ye RD. Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. J Biol Chem 282: 30273-30284, 2007.
26. Chen J, Zeng H, Lawrence ML, Blackwell TS, and Meyrick B. Angiopoietin-1-induced angiogenesis is modulated by endothelial NADPH oxidase. Am J Physiol Heart Circ Physiol 291: H1563-1572, 2006.
27. Chen K, Kirber MT, Xiao H, Yang Y, and Keaney JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008.
28. Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, and Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol 27: 3313-3326, 2007.
29. Cheng G, Cao Z, Xu X, Meir EGV, and Lambeth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269: 131-140, 2001.
30. Cheng G, Diebold BA, Hughes Y, and Lambeth JD. Nox1-dependent reactive oxygen generation is regulated by Rac1. J Biol Chem 281: 17718-17726, 2006.
31. Cheng G and Lambeth JD. Alternative mRNA splice forms of NOXO1: Differential tissue expression and regulation of Nox1 and Nox3. Gene 356: 118-126, 2005.
32. Cheng G, Ritsick D, and Lambeth JD. Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem 279: 34250-34255, 2004.
33. Choi H, Leto TL, Hunyady L, Catt KJ, Bae YS, and Rhee SG. Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase. J Biol Chem 283: 255-267, 2008.
34. Choi SH, Lee DY, Chung ES, Hong YB, Kim SU, and Jin BK. Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo. J Neurochem 95: 1755-1765, 2005.
35. Claesson-Welsh L. Platelet-derived growth factor receptor signals. J Biol Chem 269: 32023-32026, 1994.
36. Clempus RE, Sorescu D, Dikalova AE, Pounkova L, Jo P, Sorescu GP, Schmidt HHH, Lassègue B, and Griendling KK. Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 27: 42-48, 2007.
37. Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3: 1800-1814, 2005.
38. Cross AR and Segal AW. The NADPH oxidase of professional phagocytes\Prototype of the NOX electron transport chain systems. Biochim Biophys Acta 1657: 1-22, 2004.
39. Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, and Sorescu D. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97: 900-907, 2005.
40. Dang PM, Stensballe A, Boussetta T, Raad H, Dewas C, Kroviarski Y, Hayem G, Jensen ON, Gougerot-Pocidalo M, and El-Benna J. A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxi-dase priming at inflammatory sites. J Clin Invest 116: 2033-2043, 2006.
41. De Deken X, Wang D, Many MC, Costagliola S, Libert F, Vassart G, Dumont JE, and Miot F. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem 275: 23227-23233, 2000.
42. De Deken X, Wang D, Dumont JE, and Miot F. Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. Exp Cell Res 273: 187-196, 2002.
43. Decoursey TE and Ligeti E. Regulation and termination of NADPH oxidase activity. Cell Mol Life Sci 62: 2173-2193, 2005.
44. Dewas C, Dang PM, Gougerot-Pocidalo M, and El-Benna J. TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: Partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor. J Immunol 171: 4392-4398, 2003.
45. Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, and Courtneidge SA. Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2: ra53, 2009.
46. Diebold BA and Bokoch GM. Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol 2: 211-215, 2001.
47. Diebold I, Djordjevic T, Hess J, and Görlach A. Rac-1 promotes pulmonary artery smooth muscle cell proliferation by upregulation of plasminogen activator inhibitor-1: role of NFkappaB-dependent hypoxia-inducible factor-1alpha transcription. Thromb Haemost 100: 1021-1028, 2008.
48. Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, and Görlach A. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angio-genesis by thrombin via Rac1 and NADPH oxidase 2. Circ Res 104: 1169-1177, 2009.
49. Diebold I, Petry A, Djordjevic T, BelAiba RS, Fineman J, Black S, Schreiber C, Fratz S, Hess J, Kietzmann T, and Görlach A. Reciprocal regulation of Rac1 and PAK-1 by HIF-1a: A positive-feedback loop promoting pulmonary vascular remodeling. Antioxid Redox Signal 13, 399-412, 2010.
50. Dikalov SI, Dikalova AE, Bikineyeva AT, Schmidt HH, Harrison DG, and Griendling KK. Distinct rolesofNox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med 45: 1340-1351, 2008.
51. Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, and Parkos CA. The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neu-trophil cytochrome b complex. Nature 327: 717-720, 1987.
52. Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, and Orkin SH. Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J Clin Invest 86: 1729-1737, 1990.
53. Dinauer MC. Regulation of neutrophil function by Rac GTPases. Curr Opin Hematol 10: 8-15, 2003.
54. Djordjevic T, Pogrebniak A, Belaiba R, Bonello S, Wotzlaw C, Acker H, Hess J, and Gorlach A. The expression of the NADPH oxidase subunit p22phox is regulated by a redox-sensitive pathway in endothelial cells. Free Radic Biol Med 38: 616-630, 2005.
55. Djordjevic T, BelAiba RS, Bonello S, Pfeilschifter J, Hess J, and Görlach A. Human urotensin II is a novel activator of NADPH oxidase in human pulmonary artery smooth muscle cells. Arterioscler Thromb Vasc Biol 25: 519-525, 2005.
56. Djordjevic T, Hess J, Herkert O, Görlach A, and BelAiba RS. Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway. Antioxid Redox Signal 6: 713-720, 2004.
57. Dröge W. Free radicals in the physiological control of cell function. Physiol Rev 82: 47-95, 2002.
58. Dusi S, Donini M, Lissandrini D, Mazzi P, Bianca VD, and Rossi F. Mechanisms of expression of NADPH oxidase components in human cultured monocytes: Role of cyto-kines and transcriptional regulators involved. Eur J Immunol 31: 929-938, 2001.
59. El Jamali A, Valente AJ, Lechleiter JD, Gamez MJ, Pearson DW, Nauseef WM, and Clark RA. Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl. Free Radic Biol Med 44: 868-881, 2008.
