메뉴 건너뛰기




Volumn 163, Issue 4, 2014, Pages 418-431

Adult tissue sources for new β cells

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; TRANSCRIPTION FACTOR;

EID: 84897556468     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2013.11.012     Document Type: Review
Times cited : (12)

References (122)
  • 1
    • 33847657143 scopus 로고    scopus 로고
    • Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth
    • K. Vehik, R.F. Hamman, and D. Lezotte et al. Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth Diabetes Care 30 2007 503 509
    • (2007) Diabetes Care , vol.30 , pp. 503-509
    • Vehik, K.1    Hamman, R.F.2    Lezotte, D.3
  • 2
    • 0033429304 scopus 로고    scopus 로고
    • Worldwide increase in incidence of type i diabetes: The analysis of the data on published incidence trends
    • P. Onkamo, S. Vaananen, M. Karvonen, and J. Tuomilehto Worldwide increase in incidence of type I diabetes: the analysis of the data on published incidence trends Diabetologia 42 1999 1395 1403
    • (1999) Diabetologia , vol.42 , pp. 1395-1403
    • Onkamo, P.1    Vaananen, S.2    Karvonen, M.3    Tuomilehto, J.4
  • 3
    • 70349207817 scopus 로고    scopus 로고
    • Projecting the future diabetes population size and related costs for the US
    • E.S. Huang, A. Basu, M. O'Grady, and J.C. Capretta Projecting the future diabetes population size and related costs for the U.S Diabetes Care 32 2009 2225 2229
    • (2009) Diabetes Care , vol.32 , pp. 2225-2229
    • Huang, E.S.1    Basu, A.2    O'Grady, M.3    Capretta, J.C.4
  • 4
    • 78149373656 scopus 로고    scopus 로고
    • Projection of the year 2050 burden of diabetes in the US adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence
    • J.P. Boyle, T.J. Thompson, E.W. Gregg, L.E. Barker, and D.F. Williamson Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence Population Health Metrics 8 2011 29
    • (2011) Population Health Metrics , vol.8 , pp. 29
    • Boyle, J.P.1    Thompson, T.J.2    Gregg, E.W.3    Barker, L.E.4    Williamson, D.F.5
  • 5
    • 20144363712 scopus 로고    scopus 로고
    • A potential decline in life expectancy in the United States in the 21st century
    • S.J. Olshansky, D.J. Passaro, and R.C. Hershow et al. A potential decline in life expectancy in the United States in the 21st century N Engl J Med 352 2005 1138 1145
    • (2005) N Engl J Med , vol.352 , pp. 1138-1145
    • Olshansky, S.J.1    Passaro, D.J.2    Hershow, R.C.3
  • 6
    • 84868018479 scopus 로고    scopus 로고
    • Improvements in the life expectancy of type 1 diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study cohort
    • R.G. Miller, A.M. Secrest, R.K. Sharma, T.J. Songer, and T.J. Orchard Improvements in the life expectancy of type 1 diabetes: the Pittsburgh Epidemiology of Diabetes Complications Study cohort Diabetes 61 2012 2987 2992
    • (2012) Diabetes , vol.61 , pp. 2987-2992
    • Miller, R.G.1    Secrest, A.M.2    Sharma, R.K.3    Songer, T.J.4    Orchard, T.J.5
  • 7
    • 70349645780 scopus 로고    scopus 로고
    • Current advances and travails in islet transplantation
    • D.M. Harlan, N.S. Kenyon, O. Korsgren, and B.O. Roep Current advances and travails in islet transplantation Diabetes 58 2009 2175 2184
    • (2009) Diabetes , vol.58 , pp. 2175-2184
    • Harlan, D.M.1    Kenyon, N.S.2    Korsgren, O.3    Roep, B.O.4
  • 9
    • 84878340278 scopus 로고    scopus 로고
    • How to make a functional beta-cell
    • F.W. Pagliuca, and D.A. Melton How to make a functional beta-cell Development 140 2013 2472 2483
    • (2013) Development , vol.140 , pp. 2472-2483
    • Pagliuca, F.W.1    Melton, D.A.2
  • 10
    • 0012848518 scopus 로고
    • Adenomas of the islands of Langerhans
    • S. Warren Adenomas of the islands of Langerhans Am J Pathol 2 1926 335 340.3
    • (1926) Am J Pathol , vol.2 , pp. 335-3403
    • Warren, S.1
  • 11
    • 0001588978 scopus 로고
    • Carcinoma of the islands of the pancreas: Hyperinsulinism and hypoglycemia
    • R.M. Wilder, F.N. Allan, M.H. Power, and H.E. Robertson Carcinoma of the islands of the pancreas: hyperinsulinism and hypoglycemia JAMA 89 1927 348 355
    • (1927) JAMA , vol.89 , pp. 348-355
    • Wilder, R.M.1    Allan, F.N.2    Power, M.H.3    Robertson, H.E.4
  • 12
    • 0015381073 scopus 로고
    • Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans
    • I.C. Green, and K.W. Taylor Effects of pregnancy in the rat on the size and insulin secretory response of the islets of Langerhans J Endocrinol 54 1972 317 325
    • (1972) J Endocrinol , vol.54 , pp. 317-325
    • Green, I.C.1    Taylor, K.W.2
  • 13
    • 0018182423 scopus 로고
    • A morphological study of the endocrine pancreas in human pregnancy
    • F.A. Van Assche, L. Aerts, and F. De Prins A morphological study of the endocrine pancreas in human pregnancy Br J Obstet Gynaecol 85 1978 818 820
    • (1978) Br J Obstet Gynaecol , vol.85 , pp. 818-820
    • Van Assche, F.A.1    Aerts, L.2    De Prins, F.3
  • 14
    • 0030825432 scopus 로고    scopus 로고
