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Volumn 144, Issue , 2014, Pages

Selective manipulation of aging: A novel strategy for the treatment of neurodegenerative disorders

Author keywords

Aging; Insulin IGF signalling; Neurodegenerative disorders; Proteostasis; Proteotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; ATAXIN 3; HEAT SHOCK TRANSCRIPTION FACTOR 1; HUNTINGTIN; INSULIN; POLYGLUTAMINE; SOMATOMEDIN; TRANSCRIPTION FACTOR FOXO; SOMATOMEDIN C;

EID: 84899729969     PISSN: 14247860     EISSN: 14243997     Source Type: Journal    
DOI: 10.4414/smw.2014.13917     Document Type: Review
Times cited : (12)

References (78)
  • 1
    • 79960652801 scopus 로고    scopus 로고
    • Molecular chaperones in protein folding and proteostasis
    • Hartl FU, Bracher A, Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature. 2011;475:324-32.
    • (2011) Nature , vol.475 , pp. 324-332
    • Hartl, F.U.1    Bracher, A.2    Hayer-Hartl, M.3
  • 2
    • 33644859083 scopus 로고    scopus 로고
    • The ubiquitin proteolytic system: From a vague idea, through basic mechanisms, and onto human diseases and drug targeting
    • Ciechanover A. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology. 2006;66:S7-19.
    • (2006) Neurology , vol.66
    • Ciechanover, A.1
  • 3
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM. Autophagy gone awry in neurodegenerative diseases. Nat Neurosci. 2010;13:805-11.
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 4
    • 39349083915 scopus 로고    scopus 로고
    • Adapting proteostasis for disease intervention
    • DOI 10.1126/science.1141448
    • Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science. 2008;319:916-9. (Pubitemid 351263754)
    • (2008) Science , vol.319 , Issue.5865 , pp. 916-919
    • Balch, W.E.1    Morimoto, R.I.2    Dillin, A.3    Kelly, J.W.4
  • 5
    • 50649116818 scopus 로고    scopus 로고
    • Misfolded proteins partition between two distinct quality control compartments
    • Kaganovich D, Kopito R, Frydman J. Misfolded proteins partition between two distinct quality control compartments. Nature. 2008;454:1088-95.
    • (2008) Nature , vol.454 , pp. 1088-1095
    • Kaganovich, D.1    Kopito, R.2    Frydman, J.3
  • 6
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • DOI 10.1038/nature02998
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature. 2004;31:805-10. (Pubitemid 39434070)
    • (2004) Nature , vol.431 , Issue.7010 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 7
    • 84859622560 scopus 로고    scopus 로고
    • Quality control compartments coming of age
    • Ben-Gedalya T, Cohen E. Quality control compartments coming of age. Traffic. 2012;13:635-42.
    • (2012) Traffic , vol.13 , pp. 635-642
    • Ben-Gedalya, T.1    Cohen, E.2
  • 9
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • DOI 10.1038/nrn1007
    • Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci. 2003;4:49-60. (Pubitemid 37271088)
    • (2003) Nature Reviews Neuroscience , vol.4 , Issue.1 , pp. 49-60
    • Soto, C.1
  • 11
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • 2008
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008;14(8):837-42.
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5
  • 12
    • 78049326855 scopus 로고    scopus 로고
    • Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils
    • O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, et al. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. J Neurosci. 2010;30:14411-9.
    • (2010) J Neurosci , vol.30 , pp. 14411-14419
    • O'Nuallain, B.1    Freir, D.B.2    Nicoll, A.J.3    Risse, E.4    Ferguson, N.5
  • 13
    • 0028812820 scopus 로고
    • Mutations of the presenilin/gene in families with early-onset Alzheimer's disease
    • Campion D, Flaman JM, Brice A, Hannequin D, Dubois B, Martin C, et al. Mutations of the presenilin/gene in families with early-onset Alzheimer's disease. Hum Mol Genet. 1995;4:2373-7.
    • (1995) Hum Mol Genet , vol.4 , pp. 2373-2377
    • Campion, D.1    Flaman, J.M.2    Brice, A.3    Hannequin, D.4    Dubois, B.5    Martin, C.6
  • 14
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature. 2012;488(7409):96-9.
    • (2012) Nature , vol.488 , Issue.7409 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5
  • 17
    • 84865086929 scopus 로고    scopus 로고
    • Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
    • Coen K, Flannagan RS, Baron S, Carraro-Lacroix LR, Wang D, et al. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J Cell Biol. 2012;198:23-35.
