ChREBP mediates glucose-stimulated pancreatic β-cell proliferation

Diabetes

Volumn 61, Issue 8, 2012, Pages 2004-2015

  Metukuri, Mallikarjuna R ^a,b   Zhang, Pili ^a   Basantani, Mahesh K ^a   Chin, Connie ^a   Stamateris, Rachel E ^a   Alonso, Laura C ^a   Takane, Karen K ^a   Gramignoli, Roberto ^a   Strom, Stephen C ^a   O'Doherty, Robert M ^a   Stewart, Andrew F ^a   Vasavada, Rupangi C ^a   Garcia Ocaña, Adolfo ^a   Scott, Donald K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; BROXURIDINE; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; GLUCOSE; SMALL INTERFERING RNA; THYMIDINE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; GAIN OF FUNCTION MUTATION; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CELL; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELL PROLIFERATION; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; INSULINOMA; MICE; NUCLEAR PROTEINS; RATS; TRANSCRIPTION FACTORS;

EID: 84864390297     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0802     Document Type: Article

References (50)

1. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008;9:193-205 (Pubitemid 351301824)
2. Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, et al. Molecular control of cell cycle progression in the pancreatic beta-cell. Endocr Rev 2006;27: 356-370 (Pubitemid 43848303)
3. Cozar-Castellano I, Harb G, Selk K, et al. Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes 2008;57:3056-3068
4. Fiaschi-Taesch NM, Salim F, Kleinberger J, et al. Induction of human β-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 2010;59:1926-1936
5. Fiaschi-Taesch N, Bigatel TA, Sicari B, et al. Survey of the human pancreatic β-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human β-cell replication and function in vivo. Diabetes 2009;58:882-893
6. Buteau J, Spatz ML, Accili D. Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic β-cell mass. Diabetes 2006;55: 1190-1196 (Pubitemid 44195354)
7. Vasavada RC, Wang L, Fujinaka Y, et al. Protein kinase C-zeta activation markedly enhances β-cell proliferation: an essential role in growth factor mediated β-cell mitogenesis. Diabetes 2007;56:2732-2743 (Pubitemid 350044916)
8. Cozar-Castellano I, Weinstock M, Haught M, Velázquez-Garcia S, Sipula D, Stewart AF. Evaluation of β-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip. Diabetes 2006;55:70-77 (Pubitemid 43343300)
9. Porat S, Weinberg-Corem N, Tornovsky-Babaey S, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab 2011;13:440-449
10. Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol 2009;29:3219-3228
11. Del Zotto H, Gómez Dumm CL, Drago S, Fortino A, Luna GC, Gagliardino JJ. Mechanisms involved in the beta-cell mass increase induced by chronic sucrose feeding to normal rats. J Endocrinol 2002;174:225-231 (Pubitemid 34975603)
12. Koiter TR, Wijkstra S, van Der Schaaf-Verdonk CJ, Moes H, Schuiling GA. Pancreatic beta-cell function and islet-cell proliferation: effect of hyper-insulinaemia. Physiol Behav 1995;57:717-721
13. Liu YQ, Han J, Epstein PN, Long YS. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. Am J Physiol Endocrinol Metab 2005;288: E471-E478 (Pubitemid 40250540)
14. Liu YQ, Montanya E, Leahy JL. Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60% pancreatectomy rats. Diabetologia 2001;44:1026-1033 (Pubitemid 32778136)
15. Alonso LC, Yokoe T, Zhang P, et al. Glucose infusion in mice: a new model to induce β-cell replication. Diabetes 2007;56:1792-1801 (Pubitemid 47025447)
16. Bonner-Weir S, Deery D, Leahy JL, Weir GC. Compensatory growth of pancreatic β-cells in adult rats after short-term glucose infusion. Diabetes 1989;38:49-53 (Pubitemid 19021816)
17. Jetton TL, Everill B, Lausier J, et al. Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion. Am J Physiol Endocrinol Metab 2008;294:E679-E687 (Pubitemid 351483592)
18. Levitt HE, Cyphert TJ, Pascoe JL, et al. Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia 2011;54:572-582
19. Postic C, Dentin R, Denechaud PD, Girard J. ChREBP, a transcriptional regulator of glucose and lipid metabolism. Annu Rev Nutr 2007;27:179-192 (Pubitemid 351373354)
20. Tong X, Zhao F, Mancuso A, Gruber JJ, Thompson CB. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proc Natl Acad Sci USA 2009;106: 21660-21665
21. +channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 2000;49:424-430
22. Pedersen KB, Zhang P, Doumen C, et al. The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. Am J Physiol Endocrinol Metab 2007; 292:E788-E801 (Pubitemid 46411057)
