Physiological roles revealed by ghrelin and ghrelin receptor deficient mice

Peptides

Volumn 32, Issue 11, 2011, Pages 2229-2235

  Albarran Zeckler, Rosie G ^a,b   Sun, Yuxiang ^b,c   Smith, Roy G ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

Ghrein knockout mice; Ghrelin; Ghrelin receptor (GHS R1a); Ghrelin receptor knockout mice

Indexed keywords

GHRELIN; GHRELIN RECEPTOR; GLUCOSE;

APPETITE; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC SYSTEM; ENERGY BALANCE; GLUCOSE HOMEOSTASIS; GROWTH HORMONE RELEASE; HEALTH; HORMONE ACTION; IMMUNE SYSTEM; LEARNING; LONGEVITY; MEMORY; MOUSE; NEUROPROTECTION; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; THYMUS;

ANIMALS; CENTRAL NERVOUS SYSTEM; DOPAMINERGIC NEURONS; ENERGY METABOLISM; FEMALE; GHRELIN; GLUCOSE; HUMANS; LEARNING; LEPTIN; LONGEVITY; MALE; MEMORY; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; NEUROPROTECTIVE AGENTS; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION; STOMACH;

MUS;

EID: 81755173582     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.07.003     Document Type: Review

References (47)

1. A. Abizaid, Z.W. Liu, Z.B. Andrews, M. Shanabrough, E. Borok, and J.D. Elsworth Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite J Clin Invest 116 2006 3229 3239
2. Z.B. Andrews, D. Erion, R. Beiler, Z.W. Liu, A. Abizaid, and J. Zigman Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism J Neurosci 29 2009 14057 14065
3. C.Y. Bowers, F.A. Momany, G.A. Reynolds, and A. Hong On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone Endocrinology 114 1984 1537 1545
4. V.P. Carlini, M.E. Monzon, M.M. Varas, A.B. Cragnolini, H.B. Schioth, and T.N. Scimonelli Ghrelin increases anxiety-like behavior and memory retention in rats Biochem Biophys Res Commun 299 2002 739 743
5. I.M. Chapman, M.A. Bach, E. Van Cauter, M. Farmer, D.A. Krupa, and A.M. Taylor Stimulation of the growth hormone (GH)-insulin-like growth factor-I axis by daily oral administration of a GH secretagogue (MK-0677) in healthy elderly subjects J Clin Endocrinol Metab 81 1996 4249 4257
6. K. Cheng, W.W.-S. Chan, B.S. Butler, A. Barreto, and R.G. Smith The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on GRF stimulated growth hormone release and intracellular cAMP accumulation in rat primary pituitary cell cultures Endocrinology 124 1989 2791 2797
7. K. Cheng, W.W.-S. Chan, B.S. Butler, A. Barreto, and R.G. Smith Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells Endocrinology 129 1991 3337 3342
8. H. Chung, E. Kim, D.H. Lee, S. Seo, S. Ju, and D. Lee Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation Endocrinology 148 2007 148 159
9. S. Clifford, R.A. Zeckler, S. Buckman, J. Thompson, N. Hart, and P.J. Wellman Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice Addict Biol 2010
10. M.A. Cowley, R.G. Smith, S. Diano, M. Tschop, N. Pronchuk, and K.L. Grove The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661
11. K. Dezaki, H. Sone, and T. Yada Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis Pharmacol Ther 118 2008 239 249
12. S. Diano, S.A. Farr, S.C. Benoit, E.C. McNay, I. da Silva, and B. Horvath Ghrelin controls hippocampal spine synapse density and memory performance Nat Neurosci 9 2006 381 388
13. V.D. Dixit, H. Yang, Y. Sun, A.T. Weeraratna, Y.H. Youm, and R.G. Smith Ghrelin promotes thymopoiesis during aging J Clin Invest 117 2007 2778 2790
14. E. Egecioglu, E. Jerlhag, N. Salome, K.P. Skibicka, D. Haage, and Y.M. Bohlooly Ghrelin increases intake of rewarding food in rodents Addict Biol 15 2010 304 311
15. S. Gandhi, and N.W. Wood Molecular pathogenesis of Parkinson's disease Hum Mol Genet 14 Spec No 2 2005 2749 2755
16. D. Grouselle, E. Chaillou, A. Caraty, M.T. Bluet-Pajot, P. Zizzari, and Y. Tillet Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep J Neuroendocrinol 20 2008 1138 1146
17. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Brain Res Mol Brain Res 48 1997 23 29
18. T.L. Horvath, S. Diano, P. Sotonyi, M. Heiman, and M. Tschop Minireview: ghrelin and the regulation of energy balance - a hypothalamic perspective Endocrinology 142 2001 4163 4169
19. A.D. Howard, S.D. Feighner, D.F. Cully, J.P. Arena, P.A. Liberator, and C.I. Rosenblum A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974 977
