Induction of cell death on Plasmodium falciparum asexual blood stages by Solanum nudum steroids

Parasitology International

Volumn 59, Issue 2, 2010, Pages 217-225

  López, Mary Luz ^a   Vommaro, Rossiane ^b   Zalis, Mariano ^b   de Souza, Wanderley ^b   Blair, Silvia ^a   Segura, Cesar ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antimalarial drugs; Cell death; Plasmodium falciparum; Solanum nudum

Indexed keywords

CHLOROQUINE; DIOSGENONE; PHYTOSTEROL; UNCLASSIFIED DRUG;

ACIDIFICATION; ANTIBIOTIC SENSITIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL PH; CELL VACUOLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOPLASM; DNA FRAGMENTATION; DRUG STRUCTURE; ERYTHROCYTE; GIEMSA STAIN; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MORPHOLOGY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SCHIZONT; SOLANUM; SOLANUM NUDUM; TRANSMISSION ELECTRON MICROSCOPY; TROPHOZOITE; ULTRASTRUCTURE;

ANIMALS; DNA FRAGMENTATION; ERYTHROCYTES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; PLASMODIUM FALCIPARUM; SOLANUM; STEROIDS; TROPHOZOITES;

PLASMODIUM FALCIPARUM; SOLANACEAE; SOLANUM NUDUM;

EID: 77951623792     PISSN: 13835769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parint.2010.02.002     Document Type: Article

References (41)