60. El-Benna J, Dang PM, Gougerot-Pocidalo MA, Marie JC, and Braut-Boucher F. p47phox, the phagocyte NADPH oxidase=NOX2 organizer: structure, phosphorylation and implication in diseases. Exp Mol Med 41: 217-225, 2009.
61. El-Benna J, Dang PM, and Gougerot-Pocidalo M. Priming of the neutrophil NADPH oxidase activation: Role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane. Semin Immunopathol 30: 279-289, 2008.
62. Ellgaard L and Ruddock LW. The human protein dis-ulphide isomerase family: Substrate interactions and functional properties. EMBO Rep 6: 28-32, 2005.
63. Eswarakumar V, Lax I, and Schlessinger J. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16: 139-149, 2005.
64. Fan J, Frey RS, Rahman A, and Malik AB. Role of neutro-phil NADPH oxidase in the mechanism of tumor necrosis factor-alpha-induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells. J Biol Chem 277: 3404-3411, 2002.
65. Fernandes DC, Manoel AHO, Wosniak J, and Laurindo FR. Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposure. Arch Biochem Biophys 484: 197-204, 2009.
66. Finkel T. Signal transduction by reactive oxygen species in non-phagocytic cells. J Leukoc Biol 65: 337-340, 1999.
67. Fischer H. Mechanisms and function of DUOX in epithelia of the lung. Antioxid Redox Signal 11: 2453-2465, 2009.
68. Fischer OM, Giordano S, Comoglio PM, and Ullrich A. Reactive oxygen species mediate Met receptor transactiva-tion by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem 279: 28970-28978, 2004.
69. Fortemaison N, Miot F, Dumont JE, and Dremier S. Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation. Eur J Endocrinol 152: 127-133, 2005.
70. Fortuño A, Bidegain J, San José G, Robador PA, Landecho MF, Beloqui O, D́iez J, and Zalba G. Insulin resistance determines phagocytic nicotinamide adenine dinucleotide phosphate oxidase overactivation in metabolic syndrome patients. J Hypertens 27: 1420-1430, 2009.
71. Frey RS, Rahman A, Kefer JC, Minshall RD, and Malik AB. PKCzeta regulates TNF-alpha-induced activation ofNADPH oxidase in endothelial cells. Circ Res 90: 1012-1019, 2002.
72. Fu X, Beer DG, Behar J, Wands J, Lambeth D, and Cao W. cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem 281: 20368-20382, 2006.
73. Fürst R, Brueckl C, Kuebler WM, Zahler S, Krötz F, Görlach A, Vollmar AM, and Kiemer AK. Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxi-dase=Nox2-activation. Circ Res 96: 43-53, 2005.
74. de Gasparo M, Catt KJ, Inagami T, Wright JW, and Unger T. International union of pharmacology. XXIII. The angio-tensin II receptors. Pharmacol Rev 52: 415-472, 2000.
75. Gavazzi G, Deffert C, Trocme C, Schäppi M, Herrmann FR, and Krause K. NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension 50: 189-196, 2007.
76. Gianni D, Bohl B, Courtneidge SA, and Bokoch GM. The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. Mol Biol Cell 19: 2984-2994, 2008.
77. Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, and Bokoch GM. Novel p47phox-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2: ra54, 2009.
78. Goldstein BJ, Mahadev K, Wu X, Zhu L, and Motoshima H. Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal 7: 1021-1031, 2005.
79. Gong K, Li Z, Xu M, Du J, Lv Z, and Zhang Y. A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein ki-nase activation by beta2-adrenergic receptors. J Biol Chem 283: 29028-29036, 2008.
80. Gorin Y, Ricono JM, Kim N, Bhandari B, Choudhury GG, and Abboud HE. Nox4 mediates angiotensin II-induced activation of Akt=protein kinase B in mesangial cells. Am J Physiol Renal Physiol 285: F219-229, 2003.
81. Görlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, and Busse R. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res 87: 26-32, 2000.
82. Görlach A, Diebold I, Schini-Kerth VB, Berchner-Pfannschmidt U, Roth U, Brandes RP, Kietzmann T, and Busse R. Thrombin activates the hypoxia-inducible factor-1 signaling pathway in vascular smooth muscle cells: Role of the p22(phox)-containing NADPH oxidase. Circ Res 89: 47-54, 2001.
83. Görlach A, Berchner-Pfannschmidt U, Wotzlaw C, Cool RH, Fandrey J, Acker H, Jungermann K, and Kietzmann T. Reactive oxygen species modulate HIF-1 mediated PAI-1 expression: Involvement of the GTPase Rac1. Thromb Hae-most 89: 926-935, 2003.
84. Goyal P, Weissmann N, Rose F, Grimminger F, Schäfers HJ, Seeger W, and Hänze J. Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells. Biochem Biophys Res Commun 329: 32-39, 2005.
85. Graham DB, Robertson CM, Bautista J, Mascarenhas F, Diacovo MJ, Montgrain V, Lam SK, Cremasco V, Dunne WM, Faccio R, Coopersmith CM, and Swat W. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest 117: 3445-3452, 2007.
86. Grandvaux N, Soucy-Faulkner A, and Fink K. Innate host defense: Nox and Duox on phox's tail. Biochimie 89: 1113-1122, 2007.
87. Grasberger H and Refetoff S. Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent. J Biol Chem 281: 18269-18272, 2006.
88. Griendling KK, Sorescu D, and Ushio-Fukai M. NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000.
89. Griendling K, Minieri C, Ollerenshaw J, and Alexander R. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
90. Groemping Y, Lapouge K, Smerdon SJ, and Rittinger K. Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell 113: 343-355, 2003.
91. Guzik TJ, Chen W, Gongora MC, Guzik B, Lob HE, Man-galat D, Hoch N, Dikalov S, Rudzinski P, Kapelak B, Sadowski J, and Harrison DG. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxi-dase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol 52: 1803-1809, 2008.
92. Ha E, Lee K, Park SH, Kim S, Nam H, Lee H, Kang D, and Lee W. Regulation of DUOX by the Galphaq-phospholi-pase Cbeta-Ca2\+ pathway in Drosophila gut immunity. Dev Cell 16: 386-397, 2009.
