Transcription factor c-jun activation represses mdr-1 gene expression

Cancer Research

Volumn 63, Issue 15, 2003, Pages 4527-4532

  Miao, Ze Hong ^a   Ding, Jian ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GYRASE INHIBITOR; PROTEIN C JUN; SALVICINE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG TARGETING; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MDR 1 GENE; MULTIDRUG RESISTANCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; DNA, NEOPLASM; DOWN-REGULATION; GENE EXPRESSION REGULATION, LEUKEMIC; GENES, MDR; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; K562 CELLS; MITOGEN-ACTIVATED PROTEIN KINASES; NAPHTHOQUINONES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1;

EID: 0042591363     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Gottesman, M. M., Fojo, T., and Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nature Rev. Cancer (Phila.), 2: 48-58, 2002.
2. Johnstone, R. W. Dual mechanisms of drug resistance by P-glycoprotein: inhibition of drug accumulation and caspase activation. 93rd AACR Annual Meeting, April 6-12, 2002, San Francisco. CA, pp. 28-29. Philadelphia, PA: AACR, 2002.
3. Zhang, J. S., Ding, J., Tang, Q. M., Li, M., Zhao, M., Lu, L. J., Chen, L. J., and Yuan, S. T. Synthesis and antitumor activity of novel diterpenequinone salvicine and the analogs. Bioorg. Med. Chem. Lett., 9: 2731-2736, 1999.
4. Qing, C., Zhang, J. S., and Ding, J. In vitro cytotoxicity of salvicine, a novel diterpenoid quinone. Acta Pharmacol. Sin., 20: 297-302, 1999.
5. Meng, L. H., He, X. H., Zhang, J. S., Ding, J. DNA topoisomerase II as primary cellular target for salvicine in Saccharomyces cerevisiae. Acta Pharmacol. Sin., 21: 741-746, 2001.
6. Meng, L. H., Zhang, J. S., Ding, J. Salvicine, a novel DNA topoisomerase II inhibitor, exerting its effect by trapping the enzyme-DNA cleavage complex. Biochem. Pharmacol., 62: 733-741, 2001.
7. Miao, Z-H., Tang, T., Zhang, Y-X., Zhang, J-S., and Ding, J. Cytotoxicity and apoptosis induction by the anti-topoisomerase II agent, salvicine, associated with downregulating P-glycoprotein expression in multidrug-resistant cells. Int. J. Cancer, 106: 108-115, 2003.
8. Meng, L., and Ding, J. Induction of bulk and c-myc P2 promoter-specific DNA damage by an anti-topoisomerase II agent salvicine is an early event leading to apoptosis in HL-60 cells. FEBS Lett., 501: 59-64, 2001.
9. Chin, K-V., Pastan, I., and Gottesman, M. M. Function and regulation of the human multidrug resistance gene. Adv. Cancer Res., 60: 157-180, 1993.
10. Kang, C-D., Ahn, B-K., Jeong, C-S., Kim, K. W., Lee, H-J., Yoo, S-D., Chung, B-S., and Kim, S-H. Downregulation of JNK/SAPK activity is associated with the cross-resistance to P-glycoprotein-unrelated drugs in multidrug-resistant FM3A/M cells overexpressing P-glycoprotein. Exp. Cell Res., 256: 300-307, 2000.
11. Wartenberg, M., Ling, F. C., Schallenberg, M., Baumer, A. T., Petrat, K., Hescheler, J., and Sauer, H. Down-regulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J. Biol. Chem., 276: 17420-17428, 2001.
12. Ogretmen, B., and Safa, A. Negative regulation of MDR-1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kB/p65 and c-Fos transcription factors and their interaction with the CAAT region. Biochemistry, 38: 2189-2199, 1999.
13. Ikeguchi, M., Teeter, L. D., Eckersberg, T., Ganapathi, R., and Kuo, M. T. Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr-1a reveal a negative element containing the AAP-1 binding site. DNA Cell Biol., 10: 639-649, 1991.