    • Adaptation of islets of Langerhans to pregnancy: Beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones
    • R.L. Sorenson, and T.C. Brelje Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones Hormone Metab Res 29 1997 301 307
    • (1997) Hormone Metab Res , vol.29 , pp. 301-307
    • Sorenson, R.L.1    Brelje, T.C.2
  • 15
    • 0034042959 scopus 로고    scopus 로고
    • Islet growth and development in the adult
    • S. Bonner-Weir Islet growth and development in the adult J Mol Endocrinol 24 2000 297 302
    • (2000) J Mol Endocrinol , vol.24 , pp. 297-302
    • Bonner-Weir, S.1
  • 18
    • 33744979065 scopus 로고    scopus 로고
    • Relationship between beta-cell mass and fasting blood glucose concentration in humans
    • R.A. Ritzel, A.E. Butler, R.A. Rizza, J.D. Veldhuis, and P.C. Butler Relationship between beta-cell mass and fasting blood glucose concentration in humans Diabetes Care 29 2006 717 718
    • (2006) Diabetes Care , vol.29 , pp. 717-718
    • Ritzel, R.A.1    Butler, A.E.2    Rizza, R.A.3    Veldhuis, J.D.4    Butler, P.C.5
  • 19
    • 44749088201 scopus 로고    scopus 로고
    • Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    • J.J. Meier, A.E. Butler, and Y. Saisho et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans Diabetes 57 2008 1584 1594
    • (2008) Diabetes , vol.57 , pp. 1584-1594
    • Meier, J.J.1    Butler, A.E.2    Saisho, Y.3
  • 21
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    • J.C. Bruning, J. Winnay, S. Bonner-Weir, S.I. Taylor, D. Accili, and C.R. Kahn Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell 88 1997 561 572
    • (1997) Cell , vol.88 , pp. 561-572
    • Bruning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 22
    • 34547482573 scopus 로고    scopus 로고
    • Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    • T. Okada, C.W. Liew, and J. Hu et al. Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance Proc Natl Acad Sci U S A 104 2007 8977 8982
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 8977-8982
    • Okada, T.1    Liew, C.W.2    Hu, J.3
  • 23
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by beta cell regeneration
    • T. Nir, D.A. Melton, and Y. Dor Recovery from diabetes in mice by beta cell regeneration J Clin Invest 117 2007 2553 2561
    • (2007) J Clin Invest , vol.117 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 24
    • 84865029204 scopus 로고    scopus 로고
    • Pancreatic beta cells in very old mice retain capacity for compensatory proliferation
    • M. Stolovich-Rain, A. Hija, J. Grimsby, B. Glaser, and Y. Dor Pancreatic beta cells in very old mice retain capacity for compensatory proliferation J Biol Chem 287 2012 27407 27414
    • (2012) J Biol Chem , vol.287 , pp. 27407-27414
    • Stolovich-Rain, M.1    Hija, A.2    Grimsby, J.3    Glaser, B.4    Dor, Y.5
  • 25
    • 42449086826 scopus 로고    scopus 로고
    • Regulated beta-cell regeneration in the adult mouse pancreas
    • D.A. Cano, I.C. Rulifson, and P.W. Heiser et al. Regulated beta-cell regeneration in the adult mouse pancreas Diabetes 57 2008 958 966
    • (2008) Diabetes , vol.57 , pp. 958-966
    • Cano, D.A.1    Rulifson, I.C.2    Heiser, P.W.3
  • 26
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • F. Thorel, V. Nepote, and I. Avril et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss Nature 464 2010 1149 1154
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3
  • 27
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • X. Xu, J. D'Hoker, and G. Stange et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas Cell 132 2008 197 207
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1    D'Hoker, J.2    Stange, G.3
  • 28
    • 77957787230 scopus 로고    scopus 로고
    • Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating
    • S. Perl, J.A. Kushner, and B.A. Buchholz et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating J Clin Endocrinol Metab 95 2010 E234 E239
    • (2010) J Clin Endocrinol Metab , vol.95
    • Perl, S.1    Kushner, J.A.2    Buchholz, B.A.3
  • 29
    • 77954277549 scopus 로고    scopus 로고
    • Beta-cell replication is increased in donor organs from young patients after prolonged life support
    • P. In't Veld, N. De Munck, and K. Van Belle et al. Beta-cell replication is increased in donor organs from young patients after prolonged life support Diabetes 59 2010 1702 1708
    • (2010) Diabetes , vol.59 , pp. 1702-1708
    • In'T Veld, P.1    De Munck, N.2    Van Belle, K.3
  • 30
    • 61449258391 scopus 로고    scopus 로고
    • Impaired islet turnover in human donor pancreata with aging
    • C. Reers, S. Erbel, and I. Esposito et al. Impaired islet turnover in human donor pancreata with aging Eur J Endocrinol 160 2009 185 191
    • (2009) Eur J Endocrinol , vol.160 , pp. 185-191
    • Reers, C.1    Erbel, S.2    Esposito, I.3
  • 31
    • 84866153904 scopus 로고    scopus 로고
    • Formation of a human beta-cell population within pancreatic islets is set early in life
