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Volumn 123, Issue 5, 2013, Pages 2207-2217

No evidence for β cell neogenesis in murine adult pancreas

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; INSULIN; MEMBRANE PROTEIN; MTOMATO PROTEIN; NEUROGENIN 3; UNCLASSIFIED DRUG;

EID: 84875452820     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66323     Document Type: Article
Times cited : (171)

References (53)
  • 1
    • 0036274356 scopus 로고    scopus 로고
    • A view on β cell transplantation in diabetes
    • Pipeleers D, et al. A view on β cell transplantation in diabetes. Ann N Y Acad Sci. 2002;958:69-76.
    • (2002) Ann N y Acad Sci. , vol.958 , pp. 69-76
    • Pipeleers, D.1
  • 2
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science. 2008; 322(5907):1490-1494.
    • (2008) Science , vol.322 , Issue.5907 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 3
    • 33847687194 scopus 로고    scopus 로고
    • Molecular regulation of pancreatic beta-cell mass development, main-tenance, and expansion
    • Ackermann AM, Gannon M. Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol. 2007; 38(1-2):193-206.
    • (2007) J Mol Endocrinol. , vol.38 , Issue.1-2 , pp. 193-206
    • Ackermann, A.M.1    Gannon, M.2
  • 4
    • 1042288598 scopus 로고    scopus 로고
    • Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas
    • Lardon J, Huyens N, Rooman I, Bouwens L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch. 2004;444(1):61-65.
    • (2004) Virchows Arch. , vol.444 , Issue.1 , pp. 61-65
    • Lardon, J.1    Huyens, N.2    Rooman, I.3    Bouwens, L.4
  • 5
    • 0029864906 scopus 로고    scopus 로고
    • Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells
    • Mashima H, et al. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest. 1996; 97(7):1647-1654.
    • (1996) J Clin Invest. , vol.97 , Issue.7 , pp. 1647-1654
    • Mashima, H.1
  • 6
    • 34147190365 scopus 로고    scopus 로고
    • Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration
    • Desai BM, et al. Preexisting pancreatic acinar cells contribute to acinar cell, but not islet β cell, regeneration. J Clin Invest. 2007;117(4):971-977.
    • (2007) J Clin Invest. , vol.117 , Issue.4 , pp. 971-977
    • Desai, B.M.1
  • 7
    • 0033984886 scopus 로고    scopus 로고
    • Independent development of pancreatic alpha-and beta-cells from neurogenin3-expressing precursors: A role for the notch pathway in repression of premature differentiation
    • Jensen J, et al. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes. 2000;49(2):163-176.
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 163-176
    • Jensen, J.1
  • 8
    • 0036340074 scopus 로고    scopus 로고
    • + cells are islet progenitors and are distinct from duct progenitors
    • + cells are islet progenitors and are distinct from duct progenitors. Development. 2002;129(10):2447-2457.
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 9
    • 0033825383 scopus 로고    scopus 로고
    • Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    • Schwitzgebel VM, et al. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development. 2000;127(16):3533-3542.
    • (2000) Development , vol.127 , Issue.16 , pp. 3533-3542
    • Schwitzgebel, V.M.1
  • 10
    • 58549093915 scopus 로고    scopus 로고
    • Developmental biology of the pancreas: A comprehensive review
    • Gittes GK. Developmental biology of the pancreas: a comprehensive review. Dev Biol. 2009;326(1):4-35.
    • (2009) Dev Biol. , vol.326 , Issue.1 , pp. 4-35
    • Gittes, G.K.1
  • 11
    • 0345687862 scopus 로고    scopus 로고
    • Genes, signals, and lineages in pancreas development
    • Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol. 2003;19:71-89.
    • (2003) Annu Rev Cell Dev Biol. , vol.19 , pp. 71-89
    • Murtaugh, L.C.1    Melton, D.A.2
  • 12
    • 79951648873 scopus 로고    scopus 로고
    • Pancreas organogenesis: From bud to plexus to gland
    • Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn. 2011;240(3):530-565.
    • (2011) Dev Dyn. , vol.240 , Issue.3 , pp. 530-565
    • Pan, F.C.1    Wright, C.2
  • 14
    • 2442666735 scopus 로고    scopus 로고
    • Transcriptional networks controlling pancreatic development and β cell function
    • Servitja JM, Ferrer J. Transcriptional networks controlling pancreatic development and β cell function. Diabetologia. 2004;47(4):597-613.