93. Ha E, Oh C, Bae YS, and Lee W. A direct role for dual oxidase in Drosophila gut immunity. Science 310: 847-850, 2005.
94. Haque MZ. Assessment of renal functional phenotype in mice lacking gp91PHOX subunit of NAD(P)H exidase. Hypertension 43: 335-340, 2004.
95. Harfouche R, Malak NA, Brandes RP, Karsan A, Irani K, and Hussain SNA. Roles of reactive oxygen species in angiopoietin-1=tie-2 receptor signaling. FASEB J 19: 1728-1730, 2005.
96. Harper AM, Dunne MJ, and Segal AW. Purification of cy-tochrome b-245 from human neutrophils. Biochem J 219: 519-527, 1984.
97. van der HeijdenM, van Nieuw Amerongen GP, Chedamni S, van Hinsbergh VWM, and Johan Groeneveld AB. The an-giopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury. Expert Opin Ther Targets 13: 39-53, 2009.
98. Helmcke I, Heumüller S, Tikkanen R, Schröder K, and Brandes RP. Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal 11: 1279-1287, 2009.
99. Herkert O, Diebold I, Brandes RP, Hess J, Busse R, and Görlach A. NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells. Circulation 105: 2030-2036, 2002.
100. Herkert O, Djordjevic T, BelAiba RS, and Görlach A. Insights into the redox control of blood coagulation: Role of vascular NADPH oxidase-derived reactive oxygen species in the thrombogenic cycle. Antioxid Redox Signal 6: 765-776, 2004.
101. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, and Eguchi S. Angiotensin II signal transduction through the AT1 receptor: Novel insights into mechanisms and patho-physiology. Clin Sci 112: 417-428, 2007.
102. Hilenski LL, Clempus RE, Quinn MT, Lambeth JD, and Griendling KK. Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 24: 677-683, 2004.
103. Hingtgen SD. Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardi-omyocyte hypertrophy. Physiol Genom 26: 180-191, 2006.
104. Höhler B, Holzapfel B, and Kummer W. NADPH oxidase subunits and superoxide production in porcine pulmonary artery endothelial cells. Histochem Cell Biol 114: 29-37, 2000.
105. Hollinger S and Hepler JR. Cellular regulation of RGS proteins: Modulators and integrators of G protein signaling. Pharmacol Rev 54: 527-559, 2002.
106. Hu R, Wang Y, Edderkaoui M, Lugea A, Apte MV, and Pandol SJ. Ethanol augments PDGF-induced NADPH oxi-dase activity and proliferation in rat pancreatic stellate cells. Pancreatology 7: 332-340, 2007.
107. Ikeda S, Yamaoka-Tojo M, Hilenski L, Patrushev NA, Anwar GM, Quinn MT, and Ushio-Fukai M. IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2. Arterioscler Thromb Vasc Biol 25: 2295-2300, 2005.
108. Imamura T, Vollenweider P, Egawa K, Clodi M, Ishibashi K, Nakashima N, Ugi S, Adams JW, Brown JH, and Olefsky JM. G alpha-q=11 protein plays a key role in insulin-induced glucose transport in 3T3-L1 adipocytes. Mol Cell Biol 19: 6765-6774, 1999.
109. Jagnandan D, Church JE, Banfi B, Stuehr DJ, Marrero MB, and Fulton DJR. Novel mechanism of activation of NADPH oxidase 5. Calcium sensitization via phosphorylation. J Biol Chem 282: 6494-6507, 2007.
110. Janiszewski M, Lopes LR, Carmo AO, Pedro MA, Brandes RP, Santos CXC, and Laurindo FRM. Regulation of NAD(P)H oxidase by associated protein disulfide isomer-ase in vascular smooth muscle cells. J Biol Chem 280: 40813-40819, 2005.
111. Jay DB, Papaharalambus CA, Seidel-Rogol B, Dikalova AE, Lassègue B, and Griendling KK. Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med 45: 329-335, 2008.
112. Jones SA, O'Donnell VB, Wood JD, Broughton JP, Hughes EJ, and Jones OT. Expression of phagocyte NADPH oxi-dase components in human endothelial cells. Am J Physiol 271: H1626-1634, 1996.
113. Kanzaki M, Watson RT, Artemyev NO, and Pessin JE. The trimeric GTP-binding protein (G(q)=G(11)) alpha subunit is required for insulin-stimulated GLUT4 translocation in 3T3L1 adipocytes. J Biol Chem 275: 7167-7175, 2000.
114. Kao Y, Gianni D, Bohl B, Taylor RM, and Bokoch GM. Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J Biol Chem 283: 12736-12746, 2008.
115. Katoh S, Kamimoto T, Yamakawa D, and Takakura N. Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells. Exp Cell Res 315: 2818-2823, 2009.
116. Kawahara T, Kohjima M, Kuwano Y, Mino H, Teshima-Kondo S, Takeya R, Tsunawaki S, Wada A, Sumimoto H, and Rokutan K. Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol 288: C450-457, 2005.
117. Kawahara T, and Lambeth JD. Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes. BMC Evol Biol 7: 178, 2007.
118. Kawahara T, and Lambeth JD. Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell 19: 4020-4031, 2008.
119. Kawahara T, Quinn MT, and Lambeth JD. Molecular evolution of the reactive oxygen-generating NADPH oxi-dase (Nox=Duox) family of enzymes. BMC Evol Biol 7: 109, 2007.
120. Kawahara T, Ritsick D, Cheng G, and Lambeth JD. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1-and Nox2-dependent reactive oxygen generation. J Biol Chem 280: 31859-31869, 2005.
121. Kim J, Diebold BA, Babior BM, Knaus UG, and Bokoch GM. Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem. 282: 34787-34800, 2007.
122. Kim YM, Kim KE, Koh GY, Ho Y, and Lee K. Hydrogen peroxide produced by angiopoietin-1 mediates angiogene-sis. Cancer Res 66: 6167-6174, 2006.