    • B.E. Gregg, P.C. Moore, and D. Demozay et al. Formation of a human beta-cell population within pancreatic islets is set early in life J Clin Endocrinol Metab 97 2012 3197 3206
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3197-3206
    • Gregg, B.E.1    Moore, P.C.2    Demozay, D.3
  • 32
    • 0030444607 scopus 로고    scopus 로고
    • Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro
    • B. Tyrberg, D.L. Eizirik, C. Hellerstrom, D.G. Pipeleers, and A. Andersson Human pancreatic beta-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro Endocrinology 137 1996 5694 5699
    • (1996) Endocrinology , vol.137 , pp. 5694-5699
    • Tyrberg, B.1    Eizirik, D.L.2    Hellerstrom, C.3    Pipeleers, D.G.4    Andersson, A.5
  • 33
    • 0035143062 scopus 로고    scopus 로고
    • Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: Effects of the ob gene and compensatory growth of the implantation organ
    • B. Tyrberg, J. Ustinov, T. Otonkoski, and A. Andersson Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ Diabetes 50 2001 301 307
    • (2001) Diabetes , vol.50 , pp. 301-307
    • Tyrberg, B.1    Ustinov, J.2    Otonkoski, T.3    Andersson, A.4
  • 34
    • 79953752183 scopus 로고    scopus 로고
    • Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice
    • H.E. Levitt, T.J. Cyphert, and J.L. Pascoe et al. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice Diabetologia 54 2011 572 582
    • (2011) Diabetologia , vol.54 , pp. 572-582
    • Levitt, H.E.1    Cyphert, T.J.2    Pascoe, J.L.3
  • 36
    • 80053345327 scopus 로고    scopus 로고
    • CMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication
    • E. Karslioglu, J.W. Kleinberger, and F.G. Salim et al. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication Mol Endocrinol 25 2011 1760 1772
    • (2011) Mol Endocrinol , vol.25 , pp. 1760-1772
    • Karslioglu, E.1    Kleinberger, J.W.2    Salim, F.G.3
  • 37
    • 84864390297 scopus 로고    scopus 로고
    • ChREBP mediates glucose-stimulated pancreatic beta-cell proliferation
    • M.R. Metukuri, P. Zhang, and M.K. Basantani et al. ChREBP mediates glucose-stimulated pancreatic beta-cell proliferation Diabetes 61 2012 2004 2015
    • (2012) Diabetes , vol.61 , pp. 2004-2015
    • Metukuri, M.R.1    Zhang, P.2    Basantani, M.K.3
  • 38
    • 43249122991 scopus 로고    scopus 로고
    • Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1
    • J.C. Schisler, P.T. Fueger, and D.A. Babu et al. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1 Mol Cell Biol 28 2008 3465 3476
    • (2008) Mol Cell Biol , vol.28 , pp. 3465-3476
    • Schisler, J.C.1    Fueger, P.T.2    Babu, D.A.3
  • 39
    • 77956102457 scopus 로고    scopus 로고
    • FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation
    • D.B. Davis, J.A. Lavine, and J.I. Suhonen et al. FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation Mol Endocrinol 24 2010 1822 1834
    • (2010) Mol Endocrinol , vol.24 , pp. 1822-1834
    • Davis, D.B.1    Lavine, J.A.2    Suhonen, J.I.3
  • 40
    • 84865596106 scopus 로고    scopus 로고
    • Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets
    • S. Rieck, J. Zhang, and Z. Li et al. Overexpression of hepatocyte nuclear factor-4alpha initiates cell cycle entry, but is not sufficient to promote beta-cell expansion in human islets Mol Endocrinol 26 2012 1590 1602
    • (2012) Mol Endocrinol , vol.26 , pp. 1590-1602
    • Rieck, S.1    Zhang, J.2    Li, Z.3
  • 41
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Y. Dor, J. Brown, O.I. Martinez, and D.A. Melton Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation Nature 429 2004 41 46
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 43
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion
    • S. Bonner-Weir, D. Deery, J.L. Leahy, and G.C. Weir Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion Diabetes 38 1989 49 53
    • (1989) Diabetes , vol.38 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 44
    • 84877707122 scopus 로고    scopus 로고
    • Betatrophin: A hormone that controls pancreatic beta cell proliferation
    • P. Yi, J.S. Park, and D.A. Melton Betatrophin: a hormone that controls pancreatic beta cell proliferation Cell 153 2013 747 758
    • (2013) Cell , vol.153 , pp. 747-758
    • Yi, P.1    Park, J.S.2    Melton, D.A.3
  • 45
    • 77954480533 scopus 로고    scopus 로고
    • Serotonin regulates pancreatic beta cell mass during pregnancy
    • H. Kim, Y. Toyofuku, and F.C. Lynn et al. Serotonin regulates pancreatic beta cell mass during pregnancy Nat Med 16 2010 804 808
    • (2010) Nat Med , vol.16 , pp. 804-808
    • Kim, H.1    Toyofuku, Y.2    Lynn, F.C.3
  • 46
    • 0034686028 scopus 로고    scopus 로고
    • Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia
    • R.C. Vasavada, A. Garcia-Ocana, and W.S. Zawalich et al. Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia J Biol Chem 275 2000 15399 15406
    • (2000) J Biol Chem , vol.275 , pp. 15399-15406
    • Vasavada, R.C.1    Garcia-Ocana, A.2    Zawalich, W.S.3
  • 47
    • 18344382724 scopus 로고    scopus 로고
