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Volumn 40, Issue 14, 2012, Pages 6477-6494

Postnatal development- and age-related changes in DNA-methylation patterns in the human genome

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; AGING; ALPP GENE; ALPPL2 GENE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; DNA METHYLATION; ECEL1 GENE; ECEL1P2 GENE; EPIGENETICS; FAM90A GENE; FEMALE; FGF17 GENE; FZD1 GENE; FZD7 GENE; GENE; GENE AMPLIFICATION; GENE MAPPING; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOME; HRNR GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MALE; MOLECULAR DYNAMICS; MONOCYTE; NEWBORN; NORMAL HUMAN; PCDHG GENE; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TANDEM REPEAT;

EID: 84864946547     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks312     Document Type: Article
Times cited : (42)

References (95)
  • 2
    • 69949085788 scopus 로고    scopus 로고
    • Genome instability, cancer and aging
    • Maslov, A.Y. and Vijg, J. (2009) Genome instability, cancer and aging. Biochim. Biophys. Acta, 1790, 963-969.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 963-969
    • Maslov, A.Y.1    Vijg, J.2
  • 3
    • 34547941973 scopus 로고    scopus 로고
    • The common biology of cancer and ageing
    • DOI 10.1038/nature05985, PII NATURE05985
    • Finkel, T., Serrano, M. and Blasco, M.A. (2007) The common biology of cancer and ageing. Nature, 448, 767-774. (Pubitemid 47266334)
    • (2007) Nature , vol.448 , Issue.7155 , pp. 767-774
    • Finkel, T.1    Serrano, M.2    Blasco, M.A.3
  • 4
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • DOI 10.1016/j.cell.2005.01.027
    • Kirkwood, T.B. (2005) Understanding the odd science of aging. Cell, 120, 437-447. (Pubitemid 40269759)
    • (2005) Cell , vol.120 , Issue.4 , pp. 437-447
    • Kirkwood, T.B.L.1
  • 5
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • DOI 10.1038/ng1089
    • Jaenisch, R. and Bird, A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet., 33(Suppl), 245-254. (Pubitemid 36278835)
    • (2003) Nature Genetics , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 6
    • 33749022748 scopus 로고    scopus 로고
    • How lifetimes shape epigenotype within and across generations
    • DOI 10.1093/hmg/ddl200
    • Whitelaw, N.C. and Whitelaw, E. (2006) How lifetimes shape epigenotype within and across generations. Hum. Mol. Genet., 15(Spec No 2), R131-R137. (Pubitemid 44446786)
    • (2006) Human Molecular Genetics , vol.15 , Issue.SUPPL. 2
    • Whitelaw, N.C.1    Whitelaw, E.2
  • 7
    • 0029935604 scopus 로고    scopus 로고
    • Replicative senescence: Considerations relating to the stability of heterochromatin domains
    • DOI 10.1016/0531-5565(95)00022-4
    • Howard, B.H. (1996) Replicative senescence: considerations relating to the stability of heterochromatin domains. Exp. Gerontol., 31, 281-293. (Pubitemid 26079679)
    • (1996) Experimental Gerontology , vol.31 , Issue.1-2 , pp. 281-293
    • Howard, B.H.1
  • 8
    • 24044509509 scopus 로고    scopus 로고
    • Genomes optimize reproduction: Aging as a consequence of the developmental program
    • de Magalhaes, J.P. and Church, G.M. (2005) Genomes optimize reproduction: aging as a consequence of the developmental program. Physiology, 20, 252-259. (Pubitemid 41215199)
    • (2005) Physiology , Issue.4 , pp. 252-259
    • De Magalhaes, J.P.1    Church, G.M.2
  • 10
    • 80052555415 scopus 로고    scopus 로고
    • Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans
    • Martino, D.J., Tulic, M.K., Gordon, L., Hodder, M., Richman, T., Metcalfe, J., Prescott, S.L. and Saffery, R. (2011) Evidence for age-related and individual-specific changes in DNA methylation profile of mononuclear cells during early immune development in humans. Epigenetics, 6, 1085-1094.
