7,3′,4′-trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase

Journal of Biological Chemistry

Volumn 285, Issue 28, 2010, Pages 21458-21466

  Lee, Dong Eun ^a,b,c   Lee, Ki Won ^c   Song, Nu Ry ^b   Seo, Sang Kwon ^b   Heo, Yong Seok ^c   Kang, Nam Joo ^d   Bode, Ann M ^a   Lee, Hyong Joo ^b   Dong, Zigang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Seoul National University   (South Korea)

^c Konkuk University   (South Korea)

^d Kyungpook National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; BIOLOGICAL ACTIONS; CELL CYCLE; CELL-CYCLE PROGRESSION; CHEMOPREVENTIVE ACTIVITY; CYCLIN E; CYCLIN-DEPENDENT KINASE; CYCLIND1; DAIDZEIN; EPIDERMAL CELLS; EPIDERMAL GROWTH FACTORS; IN-VITRO; ISOFLAVONES; KINASE ACTIVITY; MOLECULAR BASIS; MOLECULAR MECHANISM; MOLECULAR TARGETS; NEOPLASTIC TRANSFORMATION; PHOSPHATIDYLINOSITOL 3-KINASE; REGULATORY PROTEIN; RETINOBLASTOMA PROTEIN; SPECIFIC SITES; STIMULATED CELLS; WESTERN BLOTS;

BIOACTIVITY; CELL PROLIFERATION; PHOSPHORYLATION;

PEPTIDES;

7,3',4' TRIHYDROXYISOFLAVONE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; DAIDZEIN; EPIDERMAL GROWTH FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN; SERINE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; 3',4',7 TRIHYDROXYISOFLAVONE; 3',4',7-TRIHYDROXYISOFLAVONE; ANTINEOPLASTIC AGENT; ISOFLAVONE DERIVATIVE;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG TARGETING; ENZYME INHIBITION; EPIDERMIS CELL; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WESTERN BLOTTING; ANIMAL; CHEMISTRY; HUMAN; METABOLISM; SKIN TUMOR; TUMOR CELL LINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOFLAVONES; MICE; RETINOBLASTOMA PROTEIN; SERINE; SKIN NEOPLASMS;

EID: 77954350740     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.094797     Document Type: Article

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