123. Kim Y, Morgan MJ, Choksi S, and Liu Z. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell 26: 675-687, 2007.
124. Klaile E, Kukalev A, Obrink B, and Mü ller MM. PDIP38 is a novel mitotic spindle-associated protein that affects spindle organization and chromosome segregation. Cell Cycle 7: 3180-3186, 2008.
125. Koga H, Terasawa H, Nunoi H, Takeshige K, Inagaki F, and Sumimoto H. Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase. J Biol Chem 274: 25051-25060, 1999.
126. Kontos CD, Cha EH, York JD, and Peters KG. The endo-thelial receptor tyrosine kinase Tie1 activates phosphati-dylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol 22: 1704-1713, 2002.
127. Kreuzer J, Nürnberg B, and Krieger-Brauer HI. Ligand-dependent autophosphorylation of the insulin receptor is positively regulated by Gi-proteins. Biochem J 380: 831-836, 2004.
128. Kreuzer J, Viedt C, Brandes RP, Seeger F, Rosenkranz AS, Sauer H, Babich A, Nürnberg B, Kather H, and Krieger-Brauer HI. Platelet-derived growth factor activates production of reactive oxygen species by NAD(P)H oxidase in smooth muscle cells through Gi1,2. FASEB J 17: 38-40, 2003.
129. Krieger-Brauer HI and Kather H. Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase. J Clin Invest 89: 1006-1013, 1992.
130. Krieger-Brauer HI and Kather H. Antagonistic effects of different members of the fibroblast and platelet-derived growth factor families on adipose conversion and NADPH-dependent H2O2 generation in 3T3 L1-cells. Biochem J 307: 549-556, 1995.
131. Krieger-Brauer HI and Kather H. The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines. Biochem J 307: 543-548, 1995.
132. Krieger-Brauer HI, Medda PK, and Kather H. Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2. J Biol Chem 272: 10135-10143, 1997.
133. Kuribayashi F, Nunoi H, Wakamatsu K, Tsunawaki S, Sato K, Ito T, and Sumimoto H. The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase. EMBO J 21: 6312-6320, 2002.
134. Kuroda J, Nakagawa K, Yamasaki T, Nakamura K, Takeya R, Kuribayashi F, Imajoh-Ohmi S, Igarashi K, Shibata Y, Sueishi K, and Sumimoto H. The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells. Genes Cells 10: 1139-1151, 2005.
135. Kuwano Y, Tominaga K, Kawahara T, Sasaki H, Takeo K, Nishida K, Masuda K, Kawai T, Teshima-Kondo S, and Rokutan K. Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. Free Radic Biol Med 45: 1642-1652, 2008.
136. Kwon J, Lee S, Yang K, Ahn Y, Kim YJ, Stadtman ER, and Rhee SG. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci USA 101: 16419-16424, 2004.
137. Lamalice L, Le Boeuf F, and Huot J. Endothelial cell migration during angiogenesis. Circ Res 100: 782-794, 2007.
138. Lambeth JD, Cheng G, Arnold RS, and Edens WA. Novel homologs of gp91phox. Trends Biochem Sci 25: 459-461, 2000.
139. Lambeth JD, Kawahara T, and Diebold B. Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med 43: 319-331, 2007.
140. Lange S, Heger J, Euler G, Wartenberg M, Piper HM, and Sauer H. Platelet-derived growth factor BB stimulates vasculogenesis of embryonic stem cell-derived endothelial cells by calcium-mediated generation of reactive oxygen species. Cardiovasc Res 81: 159-168, 2009.
141. Larrick JW, Graham D, Toy K, Lin LS, Senyk G, and Fendly BM. Recombinant tumor necrosis factor causes activation of human granulocytes. Blood 69: 640-644, 1987.
142. Larsen BT, Bubolz AH, Mendoza SA, Pritchard KA, and Gutterman DD. Bradykinin-induced dilation of human coronary arterioles requires NADPH oxidase-derived reactive oxygen species. Arterioscler Thromb Vasc Biol 29: 739-745, 2009.
143. Lassegue B, Sorescu D, Szocs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, and Griendling KK. Novel gp91phox homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res. 88: 888-894, 2001.
144. Lee S, Gharavi NM, Honda H, Chang I, Kim B, Jen N, Li R, Zimman A, and Berliner JA. A role for NADPH oxidase 4 in the activation of vascular endothelial cells by oxidized phospholipids. Free Radic Biol Med 47: 145-151, 2009.
145. Leevers SJ, Vanhaesebroeck B, and Waterfield MD. Signalling through phosphoinositide 3-kinases: The lipids take centre stage. Curr Opin Cell Biol 11: 219-225, 1999.
146. Li J, Fan LM, Christie MR, and Shah AM. Acute tumor necrosis factor alpha signaling via NADPH oxidase in micro-vascular endothelial cells: Role of p47phox phosphorylation and binding to TRAF4. Mol Cell Biol 25: 2320-2330, 2005.
147. Li J and Shah AM. Mechanism of endothelial cell NADPH oxidase activation by angiotensin II. Role of the p47phox subunit. J Biol Chem 278: 12094-12100, 2003.
148. Li Q, Spencer NY, Oakley FD, Buettner GR, and Engelhardt J. Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNFalpha. Antioxid Redox Signal 11: 1249-1263, 2008.
149. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, and Lee MYWT. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. J Biol Chem. 278: 10041-10047, 2003.
150. von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, and Knaus UG. Mutational analysis reveals distinct features of the Nox4-p22 phox complex. J Biol Chem 283: 35273-35282, 2008.
151. Lopes LR, Dagher M, Gutierrez A, Young B, Bouin A, Fuchs A, and Babior BM. Phosphorylated p40PHOX as a negative regulator of NADPH oxidase. Biochemistry 43: 3723-3730, 2004.
152. Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, and Knaus UG. Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci 122: 1238-1247, 2009.
