Cancer cell senescence: A new frontier in drug development

Drug Discovery Today

Volumn 17, Issue 5-6, 2012, Pages 269-276

  Cairney, Claire J ^a   Bilsland, Alan E ^a   Evans, T R Jeffry ^a   Roffey, Jon ^b   Bennett, Dorothy C ^c,f   Narita, Masashi ^d,f   Torrance, Christopher J ^e,f   Keith, W Nicol ^a,f  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^e Molecular Biotechnology Center   (United Kingdom)

^f Angel Building ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; COMPLEMENTARY DNA; CYTOTOXIC AGENT; EVEROLIMUS; HEAT SHOCK PROTEIN 90 INHIBITOR; IRINOTECAN; QUINONE DERIVATIVE; SENESCENCE AGONIST; SORAFENIB; TELOMERASE REVERSE TRANSCRIPTASE; TEMSIROLIMUS; TOPOTECAN; UNCLASSIFIED DRUG; VEMURAFENIB; VORINOSTAT;

APOPTOSIS; CANCER CELL; CANCER THERAPY; CELL AGING; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN; COLORECTAL CANCER; DNA DAMAGE; DRUG DEVELOPMENT; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENOMICS; HUMAN; LUNG CANCER; MOLECULAR PATHOLOGY; NONHUMAN; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL AGING; DRUG DISCOVERY; HUMANS; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84857997174     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.01.019     Document Type: Review

References (54)

1. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
2. M. Narita Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Cell 113 2003 703 716
3. R. Zhang Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA Dev. Cell 8 2005 19 30
4. S.P. Atkinson, and W.N. Keith Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention Expert Rev. Mol. Med. 9 2007 1 26
5. F. d'Adda di Fagagna Living on a break: cellular senescence as a DNA-damage response Nat. Rev. Cancer 8 2008 512 522
6. J.P. Coppe The senescence-associated secretory phenotype: the dark side of tumor suppression Annu. Rev. Pathol. 5 2010 99 118
7. A.R. Young, and M. Narita SASP reflects senescence EMBO Rep. 10 2009 228 230
8. M. Narita, and A.R. Young Autophagy facilitates oncogene-induced senescence Autophagy 5 2009 1046 1047
9. K. Lafferty-Whyte Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma BMC Genomics 11 2010 532
10. S. Ansieau Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence Cancer Cell 14 2008 79 89
11. D.M. Feldser, and C.W. Greider Short telomeres limit tumor progression in vivo by inducing senescence Cancer Cell 11 2007 461 469
12. P.K. Majumder A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression Cancer Cell 14 2008 146 155
13. W. Xue Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Nature 445 2007 656 660
14. J.W. Shay, and W.N. Keith Targeting telomerase for cancer therapeutics Br. J. Cancer 98 2008 677 683
15. Q. Yan, and N. Wajapeyee Exploiting cellular senescence to treat cancer and circumvent drug resistance Cancer Biol. Ther. 9 2010 166 175
16. A. Prieur, and D.S. Peeper Cellular senescence in vivo: a barrier to tumorigenesis Curr. Opin. Cell Biol. 20 2008 150 155
17. J.A. Ewald Therapy-induced senescence in cancer J. Natl. Cancer Inst. 102 2010 1536 1546
18. D.A. Gewirtz Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation Biochem. Pharmacol. 76 2008 947 957
19. B.M. Padhy, and Y.K. Gupta Drug repositioning: re-investigating existing drugs for new therapeutic indications J. Postgrad. Med. 57 2011 153 160
20. J.A. Ewald A high-throughput method to identify novel senescence-inducing compounds J. Biomol. Screen. 14 2009 853 858
21. E. Labay Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence Int. J. High Throughput Screen. 2 2011 1 13
22. J.P. Coppe Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol. 6 2008 2853 2868
23. M. Collado, and M. Serrano Senescence in tumours: evidence from mice and humans Nat. Rev. Cancer 10 2010 51 57
24. R.H. te Poele DNA damage is able to induce senescence in tumor cells in vitro and in vivo Cancer Res. 62 2002 1876 1883
25. A.M. Haugstetter Cellular senescence predicts treatment outcome in metastasised colorectal cancer Br. J. Cancer 103 2010 505 509
26. C. Nardella Pro-senescence therapy for cancer treatment Nat. Rev. Cancer 11 2011 503 511
27. G.P. Dimri A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc. Natl. Acad. Sci. U. S. A. 92 1995 9363 9367
28. J.J. Going 'Senescence-associated' beta-galactosidase activity in the upper gastrointestinal tract J. Pathol. 196 2002 394 400
29. P.J. Coates Markers of senescence? J. Pathol. 196 2002 371 373
30. M. Kosar Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a) Cell Cycle 10 2011 457 468
31. R. Di Micco Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer Nat. Cell Biol. 13 2011 292 302
32. C. Lawless Quantitative assessment of markers for cell senescence Exp. Gerontol. 45 2010 772 778
33. F. Gasparri Quantification of the proliferation index of human dermal fibroblast cultures with the ArrayScan high-content screening reader J. Biomol. Screen. 9 2004 232 243
34. A. Barabasz The use of high-content screening for the discovery and characterization of compounds that modulate mitotic index and cell cycle progression by differing mechanisms of action Assay Drug Dev. Technol. 4 2006 153 163
35. L.E. Grove, and R.N. Ghosh Quantitative characterization of mitosis-blocked tetraploid cells using high content analysis Assay Drug Dev. Technol. 4 2006 421 442
36. A.A. Hill Impact of image segmentation on high-content screening data quality for SK-BR-3 cells BMC Bioinformatics 8 2007 340
37. J.M. Breier Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells Toxicol. Sci. 105 2008 119 133
38. V. Bassaneze A quantitative chemiluminescent method for studying replicative and stress-induced premature senescence in cell cultures Anal. Biochem. 372 2008 198 203
39. T. Kawaguchi Rapid screening of quorum-sensing signal N-acyl homoserine lactones by an in vitro cell-free assay Appl. Environ. Microbiol. 74 2008 3667 3671
40. O.T. Brustugun Sensitive and rapid detection of beta-galactosidase expression in intact cells by microinjection of fluorescent substrate Exp. Cell Res. 219 1995 372 378
41. S. Degerman Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures Aging Cell 9 2010 220 235
42. K. Lafferty-Whyte Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms Biochim. Biophys. Acta 1792 2009 341 352
43. A.E. Bilsland Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3 Cancer Res. 66 2006 1363 1370
44. M. Hillgenberg High-efficiency system for the construction of adenovirus vectors and its application to the generation of representative adenovirus-based cDNA expression libraries J. Virol. 80 2006 5435 5450
45. K.H. Wan High-throughput plasmid cDNA library screening Nat. Protoc. 1 2006 624 632
46. Q. Huang Identification of p53 regulators by genome-wide functional analysis Proc. Natl. Acad. Sci. U. S. A. 101 2004 3456 3461
47. K. Koenig-Hoffmann High throughput functional genomics: identification of novel genes with tumor suppressor phenotypes Int. J. Cancer 113 2005 434 439
48. A.E. Bilsland Dynamic telomerase gene suppression via network effects of GSK3 inhibition PLoS One 4 2009 e6459
49. K. Lafferty-Whyte TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression Neoplasia 12 2010 405 414
50. M.A. Cerone High-throughput RNAi screening reveals novel regulators of telomerase Cancer Res. 71 2011 3328 3340
51. A. Viale Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells Nature 457 2009 51 56
52. I.J. Restall, and I.A. Lorimer Induction of premature senescence by hsp90 inhibition in small cell lung cancer PLoS One 5 2010 e11076
53. R.S. Roberson Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers Cancer Res. 65 2005 2795 2803
54. J. Ewald Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo Br. J. Cancer 98 2008 1244 1249