    • (2011) Epigenetics , vol.6 , pp. 1085-1094
    • Martino, D.J.1    Tulic, M.K.2    Gordon, L.3    Hodder, M.4    Richman, T.5    Metcalfe, J.6    Prescott, S.L.7    Saffery, R.8
  • 11
    • 79251600254 scopus 로고    scopus 로고
    • Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues
    • Takasugi, M. (2011) Progressive age-dependent DNA methylation changes start before adulthood in mouse tissues. Mech. Ageing Dev., 132, 65-71.
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 65-71
    • Takasugi, M.1
  • 12
    • 34247508639 scopus 로고    scopus 로고
    • Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    • DOI 10.1203/pdr.0b013e318045bedb
    • Godfrey, K.M., Lillycrop, K.A., Burdge, G.C., Gluckman, P.D. and Hanson, M.A. (2007) Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr. Res., 61, 5R-10R. (Pubitemid 46653061)
    • (2007) Pediatric Research , vol.61 , Issue.5 PART 2 SUPPL.
    • Godfrey, K.M.1    Lillycrop, K.A.2    Burdge, G.C.3    Gluckman, P.D.4    Hanson, M.A.5
  • 13
    • 34250891914 scopus 로고    scopus 로고
    • Mechanisms of Disease: The developmental origins of disease and the role of the epigenotype
    • DOI 10.1038/ncpendmet0531, PII NCPENDMET0531
    • Ozanne, S.E. and Constancia, M. (2007) Mechanisms of disease: the developmental origins of disease and the role of the epigenotype. Nat. Clin. Pract. Endocrinol. Metab., 3, 539-546. (Pubitemid 46975821)
    • (2007) Nature Clinical Practice Endocrinology and Metabolism , vol.3 , Issue.7 , pp. 539-546
    • Ozanne, S.E.1    Constancia, M.2
  • 14
    • 79955970344 scopus 로고    scopus 로고
    • Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
    • Bocker, M.T., Hellwig, I., Breiling, A., Eckstein, V., Ho, A.D. and Lyko, F. (2011) Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. Blood, 117, e182-e189.
    • (2011) Blood , vol.117
    • Bocker, M.T.1    Hellwig, I.2    Breiling, A.3    Eckstein, V.4    Ho, A.D.5    Lyko, F.6
  • 15
    • 34548392803 scopus 로고    scopus 로고
    • Epigenetic control of hematopoietic stem cell aging: The case of Ezh2
    • DOI 10.1196/annals.1392.008, Hematopoietic Stem Cells VI
    • De Haan, G. and Gerrits, A. (2007) Epigenetic control of hematopoietic stem cell aging the case of Ezh2. Ann. N Y Acad. Sci., 1106, 233-239. (Pubitemid 47443044)
    • (2007) Annals of the New York Academy of Sciences , vol.1106 , pp. 233-239
    • De Haan, G.1    Gerrits, A.2
  • 16
    • 79960375714 scopus 로고    scopus 로고
    • Epigenetic regulation of aging stem cells
    • Pollina, E.A. and Brunet, A. (2011) Epigenetic regulation of aging stem cells. Oncogene, 30, 3105-3126.
    • (2011) Oncogene , vol.30 , pp. 3105-3126
    • Pollina, E.A.1    Brunet, A.2
  • 18
    • 0030743612 scopus 로고    scopus 로고
    • DNA methylation and imprinting: Why bother?
    • DOI 10.1016/S0168-9525(97)01180-3, PII S0168952597011803
    • Jaenisch, R. (1997) DNA methylation and imprinting: why bother? Trends Genet., 13, 323-329. (Pubitemid 27309909)
    • (1997) Trends in Genetics , vol.13 , Issue.8 , pp. 323-329
    • Jaenisch, R.1
  • 19
    • 0022000776 scopus 로고
    • A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA
    • Bird, A., Taggart, M., Frommer, M., Miller, O.J. and Macleod, D. (1985) A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA. Cell, 40, 91-99. (Pubitemid 15169310)
    • (1985) Cell , vol.40 , Issue.1 , pp. 91-99
    • Bird, A.1    Taggart, M.2    Frommer, M.3
  • 20
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird, A.P. (1986) CpG-rich islands and the function of DNA methylation. Nature, 321, 209-213. (Pubitemid 16016411)
    • (1986) Nature , vol.321 , Issue.6067 , pp. 209-213
    • Bird, A.P.1
  • 24
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • DOI 10.1016/S0168-9525(97)01181-5, PII S0168952597011815
    • Yoder, J.A., Walsh, C.P. and Bestor, T.H. (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet., 13, 335-340. (Pubitemid 27309911)
    • (1997) Trends in Genetics , vol.13 , Issue.8 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 25
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi, A., Park, I.H., Wen, B., Murakami, P., Aryee, M.J., Irizarry, R., Herb, B., Ladd-Acosta, C., Rho, J., Loewer, S. et al. (2009) Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet., 41, 1350-1353.
