Rate-limited steps of human oral absorption and QSAR studies

Pharmaceutical Research

Volumn 19, Issue 10, 2002, Pages 1446-1457

  Zhao, Yuan H ^a   Abraham, Michael H ^a   Le, Joelle ^a   Hersey, Anne ^b   Luscombe, Chris N ^b   Beck, Gordon ^c   Sherborne, Brad ^c   Cooper, Ian ^c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

Human intestinal absorption; Hydrogen bonding; Rate limited step; Solubility

Indexed keywords

AMINOPHENAZONE; ANTIBIOTIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; BORNAPRINE; CAFFEINE; CAMAZEPAM; CARDIAC AGENT; CICAPROST; CISAPRIDE; CORTICOSTERONE; CYPROTERONE ACETATE; DESIPRAMINE; DIAZEPAM; DICLOFENAC; FENCLOFENAC; FLUINDOSTATIN; FLUMAZENIL; GALLOPAMIL; GLIBENCLAMIDE; GRANISETRON; IMIPRAMINE; INDOMETACIN; ISOXICAM; LEVONORGESTREL; LORMETAZEPAM; LORNOXICAM; NEUROTROPIC AGENT; STEROID; UNINDEXED DRUG;

ARTICLE; CALCULATION; DRUG ABSORPTION; DRUG CLASSIFICATION; DRUG DIFFUSION; DRUG PENETRATION; DRUG SOLUBILITY; HUMAN; HYDROGEN BOND; INTESTINE ABSORPTION; KINETICS; MATHEMATICAL ANALYSIS; MODEL; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS;

ADMINISTRATION, ORAL; HUMANS; INTESTINAL ABSORPTION; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS;

EID: 0036806339     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020444330011     Document Type: Article

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