    • (2012) J Cell Biol , vol.198 , pp. 23-35
    • Coen, K.1    Flannagan, R.S.2    Baron, S.3    Carraro-Lacroix, L.R.4    Wang, D.5
  • 18
    • 77953913051 scopus 로고    scopus 로고
    • Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
    • Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, et al. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 2010;141:1146-58.
    • (2010) Cell , vol.141 , pp. 1146-1158
    • Lee, J.H.1    Yu, W.H.2    Kumar, A.3    Lee, S.4    Mohan, P.S.5
  • 20
    • 0038701684 scopus 로고    scopus 로고
    • Huntingtin aggregation and toxicity in Huntington's disease
    • DOI 10.1016/S0140-6736(03)13304-1
    • Bates G. Huntingtin aggregation and toxicity in Huntington's disease. Lancet. 2003;361:1642-4. (Pubitemid 36579005)
    • (2003) Lancet , vol.361 , Issue.9369 , pp. 1642-1644
    • Bates, G.1
  • 21
    • 84878801656 scopus 로고    scopus 로고
    • Ataxin-3 and its e3 partners: Implications for machado-joseph disease
    • Durcan TM, Fon EA. Ataxin-3 and its e3 partners: implications for machado-joseph disease. Front Neurol. 2013;4:46.
    • (2013) Front Neurol , vol.4 , pp. 46
    • Durcan, T.M.1    Fon, E.A.2
  • 22
    • 84875441083 scopus 로고    scopus 로고
    • The changing scene of amyotrophic lateral sclerosis
    • Robberecht W, Philips T. The changing scene of amyotrophic lateral sclerosis. Nat Rev Neurosci. 2013;14:248-64.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 248-264
    • Robberecht, W.1    Philips, T.2
  • 25
    • 0027956156 scopus 로고
    • Aging as a major risk for degenerative diseases of the central nervous system: Editorial commentary
    • Amaducci L, Tesco G. Aging as a major risk for degenerative diseases of the central nervous system. Curr Opin Neurol. 1994;7:283-6. (Pubitemid 24243729)
    • (1994) Current Opinion in Neurology , vol.7 , Issue.4 , pp. 283-286
    • Amaducci, L.1    Tesco, G.2
  • 26
    • 84873633910 scopus 로고    scopus 로고
    • Genetics of longevity in model organisms: Debates and paradigm shifts
    • Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol. 2013;75:621-44.
    • (2013) Annu Rev Physiol , vol.75 , pp. 621-644
    • Gems, D.1    Partridge, L.2
  • 27
    • 0024656069 scopus 로고
    • The effect of retarded growth upon the length of life span and upon the ultimate body size
    • discussion 172
    • McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition 1989;5:155-71; discussion 172.
    • (1935) Nutrition , vol.5 , pp. 155-171
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.A.3
  • 28
    • 50649099122 scopus 로고    scopus 로고
    • Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction
    • Mair W, Dillin A. Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction. Annu Rev Biochem. 2008;77:727-54.
    • (2008) Annu Rev Biochem , vol.77 , pp. 727-754
    • Mair, W.1    Dillin, A.2
  • 29
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • DOI 10.1038/nature05904, PII NATURE05904
    • Bishop NA, Guarente L. Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature. 2007;447:545-9. (Pubitemid 46868049)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 30
    • 34249888736 scopus 로고    scopus 로고
    • PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
    • DOI 10.1038/nature05837, PII NATURE05837
    • Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature. 2007;447:550-5. (Pubitemid 46868041)
    • (2007) Nature , vol.447 , Issue.7144 , pp. 550-555
    • Panowski, S.H.1    Wolff, S.2    Aguilaniu, H.3    Durieux, J.4    Dillin, A.5
  • 32
    • 0035515923 scopus 로고    scopus 로고
    • Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans
    • DOI 10.1016/S1534-5807(01)00071-5, PII S1534580701000715
    • Feng J, Bussiere F, Hekimi S. Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans. Dev Cell. 2001;1:633-44. (Pubitemid 33586116)
    • (2001) Developmental Cell , vol.1 , Issue.5 , pp. 633-644
    • Feng, J.1    Bussiere, F.2    Hekimi, S.3
  • 33
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • Durieux J, Wolff S, Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell. 2011;144:79-91.