    • (2009) Nat. Genet. , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6    Herb, B.7    Ladd-Acosta, C.8    Rho, J.9    Loewer, S.10
  • 26
    • 79959872458 scopus 로고    scopus 로고
    • Cell type-specific DNA methylation at intragenic CpG islands in the immune system
    • Deaton, A.M., Webb, S., Kerr, A.R., Illingworth, R.S., Guy, J., Andrews, R. and Bird, A. (2011) Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res., 21, 1074-1086.
    • (2011) Genome Res. , vol.21 , pp. 1074-1086
    • Deaton, A.M.1    Webb, S.2    Kerr, A.R.3    Illingworth, R.S.4    Guy, J.5    Andrews, R.6    Bird, A.7
  • 28
    • 0025043570 scopus 로고
    • Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse
    • Swisshelm, K., Disteche, C.M., Thorvaldsen, J., Nelson, A. and Salk, D. (1990) Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse. Mutat. Res., 237, 131-146. (Pubitemid 20349706)
    • (1990) Mutation Research , vol.237 , Issue.3-4 , pp. 131-146
    • Swisshelm, K.1    Disteche, C.M.2    Thorvalsden, J.3    Nelson, A.4    Salk, D.5
  • 31
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • DOI 10.1038/ng0894-536
    • Issa, J.P., Ottaviano, Y.L., Celano, P., Hamilton, S.R., Davidson, N.E. and Baylin, S.B. (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet., 7, 536-540. (Pubitemid 24308343)
    • (1994) Nature Genetics , vol.7 , Issue.4 , pp. 536-540
    • Issa, J.-P.J.1    Ottaviano, Y.L.2    Celano, P.3    Hamilton, S.R.4    Davidson, N.E.5    Baylin, S.B.6
  • 38
  • 39
    • 0033403066 scopus 로고    scopus 로고
    • Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo
    • Randolph, G.J., Inaba, K., Robbiani, D.F., Steinman, R.M. and Muller, W.A. (1999) Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. Immunity, 11, 753-761. (Pubitemid 30030714)
    • (1999) Immunity , vol.11 , Issue.6 , pp. 753-761
    • Randolph, G.J.1    Inaba, K.2    Robbiani, D.F.3    Steinman, R.M.4    Muller, W.A.5
  • 42
    • 0036284676 scopus 로고    scopus 로고
    • Endotoxin-free purification of monocytes for dendritic cell generation via discontinuous density gradient centrifugation based on diluted Ficoll-Paque Plus®
    • DOI 10.1159/000058006
    • Lehner, M. and Holter, W. (2002) Endotoxin-free purification of monocytes for dendritic cell generation via discontinuous density gradient centrifugation based on diluted Ficoll-Paque Plus. Int. Arch Allergy Immunol., 128, 73-76. (Pubitemid 34621669)
    • (2002) International Archives of Allergy and Immunology , vol.128 , Issue.1 , pp. 73-76
    • Lehner, M.1    Holter, W.2
  • 43
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • DOI 10.1038/ng1598
    • Weber, M., Davies, J.J., Wittig, D., Oakeley, E.J., Haase, M., Lam, W.L. and Schubeler, D. (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet., 37, 853-862. (Pubitemid 41077111)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 47
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • Langmead, B., Trapnell, C., Pop, M. and Salzberg, S.L. (2009) Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol., 10, R25.
