Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 350-368

  Sharma, Nandini ^a,d   Mohanakrishnan, Dinesh ^b   Sharma, Upendra Kumar ^a   Kumar, Rajesh ^a   Richa, ^a   Sinha, Arun Kumar ^a,c   Sahal, Dinkar ^b  

^a CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Allylated chalcones; Artemisinin; Chloroquine; Plasmodiumfalciparum; Synergism

Indexed keywords

1 (1,3 BENZODIOXOL 5 YL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (1,3 BENZODIOXOL 5 YL) 3 [3,4 DIMETHOXY 5 (PROP 2 EN 1 YL)PHENYL]PROP 2 EN; 1 (3 CHLOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (3,4 DICHLOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 BROMOPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 BROMOPHENYL) 3 [3,4 DIMETHOXY 5 (PROP 2 EN 1YL)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1YLOXY)PHENYL]PROP 2 EN 1 ONE1 (4 CHLOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3 METHOXY 5 (PROP 2 EN 1 YL) 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [3,4 DIMETHOXY 3 METHOXY 5 (PROP 2 EN 1 YL)PHENYL]PROP 2 EN 1 ONE; 1 (4 CHLOROPHENYL) 3 [4 HYDROXY 3 METHOXY 5 (PROP 2 EN 1 YL)PHENYL]PROP 2 EN 1 ONE; 1 (4 FLUOROPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 IODOPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (4 METHOXYPHENYL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (FURAN 2 YL) 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 [4 [LLYL(7 CHLOROQUINOLIN 4 YL)AMINO]PHENYL] 3 [4 (ALLYLOXY) 2 METHOXYPHENYL]PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL] 1 (1H PYRROL 2 YL)PROP 2 EN 1 ONE; 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 3 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)PHENYL] 1 [4 PROP 2 EN 1 ONE; 3 [3,4 DIMETHOXY 5 (PROP 2 EN 1 YL)PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,4 DIMETHOXY 5 (PROP 2 EN 1 YL)PHENYL] 1 (4 NITROPHENYL)PROP 2 EN 1 ONE; 5 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)BENZYLIDENE] 2,2 DIMETHYL 1,3 DIOXANE 4,6 DIONE; 5 [3 METHOXY 4 (PROP 2 EN 1 YLOXY)BENZYLIDENE]PYRIMIDINE 2,4,6 (1H,3H,5H)TRIONE; 5 [4 (ALLYLOXY) 3 METHOXYPHENYL] 3 (4 CHLOROPHENYL) 1 PHENYL 4,5 DIHYDRO 1H PYRAZOLE; ANTIMALARIAL AGENT; ARTEMISININ; CHALCONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLIN DERIVATIVE; ARTEMISININ DERIVATIVE; BENZALDEHYDE DERIVATIVE; CHLOROQUINE; VANILLIN;

ANTIMALARIAL ACTIVITY; APOPTOSIS; ARTICLE; CHEMICAL PARAMETERS; CONTROLLED STUDY; CRYSTALLIZATION; DNA FRAGMENTATION; DRUG ABSORPTION; DRUG EXPOSURE; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG WITHDRAWAL; IC 50; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PLASMODIUM FALCIPARUM; SCHIZONT; TROPHOZOITE; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECTS; DRUG RESISTANCE; DRUG SENSITIVITY; FIBROBLAST; GROWTH, DEVELOPMENT AND AGING; HELA CELL LINE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIMALARIALS; APOPTOSIS; ARTEMISININS; BENZALDEHYDES; CELL SURVIVAL; CELLS, CULTURED; CHALCONES; CHLOROQUINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG RESISTANCE; FIBROBLASTS; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898939837     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.079     Document Type: Article

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