7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species

Toxicology

Volumn 302, Issue 2-3, 2012, Pages 221-232

  Loa, Yu Li ^a   Wang, Wanjen ^a   Ho, Cheng Ta ^b  

^a NATIONAL UNIVERSITY OF TAINAN   (Taiwan)

^b SHIH CHIEN UNIVERSITY   (Taiwan)

Author keywords

7,3',4' trihydroxyisoflavone; Apoptosis; Epirubicin; Isoflavone; Multidrug resistance; Reactive oxygen species

Indexed keywords

7,3',4' TRIHYDROXYISOFLAVONE; CASPASE 9; CELL NUCLEUS DNA; EPIRUBICIN; FREE RADICAL; HYDROGEN PEROXIDE; ISOFLAVONE DERIVATIVE; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; 3',4',7 TRIHYDROXYISOFLAVONE; 3',4',7-TRIHYDROXYISOFLAVONE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE 3; CASPASE 8; DAIDZEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; FEMALE; GENE CONTROL; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROMOTER REGION; UPREGULATION; DRUG EFFECT; DRUG RESISTANCE; GENETICS; METABOLISM; MITOCHONDRION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; DNA FRAGMENTATION; DRUG RESISTANCE, NEOPLASM; EPIRUBICIN; HELA CELLS; HUMANS; ISOFLAVONES; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84897124002     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.003     Document Type: Article

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