    • (2009) Genome Biol. , vol.10
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4
  • 48
    • 70350042634 scopus 로고    scopus 로고
    • Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation
    • Docherty, S.J., Davis, O.S., Haworth, C.M., Plomin, R. and Mill, J. (2009) Bisulfite-based epityping on pooled genomic DNA provides an accurate estimate of average group DNA methylation. Epigenet. Chromatin, 2, 3.
    • (2009) Epigenet. Chromatin , vol.2 , pp. 3
    • Docherty, S.J.1    Davis, O.S.2    Haworth, C.M.3    Plomin, R.4    Mill, J.5
  • 49
    • 0032714089 scopus 로고    scopus 로고
    • Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes
    • Brock, G.J., Charlton, J. and Bird, A. (1999) Densely methylated sequences that are preferentially localized at telomere-proximal regions of human chromosomes. Gene, 240, 269-277.
    • (1999) Gene , vol.240 , pp. 269-277
    • Brock, G.J.1    Charlton, J.2    Bird, A.3
  • 50
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa, J.P. (2004) CpG island methylator phenotype in cancer. Nat. Rev. Cancer, 4, 988-993.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 51
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones, P.A. and Baylin, S.B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428. (Pubitemid 34587077)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 52
    • 0018649918 scopus 로고
    • Characteristics of human mononuclear phagocytes
    • van Furth, R., Raeburn, J.A. and van Zwet, T.L. (1979) Characteristics of human mononuclear phagocytes. Blood, 54, 485-500. (Pubitemid 9247717)
    • (1979) Blood , vol.54 , Issue.2 , pp. 485-500
    • Van Furth, R.1    Raeburn, J.A.2    Van Zwet, T.L.3
  • 54
    • 35548999252 scopus 로고    scopus 로고
    • Protocadherin family: diversity, structure, and function
    • DOI 10.1016/j.ceb.2007.09.006, PII S0955067407001287, Cell to Cell Contact and Extracellular Matrix
    • Morishita, H. and Yagi, T. (2007) Protocadherin family: diversity, structure, and function. Curr. Opin. Cell Biol., 19, 584-592. (Pubitemid 350016857)
    • (2007) Current Opinion in Cell Biology , vol.19 , Issue.5 , pp. 584-592
    • Morishita, H.1    Yagi, T.2
  • 55
    • 0033063445 scopus 로고    scopus 로고
    • A striking organization of a large family of human neural cadherin-like cell adhesion genes
    • DOI 10.1016/S0092-8674(00)80789-8
    • Wu, Q. and Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell, 97, 779-790. (Pubitemid 29278051)
    • (1999) Cell , vol.97 , Issue.6 , pp. 779-790
    • Wu, Q.1    Maniatis, T.2
  • 58
    • 35448996612 scopus 로고    scopus 로고
    • Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events
    • DOI 10.1093/hmg/ddm209
    • Bosch, N., Caceres, M., Cardone, M.F., Carreras, A., Ballana, E., Rocchi, M., Armengol, L. and Estivill, X. (2007) Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events. Hum. Mol. Genet., 16, 2572-2582. (Pubitemid 47617724)
    • (2007) Human Molecular Genetics , vol.16 , Issue.21 , pp. 2572-2582
    • Bosch, N.1    Caceres, M.2    Cardone, M.F.3    Carreras, A.4    Ballana, E.5    Rocchi, M.6    Armengol, L.7    Estivill, X.8
  • 59
    • 0035861737 scopus 로고    scopus 로고
    • Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin
    • Makino, T., Takaishi, M., Morohashi, M. and Huh, N.H. (2001) Hornerin, a novel profilaggrin-like protein and differentiation-specific marker isolated from mouse skin. J. Biol. Chem., 276, 47445-47452.
    • (2001) J. Biol. Chem. , vol.276 , pp. 47445-47452
    • Makino, T.1    Takaishi, M.2    Morohashi, M.3    Huh, N.H.4
  • 60
    • 14244259063 scopus 로고    scopus 로고
    • Identification of human hornerin and its expression in regenerating and psoriatic skin
    • DOI 10.1074/jbc.M409026200
    • Takaishi, M., Makino, T., Morohashi, M. and Huh, N.H. (2005) Identification of human hornerin and its expression in regenerating and psoriatic skin. J. Biol. Chem., 280, 4696-4703. (Pubitemid 40288639)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.6 , pp. 4696-4703
    • Takaishi, M.1    Makino, T.2    Morohashi, M.3    Huh, N.-H.4
  • 62
    • 0023780755 scopus 로고
    • Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution
    • Knoll, B.J., Rothblum, K.N. and Longley, M. (1988) Nucleotide sequence of the human placental alkaline phosphatase gene. Evolution of the 5' flanking region by deletion/substitution. J. Biol. Chem., 263, 12020-12027.
