Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration

Journal of Clinical Investigation

Volumn 117, Issue 4, 2007, Pages 971-977

  Desai, Biva M ^a   Oliver Krasinski, Jennifer ^a   De Leon, Diva D ^a,b   Farzad, Cyrus ^a   Hong, Nankang ^a   Leach, Steven D ^c   Stoffers, Doris A ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; TAMOXIFEN;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL REGENERATION; CONTROLLED STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; DIGESTIVE PHYSIOLOGY; INSULIN-SECRETING CELLS; INTEGRASES; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; PANCREAS; RATS; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TAMOXIFEN;

EID: 34147190365     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI29988     Document Type: Article

References (32)

1. Weir, G.C., and Bonner-Weir, S. 2004. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 53(Suppl. 3):S16-S21.
2. Naftanel, M.A., and Harlan, D.M. 2004. Pancreatic islet transplantation. PLoS Med. 1:e58; quiz e75.
3. Nanji, S.A., and Shapiro, A.M. 2006. Advances in pancreatic islet transplantation in humans. Diabetes Obes. Metab. 8:15-25.
4. Stainier, D. 2006. No stem cell is an islet (yet). N. Engl. J. Med. 354:521-523.
5. Sapir, T., et al. 2005. Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells. Proc. Natl. Acad. Sci. U. S. A. 102:7964-7969.
6. Rooman, I., Heremans, Y., Heimberg, H., and Bouwens, L. 2000. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia. 43:907-914.
7. Gmyr, V., et al. 2000. Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans. Diabetes. 49:1671-1680.
8. Means, A.L., et al. 2005. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development. 132:3767-3776.
9. Mashima, H., et al. 1996. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J. Clin. Invest. 97:1647-1654.
10. Shen, C.N., Slack, J.M., and Tosh, D. 2000. Molecular basis of transdifferentiation of pancreas to liver. Nat. Cell. Biol. 2:879-887.
11. Topp, B.G., McArthur, M.D., and Finegood, D.T. 2004. Metabolic adaptations to chronic glucose infusion in rats. Diabetologia. 47:1602-1610.
12. Gu, D., Arnush, M., and Sarvetnick, N. 1997. Endocrine/exocrine intermediate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice. Pancreas. 15:246-250.
13. Lardon, J., Huyens, N., Rooman, I., and Bouwens, L. 2004. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch. 444:61-65.
14. Zhou, J., Wang, X., Pineyro, M.A., and Egan, J.M. 1999. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes. 48:2358-2366.
15. Mashima, H., Shibata, H., Mine, T., and Kojima, I. 1996. Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor. Endocrinology. 137:3969-3976.
16. Hammer, R.E., et al. 1987. The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol. Cell. Biol. 7:2956-2967.
17. Heller, R.S., et al. 2001. Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes. 50:1553-1561.
18. Palmiter, R.D., et al. 1987. Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell. 50:435-443.
19. Soriano, P. 1999. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21:70-71.
20. Gannon, M., Herrera, P.L., and Wright, C.V. 2000. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis. 26:143-144.
21. Kobayashi, H., et al. 2002. Lectin as a marker for staining and purification of embryonic pancreatic epithelium. Biochem. Biophys. Res. Commun. 293:691-697.
22. Scoggins, C.R., et al. 2000. p53-dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas. Am. J. Physiol. Gastrointest. Liver Physiol. 279:G827-G836.
23. Xu, G., Stoffers, D.A., Habener, J.F., and Bonner-Weir, S. 1999. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 48:2270-2276.
24. De Leon, D.D., et al. 2003. Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes. 52:365-371.
25. Dor, Y., Brown, J., Martinez, O.I., and Melton, D.A. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 429:41-46.
26. Georgia, S., and Bhushan, A. 2004. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J. Clin. Invest. 114:963-968. doi:10.1172/JCI200422098.
27. Jensen, J.N., et al. 2005. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology. 128:728-741.
28. Miyatsuka, T., et al. 2006. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 20:1435-1440.
29. Minami, K., et al. 2005. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc. Natl. Acad. Sci. U. S. A. 102:15116-15121.
30. Indra, A.K., et al. 1999. Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 27:4324-4327.
31. Gu, G., Dubauskaite, J., and Melton, D.A. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 129:2447-2457.
32. Teta, M., Long, S.Y., Wartschow, L.M., Rankin, M.M., and Kushner, J.A. 2005. Very slow turnover of betacells in aged adult mice. Diabetes. 54:2557-2567.