    • (2004) Diabetologia , vol.47 , Issue.4 , pp. 597-613
    • Servitja, J.M.1    Ferrer, J.2
  • 15
    • 0037213587 scopus 로고    scopus 로고
    • Gene expression cascades in pancreatic development
    • Wilson ME, Scheel D, German MS. Gene expression cascades in pancreatic development. Mech Dev. 2003;120(1):65-80.
    • (2003) Mech Dev. , vol.120 , Issue.1 , pp. 65-80
    • Wilson, M.E.1    Scheel, D.2    German, M.S.3
  • 16
    • 0036301577 scopus 로고    scopus 로고
    • Pancreatic organogenesis - Developmental mechanisms and implications for therapy
    • Edlund H. Pancreatic organogenesis - developmental mechanisms and implications for therapy. Nat Rev Genet. 2002;3(7):524-532.
    • (2002) Nat Rev Genet. , vol.3 , Issue.7 , pp. 524-532
    • Edlund, H.1
  • 18
    • 11444252141 scopus 로고    scopus 로고
    • The pancreatic ductal epithelium serves as a potential pool of progenitor cells
    • Bonner-Weir S, et al. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes. 2004;5(suppl 2):16-22.
    • (2004) Pediatr Diabetes , vol.5 , Issue.SUPPL. 2 , pp. 16-22
    • Bonner-Weir, S.1
  • 19
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 2004; 429(6987):41-46.
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 20
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult β cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult β cells does not involve specialized progenitors. Dev Cell. 2007; 12(5):817-826.
    • (2007) Dev Cell , vol.12 , Issue.5 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 21
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu X, et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008;132(2):197-207.
    • (2008) Cell , vol.132 , Issue.2 , pp. 197-207
    • Xu, X.1
  • 22
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada A, et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008;105(50):19915-19919.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.50 , pp. 19915-19919
    • Inada, A.1
  • 23
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth
    • Solar M, et al. Pancreatic exocrine duct cells give rise to insulin-producing β cells during embryogenesis but not after birth. Dev Cell. 2009;17(6):849-860.
    • (2009) Dev Cell , vol.17 , Issue.6 , pp. 849-860
    • Solar, M.1
  • 24
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama K, et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet. 2011; 43(1):34-41.
    • (2011) Nat Genet. , vol.43 , Issue.1 , pp. 34-41
    • Furuyama, K.1
  • 25
    • 79951539242 scopus 로고    scopus 로고
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • + ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development. 2011; 138(4):653-665.
    • (2011) Development , vol.138 , Issue.4 , pp. 653-665
    • Kopp, J.L.1
  • 27
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by β cell regeneration
    • Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by β cell regeneration. J Clin Invest. 2007; 117(9):2553-2561.
    • (2007) J Clin Invest. , vol.117 , Issue.9 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 28
    • 84859046711 scopus 로고    scopus 로고
    • Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice
    • Reinert RB, et al. Tamoxifen-induced Cre-loxP recombination is prolonged in pancreatic islets of adult mice. PLoS One. 2012;7(3):e33529.
    • (2012) PLoS One. , vol.7 , Issue.3
    • Reinert, R.B.1
  • 29
    • 77954636626 scopus 로고    scopus 로고
    • Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling
    • Blaine SA, Ray KC, Anunobi R, Gannon MA, Washington MK, Means AL. Adult pancreatic acinar cells give rise to ducts but not endocrine cells in response to growth factor signaling. Development. 2010;137(14):2289-2296.
    • (2010) Development , vol.137 , Issue.14 , pp. 2289-2296
    • Blaine, S.A.1    Ray, K.C.2    Anunobi, R.3    Gannon, M.A.4    Washington, M.K.5    Means, A.L.6
  • 30
    • 0036206791 scopus 로고    scopus 로고
    • Change in the gene expression of hepatic tamoxifen-metabolizing enzymes during the process of tamoxifen-induced hepatocarcinogenesis in female rats
    • Kasahara T, Hashiba M, Harada T, Degawa M. Change in the gene expression of hepatic tamoxifen-metabolizing enzymes during the process of tamoxifen-induced hepatocarcinogenesis in female rats. Carcinogenesis. 2002;23(3):491-498.
    • (2002) Carcinogenesis , vol.23 , Issue.3 , pp. 491-498
    • Kasahara, T.1    Hashiba, M.2    Harada, T.3    Degawa, M.4
  • 31
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase
    • Postic C, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic β cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999;274(1):305-315.