    • (1988) J. Biol. Chem. , vol.263 , pp. 12020-12027
    • Knoll, B.J.1    Rothblum, K.N.2    Longley, M.3
  • 63
    • 0035307389 scopus 로고    scopus 로고
    • Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1
    • DOI 10.1006/geno.2000.6504
    • Rump, A., Kasper, G., Hayes, C., Wen, G., Starke, H., Liehr, T., Lehmann, R., Lagemann, D. and Rosenthal, A. (2001) Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1. Genomics, 73, 50-55. (Pubitemid 32382386)
    • (2001) Genomics , vol.73 , Issue.1 , pp. 50-55
    • Rump, A.1    Kasper, G.2    Hayes, C.3    Wen, G.4    Starke, H.5    Liehr, T.6    Lehmann, R.7    Lagemann, D.8    Rosenthal, A.9
  • 64
    • 0026640543 scopus 로고
    • DNA polymorphism of alkaline phosphatase isozyme genes: Linkage disequilibria between placental and germ-cell alkaline phosphatase alleles
    • Beckman, G., Beckman, L., Sikstrom, C. and Millan, J.L. (1992) DNA polymorphism of alkaline phosphatase isozyme genes: linkage disequilibria between placental and germ-cell alkaline phosphatase alleles. Am. J. Hum. Genet., 51, 1066-1070.
    • (1992) Am. J. Hum. Genet. , vol.51 , pp. 1066-1070
    • Beckman, G.1    Beckman, L.2    Sikstrom, C.3    Millan, J.L.4
  • 65
    • 52449116723 scopus 로고    scopus 로고
    • WNT signaling in stem cell biology and regenerative medicine
    • Katoh, M. (2008) WNT signaling in stem cell biology and regenerative medicine. Curr. Drug Targets, 9, 565-570.
    • (2008) Curr. Drug Targets , vol.9 , pp. 565-570
    • Katoh, M.1
  • 66
    • 78049338954 scopus 로고    scopus 로고
    • Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: General implications for tissue fusion processes
    • Yu, H., Smallwood, P.M., Wang, Y., Vidaltamayo, R., Reed, R. and Nathans, J. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development, 137, 3707-3717.
    • (2010) Development , vol.137 , pp. 3707-3717
    • Yu, H.1    Smallwood, P.M.2    Wang, Y.3    Vidaltamayo, R.4    Reed, R.5    Nathans, J.6
  • 68
    • 34047142805 scopus 로고    scopus 로고
    • Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
    • DOI 10.1093/hmg/ddm010
    • Heijmans, B.T., Kremer, D., Tobi, E.W., Boomsma, D.I. and Slagboom, P.E. (2007) Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus. Hum. Mol. Genet., 16, 547-554. (Pubitemid 46522617)
    • (2007) Human Molecular Genetics , vol.16 , Issue.5 , pp. 547-554
    • Heijmans, B.T.1    Kremer, D.2    Tobi, E.W.3    Boomsma, D.I.4    Slagboom, P.E.5
  • 72
    • 77449137288 scopus 로고    scopus 로고
    • Explaining inter-individual variability in phenotype: Is epigenetics up to the challenge?
    • Turan, N., Katari, S., Coutifaris, C. and Sapienza, C. (2010) Explaining inter-individual variability in phenotype: is epigenetics up to the challenge? Epigenetics, 5, 16-19.