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 34
    • 34447639081 scopus 로고    scopus 로고
    • Dynamics of the action of dFOXO on adult mortality in Drosophila
    • Giannakou ME, Goss M, Jacobson J, Vinti G, Leevers SJ, et al. Dynamics of the action of dFOXO on adult mortality in Drosophila. Aging Cell. 2007;6(4):429-38.
    • (2007) Aging Cell , vol.6 , Issue.4 , pp. 429-438
    • Giannakou, M.E.1    Goss, M.2    Jacobson, J.3    Vinti, G.4    Leevers, S.J.5
  • 35
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • DOI 10.1038/366461a0
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993;366:461-4. (Pubitemid 24013878)
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 37
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • DOI 10.1016/S0960-9822(01)00595-4
    • Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001;11:1950-7. (Pubitemid 33146421)
    • (2001) Current Biology , vol.11 , Issue.24 , pp. 1950-1957
    • Lee, R.Y.N.1    Hench, J.2    Ruvkun, G.3
  • 39
    • 84862930510 scopus 로고    scopus 로고
    • HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity
    • Chiang WC, Ching TT, Lee HC, Mousigian C, Hsu AL. HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity. Cell. 2012;148:322-34.
    • (2012) Cell , vol.148 , pp. 322-334
    • Chiang, W.C.1    Ching, T.T.2    Lee, H.C.3    Mousigian, C.4    Hsu, A.L.5
  • 40
    • 84881175076 scopus 로고    scopus 로고
    • PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity
    • Tepper RG, Ashraf J, Kaletsky R, Kleemann G, Murphy CT, et al. PQM-1 Complements DAF-16 as a Key Transcriptional Regulator of DAF-2-Mediated Development and Longevity. Cell. 2013;154:676-90.
    • (2013) Cell , vol.154 , pp. 676-690
    • Tepper, R.G.1    Ashraf, J.2    Kaletsky, R.3    Kleemann, G.4    Murphy, C.T.5
  • 41
    • 13944269223 scopus 로고    scopus 로고
    • The plasticity of aging: Insights from long-lived mutants
    • DOI 10.1016/j.cell.2005.02.002
    • Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell. 2005;120:449-60. (Pubitemid 40269760)
    • (2005) Cell , vol.120 , Issue.4 , pp. 449-460
    • Kenyon, C.1
  • 42
    • 0030813398 scopus 로고    scopus 로고
    • Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    • DOI 10.1126/science.277.5328.942
    • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science. 1997;277:942-6. (Pubitemid 27366677)
    • (1997) Science , vol.277 , Issue.5328 , pp. 942-946
    • Kimura, K.D.1    Tissenbaum, H.A.2    Liu, Y.3    Ruvkun, G.4
  • 43
    • 41849136901 scopus 로고    scopus 로고
    • Forkhead transcription factors and ageing
    • DOI 10.1038/onc.2008.28, PII ONC200828
    • Partridge L, Bruning JC. Forkhead transcription factors and ageing. Oncogene. 2008;27:2351-63. (Pubitemid 351501786)
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2351-2363
    • Partridge, L.1    Bruning, J.C.2
  • 48
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
    • McElwee J, Bubb K, Thomas JH. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell. 2003;2:111-21.
    • (2003) Aging Cell , vol.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 49
    • 0042092531 scopus 로고    scopus 로고
    • Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, et al. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003;424:277-83.
    • (2003) Nature , vol.424 , pp. 277-283
    • Murphy, C.T.1    McCarroll, S.A.2    Bargmann, C.I.3    Fraser, A.4    Kamath, R.S.5
  • 51
    • 31744438846 scopus 로고    scopus 로고
    • Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    • DOI 10.1038/ng1723, PII NG1723
    • Oh SW, Mukhopadhyay A, Dixit BL, Raha T, Green MR, et al. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat Genet. 2006;38:251-7. (Pubitemid 43177243)
    • (2006) Nature Genetics , vol.38 , Issue.2 , pp. 251-257
    • Seung, W.O.1    Mukhopadhyay, A.2    Dixit, B.L.3    Raha, T.4    Green, M.R.5    Tissenbaum, H.A.6
  • 53
    • 0036678146 scopus 로고    scopus 로고
    • The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
    • Morley JF, Brignull HR, Weyers JJ, Morimoto RI. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2002;99:10417-22.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10417-10422
    • Morley, J.F.1    Brignull, H.R.2    Weyers, J.J.3    Morimoto, R.I.4
  • 54
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link C. Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1995;92:9368-72.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9368-9372
    • Link, C.1
  • 55
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • DOI 10.1126/science.1124646
    • Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age-onset proteotoxicity. Science. 2006;313:1604-10. (Pubitemid 44414028)
    • (2006) Science , vol.313 , Issue.5793 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 56
    • 77953247518 scopus 로고    scopus 로고
    • Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    • Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, et al. Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell. 2010;9:126-34.