    • Targeted deletion of the PRL receptor: Effects on islet development, insulin production, and glucose tolerance
    • M. Freemark, I. Avril, and D. Fleenor et al. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance Endocrinology 143 2002 1378 1385
    • (2002) Endocrinology , vol.143 , pp. 1378-1385
    • Freemark, M.1    Avril, I.2    Fleenor, D.3
  • 48
    • 38449099624 scopus 로고    scopus 로고
    • Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus
    • S.K. Karnik, H. Chen, and G.W. McLean et al. Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus Science 318 2007 806 809
    • (2007) Science , vol.318 , pp. 806-809
    • Karnik, S.K.1    Chen, H.2    McLean, G.W.3
  • 49
    • 77449086017 scopus 로고    scopus 로고
    • Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen
    • H. Zhang, J. Zhang, and C.F. Pope et al. Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen Diabetes 59 2010 143 152
    • (2010) Diabetes , vol.59 , pp. 143-152
    • Zhang, H.1    Zhang, J.2    Pope, C.F.3
  • 50
    • 79953734660 scopus 로고    scopus 로고
    • Control of pancreatic beta cell regeneration by glucose metabolism
    • S. Porat, N. Weinberg-Corem, and S. Tornovsky-Babaey et al. Control of pancreatic beta cell regeneration by glucose metabolism Cell Metab 13 2011 440 449
    • (2011) Cell Metab , vol.13 , pp. 440-449
    • Porat, S.1    Weinberg-Corem, N.2    Tornovsky-Babaey, S.3
  • 51
    • 60849109210 scopus 로고    scopus 로고
    • Identification of small-molecule inducers of pancreatic beta-cell expansion
    • W. Wang, J.R. Walker, and X. Wang et al. Identification of small-molecule inducers of pancreatic beta-cell expansion Proc Natl Acad Sci U S A 106 2009 1427 1432
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1427-1432
    • Wang, W.1    Walker, J.R.2    Wang, X.3
  • 52
    • 84873328167 scopus 로고    scopus 로고
    • Small-molecule inducer of beta cell proliferation identified by high-throughput screening
    • W. Shen, M.S. Tremblay, and V.A. Deshmukh et al. Small-molecule inducer of beta cell proliferation identified by high-throughput screening J Am Chem Soc 135 2013 1669 1672
    • (2013) J Am Chem Soc , vol.135 , pp. 1669-1672
    • Shen, W.1    Tremblay, M.S.2    Deshmukh, V.A.3
  • 53
    • 84862001481 scopus 로고    scopus 로고
    • Adenosine signaling promotes regeneration of pancreatic beta cells in vivo
    • O. Andersson, B.A. Adams, and D. Yoo et al. Adenosine signaling promotes regeneration of pancreatic beta cells in vivo Cell Metab 15 2012 885 894
    • (2012) Cell Metab , vol.15 , pp. 885-894
    • Andersson, O.1    Adams, B.A.2    Yoo, D.3
  • 54
    • 84857972319 scopus 로고    scopus 로고
    • Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication
    • J.P. Annes, J.H. Ryu, and K. Lam et al. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication Proc Natl Acad Sci U S A 109 2012 3915 3920
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3915-3920
    • Annes, J.P.1    Ryu, J.H.2    Lam, K.3
  • 56
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas: A possible recapitulation of embryonic development
    • S. Bonner-Weir, L.A. Baxter, G.T. Schuppin, and F.E. Smith A second pathway for regeneration of adult exocrine and endocrine pancreas: a possible recapitulation of embryonic development Diabetes 42 1993 1715 1720
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 57
    • 72449164412 scopus 로고    scopus 로고
    • Pancreatic duct replication is increased with obesity and type 2 diabetes in humans
    • A.E. Butler, R. Galasso, A. Matveyenko, R.A. Rizza, S. Dry, and P.C. Butler Pancreatic duct replication is increased with obesity and type 2 diabetes in humans Diabetologia 53 2010 21 26
    • (2010) Diabetologia , vol.53 , pp. 21-26
    • Butler, A.E.1    Galasso, R.2    Matveyenko, A.3    Rizza, R.A.4    Dry, S.5    Butler, P.C.6
  • 58
    • 51249123319 scopus 로고    scopus 로고
    • Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity
    • A. Martin-Pagola, G. Sisino, and G. Allende et al. Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity Diabetologia 51 2008 1803 1813
    • (2008) Diabetologia , vol.51 , pp. 1803-1813
    • Martin-Pagola, A.1    Sisino, G.2    Allende, G.3
  • 59
    • 77956004353 scopus 로고    scopus 로고
    • Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
    • W.C. Li, J.M. Rukstalis, and W. Nishimura et al. Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats J Cell Sci 123 2010 2792 2802
    • (2010) J Cell Sci , vol.123 , pp. 2792-2802
    • Li, W.C.1    Rukstalis, J.M.2    Nishimura, W.3
  • 60
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • A. Inada, C. Nienaber, and H. Katsuta et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth Proc Natl Acad Sci U S A 105 2008 19915 19919
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19915-19919
    • Inada, A.1    Nienaber, C.2    Katsuta, H.3
  • 61
    • 84875910312 scopus 로고    scopus 로고
    • Neurogenin 3+ cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas
    • M. Van de Casteele, G. Leuckx, and L. Baeyens et al. Neurogenin 3+ cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas Cell Death Dis 4 2013 e523
    • (2013) Cell Death Dis , vol.4 , pp. 523
    • Van De Casteele, M.1    Leuckx, G.2    Baeyens, L.3
  • 62
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • F.C. Pan, E.D. Bankaitis, and D. Boyer et al. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration Development 140 2013 751 764
    • (2013) Development , vol.140 , pp. 751-764
    • Pan, F.C.1    Bankaitis, E.D.2    Boyer, D.3
  • 63
    • 84880506680 scopus 로고    scopus 로고
    • Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes
    • K. Al-Hasani, A. Pfeifer, and M. Courtney et al. Adult duct-lining cells can reprogram into beta-like cells able to counter repeated cycles of toxin-induced diabetes Dev Cell 26 2013 86 100
    • (2013) Dev Cell , vol.26 , pp. 86-100
    • Al-Hasani, K.1    Pfeifer, A.2    Courtney, M.3
  • 64
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    • M. Solar, C. Cardalda, and I. Houbracken et al. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth Dev Cell 17 2009 849 860
    • (2009) Dev Cell , vol.17 , pp. 849-860
    • Solar, M.1    Cardalda, C.2    Houbracken, I.3
  • 65
    • 77958099053 scopus 로고    scopus 로고
    • Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells
    • C.H. Chung, E. Hao, R. Piran, E. Keinan, and F. Levine Pancreatic beta-cell neogenesis by direct conversion from mature alpha-cells Stem Cells 28 2010 1630 1638
    • (2010) Stem Cells , vol.28 , pp. 1630-1638
    • Chung, C.H.1    Hao, E.2    Piran, R.3    Keinan, E.4    Levine, F.5
  • 66
    • 0034068602 scopus 로고    scopus 로고
    • Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
    • S. Ferber, A. Halkin, and H. Cohen et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia Nat Med 6 2000 568 572
    • (2000) Nat Med , vol.6 , pp. 568-572
    • Ferber, S.1    Halkin, A.2    Cohen, H.3
  • 67
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • H. Kojima, M. Fujimiya, and K. Matsumura et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice Nat Med 9 2003 596 603
    • (2003) Nat Med , vol.9 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3
  • 68
    • 15944417831 scopus 로고    scopus 로고
    • PDX-1/VP16 fusion protein, together with NeuroD or NGN3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    • H. Kaneto, Y. Nakatani, and T. Miyatsuka et al. PDX-1/VP16 fusion protein, together with NeuroD or NGN3, markedly induces insulin gene transcription and ameliorates glucose tolerance Diabetes 54 2005 1009 1022
    • (2005) Diabetes , vol.54 , pp. 1009-1022
    • Kaneto, H.1    Nakatani, Y.2    Miyatsuka, T.3
  • 69
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Q. Zhou, J. Brown, A. Kanarek, J. Rajagopal, and D.A. Melton In vivo reprogramming of adult pancreatic exocrine cells to beta-cells Nature 455 2008 627 632
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 70
    • 84891668969 scopus 로고    scopus 로고
    • Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells
    • M.J. Lima, K.R. Muir, and H.M. Docherty et al. Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing beta-like cells Diabetes 62 2013 2821 2833
    • (2013) Diabetes , vol.62 , pp. 2821-2833
    • Lima, M.J.1    Muir, K.R.2    Docherty, H.M.3
  • 71
    • 77957009475 scopus 로고    scopus 로고
    • Small-molecule inducers of insulin expression in pancreatic alpha-cells
    • D. Fomina-Yadlin, S. Kubicek, and D. Walpita et al. Small-molecule inducers of insulin expression in pancreatic alpha-cells Proc Natl Acad Sci U S A 107 2010 15099 15104
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15099-15104
    • Fomina-Yadlin, D.1    Kubicek, S.2    Walpita, D.3
  • 72
    • 34248191270 scopus 로고    scopus 로고
    • Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells
    • N. Weinberg, L. Ouziel-Yahalom, S. Knoller, S. Efrat, and Y. Dor Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells Diabetes 56 2007 1299 1304
    • (2007) Diabetes , vol.56 , pp. 1299-1304
    • Weinberg, N.1    Ouziel-Yahalom, L.2    Knoller, S.3    Efrat, S.4    Dor, Y.5
  • 73
    • 78149424683 scopus 로고    scopus 로고
    • Tamoxifen-independent recombination in the RIP-CreER mouse
    • Y. Liu, J. Suckale, and J. Masjkur et al. Tamoxifen-independent recombination in the RIP-CreER mouse PLoS One 5 2010 e13533
    • (2010) PLoS One , vol.5 , pp. 13533
    • Liu, Y.1    Suckale, J.2    Masjkur, J.3
  • 74
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • M. Teta, M.M. Rankin, S.Y. Long, G.M. Stein, and J.A. Kushner Growth and regeneration of adult beta cells does not involve specialized progenitors Dev Cell 12 2007 817 826
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 75
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • A.P. Morris, B.F. Voight, and T.M. Teslovich et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes Nat Genet 44 2012 981 990
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 76