    • (2010) Epigenetics , vol.5 , pp. 16-19
    • Turan, N.1    Katari, S.2    Coutifaris, C.3    Sapienza, C.4
  • 73
    • 0033554046 scopus 로고    scopus 로고
    • Protocadherin 2C: A new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain
    • DOI 10.1006/bbrc.1999.0950
    • Hirano, S., Ono, T., Yan, Q., Wang, X., Sonta, S. and Suzuki, S.T. (1999) Protocadherin 2C: a new member of the protocadherin 2 subfamily expressed in a redundant manner with OL-protocadherin in the developing brain. Biochem. Biophys. Res. Commun., 260, 641-645. (Pubitemid 29371104)
    • (1999) Biochemical and Biophysical Research Communications , vol.260 , Issue.3 , pp. 641-645
    • Hirano, S.1    Ono, T.2    Yan, Q.3    Wang, X.4    Sonta, S.-I.5    Suzuki, S.T.6
  • 74
    • 18744433250 scopus 로고    scopus 로고
    • Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex
    • DOI 10.1016/S0896-6273(00)80495-X
    • Kohmura, N., Senzaki, K., Hamada, S., Kai, N., Yasuda, R., Watanabe, M., Ishii, H., Yasuda, M., Mishina, M. and Yagi, T. (1998) Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron, 20, 1137-1151. (Pubitemid 28293131)
    • (1998) Neuron , vol.20 , Issue.6 , pp. 1137-1151
    • Kohmura, N.1    Senzaki, K.2    Hamada, S.3    Nobuyuki, K.4    Yasuda, R.5    Watanabe, M.6    Ishii, H.7    Yasuda, M.8    Mishina, M.9    Yagi, T.10
  • 76
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • Ahuja, N., Li, Q., Mohan, A.L., Baylin, S.B. and Issa, J.P. (1998) Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res., 58, 5489-5494. (Pubitemid 28551135)
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.-P.J.5
  • 77
    • 0034015438 scopus 로고    scopus 로고
    • CpG-island methylation in aging and cancer
    • Issa, J.P. (2000) CpG-island methylation in aging and cancer. Curr. Top Microbiol. Immunol., 249, 101-118.
    • (2000) Curr. Top Microbiol. Immunol. , vol.249 , pp. 101-118
    • Issa, J.P.1
  • 79
    • 0032126345 scopus 로고    scopus 로고
    • Cytosine methylation of repeated sequences in eukaryotes: The role of DNA pairing
    • DOI 10.1016/S0968-0004(98)01225-0, PII S0968000498012250
    • Bender, J. (1998) Cytosine methylation of repeated sequences in eukaryotes: the role of DNA pairing. Trends Biochem. Sci., 23, 252-256. (Pubitemid 28343369)
    • (1998) Trends in Biochemical Sciences , vol.23 , Issue.7 , pp. 252-256
    • Bender, J.1
  • 80
    • 0030115772 scopus 로고    scopus 로고
    • Creation of genomic methylation patterns
    • Bestor, T. and Tycko, B. (1996) Creation of genomic methylation patterns. Nat. Genet., 12, 363-367. (Pubitemid 126510021)
    • (1996) Nature Genetics , vol.12 , Issue.4 , pp. 363-367
    • Bestor, T.H.1    Tycko, B.2
  • 81
    • 0030664625 scopus 로고    scopus 로고
    • Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans
    • Dorer, D.R. and Henikoff, S. (1997) Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans. Genetics, 147, 1181-1190. (Pubitemid 27467459)
    • (1997) Genetics , vol.147 , Issue.3 , pp. 1181-1190
    • Dorer, D.R.1    Henikoff, S.2
  • 82
    • 0031984304 scopus 로고    scopus 로고
    • Repeat-induced gene silencing in mammals
    • DOI 10.1038/ng0198-56
    • Garrick, D., Fiering, S., Martin, D.I. and Whitelaw, E. (1998) Repeat-induced gene silencing in mammals. Nat. Genet., 18, 56-59. (Pubitemid 28027880)
    • (1998) Nature Genetics , vol.18 , Issue.1 , pp. 56-59
    • Garrick, D.1    Fiering, S.2    Martin, D.I.K.3    Whitelaw, E.4
  • 83
    • 0842307061 scopus 로고    scopus 로고
    • Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9
    • DOI 10.1038/sj.emboj.7600013
    • Mutskov, V. and Felsenfeld, G. (2004) Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J., 23, 138-149. (Pubitemid 38165754)
    • (2004) EMBO Journal , vol.23 , Issue.1 , pp. 138-149
    • Mutskov, V.1    Felsenfeld, G.2
  • 85
    • 4844230621 scopus 로고    scopus 로고
    • The Frizzled family: Receptors for multiple signal transduction pathways
    • Huang, H.C. and Klein, P.S. (2004) The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol., 5, 234.