    • (2010) Aging Cell , vol.9 , pp. 126-134
    • Cohen, E.1    Du, D.2    Joyce, D.3    Kapernick, E.A.4    Volovik, Y.5
  • 57
    • 43449138491 scopus 로고    scopus 로고
    • Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
    • DOI 10.1111/j.1474-9726.2008.00385.x
    • Steinkraus KA, Smith ED, Davis C, Carr D, Pendergrass WR, et al. Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell. 2008;7:394-404. (Pubitemid 351663908)
    • (2008) Aging Cell , vol.7 , Issue.3 , pp. 394-404
    • Steinkraus, K.A.1    Smith, E.D.2    Davis, C.3    Carr, D.4    Pendergrass, W.R.5    Sutphin, G.L.6    Kennedy, B.K.7    Kaeberlein, M.8
  • 58
    • 70149092727 scopus 로고    scopus 로고
    • Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice
    • Mouton PR, Chachich ME, Quigley C, Spangler E, Ingram DK. Caloric restriction attenuates amyloid deposition in middle-aged dtg APP/PS1 mice. Neurosci Lett. 2009;464:184-7.
    • (2009) Neurosci Lett , vol.464 , pp. 184-187
    • Mouton, P.R.1    Chachich, M.E.2    Quigley, C.3    Spangler, E.4    Ingram, D.K.5
  • 60
    • 79955433159 scopus 로고    scopus 로고
    • TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling
    • Zhang T, Mullane PC, Periz G, Wang J. (2011) TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. Hum Mol Genet.
    • (2011) Hum Mol Genet
    • Zhang, T.1    Mullane, P.C.2    Periz, G.3    Wang, J.4
  • 61
    • 84858638822 scopus 로고    scopus 로고
    • Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans
    • Boccitto M, Lamitina T, Kalb RG. Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PLoS One. 2012;7:e33494.
    • (2012) PLoS One , vol.7
    • Boccitto, M.1    Lamitina, T.2    Kalb, R.G.3
  • 62
    • 79960114573 scopus 로고    scopus 로고
    • Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: Rescue by the DAF-16 and HSF-1 pathways
    • 2011
    • Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaca JL, et al. (2011) Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 2011;20(15):2996-3009.
    • (2011) Hum Mol Genet , vol.20 , Issue.15 , pp. 2996-3009
    • Teixeira-Castro, A.1    Ailion, M.2    Jalles, A.3    Brignull, H.R.4    Vilaca, J.L.5
  • 63
    • 67649224051 scopus 로고    scopus 로고
    • Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
    • Killick R, Scales G, Leroy K, Causevic M, Hooper C, et al. Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun. 2009;386:257-62.
    • (2009) Biochem Biophys Res Commun , vol.386 , pp. 257-262
    • Killick, R.1    Scales, G.2    Leroy, K.3    Causevic, M.4    Hooper, C.5
  • 64
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
    • DOI 10.1126/science.274.5284.99
    • Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 1996;274:99-102. (Pubitemid 26332733)
    • (1996) Science , vol.274 , Issue.5284 , pp. 99-102
    • Hsiao, K.1    Chapman, P.2    Nilsen, S.3    Eckman, C.4    Harigaya, Y.5    Younkin, S.6    Yang, F.7    Cole, G.8
  • 65
    • 70349672704 scopus 로고    scopus 로고
    • Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
    • Freude S, Hettich MM, Schumann C, Stohr O, Koch L, et al. Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease. Faseb J. 2009;23:3315-24.
    • (2009) Faseb J , vol.23 , pp. 3315-3324
    • Freude, S.1    Hettich, M.M.2    Schumann, C.3    Stohr, O.4    Koch, L.5
  • 67
    • 33846153236 scopus 로고    scopus 로고
    • Swe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease
    • DOI 10.1111/j.1601-183X.2006.00221.x
    • Reiserer RS, Harrison FE, Syverud DC, McDonald MP. Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes Brain Behav. 2007;6:54-65. (Pubitemid 46090333)
    • (2007) Genes, Brain and Behavior , vol.6 , Issue.1 , pp. 54-65
    • Reiserer, R.S.1    Harrison, F.E.2    Syverud, D.C.3    McDonald, M.P.4
  • 68
    • 71449108913 scopus 로고    scopus 로고
    • Reduced IGF-1 signaling delays age-associated proteotoxicity in mice
    • Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, et al. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 2009;139:1157-69.
