Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 31-45

  Tadigoppula, Narender ^a   Korthikunta, Venkateswarlu ^a   Gupta, Shweta ^a   Kancharla, Papireddy ^a   Khaliq, Tanvir ^a   Soni, Awakash ^a   Srivastava, Rajeev Kumar ^a   Srivastava, Kumkum ^a   Puri, Sunil Kumar ^a   Raju, Kanumuri Siva Rama ^a   Wahajuddin, ^a   Sijwali, Puran Singh ^b   Kumar, Vikash ^a   Mohammad, Imran Siddiqi ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 5 [3 [7 HYDROXY 2 METHYL 2 (4 METHYL PENT 3 ENYL) 2H CHROMEN 8 YL] 3 OXO PROPENYL]BENZALDEHYDE; ANTIMALARIAL AGENT; CHALCONE DERIVATIVE; FALCIPAIN 2; MEDICAGENIN; MUNCHIWARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CROTALARIA; CROTALARIA MEDICAGENIA; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; STRUCTURE ACTIVITY RELATION; SURVIVAL TIME;

ANIMALS; ANTIMALARIALS; BENZOPYRANS; CATALYTIC DOMAIN; CHALCONES; CHROMANS; CROTALARIA; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; MALARIA; MALE; MICE; MOLECULAR DOCKING SIMULATION; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; RATS; RATS, SPRAGUE-DAWLEY; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872325842     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300588j     Document Type: Article

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