14. Yang, C. Z., Luan, F. J., Xiong, D. S., Liu, B. R., Xu, Y. F., and Gu, K. S. Multidrug resistance in leukemic cell line K562/A02 induced by doxorubicin. Zhongguo Yao Li Xue Bao, 16: 333-337, 1995.
15. Luan, F. J. Establishment of the multidrug-resistant cell line K562/A02 and its drug-resistant properties. Zhonghua Zhong Liu Za Zhi, 15: 101-103, 1993.
16. Kondo, T., Matsuda, T., Kitano, T., Takahashi, A., Tashima, M., Ishikura, H., Umehara, H., Domae, N., Uchiyama, T., and Okazaki, T. Role of c-jun expression increased by heat shock- and ceramide-activated caspase-3 in HL-60 cell apoptosis. Possible involvement of ceramide in heat shock-induced apoptosis. J. Biol. Chem., 275: 7668-7676, 2000.
17. Takakura, M., Kyo, S., Kanaya, T., Tanaka, M., and Inoue, M. Expression of human telomerase subunits and correlation with telomerase activity in cervical cancer. Cancer Res., 58: 1558-1561, 1998.
18. Daschner, P. J., Ciolino, H. P., Plouzek, C. A., and Yeh, G. C. Increased AP-1 activity in drug resistant human breast cancer MCF-7 cells. Breast Cancer Res. Treat., 53: 229-240, 1999.
19. Alley, M. C., Scudiero, D. A., Monks, A., Hursey, M. L., Czerwinski, M. J., and Fine, D. L. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res., 48: 589-601, 1988.
20. Zhou, J. J., Yue, X. F., Han, J. X., and Yang, W. Y. Improved MTT assay for activity of antitumor agents. Chin. J. Pharm., 24: 455-457, 1993.
21. Steward, O., and Worley, P. F. A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc. Natl. Acad. Sci. USA, 98: 7062-7068, 2001.
22. Dunn, C., Wiltshire, C., MacLaren, A., and Gillespie, D. A. F. Molecular mechanism and biological functions of c-Jun N-terminal kinase signaling via the c-Jun transcription factor. Cell. Sign., 14: 585-593, 2002.
23. Kaminska, B., Pyrzynska, B., Ciechomska, I., and Wisniewska, M. Modulation of the composition of AP-1 complex and its impact on transcriptional activity. Acta Neurobiol. Exp., 60: 395-402, 2000.
24. Dever, T. E. Gene-specific regulation by general transcription factors. Cell, 108: 545-556, 2002.
25. Stein, U., Walther, W., and Shoemaker, R. H. Modulation of mdr-1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. Br. J. Cancer, 74: 1384-1391, 1996.
26. Stein, U., Walther, W., and Shoemaker, R. H. Reversal of multidrug resistance by transduction of cytokines genes into human colon carcinoma cells. J. Natl. Cancer Inst., 88: 1383-1392, 1996.
27. Chen, G., and Goeddel, D. V. TNF-R1 signaling: a beautiful pathway. Science (Wash. DC), 296: 1634-1635, 2002.
28. Berk, B. C., Abe, J. I., Min, W., Surapisitchat, J., and Yan, C. Endothelial atheroprotective and anti-inflammatory mechanisms. Ann. N. Y. Acad. Sci., 947: 93-109, 2001.
29. Mechta-Grigoriou, F., Gerald, D., and Yaniv, M. The mammalian Jun proteins: redundancy and specificity. Oncogene, 20: 2378-2389, 2001.
30. Shaulian, E., and Karin, M. AP1 in cell proliferation and survival. Oncogene, 20: 2390-2400, 2001.
31. Johnstone, R. W., Ruefli, A. A., and Lowe, S. W. Apoptosis: a link between cancer genetics and chemotherapy. Cell, 108: 153-164, 2002.
32. INK4a contributes to the outcome of cancer therapy. Cell, 109: 335-346, 2002.
33. Smyth, M. J., Krasovskis, E., Sutton, V. R., and Johnstone, R. W. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc. Natl. Acad. USA, 95: 7024-7029, 1998.
34. Ruefli, A. A., Smyth, M. J., and Johnstone, R. W. HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein- mediated multidrug resistance. Blood, 95: 2378-2385, 2000.