    • (1999) J Biol Chem. , vol.274 , Issue.1 , pp. 305-315
    • Postic, C.1
  • 32
    • 35548932872 scopus 로고    scopus 로고
    • A global double-fluorescent Cre reporter mouse
    • Muzumdar MD, Tasic B, Miyamichi K, Li L, Luo L. A global double-fluorescent Cre reporter mouse. Genesis. 2007;45(9):593-605.
    • (2007) Genesis , vol.45 , Issue.9 , pp. 593-605
    • Muzumdar, M.D.1    Tasic, B.2    Miyamichi, K.3    Li, L.4    Luo, L.5
  • 33
    • 67649865643 scopus 로고    scopus 로고
    • Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    • Wang S, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009;106(24):9715-9720.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.24 , pp. 9715-9720
    • Wang, S.1
  • 34
    • 35848969322 scopus 로고    scopus 로고
    • Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells
    • Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia. 2007;50(12):2504-2515.
    • (2007) Diabetologia , vol.50 , Issue.12 , pp. 2504-2515
    • Dror, V.1    Nguyen, V.2    Walia, P.3    Kalynyak, T.B.4    Hill, J.A.5    Johnson, J.D.6
  • 35
    • 0037011171 scopus 로고    scopus 로고
    • Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium
    • Jenny M, et al. Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J. 2002; 21(23):6338-6347.
    • (2002) EMBO J. , vol.21 , Issue.23 , pp. 6338-6347
    • Jenny, M.1
  • 36
    • 79957737999 scopus 로고    scopus 로고
    • Pancreatic beta-cells are generated by neogenesis from non-beta-cells after birth
    • Nakamura K, Minami K, Tamura K, Iemoto K, Miki T, Seino S. Pancreatic beta-cells are generated by neogenesis from non-beta-cells after birth. Biomed Res. 2011;32(2):167-174.
    • (2011) Biomed Res. , vol.32 , Issue.2 , pp. 167-174
    • Nakamura, K.1    Minami, K.2    Tamura, K.3    Iemoto, K.4    Miki, T.5    Seino, S.6
  • 37
    • 84875480115 scopus 로고    scopus 로고
    • Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic beta cells as a regulator of beta cell mass
    • Xiao X, et al. Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic beta cells as a regulator of beta cell mass. J Biol Chem. 2013;288(12):8636-8646.
    • (2013) J Biol Chem. , vol.288 , Issue.12 , pp. 8636-8646
    • Xiao, X.1
  • 38
    • 84875479006 scopus 로고    scopus 로고
    • TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation
    • Xiao X, et al. TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes. 2013; 62(4):1217-1226.
    • (2013) Diabetes , vol.62 , Issue.4 , pp. 1217-1226
    • Xiao, X.1
  • 39
    • 78149424683 scopus 로고    scopus 로고
    • Tamoxifen-independent recombination in the RIP-CreER mouse
    • Liu Y, et al. Tamoxifen-independent recombination in the RIP-CreER mouse. PLoS One. 2010; 5(10):e13533.
    • (2010) PLoS One. , vol.5 , Issue.10
    • Liu, Y.1
  • 40
    • 68049128102 scopus 로고    scopus 로고
    • Chronology of islet differentiation revealed by temporal cell labeling
    • Miyatsuka T, Li Z, German MS. Chronology of islet differentiation revealed by temporal cell labeling. Diabetes. 2009;58(8):1863-1868.
    • (2009) Diabetes , vol.58 , Issue.8 , pp. 1863-1868
    • Miyatsuka, T.1    Li, Z.2    German, M.S.3
  • 41
    • 33846091092 scopus 로고    scopus 로고
    • Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS
    • Sugiyama T, Rodriguez RT, McLean GW, Kim SK. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A. 2007; 104(1):175-180.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.1 , pp. 175-180
    • Sugiyama, T.1    Rodriguez, R.T.2    McLean, G.W.3    Kim, S.K.4
  • 42
    • 1642474003 scopus 로고    scopus 로고
    • Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    • Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004;131(1):165-179.
    • (2004) Development , vol.131 , Issue.1 , pp. 165-179
    • Gu, G.1    Wells, J.M.2    Dombkowski, D.3    Preffer, F.4    Aronow, B.5    Melton, D.A.6
  • 43
    • 70350144386 scopus 로고    scopus 로고
    • Pancreatic neurogenin 3-expressing cells are unipotent islet precursors
    • Desgraz R, Herrera PL. Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development. 2009;136(21):3567-3574.