    • (2009) Cell , vol.139 , pp. 1157-1169
    • Cohen, E.1    Paulsson, J.F.2    Blinder, P.3    Burstyn-Cohen, T.4    Du, D.5
  • 69
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • DOI 10.1038/nrm2101, PII NRM2101
    • Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol. 2007;8:101-12. (Pubitemid 46432529)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.2 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 70
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I regulates brain amyloid-beta levels
    • DOI 10.1038/nm793
    • Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I. Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med. 2002;8:1390-7. (Pubitemid 36019424)
    • (2002) Nature Medicine , vol.8 , Issue.12 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3    LeRoith, D.4    Torres-Aleman, I.5
  • 71
    • 84856383943 scopus 로고    scopus 로고
    • Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency
    • Poirier R, Fernandez AM, Torres-Aleman I, Metzger F. Early brain amyloidosis in APP/PS1 mice with serum insulin-like growth factor-I deficiency. Neurosci Lett. 2012;509:101-4.
    • (2012) Neurosci Lett , vol.509 , pp. 101-104
    • Poirier, R.1    Fernandez, A.M.2    Torres-Aleman, I.3    Metzger, F.4
  • 72
    • 84858631674 scopus 로고    scopus 로고
    • The many faces of insulin-like peptide signalling in the brain
    • Fernandez AM, Torres-Aleman I. The many faces of insulin-like peptide signalling in the brain. Nat Rev Neurosci. 2012;13:225-39.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 225-239
    • Fernandez, A.M.1    Torres-Aleman, I.2
  • 73
    • 33746215099 scopus 로고    scopus 로고
    • Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis
    • DOI 10.1016/j.neurobiolaging.2005.06.015, PII S0197458005001892
    • Carro E, Trejo JL, Gerber A, Loetscher H, Torrado J, et al. Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. Neurobiol Aging. 2006;27:1250-7. (Pubitemid 44088577)
    • (2006) Neurobiology of Aging , vol.27 , Issue.9 , pp. 1250-1257
    • Carro, E.1    Trejo, J.L.2    Gerber, A.3    Loetscher, H.4    Torrado, J.5    Metzger, F.6    Torres-Aleman, I.7
  • 74
    • 84856089134 scopus 로고    scopus 로고
    • Small-molecule proteostasis regulators for protein conformational diseases
    • Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2012;8:185-96.
    • (2012) Nat Chem Biol , vol.8 , pp. 185-196
    • Calamini, B.1    Silva, M.C.2    Madoux, F.3    Hutt, D.M.4    Khanna, S.5
  • 75
    • 78049437929 scopus 로고    scopus 로고
    • Trehalose extends longevity in the nematode Caenorhabditis elegans
    • Honda Y, Tanaka M, Honda S. Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging Cell. 2010;9:558-69.
    • (2010) Aging Cell , vol.9 , pp. 558-569
    • Honda, Y.1    Tanaka, M.2    Honda, S.3
  • 76
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011;472:226-9.
    • (2011) Nature , vol.472 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 77
    • 67649366086 scopus 로고    scopus 로고
    • FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
    • Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, et al. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009;29:8236-47.
    • (2009) J Neurosci , vol.29 , pp. 8236-8247
    • Mojsilovic-Petrovic, J.1    Nedelsky, N.2    Boccitto, M.3    Mano, I.4    Georgiades, S.N.5
  • 78
    • 84892536221 scopus 로고    scopus 로고
    • A Novel Inhibitor of the Insulin/IGF Signaling Pathway Protects from Age-Onset, Neurodegeneration-linked Proteotoxicity
    • El-Ami T, Moll L, Marques CF, Volovik Y, Reuveni H, et al. (2013) A Novel Inhibitor of the Insulin/IGF Signaling Pathway Protects from Age-Onset, Neurodegeneration-linked Proteotoxicity. Aging Cell. 2014;13(1):165-74.
    • (2013) Aging Cell , vol.13 , Issue.1 , pp. 165-174
    • El-Ami, T.1    Moll, L.2    Marques, C.F.3    Volovik, Y.4    Reuveni, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.