Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

Free Radical Biology and Medicine

Volumn 53, Issue 2, 2012, Pages 289-296

  Jiang, Joy X ^a   Chen, Xiangling ^a   Serizawa, Nobuko ^a   Szyndralewiez, Cédric ^b   Page, Patrick ^b   Schröder, Katrin ^c   Brandes, Ralf P ^c   Devaraj, Sridevi ^d   Török, Natalie J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENKYOTEX SA   (Switzerland)

^c GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hepatocyte apoptosis; Liver fibrosis; NADPH oxidase 4; Stellate cell activation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; CASPASE 3; DACTINOMYCIN; FAS LIGAND; GKT137831; OXIDOREDUCTASE INHIBITOR; PROCOLLAGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; AUTOIMMUNE HEPATITIS; BILE DUCT LIGATION; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE DELETION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STELLATE CELL; TRANSLATIONAL RESEARCH; UPREGULATION;

ANIMALS; APOPTOSIS; BILE DUCTS; DACTINOMYCIN; FAS LIGAND PROTEIN; GENE DELETION; HEPATIC STELLATE CELLS; HEPATITIS, AUTOIMMUNE; HEPATOCYTES; HUMANS; LIGATION; LIVER; LIVER CIRRHOSIS; MICE; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; PYRAZOLES; PYRIDINES; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 84862290446     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.007     Document Type: Article

References (27)

1. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669 (Pubitemid 351615417)
2. N. Nieto, S.L. Friedman, and A.I. Cederbaum Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells J. Biol. Chem 277 2002 9853 9864 (Pubitemid 34968090)
3. Jiang, J.X.; Venugopal, S.; Serizawa, N.; Chen, X.; Scott, F.; Li, Y.; Adamson, R.; Devaraj, S.; Shah, V.; Gershwin, M.E.; Friedman, S.L.; Torok, N.J. Nicotinamide adenine dinucleotide phosphate reduced oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo. Gastroenterology; 2010.
4. Y.H. Paik, K. Iwaisako, E. Seki, S. Inokuchi, B. Schnabl, C.H. Osterreicher, T. Kisseleva, and D.A. Brenner The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice Hepatology 53 2011 1730 1741
5. W. Cui, K. Matsuno, K. Iwata, M. Ibi, M. Matsumoto, J. Zhang, K. Zhu, M. Katsuyama, N.J. Torok, and C. Yabe-Nishimura NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation Hepatology 2011
6. N.S. De Mochel, S. Seronello, S.H. Wang, C. Ito, J.X. Zheng, T.J. Liang, J.D. Lambeth, and J. Choi Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection Hepatology 52 2010 47 59
7. N.Y. Spencer, Z. Yan, R.L. Boudreau, Y. Zhang, M. Luo, Q. Li, X. Tian, A.M. Shah, R.L. Davisson, B. Davidson, B. Banfi, and J.F. Engelhardt Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4 J. Biol. Chem. 286 2011 8977 8987
8. L. Hecker, R. Vittal, T. Jones, R. Jagirdar, T.R. Luckhardt, J.C. Horowitz, S. Pennathur, F.J. Martinez, and V.J. Thannickal NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury Nat. Med 15 2009 1077 1081
9. J.L. Barnes, and Y. Gorin Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases Kidney Int. 79 2011 944 956
10. R. Reinehr, S. Becker, A. Eberle, S. Grether-Beck, and D. Haussinger Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis J. Biol. Chem. 280 2005 27179 27194 (Pubitemid 41040757)
11. I. Carmona-Cuenca, C. Roncero, P. Sancho, L. Caja, N. Fausto, M. Fernandez, and I. Fabregat Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity J. Hepatol. 49 2008 965 976
12. B. Laleu, F. Gaggini, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Houngninou-Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, and P. Page First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis J. Med. Chem. 53 2010 7715 7730
13. M.Z. Katrin Schroder, Sebastian Benkhoff, Anja Mieth, Rainer Pliquett, Judith Kosowski, Christoph Kruse, P.L.d., U. Ruth Michaelis, Norbert Weissmann, Stefanie Dimmeler, and Ajay M. Shah R. P. B. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase Circ. Res. 2012
14. A. Geerts, T. Niki, K. Hellemans, D. De Craemer, K. Van Den Berg, J.M. Lazou, G. Stange, M. Van De Winkel, and P. De Bleser Purification of rat hepatic stellate cells by side scatter-activated cell sorting Hepatology 27 1998 590 598 (Pubitemid 28081078)
15. M.E. Guicciardi, J. Deussing, H. Miyoshi, S.F. Bronk, P.A. Svingen, C. Peters, S.H. Kaufmann, and G.J. Gores Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c J. Clin. Invest. 106 2000 1127 1137
16. S. De Minicis, E. Seki, H. Uchinami, J. Kluwe, Y. Zhang, D.A. Brenner, and R.F. Schwabe Gene expression profiles during hepatic stellate cell activation in culture and in vivo Gastroenterology 132 2007 1937 1946 (Pubitemid 46677935)
17. V. Hernandez-Gea, and S.L. Friedman Pathogenesis of liver fibrosis Annu. Rev. Pathol 6 2011 425 456
18. E.S. Baskin-Bey, W. Huang, N. Ishimura, H. Isomoto, S.F. Bronk, K. Braley, R.W. Craig, D.D. Moore, and G.J. Gores Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins Hepatology 44 2006 252 262 (Pubitemid 44049157)
19. S.S. Zhan, J.X. Jiang, J. Wu, C. Halsted, S.L. Friedman, M.A. Zern, and N.J. Torok Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo Hepatology 43 2006 435 443
20. J.X. Jiang, K. Mikami, S. Venugopal, Y. Li, and N.J. Torok Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways J. Hepatol. 51 2009 139 148
21. W. Mehal, and A. Imaeda Cell death and fibrogenesis Semin. Liver Dis. 30 2010 226 231
22. M. Mohamadnejad, M.A. Sohail, A. Watanabe, D.S. Krause, E.S. Swenson, and W.Z. Mehal Adenosine inhibits chemotaxis and induces hepatocyte-specific genes in bone marrow mesenchymal stem cells Hepatology 51 2010 963 973
23. J. Jou, S.S. Choi, and A.M. Diehl Mechanisms of disease progression in nonalcoholic fatty liver disease Semin. Liver Dis. 28 2008 370 379
24. Urtasun, R.; Conde de la Rosa, L.; Nieto, N. Oxidative and nitrosative stress and fibrogenic response. Clin. Liver Dis. 12:769-790, viii; 2008.
25. F. Gaggini, B. Laleu, M. Orchard, L. Fioraso-Cartier, L. Cagnon, S. Houngninou-Molango, A. Gradia, G. Duboux, C. Merlot, F. Heitz, C. Szyndralewiez, and P. Page Design, synthesis and biological activity of original pyrazolo-pyrido-diazepine, -pyrazine and -oxazine dione derivatives as novel dual Nox4/Nox1 inhibitors Bioorg. Med. Chem. 2011
26. T.P.Y. Aoyama, S. Watanabe, and D. Brenner A. critical role for the NADPH oxidase (NOX) in experimental liver fibrosis Hepatology 2011 184
27. P. Sancho, E. Bertran, L. Caja, I. Carmona-Cuenca, M.M. Murillo, and I. Fabregat The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms Biochim. Biophys. Acta 253-263 1793 2009