153. Lyle AN, Deshpande NN, Taniyama Y, Seidel-Rogol B, Pounkova L, Du P, Papaharalambus C, Lassègue B, and Griendling KK. Poldip2, a novel regulator of nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res 105: 249-259, 2009.
154. Mahadev K, Wu X, Zilbering A, Zhu L, Lawrence JT, and Goldstein BJ. Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem 276: 48662-48669, 2001.
155. Mahadev K, Zilbering A, Zhu L, and Goldstein BJ. Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J Biol Chem 276: 21938-21942, 2001.
156. Mahadev K, Motoshima H, Wu X, Ruddy JM, Arnold RS, Cheng G, Lambeth JD, and Goldstein BJ. The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol 24: 1844-1854, 2004.
157. Martyn KD, Kim M, Quinn MT, Dinauer MC, and Knaus UG. p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood 106: 3962-3969, 2005.
158. Martyn KD, Frederick LM, Loehneysen KV, Dinauer MC, and Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18: 69-82, 2006.
159. Marumo T, Schini-Kerth VB, Fisslthaler B, and Busse R. Platelet-derived
160. Maruo Y, Takahashi H, Soeda I, Nishikura N, Matsui K, Ota Y, Mimura Y, Mori A, Sato H, and Takeuchi Y. Transient congenital hypothyroidism caused by biallelic mutations of the dual oxidase 2 gene in Japanese patients detected by a neonatal screening program. J Clin Endocrinol Metab 93: 4261-4267, 2008.
161. Matsuno K, Yamada H, Iwata K, Jin D, Katsuyama M, Matsuki M, Takai S, Yamanishi K, Miyazaki M, Matsubara H, and Yabe-Nishimura C. Nox1 is involved in angiotensin II-mediated hypertension: A study in Nox1-deficient mice. Circulation 112: 2677-2685, 2005.
162. Matsuo J, Oku H, Kanbara Y, Kobayashi T, Sugiyama T, and Ikeda T. Involvement of NADPH oxidase and protein kinase C in endothelin-1-induced superoxide production in retinal microvessels. Exp Eye Res 89: 693-695, 2009.
163. Meng D, Lv D, and Fang J. Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. Cardiovasc Res 80: 299-308, 2008.
164. Miller FJ, Filali M, Huss GJ, Stanic B, Chamseddine A, Barna TJ, and Lamb FS. Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circ Res 101: 663-671, 2007.
165. Ming W, Li S, Billadeau DD, Quilliam LA, and Dinauer MC. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol 27: 312-323, 2007.
166. Miyano K and Sumimoto H. Role of the small GTPase Rac in p22phox-dependent NADPH oxidases. Biochimie 89: 1133-1144, 2007.
167. Miyano K, Koga H, Minakami R, and Sumimoto H. The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases. Biochem J 422: 373-382, 2009.
168. Miyano K, Ueno N, Takeya R, and Sumimoto H. Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. J Biol Chem 281: 21857-21868, 2006.
169. Mizrahi A, Molshanski-Mor S, Weinbaum C, Zheng Y, Hirshberg M, and Pick E. Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphos-phate kinase. J Biol Chem 280: 3802-3811, 2005.
170. Moe KT, Aulia S, Jiang F, Chua YL, Koh TH, Wong MC, and Dusting GJ. Differential upregulation of Nox homo-logues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells. J Cell Mol Med 10: 231-239, 2006.
171. Morand S, Agnandji D, Noel-Hudson M, Nicolas V, Buis-son S, Macon-Lemaitre L, Gnidehou S, Kaniewski J, Oha-yon R, Virion A, and Dupuy C. Targeting of the dual oxidase 2N-terminal region to the plasma membrane. J Biol Chem. 279: 30244-30251, 2004.
172. Morand S, Chaaraoui M, Kaniewski J, Deme D, Ohayon R, Noel-Hudson MS, Virion A, and Dupuy C. Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles. Endocrinology 144: 1241-1248, 2003.
173. Morand S, Ueyama T, Tsujibe S, Saito N, Korzeniowska A, and Leto TL. Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J 23: 1205-1218, 2009.
174. Moreno JC, Bikker H, Kempers MJ, van Trotsenburg AP, Baas F, de Vijlder JJ, Vulsma T, and Ris-Stalpers C. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med 347: 95-102, 2002.
175. Mukherjee SP and Lynn WS. Reduced nicotinamide ade-nine dinucleotide phosphate oxidase in adipocyte plasma membrane and its activation by insulin. Possible role in the hormone's effects on adenylate cyclase and the hexose monophosphate shunt. Arch Biochem Biophys 184: 69-76, 1977.
176. Murillo MM, Carmona-Cuenca I, Del Castillo G, Ortiz C, Roncero C, Sánchez A, Fernández M, and Fabregat I. Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism. BiochemJ 405: 251-259, 2007.
177. Nakano Y, Banfi B, Jesaitis AJ, Dinauer MC, Allen LH, and Nauseef WM. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J 403: 97-108, 2007.
178. Nauseef WM. How human neutrophils kill and degrade microbes: An integrated view. Immunol Rev 219: 88-102, 2007.
179. Newburger PE, Dai Q, and Whitney C. In vitro regulation of human phagocyte cytochrome b heavy and light chain gene expression by bacterial lipopolysaccharide and recombinant human cytokines. J Biol Chem 266: 16171-16177, 1991.
180. Niethammer P, Grabher C, Look AT, and Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 459: 996-999, 2009.
181. Nisbet RE, Graves AS, Kleinhenz DJ, Rupnow HL, Reed AL, Fan TM, Mitchell PO, Sutliff RL, and Hart CM. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Am J Respir Cell Mol Biol 40: 601-609, 2009.
182. Nisimoto Y, Motalebi S, Han CH, and Lambeth JD. The p67(phox) activation domain regulates electron flow from NADPH to flavin in flavocytochrome b(558). J Biol Chem 274: 22999-23005, 1999.
