Stilbene-chalcone hybrids: Design, synthesis, and evaluation as a new class of antimalarial scaffolds that trigger cell death through stage specific apoptosis

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 297-311

  Sharma, Naina ^a   Mohanakrishnan, Dinesh ^b   Shard, Amit ^a   Sharma, Abhishek ^a,c   Saima, ^a   Sinha, Arun K ^a   Sahal, Dinkar ^b  

^a CSIR INSTITUTE OF HIMALAYAN BIORESOURCE TECHNOLOGY   (India)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 METHOXYPHENYL) 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [3 (2 PHENYLETHENYL)PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [3 [3 OXO 3 (2,4,5 TRIMETHOXYPHENYL)PROP 1 EN 1 YL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (2 PHENYLETHENYL)PHENYL] 3 (3,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (2 PHENYLETHENYL)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (2 PHENYLETHENYL)PHENYL] 3 (5 CHLORO 1H INDOL 3 YL)PROP 2 EN 1 ONE; 1 [4 (2 PHENYLETHENYL)PHENYL] 3 (FURAN 2 YL)PROP 2 EN 1 ONE; 1 [4 (2 PHENYLETHENYL)PHENYL] 3 (THIOPHEN 2 YL)PROP 2 EN 1 ONE; 1 [4 [2 (3,4 DIHYDROXYPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (3,4,5 TRIMETHOXYPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 CHLOROPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 HYDROXY 3 METHOXYPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL]PHENYL] 3 (2,3,4 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL]PHENYL] 3 (2,4,6 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 [2 (4 HYDROXYPHENYL)ETHENYL]PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1,4 BIS(4 HYDROXY 3,5 DIMETHOXY)STYRYLBENZENE; 2,6 DIMETHOXY 4 [2 [4 [3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 ENOYL]PHENYL]ETHENYL]PHENYL 3,5 DICHLOROBENZENE 1 SULFONATE; 2,6 DIMETHOXY 4 [2 [4 [3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 ENOYL]PHENYL]ETHENYL]PHENYL 4 METHYLBENZENE 1 SULFONATE; 2,6 DIMETHOXY 4 [2 [4 [3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 ENOYL]PHENYL]ETHENYL]PHENYL ACETATE; 3 [4 [2 (4 HYDROXY 3 METHOXYPHENYL)ETHENYL]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL]PHENYL] 1 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [2 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ETHENYL]PHENYL] 1 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 4 HYDROXY 3,4',5 TRIMETHOXYSTILBENE; ANTIMALARIAL AGENT; CHALCONE DERIVATIVE; CHLOROQUINE; STILBENE CHALCONE HYBRID; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CLAISEN CONDENSATION; CLAISEN SCHMIDT CONDENSATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENCY; DRUG SCREENING; GROWTH INHIBITION; HECK REACTION; HUMAN; HUMAN CELL; IC 50; KNOEVENAGEL CONDENSATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PLASMODIUM FALCIPARUM; SCHIZONT; STRUCTURE ACTIVITY RELATION; TROPHOZOITE;

ANTIMALARIALS; APOPTOSIS; CHALCONES; CHROMATIN; DNA FRAGMENTATION; DRUG RESISTANCE; MEMBRANE POTENTIAL, MITOCHONDRIAL; PLASMODIUM FALCIPARUM; SCHIZONTS; STEREOISOMERISM; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TROPHOZOITES;

EID: 84863411418     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201216y     Document Type: Article

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