20. H. Jiang, L. Betancourt, and R.G. Smith Ghrelin amplifies.dopamine signaling by crosstalk involving formation of GHS-R/D1R heterodimers Mol Endocrinol 20 2006 1772 1785
21. H. Jiang, L.J. Li, J. Wang, and J.X. Xie Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra Exp Neurol 212 2008 532 537
22. M. Kojima, R. Haruno, M. Nakazato, Y. Date, N. Murakami, and R. Hanada Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3) Biochem Biophys Res Commun 276 2000 435 438
23. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
24. K.A. Longo, S. Charoenthongtrakul, D.J. Giuliana, E.K. Govek, T. McDonagh, and Y. Qi Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice Regul Pept 150 2008 55 61
25. A.E. Meinders, A.C. Toornvliet, and H. Pijl Leptin Neth J Med 49 1996 247 252
26. M. Moon, H.G. Kim, L. Hwang, J.H. Seo, S. Kim, and S. Hwang Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation Neurotox Res 15 2009 332 347
27. P. Muzzin, R.C. Eisensmith, K.C. Copeland, and S.L. Woo Correction of obesity and diabetes in genetically obese mice by leptin gene therapy Proc Natl Acad Sci USA 93 1996 14804 14808
28. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
29. C.W. Olanow, and W.G. Tatton Etiology and pathogenesis of Parkinson's disease Annu Rev Neurosci 22 1999 123 144
30. O.C. Palyha, S.D. Feighner, C.P. Tan, K.K. McKee, D.L. Hreniuk, and Y-D. Gao Ligand activation domain of human orphan growth hormone secretagogue receptor (GHS-R) conserved from Pufferfish to humans Mol Endocrinol 14 2000 160 169
31. A.A. Patchett, R.P. Nargund, J.R. Tata, M-H. Chen, K.J. Barakat, and D.B.R. Johnston The design and biological activities of L-163,191 (MK-0677): a potent orally active growth hormone secretagogue Proc Natl Acad Sci USA 92 1995 7001 7005
32. R.G. Smith, S. Feighner, K. Prendergast, X. Guan, and A. Howard A new orphan receptor involved in pulsatile growth hormone release Trends Endocrinol Metab 10 1999 128 135
33. Y. Sun, S. Ahmed, and R.G. Smith Deletion of ghrelin impairs neither growth nor appetite Mol Cell Biol 23 2003 7973 7981
34. Y. Sun, M. Asnicar, P.K. Saha, L. Chan, and R.G. Smith Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metab 3 2006 379 386
35. Y. Sun, N.F. Butte, J.M. Garcia, and R.G. Smith Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance Endocrinology 149 2008 843 850
36. Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc Natl Acad Sci USA 101 2004 4679 4684
37. J. Svensson, L. Lonn, J.O. Jansson, G. Murphy, D. Wyss, and D. Krupa Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure J Clin Endocrinol Metab 83 1998 362 369
38. E. Szentirmai, L. Kapas, Y. Sun, R.G. Smith, and J.M. Krueger The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice Proc Natl Acad Sci USA 106 2009 14069 14074
39. M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
40. P.J. Wellman, C.N. Hollas, and A.E. Elliott Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats Regul Pept 146 2008 33 37
41. K.E. Wortley, K.D. Anderson, K. Garcia, J.D. Murray, L. Malinova, and R. Liu Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc Natl Acad Sci USA 101 2004 8227 8232
42. K.E. Wortley, J.P. Del Rincon, J.D. Murray, K. Garcia, K. Iida, and M.O. Thorner Absence of ghrelin protects against early-onset obesity J Clin Invest 115 2005 3573 3578
43. A.M. Wren, L.J. Seal, M.A. Cohen, A.E. Brynes, G.S. Frost, and K.G. Murphy Ghrelin enhances appetite and increases food intake in humans J Clin Endocrinol Metab 86 2001 5992
44. A.M. Wren, C.J. Small, C.R. Abbott, W.S. Dhillo, L.J. Seal, and M.A. Cohen Ghrelin causes hyperphagia and obesity in rats Diabetes 50 2001 2540 2547
45. Y.H. Youm, H. Yang, Y. Sun, R.G. Smith, N.R. Manley, and B. Vandanmagsar Deficient ghrelin receptor-mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity J Biol Chem 284 2009 7068 7077
46. T.J. Zhao, G. Liang, R.L. Li, X. Xie, M.W. Sleeman, and A.J. Murphy Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice Proc Natl Acad Sci USA 107 2010 7467 7472
47. J.M. Zigman, Y. Nakano, R. Coppari, N. Balthasar, J.N. Marcus, and C.E. Lee Mice lacking ghrelin receptors resist the development of diet-induced obesity J Clin Invest 115 2005 3564 3572