183. Niu J, Profirovic J, Pan H, Vaiskunaite R, and Voyno-Yasenetskaya T. G protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: Regulation of cell shape and reactive oxygen species production. Circ Res 93: 848-856, 2003.
184. Oakley FD, Abbott D, Li Q, and Engelhardt J. Signaling components of redox active endosomes: The redoxosomes. Antioxid Redox Signal 11: 1313-1333, 2009.
185. Pachucki J, Wang D, Christophe D, and Miot F. Structural and functional characterization of the two human ThOX=Duox genes and their 5'-flanking regions. Mol Cell Endocrinol 214: 53-62, 2004.
186. Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, and Knaus UG. Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem 283: 24649-24658, 2008.
187. Paffenholz R, Bergstrom RA, Pasutto F, Wabnitz P, Munroe RJ, Jagla W, Heinzmann U, Marquardt A, Bareiss A, Laufs J, Russ A, Stumm G, Schimenti JC, and Bergstrom DE. Vestib-ular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev 18: 486-491, 2004.
188. Pantano C, Shrivastava P, McElhinney B, and Janssen-Heininger Y. Hydrogen peroxide signaling through tumor necrosis factor receptor 1 leads to selective activation of c-Jun N-terminal kinase. J Biol Chem 278: 44091-44096, 2003.
189. Park HS, Lee SH, Park D, Lee JS, Ryu SH, Lee WJ, Rhee SG, and Bae YS. Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2. Mol Cell Biol 24: 4384-4394, 2004.
190. Park KW and Jin BK. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: Role of neuronal NADPH oxidase. J Neurosci Res 86: 1053-1063, 2008.
191. Patterson C, Ruef J, Madamanchi NR, Barry-Lane P, Hu Z, Horaist C, Ballinger CA, Brasier AR, Bode C, and Runge MS. Stimulation of a vascular smooth muscle cell NAD(P)H oxidase by thrombin. Evidence that p47(phox) may participate in forming this oxidase in vitro and in vivo. J Biol Chem 274: 19814-19822, 1999.
192. Paxton WG, Marrero MB, Klein JD, Delafontaine P, Berk BC, and Bernstein KE. The angiotensin II AT1 receptor is tyrosine and serine phosphorylated and can serve as a substrate for the src family of tyrosine kinases. Biochem Biophys Res Commun 200: 260-267, 1994.
193. Pedruzzi E, Guichard C, Ollivier V, Driss F, Fay M, Prunet C, Marie J, Pouzet C, Samadi M, Elbim C, O'Dowd Y, Bens M, Vandewalle A, Gougerot-Pocidalo M, Lizard G, and Ogier-Denis E. NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cells. Mol Cell Biol 24: 10703-10717, 2004.
194. Pendergrass KD, Gwathmey TM, Michalek RD, Grayson JM, and Chappell MC. The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus. Biochem Biophys Res Commun 384: 149-154, 2009.
195. Peshavariya H, Jiang F, Taylor CJ, Selemidis S, Chang CWT, and Dusting G. Translation-linked mRNA destabilization accompanying serum-induced Nox4 expression in human endothelial cells. Antioxid Redox Signal 11: 2399-2408, 2009.
196. Petry A, Djordjevic T, Weitnauer M, Kietzmann T, Hess J, and Görlach A. NOX2 and NOX4 mediate proliferative response in endothelial cells. Antioxid Redox Signal 8: 1473-1484, 2006.
197. Piccoli C, D'Aprile A, Scrima R, Ripoli M, Boffoli D, Tabilio A, and Capitanio N. Role of reactive oxygen species as signal molecules in the pre-commitment phase of adult stem cells. Ital J Biochem 56: 295-301, 2007.
198. Plesková M, Beck K, Behrens MH, Huwiler A, Fichtlscherer B, Wingerter O, Brandes RP, Mülsch A, and Pfeilschifter J. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. FASEB J 20: 139-141, 2006.
199. Price MO, Atkinson SJ, Knaus UG, and Dinauer MC. Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem 277: 19220-19228, 2002.
200. Raad H, Paclet M, Boussetta T, Kroviarski Y, Morel F, Quinn MT, Gougerot-Pocidalo M, Dang PM, and El-Benna J. Regulation of the phagocyte NADPH oxidase activity: Phosphorylation of gp91phox=NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox. FASEB J. 23: 1011-1022, 2009.
201. Rada B and Leto TL. Oxidative innate immune defenses by Nox=Duox family NADPH oxidases. Contrib Microbiol 15: 164-187, 2008.
202. Rameh LE and Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274: 8347-8350, 1999.
203. Regier DS, Greene DG, Sergeant S, Jesaitis AJ, and McPhail LC. Phosphorylation of p22phox is mediated by phospho-lipase D-dependent and-independent mechanisms. J Biol Chem 275: 28406-28412, 2000.
204. Rhee SG. Regulation of phosphoinositide-specific phos-pholipase. Annu Rev Biochem. 70: 281-312, 2001.
205. Rhee SG, Chang T, Bae YS, Lee S, and Kang SW. Cellular regulation by hydrogen peroxide. J Am Soc Nephrol 14: S211-215, 2003.
206. Rigutto S, Hoste C, Grasberger H, Milenkovic M, Communi D, Dumont JE, Corvilain B, Miot F, and De Deken X. Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem 284: 6725-6734, 2009.
207. Roepstorff K, Rasmussen I, Sawada M, Cudre-Maroux C, Salmon P, Bokoch G, van Deurs B, and Vilhardt F. Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. J Biol Chem 283: 7983-7993, 2008.
208. Rotrosen D, Yeung CL, Leto TL, Malech HL, and Kwong CH. Cytochrome b558: The flavin-binding component of the phagocyte NADPH oxidase. Science 256: 1459-1462, 1992.
209. Rygiel TP, Mertens AE, Strumane K, van der Kammen R, and Collard JG. The Rac activator Tiam1 prevents kerati-nocyte apoptosis by controlling ROS-mediated ERK phos-phorylation. J Cell Sci 121: 1183-1192, 2008.