    • (2004) Genome Biol. , vol.5 , pp. 234
    • Huang, H.C.1    Klein, P.S.2
  • 86
    • 43749110077 scopus 로고    scopus 로고
    • Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning
    • DOI 10.1038/nature06876, PII NATURE06876
    • Mariani, F.V., Ahn, C.P. and Martin, G.R. (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature, 453, 401-405. (Pubitemid 351693123)
    • (2008) Nature , vol.453 , Issue.7193 , pp. 401-405
    • Mariani, F.V.1    Ahn, C.P.2    Martin, G.R.3
  • 88
    • 0034103657 scopus 로고    scopus 로고
    • Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development
    • DOI 10.1038/75644
    • Sun, X., Lewandoski, M., Meyers, E.N., Liu, Y.H., Maxson, R.E. Jr and Martin, G.R. (2000) Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat. Genet., 25, 83-86. (Pubitemid 30257042)
    • (2000) Nature Genetics , vol.25 , Issue.1 , pp. 83-86
    • Sun, X.1    Lewandoski, M.2    Meyers, E.N.3    Liu, Y.-H.4    Maxson Jr., R.E.5    Martin, G.R.6
  • 89
    • 0035950183 scopus 로고    scopus 로고
    • Frizzled-7 signalling controls tissue separation during Xenopus gastrulation
    • DOI 10.1038/35101621
    • Winklbauer, R., Medina, A., Swain, R.K. and Steinbeisser, H. (2001) Frizzled-7 signalling controls tissue separation during Xenopus gastrulation. Nature, 413, 856-860. (Pubitemid 33026854)
    • (2001) Nature , vol.413 , Issue.6858 , pp. 856-860
    • Winklbauer, R.1    Medina, A.2    Swain, R.K.3    Steinbeisser, H.4
  • 90
    • 0029874533 scopus 로고    scopus 로고
    • Age-dependent silencing of globin transgenes in the mouse
    • DOI 10.1093/nar/24.8.1465
    • Robertson, G., Garrick, D., Wilson, M., Martin, D.I. and Whitelaw, E. (1996) Age-dependent silencing of globin transgenes in the mouse. Nucleic Acids Res., 24, 1465-1471. (Pubitemid 26118979)
    • (1996) Nucleic Acids Research , vol.24 , Issue.8 , pp. 1465-1471
    • Robertson, G.1    Garrick, D.2    Wilson, M.3    Martin, D.I.K.4    Whitelaw, E.5
  • 91
    • 0030660580 scopus 로고    scopus 로고
    • Gene families: The taxonomy of protein paralogs and chimeras
    • DOI 10.1126/science.278.5338.609
    • Henikoff, S., Greene, E.A., Pietrokovski, S., Bork, P., Attwood, T.K. and Hood, L. (1997) Gene families: the taxonomy of protein paralogs and chimeras. Science, 278, 609-614. (Pubitemid 27464952)
    • (1997) Science , vol.278 , Issue.5338 , pp. 609-614
    • Henikoff, S.1    Greene, E.A.2    Pietrokovski, S.3    Bork, P.4    Attwood, T.K.5    Hood, L.6
  • 92
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • DOI 10.1016/j.tig.2004.08.007, PII S0168952504002410
    • Itoh, N. and Ornitz, D.M. (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet., 20, 563-569. (Pubitemid 39314564)
    • (2004) Trends in Genetics , vol.20 , Issue.11 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 93
    • 45549083763 scopus 로고    scopus 로고
    • Functional diversification of duplicate genes through subcellular adaptation of encoded proteins
    • Marques, A.C., Vinckenbosch, N., Brawand, D. and Kaessmann, H. (2008) Functional diversification of duplicate genes through subcellular adaptation of encoded proteins. Genome Biol., 9, R54.
    • (2008) Genome Biol. , vol.9
    • Marques, A.C.1    Vinckenbosch, N.2    Brawand, D.3    Kaessmann, H.4


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