    • (2009) Development , vol.136 , Issue.21 , pp. 3567-3574
    • Desgraz, R.1    Herrera, P.L.2
  • 44
    • 9644266753 scopus 로고    scopus 로고
    • β cell replication is the primary mechanism for maintaining postnatal β cell mass
    • Georgia S, Bhushan A. β cell replication is the primary mechanism for maintaining postnatal β cell mass. J Clin Invest. 2004;114(7):963-968.
    • (2004) J Clin Invest. , vol.114 , Issue.7 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 45
    • 33845513370 scopus 로고    scopus 로고
    • P27 Regulates the transition of beta-cells from quiescence to proliferation
    • Georgia S, Bhushan A. p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006;55(11):2950-2956.
    • (2006) Diabetes , vol.55 , Issue.11 , pp. 2950-2956
    • Georgia, S.1    Bhushan, A.2
  • 46
    • 0026329445 scopus 로고
    • Functional maturation and proliferation of fetal pancreatic β-cells
    • Hellerstrom C, Swenne I. Functional maturation and proliferation of fetal pancreatic β-cells. Diabetes. 1991;40(suppl 2):89-93.
    • (1991) Diabetes , vol.40 , Issue.SUPPL. 2 , pp. 89-93
    • Hellerstrom, C.1    Swenne, I.2
  • 47
    • 0026515343 scopus 로고
    • Pancreatic beta-cell growth and diabetes mellitus
    • Swenne I. Pancreatic beta-cell growth and diabetes mellitus. Diabetologia. 1992;35(3):193-201.
    • (1992) Diabetologia , vol.35 , Issue.3 , pp. 193-201
    • Swenne, I.1
  • 48
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
    • Talchai C, Xuan S, Lin HV, Sussel L, Accili D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell. 2012;150(6):1223-1234.
    • (2012) Cell , vol.150 , Issue.6 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3    Sussel, L.4    Accili, D.5
  • 49
    • 84856394012 scopus 로고    scopus 로고
    • Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture
    • Negi S, Jetha A, Aikin R, Hasilo C, Sladek R, Paraskevas S. Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture. PLoS One. 2012;7(1):e30415.
    • (2012) PLoS One. , vol.7 , Issue.1
    • Negi, S.1    Jetha, A.2    Aikin, R.3    Hasilo, C.4    Sladek, R.5    Paraskevas, S.6
  • 50
    • 84865608506 scopus 로고    scopus 로고
    • β cell count instead of β cell mass to assess and localize growth in β cell population following pancreatic duct ligation in mice
    • Chintinne M, Stange G, Denys B, Ling Z, In 't Veld P, Pipeleers D. β cell count instead of β cell mass to assess and localize growth in β cell population following pancreatic duct ligation in mice. PLoS One. 2012;7(8):e43959.
    • (2012) PLoS One. , vol.7 , Issue.8
    • Chintinne, M.1    Stange, G.2    Denys, B.3    Ling, Z.4    In'T Veld, P.5    Pipeleers, D.6
  • 51
    • 77958099053 scopus 로고    scopus 로고
    • Pancreatic β-cell neogenesis by direct conversion from mature α-cells
    • Chung CH, Hao E, Piran R, Keinan E, Levine F. Pancreatic β-cell neogenesis by direct conversion from mature α-cells. Stem Cells. 2010;28(9):1630-1638.
    • (2010) Stem Cells , vol.28 , Issue.9 , pp. 1630-1638
    • Chung, C.H.1    Hao, E.2    Piran, R.3    Keinan, E.4    Levine, F.5
  • 52
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
    • Thorel F, et al. Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss. Nature. 2010;464(7292):1149-1154.
    • (2010) Nature , vol.464 , Issue.7292 , pp. 1149-1154
    • Thorel, F.1
  • 53
    • 0037235364 scopus 로고    scopus 로고
    • Transgenic mice with green fluorescent protein-labeled pancreatic β-cells
    • Hara M, et al. Transgenic mice with green fluorescent protein-labeled pancreatic β-cells. Am J Physiol Endocrinol Metab. 2003;284(1):E177-E183.
    • (2003) Am J Physiol Endocrinol Metab. , vol.284 , Issue.1
    • Hara, M.1


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