23. Ma L, Robinson LN, Towle HC. ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem 2006;281:28721-28730 (Pubitemid 44507014)
24. Garcia-Ocana A, Takane KK, Reddy VT, Lopez-Talavera JC, Vasavada RC, Stewart AF. Adenovirus-mediated hepatocyte growth factor expression in mouse islets improves pancreatic islet transplant performance and reduces beta cell death. J Biol Chem 2003;278:343-351 (Pubitemid 36043582)
25. Zhang P, Metukuri MR, Bindom SM, Prochownik EV, O'Doherty RM, Scott DK. c-Myc is required for the CHREBP-dependent activation of glucose-responsive genes. Mol Endocrinol 2010;24:1274-1286
26. Ricordi CRC. Methods in pancreatic islet separation. In Methods in Cell Transplantation C R, Ed. Austin, TX, R.G. Landes, 2000, p. 433-443
27. Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci USA 2004;101:7281-7286 (Pubitemid 38638024)
28. García-Ocaña A, Vasavada RC, Cebrian A, et al. Transgenic overexpression of hepatocyte growth factor in the β-cell markedly improves islet function and islet transplant outcomes in mice. Diabetes 2001;50:2752-2762 (Pubitemid 33733126)
29. Strom SC, Pisarov LA, Dorko K, Thompson MT, Schuetz JD, Schuetz EG. Use of human hepatocytes to study P450 gene induction. Methods Enzymol 1996;272:388-401 (Pubitemid 26299903)
30. Harb G, Vasavada RC, Cobrinik D, Stewart AF. The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic β-cells. Diabetes 2009;58:1852-1862
31. da Silva Xavier G, Rutter GA, Diraison F, Andreolas C, Leclerc I. ChREBP binding to fatty acid synthase and L-type pyruvate kinase genes is stimulated by glucose in pancreatic beta-cells. J Lipid Res 2006;47:2482-2491
32. Deering TG, Ogihara T, Trace AP, Maier B, Mirmira RG. Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes. Diabetes 2009;58:185-193
33. Burke SJ, Collier JJ, Scott DK. cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. FASEB J 2009;23:2855-2865
34. Ma L, Tsatsos NG, Towle HC. Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. J Biol Chem 2005;280:12019-12027 (Pubitemid 40418520)
35. Guthalu Kondegowda N, Joshi-Gokhale S, Harb G, et al. Parathyroid hormone-related protein enhances human β-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes 2010;59:3131-3138
36. Schisler JC, Fueger PT, Babu DA, et al. Stimulation of human and rat islet β-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol 2008;28:3465-3476 (Pubitemid 351657108)
37. Song WJ, Schreiber WE, Zhong E, et al. Exendin-4 stimulation of cyclin A2 in β-cell proliferation. Diabetes 2008;57:2371-2381
38. Kushner JA, Ciemerych MA, Sicinska E, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 2005;25: 3752-3762 (Pubitemid 40559580)
39. Collier JJ, Zhang P, Pedersen KB, Burke SJ, Haycock JW, Scott DK. c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells. Am J Physiol Endocrinol Metab 2007;293:E48-E56 (Pubitemid 47105915)
40. Li MV, Chang B, Imamura M, Poungvarin N, Chan L. Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes 2006;55:1179-1189 (Pubitemid 44195353)
41. Noordeen NA, Khera TK, Sun G, et al. Carbohydrate-responsive element-binding protein (ChREBP) is a negative regulator of ARNT/HIF-1β gene expression in pancreatic islet β-cells. Diabetes 2010;59:153-160
42. Wang H, Wollheim CB. ChREBP rather than USF2 regulates glucose stimulation of endogenous L-pyruvate kinase expression in insulin-secreting cells. J Biol Chem 2002;277:32746-32752 (Pubitemid 34984782)
43. Gao N, Le Lay J, Qin W, et al. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol 2010;24:1594-1604
44. Soyer J, Flasse L, Raffelsberger W, et al. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development 2010;137:203-212
45. Salpeter SJ, Klochendler A, Weinberg-Corem N, et al. Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels. Endocrinology 2011;152:2589-2598
46. Folli F, Okada T, Perego C, et al. Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus. PLoS ONE 2011;6:e28050
47. Hussain MA, Porras DL, Rowe MH, et al. Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation. Mol Cell Biol 2006;26:7747-7759 (Pubitemid 44547720)
48. 2+-dependent calcineurin/NFAT signaling in primary pancreatic islet b-cells. Diabetes 2011;60:2892-2902
49. Jansen-Dürr P, Meichle A, Steiner P, et al. Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci USA 1993;90:3685-3689 (Pubitemid 23111432)
50. Heit JJ, Apelqvist AA, Gu X, et al. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature 2006;443:345-349 (Pubitemid 44435154)