210. Saltiel AR and Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001.
211. Sánchez-Margalet V, González-Yanes C, Santos-Alvarez J, and Najib S. Insulin activates G alpha il,2 protein in rat hepatoma (HTC) cell membranes. Cell Mol Life Sci 55: 142-147, 1999.
212. Santos CXC, Stolf BS, Takemoto PVA, Amanso AM, Lopes LR, Souza EB, Goto H, and Laurindo FRM. Protein dis-ulfide isomerase (PDI) associates with NADPH oxidase and is required for phagocytosis of Leishmania chagasi promas-tigotes by macrophages. J Leukoc Biol 86: 989-998, 2009.
213. Sarfstein R, Gorzalczany Y, Mizrahi A, Berdichevsky Y, Molshanski-Mor S, Weinbaum C, Hirshberg M, Dagher M, and Pick E. Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: A study based on mutagenesis of p67phox-Rac1 chimeras. J Biol Chem 279: 16007-16016, 2004.
214. Sasaki H, Yamamoto H, Tominaga K, Masuda K, Kawai T, Teshima-Kondo S, and Rokutan K. NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts. J Med Invest 56: 33-41, 2009.
215. Schiller MR. Coupling receptor tyrosine kinases to Rho GTPases\GEFs what's the link. Cell Signal 18: 1834-1843, 2006.
216. Schroder K, Helmcke I, Palfi K, Krause K, Busse R, and Brandes RP. Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arter-ioscler Thromb Vasc Biol 27: 1736-1743, 2007.
217. Schröder K, Wandzioch K, Helmcke I, and Brandes RP. Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol 29: 239-245, 2009.
218. Seo JH, Ahn Y, Lee S, Yeol Yeo C, and Chung Hur K. The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phospha-tase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase=Akt pathway. Mol Biol Cell 16: 348-357, 2005.
219. Serrander L, Jaquet V, Bedard K, Plastre O, Hartley O, Arnaudeau S, Demaurex N, Schlegel W, and Krause K. NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie 89: 1159-1167, 2007.
220. Seshiah PN, Weber DS, Rocic P, Valppu L, Taniyama Y, and Griendling KK. Angiotensin II stimulation of NAD(P)H oxidase activity: Upstream mediators. Circ Res 91: 406-413, 2002.
221. Seta K, Nanamori M, Modrall JG, Neubig RR, and Sa-doshima J. AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol Chem 277: 9268-9277, 2002.
222. Shin E, Shin K, Lee C, Woo K, Quan S, Soung N, Kim YG, Cha CI, Kim S, Park D, Bokoch GM, and Kim E. Phos-phorylation of p85 beta PIX, a Rac=Cdc42-specific guanine nucleotide exchange factor, via the Ras=ERK=PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem 277: 44417-44430, 2002.
223. Simon F and Stutzin A. Protein kinase C-mediated phos-phorylation of p47 phox modulates platelet-derived growth factor-induced H2O2 generation and cell proliferation in human umbilical vein endothelial cells. Endothelium 15: 175-188, 2008.
224. Smith NJ, Chan H, Osborne JE, Thomas WG, and Hannan RD. Hijacking epidermal growth factor receptors by an-giotensin II: New possibilities for understanding and treating cardiac hypertrophy. Cell Mol Life Sci 61: 2695-2703, 2004.
225. Sthilaire C, Koupenova M, Carroll S, Smith B, and Ravid K. TNF-a upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4. Biochem Biophys Res Comm 375: 292-296, 2008.
226. Sturrock A, Huecksteadt TP, Norman K, Sanders K, Murphy TM, Chitano P, Wilson K, Hoidal JR, and Kennedy TP. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 292: L1543-1555, 2007.
227. Suh YA, Arnold RS, Lassègue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, and Lambeth JD. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: 79-82, 1999.
228. Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J 275: 3249-3277, 2008.
229. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, and Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270: 296-299, 1995.
230. Takeya R, Taura M, Yamasaki T, Naito S, and Sumimoto H. Expression and function of Noxo1g, an alternative splicing form of the NADPH oxidase organizer 1. FEBS J. 273: 3663-3677, 2006.
231. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, and Sumimoto H. Novel human homologues of p47phox and p67phox participate in activation of super-oxide-producing NADPH oxidases. J Biol Chem 278: 25234-25246, 2003.
232. Taura M, Miyano K, Minakami R, Kamakura S, Takeya R, and Sumimoto H. A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase. BiochemJ419: 329-338, 2009.
233. Tennenberg SD and Solomkin JS. Activation of neutrophils by cachectin=tumor necrosis factor: Priming of N-formyl-methionyl-leucyl- phenylalanine-induced oxidative responsiveness via receptor mobilization without degranulation. J Leukoc Biol 47: 217-223, 1990.
234. Tirone F and Cox JA. NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. FEBS Lett 581: 1202-1208, 2007.
235. Touyz RM and Berry C. Recent advances in angiotensin II signaling. Braz J Med Biol Res 35: 1001-1015, 2002.
236. Touyz RM, Yao G, and Schiffrin EL. c-Src induces phos-phorylation and translocation of p47phox: Role in super-oxide generation by angiotensin II in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23: 981-987, 2003.
237. Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, and Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II. Circ Res 90: 1205-1213, 2002.
238. Turano C, Coppari S, Altieri F, and Ferraro A. Proteins of the PDI family: unpredicted non-ER locations and functions. J Cell Physiol 193: 154-163, 2002.
239. Turner M and Billadeau DD. VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol 2: 476-486, 2002.
240. Tybulewicz VLJ. Vav-family proteins in T-cell signalling. Curr Opin Immunol 17: 267-274, 2005.
241. Ueyama T, Geiszt M, and Leto TL. Involvement of Rac1 in activation of multicomponent Nox1-and Nox3-based NADPH oxidases. Mol Cell Biol 26: 2160-2174, 2006.