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • D.M. Muoio, and C.B. Newgard Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes Nat Rev Mol Cell Biol 9 2008 193 205
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 77
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • M.D. Michael, R.N. Kulkarni, and C. Postic et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction Mol Cell 6 2000 87 97
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 78
    • 0035912766 scopus 로고    scopus 로고
    • Evidence for a circulating islet cell growth factor in insulin-resistant states
    • S.N. Flier, R.N. Kulkarni, and C.R. Kahn Evidence for a circulating islet cell growth factor in insulin-resistant states Proc Natl Acad Sci U S A 98 2001 7475 7480
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7475-7480
    • Flier, S.N.1    Kulkarni, R.N.2    Kahn, C.R.3
  • 79
    • 33748929299 scopus 로고    scopus 로고
    • Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function
    • J.J. Heit, A.A. Apelqvist, and X. Gu et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function Nature 443 2006 345 349
    • (2006) Nature , vol.443 , pp. 345-349
    • Heit, J.J.1    Apelqvist, A.A.2    Gu, X.3
  • 80
    • 84874241199 scopus 로고    scopus 로고
    • Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states
    • A. El Ouaamari, D. Kawamori, and E. Dirice et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states Cell Rep 3 2013 401 410
    • (2013) Cell Rep , vol.3 , pp. 401-410
    • El Ouaamari, A.1    Kawamori, D.2    Dirice, E.3
  • 81
    • 34547690686 scopus 로고    scopus 로고
    • Endocrine regulation of energy metabolism by the skeleton
    • N.K. Lee, H. Sowa, and E. Hinoi et al. Endocrine regulation of energy metabolism by the skeleton Cell 130 2007 456 469
    • (2007) Cell , vol.130 , pp. 456-469
    • Lee, N.K.1    Sowa, H.2    Hinoi, E.3
  • 82
    • 85010778405 scopus 로고    scopus 로고
    • Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a
    • J. Wei, T. Hanna, N. Suda, G. Karsenty, and P. Ducy Osteocalcin promotes beta-cell proliferation during development and adulthood through Gprc6a Diabetes 2013
    • (2013) Diabetes
    • Wei, J.1    Hanna, T.2    Suda, N.3    Karsenty, G.4    Ducy, P.5
  • 83
    • 77955035304 scopus 로고    scopus 로고
    • Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    • M. Ferron, J. Wei, and T. Yoshizawa et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 2010 296 308
    • (2010) Cell , vol.142 , pp. 296-308
    • Ferron, M.1    Wei, J.2    Yoshizawa, T.3
  • 84
    • 0031659962 scopus 로고    scopus 로고
    • Functional analysis of a conditionally transformed pancreatic beta-cell line
    • N. Fleischer, C. Chen, and M. Surana et al. Functional analysis of a conditionally transformed pancreatic beta-cell line Diabetes 47 1998 1419 1425
    • (1998) Diabetes , vol.47 , pp. 1419-1425
    • Fleischer, N.1    Chen, C.2    Surana, M.3
  • 85
    • 84858968454 scopus 로고    scopus 로고
    • A human islet cell culture system for high-throughput screening
    • D. Walpita, T. Hasaka, and J. Spoonamore et al. A human islet cell culture system for high-throughput screening J Biomol Screen 17 2012 509 518
    • (2012) J Biomol Screen , vol.17 , pp. 509-518
    • Walpita, D.1    Hasaka, T.2    Spoonamore, J.3
  • 86
    • 80052343967 scopus 로고    scopus 로고
    • A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion
    • P. Ravassard, Y. Hazhouz, and S. Pechberty et al. A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion J Clin Invest 121 2011 3589 3597
    • (2011) J Clin Invest , vol.121 , pp. 3589-3597
    • Ravassard, P.1    Hazhouz, Y.2    Pechberty, S.3
  • 87
    • 80054991835 scopus 로고    scopus 로고
    • PDGF signalling controls age-dependent proliferation in pancreatic beta-cells
    • H. Chen, X. Gu, and Y. Liu et al. PDGF signalling controls age-dependent proliferation in pancreatic beta-cells Nature 478 2011 349 355
    • (2011) Nature , vol.478 , pp. 349-355
    • Chen, H.1    Gu, X.2    Liu, Y.3
  • 88
    • 78650561100 scopus 로고    scopus 로고
    • Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene
    • Y. Yang, B. Gurung, T. Wu, H. Wang, D.A. Stoffers, and X. Hua Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene Proc Natl Acad Sci U S A 107 2010 20358 20363
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20358-20363
    • Yang, Y.1    Gurung, B.2    Wu, T.3    Wang, H.4    Stoffers, D.A.5    Hua, X.6
  • 90
    • 84880436692 scopus 로고    scopus 로고
    • The plastic pancreas
    • O. Ziv, B. Glaser, and Y. Dor The plastic pancreas Dev Cell 26 2013 3 7
    • (2013) Dev Cell , vol.26 , pp. 3-7
    • Ziv, O.1    Glaser, B.2    Dor, Y.3
  • 91
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • J. Jonsson, L. Carlsson, T. Edlund, and H. Edlund Insulin-promoter-factor 1 is required for pancreas development in mice Nature 371 1994 606 609
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 92
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • D.A. Stoffers, N.T. Zinkin, V. Stanojevic, W.L. Clarke, and J.F. Habener Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence Nat Genet 15 1997 106 110
