Human pancreatic β-cell deoxyribonucleic acid-synthesis in islet grafts decreases with increasing organ donor age but increases in response to glucose stimulation in vitro

Endocrinology

Volumn 137, Issue 12, 1996, Pages 5694-5699

  Tyrberg, Björn ^a   Eizirik, Décio L ^a,b   Hellerström, Claes ^a   Pipeleers, Danny G ^b   Andersson, Arne ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCOSE; INSULIN; THYMIDINE; TRITIUM;

ADOLESCENT; ADULT; AGE; ALLOXAN DIABETES MELLITUS; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MALE; MOUSE; NONHUMAN; NUDE MOUSE; ORGAN DONOR; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 0030444607     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.12.8940401     Document Type: Article

References (30)

1. Bonner-Weir S, Smith FE 1994 Islet cell growth and the growth factors involved. Trends Endocrinol Metab 5:60-64
2. Swenne I 1992 Pancreatic beta-cell growth and diabetes mellitus. Diabetologia 35:193-201
3. Hellerström C, Swenne I 1985 Growth pattern of pancreatic islets in animals. In: Arquilla ER, Volk BW (eds) The Diabetic Pancreas. Plenum Publishing Corporation, NY, pp 53-79
4. Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC 1995 A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation 59:817-820
5. Brelje TC, Scharp DW, Lacy PE, Ogren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL 1993 Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology 132:879-887
6. Hayek A, Beattie GM, Cirulli V, Lopez AD, Ricordi C, Rubin JS 1995 Growth factor/matrix-induced proliferation of human adult β-cells. Diabetes 44:1458-1460
7. Chick WL 1973 Beta cell replication in rat pancreatic monolayer cultures. Effects of glucose, tolbutamide, glucocorticoid, growth hormone and glucagon. Diabetes 22:687-693
8. King DL, Chick WL 1976 Pancreatic beta cell replication: effects of hexose sugars. Endocrinology 99:1003-1009
9. De Clercq L, Schmidt G, Delaere P, Remacle C 1980 Nuclear events in B-cells of young and senescent rat islets in organ culture. Cell Biol Int Rep 4:817-827
10. Rabinovitch A, Blondel B, Murray T, Mintz DH 1980 Cyclic adenosine-3′,5′-monophosphate stimulates islet B cell replication in neonatal rat pancreatic monolayer cultures. J Clin Invest 66:1065-1071
11. Nielsen JH, Linde S, Welinder BS, Billestrup N, Madsen OD 1989 Growth hormone is a growth factor for the differentiated pancreatic β-cell. Mol Endocrinol 3:165-173
12. Rabinovitch A, Quigley C, Rechler MM 1983 Growth hormone stimulates islet B-cell replication in neonatal rat pancreatic monolayer cultures. Diabetes 32:307-312
13. Swenne I, Bone AJ, Howell SL, Hellerström C 1980 Effects of glucose and amino acids on the biosynthesis of DNA and insulin in fetal rat islets maintained in tissue culture. Diabetes 29:686-692
14. De Vroede MA, In't Veld PA, Pipeleers DG 1990 Deoxyribonucleic acid synthesis in cultured adult rat pancreatic B cells. Endocrinology 127:1510-1516
15. Eizirik DL, Korbutt GS, Hellerström C 1992 Prolonged exposure of human pancreatic islets to high glucose concentrations m vitro impairs the β-cell function. J Clin Invest 90:1263-1268
16. Sandlr S, Eizirik DL 1996 Culture of human pancreatic islets. In: Jones GE (ed) Methods in Molecular Medicine, Humana Press Inc., Totowa, NJ, pp 391-407
17. Swenne I 1984 The cell cycle and growth regulation of pancreatic β cells. In: Lamer J, Pohl SL (eds) Methods in Diabetes Research. John Wiley & Sons, New York, vol 1:175-191
18. Heding LG 1972 Determination of total serum insulin (IRI) in insulin treated diabetic patients. Diabetologia 8:260-266
19. Jansson L, Eizirik DL, Pipeleers DG, Borg LAH, Hellerström C, Andersson A 1995 Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. J Clin Invest 96:721-726
20. Swenne I 1982 The role of glucose in the in vitro regulation of cell cycle kinetics and proliferation of fetal pancreatic B-cells. Diabetes 31:754-760
21. Andersson A, Korsgren O, Naeser P 1989 DNA replication in transplanted and endogenous pancreatic islets of obese-hyperglycemic mice at different stages of the syndrome. Metabolism 38:974-978
22. Welsh M, Andersson A 1994 Transplantation of transfected pancreatic islets. Stimulation of β cell DNA synthesis by the src oncogene. Transplantation 57:297-299
23. Like AA, Chick WL 1969 Mitotic division in pancreatic beta cells. Science 163:941-943
24. Westman J, Andersson A, Hellerström C, Petersson B 1970 Ultrastructure of monolayer cultures of pancreatic islet cells. Acta Diabetol Latina 7:557-589
25. Swenne I 1983 Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat. Diabetes 32:14-19
26. Finegood DT, Scaglia L, Bonnet-Weir S 1995 Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249-256
27. Andersson A, Eriksson U, Petersson B, Reibring L, Swenne I 1981 Failure of successful intrasplenic transplantation of islets from lean mice to cure obese-hyperglycaemic mice, despite islet growth. Diabetologia 20:237-241
28. Swenne I, Andersson A 1984 Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27:464-467
29. Borg LAH, Dahl N, Swenne I 1995 Age-dependent differences in insulin secretion and intracellular handling of insulin in isolated pancreatic islets of the rat. Diabete Metab 21:408-414
30. Perfetti R, Rafizadeh CM, Liotta AS, Egan JM 1995 Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats. Am J Physiol 269:E983-990