Simultaneous suppression of multidrug resistance and antiapoptotic cellular defense induces apoptosis in chemoresistant human acute myeloid leukemia cells

Leukemia Research

Volumn 31, Issue 7, 2007, Pages 989-994

  Wang, Xiaofang ^a   Wang, Chun ^b   Qin, You wen ^b   Yan, Shi ke ^b   Gao, Yan rong ^b  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Antisense oligonucleotides; Apoptosis; Drug resistance; Leukemia; MRP; XIAP

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MULTIDRUG RESISTANCE PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; OLIGORIBONUCLEOTIDES, ANTISENSE; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 34249773997     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2006.09.001     Document Type: Article

References (16)

1. Pakunlu R.I., Cook T.J., and Minko T. Simultaneous modulation of multidrug resistance and antiapoptotic cellular defense by MDR1 and BCL2 targeted antisense oligonucleotides enhances the anticancer efficacy of doxorubicin. Pharmaceut Res 20 (2003) 351-359
2. Minko T., Dharap S.S., Pakunlu R.I., and Wang Y. Molecular targeting of drug delivery systems to cancer. Curr Drug Targets 5 (2004) 389-406
3. Deveraux Q.L., Takahashi R., Salvesen G.S., and Reed J.C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388 (1997) 300-304
4. Roy N., Deveraux Q.L., Takahashi R., Salvesen G.S., and Reed J.C. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J 16 (1997) 6914-6925
5. Tamm I., Wang Y., Sausville E., Scudiero D.A., Vigna N., Oltersdorf T., et al. IAP-family protein surviving inhibits caspase activity and apoptosis induced by Fas (CD95), Dax, caspases and anticancer drugs. Cancer Res 58 (1998) 5315-5320
6. Deveraux Q.L., Roy N., Stennicke H.R., Van Arsdale T., Zhou Q., Srinivasula S.M., et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by distinct inhibition of distinct caspases. EMBO J 17 (1998) 2215-2223
7. Deveraux Q.L., Leo E., Stennicke H.R., Welsh K., Salvesen G.S., and Reed J.C. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 18 (1999) 5242-5251
8. Hu Y.P., Cherton-Horvat G., Dragowska V., Baird S., Korneluk R.G., Durkin J.P., et al. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 9 (2003) 2826-2836
9. Carter B.Z., Milella M., Tsao T., McQueen T., Schober W.D., Hu W., et al. Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia. Leukemia 17 (2003) 2081-2089
10. Bilim V., Kasahara T., Hara N., Takahashi K., and Tomita Y. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. Int J Cancer 103 (2003) 29-37
11. Stewart A.J., Canitrot Y., Baracchini E., Dean N.M., Deeley R.G., and Cole S.P. Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides. Biochem Pharmacol 51 (1996) 461-469
12. Szakacs G., Jakab K., Antal F., and Sarkadi B. Diagnostics of multidrug resistance in cancer. Pathol Oncol Res 4 (1998) 251-257
13. van Veen H.W., and Konings W.N. The ABC family of multidrug transporters in microorganisms. Biochim Biophys Acta 1365 (1998) 31-36
14. Corrias M.V., and Tonini G.P. An oligomer complementary to the 5′ end region of MDR1 gene decreases resistance to doxorubicin of human adenocarcinoma-resistant cells. Anticancer Res 12 (1992) 1431-1438
15. Fong W.G., Liston P., Rajcan-Separovic E., St-Jean M., Craig C., and Korneluk R.G. Expression and genetic analysis of XIAP-associated factor 1 (XAF1) in cancer cell lines. Genomics 70 (2000) 113-122
16. Sasaki H., Sheng Y., Kotsuji F., and Tsang B.K. Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res 60 (2000) 5659-5666