Synthetic chalcones, flavanones, and flavones as antitumoral agents: Biological evaluation and structure-activity relationships

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 10, 2007, Pages 3356-3367

  Cabrera, Mauricio ^a   Simoens, Macarena ^a   Falchi, Gabriela ^a   Lavaggi, M Laura ^a   Piro, Oscar E ^b   Castellano, Eduardo E ^c   Vidal, Anabel ^a   Azqueta, Amaia ^d   Monge, Antonio ^d   de Ceráin, Adela López ^d   Sagrera, Gabriel ^a   Seoane, Gustavo ^a   Cerecetto, Hugo ^a   González, Mercedes ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Antitumoral; Comet assay; Flavonoids; QSAR

Indexed keywords

1 (2 HYDROXYPHENYL) 3 (2 PYRIDINYL) 2 PROPEN 1 ONE; 1 (2 HYDROXYPHENYL) 3 (4 BENZYLOXYPHENYL) 1 PROPANONE; 1 (2 HYDROXYPHENYL) 3 (4 METHYLTHIOPHENYL) 2 PROPEN 1 ONE; 1 (2 HYDROXYPHENYL) 3 (4 NONYLOXYPHENYL) 2 PROPEN 1 ONE; 1 (2 HYDROXYPHENYL) 5 PHENYL 2,4 PENTADIEN 1 ONE; 1 (4 BENZYLOXY 2 HYDROXYPHENYL) 3 (2 BROMOPHENYL) 2 PROPEN 1 ONE; 1 (4 BUTOXY 2 HYDROXYPHENYL) 3 (4 BUTOXYPHENYL) 2 PROPEN 1 ONE; 2 (2 BROMOPHENYL) 4H CHROMEN 4 ONE; 2 (4 BROMOPHENYL) 2,3 DIHYDROCHROMEN 4 ONE; 2 (4 CHLOROPHENYL) 4H CHROMEN 4 ONE; 3 (2 BROMOPHENYL) 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL) 2 PROPEN 1 ONE; 3 (2 BROMOPHENYL) 1 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 (2 BROMOPHENYL) 1 PHENYL 2 PROPEN 1 ONE; 3 (4 AMINOPHENYL) 1 (2 HYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (4 BENZYLOXY 3 IODOPHENYL) 1 (2 HYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (4 BROMOPHENYL) 1 PHENYL 2 PROPEN 1 ONE; 3 (4 CHLOROPHENYL) 1 (2 HYDROXYPHENYL)PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 PHENYL 2 PROPEN 1 ONE; 3 (4 HEXYLOXYPHENYL) 1 (2 HYDROXYPHENYL) 2 PROPEN 1 ONE; 3 (4 METHOXYPHENYL) 1 PHENYL 2 PROPEN 1 ONE; 3 (4 METHYLTHIOPHENYL) 1 PHENYL 2 PROPEN 1 ONE; 3 HYDROXY 1 (2 HYDROXYPHENYL) 3 (4 METHYLTHIOPHENYL) 1 PROPANONE; ANTINEOPLASTIC AGENT; CHALCONE; FLAVANONE; FLAVONE; N [4 (3 OXO 3 PHENYL 1 PROPENYL)PHENYL]ACETAMIDE; N [4 [3 (2 HYDROXYPHENYL) 3 OXO 1 PROPENYL]PHENYL]ACETAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CARCINOMA CELL; CHROMOSOME ABERRATION; COLON ADENOCARCINOMA; COMET ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; CHROMATOGRAPHY, THIN LAYER; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; DNA, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONES; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 34047185373     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.031     Document Type: Article

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