The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

Journal of Infectious Diseases

Volumn 176, Issue 5, 1997, Pages 1327-1333

  Chen, M ^b   Christensen, S Brøgger ^b   Zhai, L ^b   Rasmussen, M H ^b   Theander, T G ^b   Frokjaer S ^b   Steffansen, B ^b   Davidsen, J ^b   Kharazmi, A ^a  

^a Illinois   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHOXY 4' BUTOXYCHALCONE; CHALCONE DERIVATIVE; LICOCHALCONE A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL;

EID: 0030830227     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514129     Document Type: Article

References (10)

1. World Health Organization. World malaria situation 1988. Part 1. Weekly Epidemiol Rec 1990;65:189-96.
2. Tropical disease research progress 1991-92. Eleventh programme report of the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases. Geneva: World Health Organization, 1993:15-27.
3. Peters W. Drug resistance in malaria. Recent Prog Med 1990;81:749-53.
4. Phillips RE, Solomon T. Cerebral malaria in children. Lancet 1990;336:1355-60.
5. Panisko DM, Keystone JS. Treatment of malaria - 1990. Drugs 1990;39:160-89.
6. Chen M, Theander TG, Christensen BS, Hviid L, Zhai L, Kharazmi A. Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrob Agents Chemother 1994;38:1470-5.
7. Li R, Kenyon GL, Cohen FE, et al. In vitro antimalarial activity of chalcones and their derivatives. J Med Chem 1995;38:5031-7.
8. Chen M, Christensen SB, Blom J, et al. Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania. Antimicrob Agents Chemother 1993;37:2550-6.
9. Chen M, Christensen SB, Theander TG, Kharazmi A. Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother 1994;38:1339-44.
10. Bockstahler ER, Wright DL. Some ethers derived from diethylaminoethyl benzilate. J Am Chem Soc 1949;71:3760-3.