Artesunate/mefloquine treatment of multi-drug resistant falciparum malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 91, Issue 5, 1997, Pages 574-577

  Price, R N ^a,b,e   Nosten, F ^a,c,e   Luxemburger, C ^a,c,e   Van Vugt, M ^a,c,d   Phaipun, L ^a   Chongsuphajaisiddhi, T ^c   White, N J ^c,e  

^a SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Artesunate; Chemotherapy; Malaria; Mefloquine; Plasmodium falciparum urn; Thailand

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; CHLORPHENIRAMINE; DIAZEPAM; MEFLOQUINE;

ADOLESCENT; ADULT; AGE; ANOREXIA; ANXIETY NEUROSIS; ARTICLE; CHILD; CLINICAL TRIAL; DIARRHEA; DISEASE SEVERITY; DRUG EFFICACY; FEMALE; HEART PALPITATION; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MULTIDRUG RESISTANCE; NAUSEA; ORAL DRUG ADMINISTRATION; PLASMODIUM FALCIPARUM; PROPRIOCEPTION; PRURITUS; RASH; RELAPSE; SEIZURE; SLEEP DISORDER; THAILAND; URTICARIA; VERTIGO; VOMITING;

ARTESUNATE; PLASMODIUM FALCIPARUM;

EID: 0030662494     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0035-9203(97)90032-8     Document Type: Article

References (13)

1. Boyd, M. F. & Kitchen, S. F. (1937). Simultaneous inoculation with Plasmodium vivax and Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene, 17, 855-861.
2. Looareesuwan, S., Viravan, C., Vanijanonta, S., Wilairatana, P., Suntharasamai, P., Charoenlarp, P., Arnold, K., Kyle, D., Canfield, C. & Webster, K. (1992). Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malaria. Lancet, 339, 821-824.
3. Looareesuwan, S., Viaravan, C., Vanijanonta, S., Wilairatana, P., Pitisuttithum, P. & Andrial, M. (1996). Comparative clinical trial of artesunate followed by mefloquine in the treatment of acute uncomplicated falciparum malaria: two- and three-day regimens. American Journal of Tropical Medicine and Hygiene, 54, 210-213.
4. Luxemburger, C., ter Kuile, F. O., Nosten, F., Dolan, G., Bradol, J. H., Phaipun, L., Chongsuphajaisiddhi, T. & White, N. J. (1994). Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 213-217.
5. Luxemburger, C., Nosten, F., Shotar, Raimond, D., Chongsuphajaisiddhi, T. & White, N. J. (1995). Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria. American Journal of Tropical Medicine and Hygiene, 53, 522-525.
6. Luxemburger, C., Kyaw Ley Thwai, White, N. J., Webster, H. K., Kyle, D. E., Maelankirri, L., Chongsuphajaisiddhi, T. & Nosten, F. (1996). The epidemiology of malaria in a Karen population on the western border of Thailand. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 105-111.
7. Nosten, F., ter Kuile, F. O., Luxemburger, C., Woodrow, C., Kyle, D. E., Chongsuphajaisiddhi, T. & White, N. J. (1993). Cardiac effects of antimalarial treatment with halofantrine. Lancet, 341, 1054-1056.
8. Nosten, F., Luxemburger, C., ter Kuile, F. O., Woodrow, C., Pa Eh, J., Chongsuphajaisiddhi, T. & White, N. J. (1994). Optimum artesunate-mefloquine combination for the treatment of multi-drug resistant Plasmodium falciparum malaria. Journal of Infectious Diseases, 170, 971-977.
9. Price, R. N., Nosten, F., Luxemburger, C., Am Kham, Brockman, A., Chongsuphajaisiddhi, T. & White, N. J. (1995). Artesunate versus artemether in combination with mefloquine for the treatment of multidrug-resistant falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 523-527.
10. Price, R. N., Nosten, F., Luxemburger, C., ter Kuile, F., Paiphun, L., Chongsuphajaisiddhi, T. & White, N. J. (1996). The effects of artemisinin derivatives on malaria transmissability. Lancet, 347, 1654-1658.
11. Ter Kuile, F. O., Luxemburger, C., Nosten, F., Kyaw Lay Thwai, Chongsuphajaisiddhi, T. & White, N. J. (1995). Predictors of mefloquine treatment failure: a prospective study in 1590 patients with uncomplicated falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 660-664.
12. White, N. J. (1992). Antimalarial drug resistance: the pace quickens. Journal of Antimicrobial Chemotherapy, 30, 571-585.
13. White, N. J. (in press). Assessment of the pharmacodynamic properties of antimalarial drugs in-vivo. Antimicrobial Agents and Chemotherapy.