242. Ueyama T, Lekstrom K, Tsujibe S, Saito N, and Leto TL. Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med 42: 180-190, 2007.
243. Ugolev Y, Berdichevsky Y, Weinbaum C, and Pick E. Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phos-phatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP. J Biol Chem 283: 22257-22271, 2008.
244. Ugolev Y, Molshanski-Mor S, Weinbaum C, and Pick E. Liposomes comprising anionic but not neutral phospho-lipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes. J Biol Chem 281: 19204-19219, 2006.
245. Urano D, Nakata A, Mizuno N, Tago K, and Itoh H. Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA. Cell Signal 20: 1545-1554, 2008.
246. Ushio-Fukai M. Localizing NADPH oxidase-derived ROS. Sci STKE 2006: re8, 2006.
247. Ushio-Fukai M. VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 9: 731-739, 2007.
248. Ushio-Fukai M, Griendling KK, Becker PL, Hilenski L, Halleran S, and Alexander RW. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 21: 489-495, 2001.
249. Ushio-Fukai M, Tang Y, Fukai T, Dikalov SI, Ma Y, Fuji-moto M, Quinn MT, Pagano PJ, Johnson C, and Alexander RW. Novel role of gp91(phox)-containing NAD(P)H oxi-dase in vascular endothelial growth factor-induced signaling and angiogenesis. Circ. Res 91: 1160-1167, 2002.
250. Ushio-Fukai M, Zafari AM, Fukui T, Ishizaka N, and Griendling KK. p22phox is a ritical omponent of the superoxide-generating NADH=NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271: 23317-23321, 1996.
251. Utomo A, Cullere X, Glogauer M, Swat W, and Mayadas TN. Vav proteins in neutrophils are required for Fcgam-maR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol 177: 6388-6397, 2006.
252. Valente AJ, El Jamali A, Epperson TK, Gamez MJ, Pearson DW, and Clark RA. NOX1 NADPH oxidase regulation by the NOXA1 SH3 domain. Free Radic Biol Med 43: 384-396, 2007.
253. Van Buul JD, Fernandez-Borja M, Anthony EC, and Hor-dijk PL. Expression and localization of NOX2 and NOX4 in primary human endothelial cells. Antioxid Redox Signal 7: 308-317, 2005.
254. Viedt C, Fei J, Krieger-Brauer HI, Brandes RP, Teupser D, Kamimura M, Katus HA, and Kreuzer J. Role of p22phox in angiotensin II and platelet-derived growth factor AA induced activator protein 1 activation in vascular smooth muscle cells. J Mol Med 82: 31-38, 2004. (Pubitemid 38168100)
255. Wajant H, Pfizenmaier K, and Scheurich P. Tumor necrosis factor signaling. Cell Death Differ 10: 45-65, 2003.
256. Wang D, De Deken X, Milenkovic M, Song Y, Pirson I, Dumont JE, and Miot F. Identification of a novel partner of Duox: EFP1, a thioredoxin-related protein. J Biol Chem 280: 3096-3103, 2005.
257. Welch EJ, Naikawadi RP, Li Z, Lin P, Ishii S, Shimizu T, Tiruppathi C, Du X, Subbaiah PV, and Ye RD. Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. Mol Pharmacol 75: 227-234, 2009.
258. Welch HC, Condliffe AM, Milne LJ, Ferguson GJ, Hill K, Webb LM, Okkenhaug K, Coadwell WJ, Andrews SR, and Thelen M. P-Rex1 regulates neutrophil function. Curr Biol 15: 1867-1873, 2005.
259. Wilkinson B, Koenigsknecht-Talboo J, Grommes C, Lee CYD, and Landreth G. Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and mi-croglia. J Biol Chem 281: 20842-20850, 2006.
260. Wolin MS. Reactive oxygen species and vascular signal transduction mechanisms. Microcirculation 3: 1-17, 1996.
261. Wong HL, Pinontoan R, Hayashi K, Tabata R, Yaeno T, Hasegawa K, Kojima C, Yoshioka H, Iba K, Kawasaki T, and Shimamoto K. Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension. Plant Cell 19: 4022-4034, 2007.
262. Wu RF, Gu Y, Xu YC, Nwariaku FE, and Terada LS. Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1. J Biol Chem 278: 36830-36840, 2003.
263. Xiao Q, Luo Z, Pepe AE, Margariti A, Zeng L, and Xu Q. Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2. Am J Physiol Cell Physiol 296: C711-723, 2009.
264. Yamamoto A, Kami K, Takeya R, and Sumimoto H. Interaction between the SH3 domains and C-terminal pro-line-rich region in NADPH oxidase organizer 1 (Noxo1). Biochem Biophys Res Commun 352: 560-565, 2007.
265. Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, Dikalov SI, Chen YE, Tojo T, Fukai T, Fujimoto M, Patrushev NA, Wang N, Kontos CD, Bloom GS, and Alexander RW. IQ-GAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ Res 95: 276-283, 2004.
266. Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pon-gratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, and Krönke M. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature 460: 1159-1163, 2009.
267. Yoshida LS and Tsunawaki S. Expression of NADPH oxi-dases and enhanced H(2)O(2)-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-alpha. Int Immunopharmacol 8: 1377-1385, 2008.
268. Yuo A, Kitagawa S, Suzuki I, Urabe A, Okabe T, Saito M, and Takaku F. Tumor necrosis factor as an activator of human granulocytes. Potentiation of the metabolisms triggered by the Ca2\+-mobilizing agonists. J Immunol 142: 1678-1684, 1989.
269. Zhang X, Shan P, Jiang G, Cohn L, and Lee PJ. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest 116: 3050-3059, 2006.
270. Zhao T, Benard V, Bohl BP, and Bokoch GM. The molecular basis for adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. J Clin Invest 112: 1732-1740, 2003.
271. Zuo L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, and Alexander RW. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: Role in redox signaling and vascular hypertrophy. Arterioscler Thromb Vasc Biol 25: 1824-1830, 2005.