    • (1997) Nat Genet , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 93
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • G. Gradwohl, A. Dierich, M. LeMeur, and F. Guillemot Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas Proc Natl Acad Sci U S A 97 2000 1607 1611
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    Lemeur, M.3    Guillemot, F.4
  • 94
    • 0033825383 scopus 로고    scopus 로고
    • Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    • V.M. Schwitzgebel, D.W. Scheel, and J.R. Conners et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas Development 127 2000 3533 3542
    • (2000) Development , vol.127 , pp. 3533-3542
    • Schwitzgebel, V.M.1    Scheel, D.W.2    Conners, J.R.3
  • 95
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • G. Gu, J. Dubauskaite, and D.A. Melton Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors Development 129 2002 2447 2457
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 97
    • 84876579681 scopus 로고    scopus 로고
    • Beta-cells are not generated in pancreatic duct ligation-induced injury in adult mice
    • M.M. Rankin, C.J. Wilbur, K. Rak, E.J. Shields, A. Granger, and J.A. Kushner Beta-cells are not generated in pancreatic duct ligation-induced injury in adult mice Diabetes 62 2013 1634 1645
    • (2013) Diabetes , vol.62 , pp. 1634-1645
    • Rankin, M.M.1    Wilbur, C.J.2    Rak, K.3    Shields, E.J.4    Granger, A.5    Kushner, J.A.6
  • 98
    • 84875452820 scopus 로고    scopus 로고
    • No evidence for beta cell neogenesis in murine adult pancreas
    • X. Xiao, Z. Chen, and C. Shiota et al. No evidence for beta cell neogenesis in murine adult pancreas J Clin Invest 123 2013 2207 2217
    • (2013) J Clin Invest , vol.123 , pp. 2207-2217
    • Xiao, X.1    Chen, Z.2    Shiota, C.3
  • 99
    • 34147190365 scopus 로고    scopus 로고
    • Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration
    • B.M. Desai, J. Oliver-Krasinski, and D.D. De Leon et al. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration J Clin Invest 117 2007 971 977
    • (2007) J Clin Invest , vol.117 , pp. 971-977
    • Desai, B.M.1    Oliver-Krasinski, J.2    De Leon, D.D.3
  • 100
    • 4444320484 scopus 로고    scopus 로고
    • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    • R.M. Seaberg, S.R. Smukler, and T.J. Kieffer et al. Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages Nat Biotechnol 22 2004 1115 1124
    • (2004) Nat Biotechnol , vol.22 , pp. 1115-1124
    • Seaberg, R.M.1    Smukler, S.R.2    Kieffer, T.J.3
  • 101
    • 79952119288 scopus 로고    scopus 로고
    • The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
    • S.R. Smukler, M.E. Arntfield, and R. Razavi et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin Cell Stem Cell 8 2011 281 293
    • (2011) Cell Stem Cell , vol.8 , pp. 281-293
    • Smukler, S.R.1    Arntfield, M.E.2    Razavi, R.3
  • 102
    • 34250858628 scopus 로고    scopus 로고
    • All beta cells contribute equally to islet growth and maintenance
    • K. Brennand, D. Huangfu, and D. Melton All beta cells contribute equally to islet growth and maintenance PLoS Biol 5 2007 e163
    • (2007) PLoS Biol , vol.5 , pp. 163
    • Brennand, K.1    Huangfu, D.2    Melton, D.3
  • 103
    • 76249094159 scopus 로고    scopus 로고
    • Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
    • M. Rovira, S.G. Scott, A.S. Liss, J. Jensen, S.P. Thayer, and S.D. Leach Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas Proc Natl Acad Sci U S A 107 2010 75 80
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 75-80
    • Rovira, M.1    Scott, S.G.2    Liss, A.S.3    Jensen, J.4    Thayer, S.P.5    Leach, S.D.6
  • 104
    • 33644828800 scopus 로고    scopus 로고
    • Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas
    • E. Hao, B. Tyrberg, and P. Itkin-Ansari et al. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas Nat Med 12 2006 310 316
    • (2006) Nat Med , vol.12 , pp. 310-316
    • Hao, E.1    Tyrberg, B.2    Itkin-Ansari, P.3
  • 105
    • 34347384162 scopus 로고    scopus 로고
    • Differentiation of affinity-purified human pancreatic duct cells to beta-cells
    • S. Yatoh, R. Dodge, and T. Akashi et al. Differentiation of affinity-purified human pancreatic duct cells to beta-cells Diabetes 56 2007 1802 1809
    • (2007) Diabetes , vol.56 , pp. 1802-1809
    • Yatoh, S.1    Dodge, R.2    Akashi, T.3
  • 106
    • 0034608816 scopus 로고    scopus 로고
    • In vitro cultivation of human islets from expanded ductal tissue
    • S. Bonner-Weir, M. Taneja, and G.C. Weir et al. In vitro cultivation of human islets from expanded ductal tissue Proc Natl Acad Sci U S A 97 2000 7999 8004
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7999-8004
    • Bonner-Weir, S.1    Taneja, M.2    Weir, G.C.3
  • 107
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 108
    • 80054726357 scopus 로고    scopus 로고
    • Direct lineage conversions: Unnatural but useful?