1. WHO. World malaria report 2008. Geneva: WHO2008 Contract No.: WHO/HTM/GMP/2008.1.
2. Sáez J., Cardona W., Espinal D., Blair S., Mesa J., Bocar M., et al. Five new steroids from Solanum nudum. Tetrahedron 54 (1998) 10771-10778
3. Pabón A., Carmona J., Maestre A., Camargo M., and Blair S. Inhibition of P. falciparum by steroids isolated from Solanum nudum. Phytother Res 16 (2002) 59-62
4. Londoño B., Arango E., Zapata C., Herrera S., Saez J., Blair S., et al. Effect of Solanum nudum Dunal (Solanaceae) steroids on hepatic trophozoites of Plasmodium vivax. Phytother Res 20 (2006) 267-273
5. López M.L., Blair S., Saez J., and Segura C. Effect of Solanum nudum steroids on uninfected and Plasmodium falciparum-infected erythrocytes. Mem Inst Oswaldo Cruz 104 (2009) 683-688
6. Haines T.H. Do sterols reduce proton and sodium leaks through lipid bilayers?. Prog Lipid Res 40 (2001) 299-324
7. Krauss G. Signaling by nuclear receptors. In: Krauss G. (Ed). Biochemistry of Signal Transduction and Regulation. 2nd ed. (2001), Wiley-VCH Verlag GmbH, Weinheim 148-172
8. Freilich D., Ferris S., Wallace M., Leach L., Kallen A., Frincke J., et al. 16alpha-bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth. Am J Trop Med Hyg 63 (2000) 280-283
9. Devkota K.P., Lenta B.N., Choudhary M.I., Naz Q., Fekam F.B., Rosenthal P.J., et al. Cholinesterase inhibiting and antiplasmodial steroidal alkaloids from Sarcococca hookeriana. Chem Pharm Bull 55 (2007) 1397-1401
10. Al-Olayan E.M., Williams G.T., and Hurd H. Apoptosis in the malaria protozoan, Plasmodium berghei: a possible mechanism for limiting intensity of infection in the mosquito. Int J Parasitol 32 (2002) 1133-1143
11. Deponte M., and Becker K. Plasmodium falciparum-do killers commit suicide?. Trends Parasitol 20 (2004) 165-169
12. Le Chat L., Sinden R.E., and Dessens J.T. The role of metacaspase 1 in Plasmodium berghei development and apoptosis. Mol Biochem Parasitol 153 (2007) 41-47
13. Meslin B., Barnadas C., Boni V., Latour C., Monbrison F.D., Kaiser K., et al. Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein. J Infect Dis 195 (2007) 1852-1859
14. Oakley M.S., Kumar S., Anantharaman V., Zheng H., Mahajan B., Haynes J.D., et al. Molecular factors and biochemical pathways induced by febrile temperature in Plasmodium falciparum parasites. Infect Immun 75 4 (2007) 2012-2025
15. Picot S., Burnod J., Bracchi V., Chumpitazi B.F., and Ambroise-Thomas P. Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum. Trans R Soc Trop Med Hyg 91 (1997) 590-591
16. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E.S., Baehrecke E.H., et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16 (2009) 3-11
17. Lockshin R.A., and Zakeri Z. Apoptosis, autophagy, and more. Int J Biochem Cell Biol 36 (2004) 2405-2419
18. Pankova-Kholmyansky I., Dagan A., Gold D., Zaslavsky Z., Skutelsky E., Gatt S., et al. Ceramide mediates growth inhibition of the Plasmodium falciparum parasite. Cell Mol Life Sci 60 (2003) 577-587
19. Nyakeriga A.M., Perlmann H., Hagstedt M., Berzins K., Troye-Blomberg M., Zhivotovsky B., et al. Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis. Microbes Infect 8 (2006) 1560-1568
20. Totino P.R., Daniel-Ribeiro C.T., Corte-Real S., and de Fatima Ferreira-da-Cruz M. Plasmodium falciparum: erythrocytic stages die by autophagic-like cell death under drug pressure. Exp Parasitol 118 (2008) 478-486
21. Porter H., Gamette M.J., Cortes-Hernandez D.G., and Jensen J.B. Asexual blood stages of Plasmodium falciparum exhibit signs of secondary necrosis, but not classical apoptosis after exposure to febrile temperature (40 C). J Parasitol 94 (2008) 473-480
22. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
23. Lambros C., and Vanderberg J.P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65 (1979) 418-420
24. Dluzewski A.R., Ling I.T., Rangachari K., Bates P.A., and Wilson R.J. A simple method for isolating viable mature parasites of Plasmodium falciparum from cultures. Trans R Soc Trop Med Hyg 78 (1984) 622-624
25. Desjardins R.E., Canfield C.J., Haynes J.D., and Chulay J.D. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 16 (1979) 710-718
26. Rieckmann K.H., Campbell G.H., Sax L.J., and Mrema J.E. Drug sensitivity of Plasmodium falciparum: an in vitro microtechnique. Lancet 1 (1978) 22
27. Rzepczyk C.M., Saul A.J., and Ferrante A. Polyamine oxidase-mediated intraerythrocytic killing of Plasmodium falciparum: evidence against the role of reactive oxygen metabolites. Infect Immun 43 (1984) 238-244
28. Srivastava I.K., Rottenberg H., and Vaidya A.B. Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J Biol Chem 272 (1997) 3961-3966
29. Chow S., and Hedley D. Flow cytometric measurement of intracellular. In: Chow S., and Hedley D. (Eds). Current Protocols in Cytometry (1997), John Wiley & Sons, Inc
30. Wissing F., Sanchez C.P., Rohrbach P., Ricken S., and Lanzer M. Illumination of the malaria parasite Plasmodium falciparum alters intracellular pH. Implications for live cell imaging. J Biol Chem 277 (2002) 37747-37755
31. Kalbacova M., Vrbacky M., Drahota Z., and Melkova Z. Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry A 52 (2003) 110-116
32. Pabon A., Deharo E., Zuluaga L., Maya J.D., Saez J., and Blair S. Plasmodium falciparum: effect of Solanum nudum steroids on thiol contents and beta-hematin formation in parasitized erythrocytes. Exp Parasitol 122 (2009) 273-279
33. Ryan E., Chopra J., McCarthy F., Maguire A.R., and O'Brien N.M. Qualitative and quantitative comparison of the cytotoxic and apoptotic potential of phytosterol oxidation products with their corresponding cholesterol oxidation products. Br J Nutr 94 (2005) 443-451
34. Ignatushchenko M.V., Winter R.W., and Riscoe M. Xanthones as antimalarial agents: stage specificity. Am J Trop Med Hyg 62 (2000) 77-81
35. Painter H.J., Morrisey J.M., Mather M.W., and Vaidya A.B. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446 (2007) 88-91
36. Wunsch S., Sanchez C.P., Gekle M., Grosse-Wortmann L., Wiesner J., and Lanzer M. Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum. J Cell Biol 140 (1998) 335-345
37. Nilsson C., Kagedal K., Johansson U., and Ollinger K. Analysis of cytosolic and lysosomal pH in apoptotic cells by flow cytometry. Methods Cell Sci 25 (2003) 185-194
38. Liu D., Martino G., Thangaraju M., Sharma M., Halwani F., Shen S.H., et al. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J Biol Chem 275 (2000) 9244-9250
39. Galluzzi L., Maiuri M.C., Vitale I., Zischka H., Castedo M., Zitvogel L., et al. Cell death modalities: classification and pathophysiological implications. Cell Death Differ 14 (2007) 1237-1243
40. Bonilla J.A., Bonilla T.D., Yowell C.A., Fujioka H., and Dame J.B. Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function. Mol Microbiol 65 (2007) 64-75
41. Ponts N., Yang J., Chung D.W., Prudhomme J., Girke T., Horrocks P., et al. Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence. PLoS ONE 3 (2008) e2386