Cancer cell senescence: A new frontier in drug development

Drug Discovery Today

Volumn 17, Issue 5-6, 2012, Pages 269-276

  Cairney, Claire J ^a   Bilsland, Alan E ^a   Evans, T R Jeffry ^a   Roffey, Jon ^b   Bennett, Dorothy C ^c,f   Narita, Masashi ^d,f   Torrance, Christopher J ^e,f   Keith, W Nicol ^a,f  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^e IQ Cambridge ^*  (United Kingdom)

^f Angel Building ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; COMPLEMENTARY DNA; CYTOTOXIC AGENT; EVEROLIMUS; HEAT SHOCK PROTEIN 90 INHIBITOR; IRINOTECAN; QUINONE DERIVATIVE; SENESCENCE AGONIST; SORAFENIB; TELOMERASE REVERSE TRANSCRIPTASE; TEMSIROLIMUS; TOPOTECAN; UNCLASSIFIED DRUG; VEMURAFENIB; VORINOSTAT;

APOPTOSIS; CANCER CELL; CANCER THERAPY; CELL AGING; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN; COLORECTAL CANCER; DNA DAMAGE; DRUG DEVELOPMENT; DRUG TARGETING; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENOMICS; HUMAN; LUNG CANCER; MOLECULAR PATHOLOGY; NONHUMAN; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; REVIEW; SENESCENCE; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL AGING; DRUG DISCOVERY; HUMANS; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84857997174     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.01.019     Document Type: Review

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