    • T. Vierbuchen, and M. Wernig Direct lineage conversions: unnatural but useful? Nat Biotechnol 29 2011 892 907
    • (2011) Nat Biotechnol , vol.29 , pp. 892-907
    • Vierbuchen, T.1    Wernig, M.2
  • 109
    • 84866550121 scopus 로고    scopus 로고
    • In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts
    • A. Banga, E. Akinci, L.V. Greder, J.R. Dutton, and J.M. Slack In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts Proc Natl Acad Sci U S A 109 2012 15336 15341
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 15336-15341
    • Banga, A.1    Akinci, E.2    Greder, L.V.3    Dutton, J.R.4    Slack, J.M.5
  • 110
    • 20344394437 scopus 로고    scopus 로고
    • Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
    • T. Sapir, K. Shternhall, and I. Meivar-Levy et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells Proc Natl Acad Sci U S A 102 2005 7964 7969
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7964-7969
    • Sapir, T.1    Shternhall, K.2    Meivar-Levy, I.3
  • 111
    • 77951840060 scopus 로고    scopus 로고
    • Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development
    • J. Lu, P.L. Herrera, and C. Carreira et al. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development Gastroenterology 138 2010 1954 1965
    • (2010) Gastroenterology , vol.138 , pp. 1954-1965
    • Lu, J.1    Herrera, P.L.2    Carreira, C.3
  • 112
    • 84874626174 scopus 로고    scopus 로고
    • Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming
    • N.C. Bramswig, L.J. Everett, and J. Schug et al. Epigenomic plasticity enables human pancreatic alpha to beta cell reprogramming J Clin Invest 123 2013 1275 1284
    • (2013) J Clin Invest , vol.123 , pp. 1275-1284
    • Bramswig, N.C.1    Everett, L.J.2    Schug, J.3
  • 113
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    • B. Sosa-Pineda, K. Chowdhury, M. Torres, G. Oliver, and P. Gruss The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas Nature 386 1997 399 402
    • (1997) Nature , vol.386 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 114
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • P. Collombat, X. Xu, and P. Ravassard et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells Cell 138 2009 449 462
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3
  • 115
    • 0142091542 scopus 로고    scopus 로고
    • Opposing actions of Arx and Pax4 in endocrine pancreas development
    • P. Collombat, A. Mansouri, and J. Hecksher-Sorensen et al. Opposing actions of Arx and Pax4 in endocrine pancreas development Genes Dev 17 2003 2591 2603
    • (2003) Genes Dev , vol.17 , pp. 2591-2603
    • Collombat, P.1    Mansouri, A.2    Hecksher-Sorensen, J.3
  • 116
    • 79954563768 scopus 로고    scopus 로고
    • Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx
    • S. Dhawan, S. Georgia, S.I. Tschen, G. Fan, and A. Bhushan Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx Dev Cell 20 2011 419 429
    • (2011) Dev Cell , vol.20 , pp. 419-429
    • Dhawan, S.1    Georgia, S.2    Tschen, S.I.3    Fan, G.4    Bhushan, A.5
  • 117
    • 34147092649 scopus 로고    scopus 로고
    • Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression
    • P. Collombat, J. Hecksher-Sorensen, and J. Krull et al. Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression J Clin Invest 117 2007 961 970
    • (2007) J Clin Invest , vol.117 , pp. 961-970
    • Collombat, P.1    Hecksher-Sorensen, J.2    Krull, J.3
  • 119
    • 44749087001 scopus 로고    scopus 로고
    • In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing
    • H.A. Russ, Y. Bar, P. Ravassard, and S. Efrat In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing Diabetes 57 2008 1575 1583
    • (2008) Diabetes , vol.57 , pp. 1575-1583
    • Russ, H.A.1    Bar, Y.2    Ravassard, P.3    Efrat, S.4
  • 120
    • 84859350525 scopus 로고    scopus 로고
    • Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    • C. Talchai, S. Xuan, T. Kitamura, R.A. DePinho, and D. Accili Generation of functional insulin-producing cells in the gut by Foxo1 ablation Nat Genet 44 2012 406 412
    • (2012) Nat Genet , vol.44 , pp. 406-412
    • Talchai, C.1    Xuan, S.2    Kitamura, T.3    Depinho, R.A.4    Accili, D.5
  • 121
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial
    • J. Weng, Y. Li, and W. Xu et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial Lancet 371 2008 1753 1760
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3
  • 122
    • 84861216975 scopus 로고    scopus 로고
    • Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway
    • Y. Bar, H.A. Russ, E. Sintov, L. Anker-Kitai, S. Knoller, and S. Efrat Redifferentiation of expanded human pancreatic beta-cell-derived cells by inhibition of the NOTCH pathway J Biol Chem 287 2012 17269 17280
    • (2012) J Biol Chem , vol.287 , pp. 17269-17280
    • Bar, Y.1    Russ, H.A.2    Sintov, E.3    Anker-Kitai, L.4    Knoller, S.5    Efrat, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.