7,3',4'-trihydroxyisoflavone, a metabolite of the soy isoflavone Daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4

Journal of Biological Chemistry

Volumn 286, Issue 16, 2011, Pages 14246-14256

  Lee, Dong Eun ^a,b,c   Lee, Ki Won ^b   Byun, Sanguine ^a,b,c   Jung, Sung Keun ^a,b,c   Song, Nury ^a,b,c   Lim, Sung Hwan ^a   Heo, Yong Seok ^d   Kim, Jong Eun ^a,b,c   Kang, Nam Joo ^e   Kim, Bo Yeon ^f   Bowden, G Tim ^g   Bode, Ann M ^b   Lee, Hyong Joo ^a   Dong, Zigang ^b,c  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF MINNESOTA   (United States)

^d Konkuk University   (South Korea)

^e Kyungpook National University   (South Korea)

^f Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^g UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING SITE; BIOLOGICAL ACTIONS; CHEMOPREVENTIVE AGENTS; CHEMOPREVENTIVE EFFECTS; CHRONIC EXPOSURE; CYCLOOXYGENASE 2; DAIDZEIN; EXPRESSION LEVELS; GENISTEIN; ISOFLAVONES; KINASE ACTIVITY; KINASE ASSAYS; KINASE DOMAINS; MITOGEN ACTIVATED PROTEIN KINASE; MOUSE SKIN; NONMELANOMA SKIN; SKIN CANCERS; TOPICAL APPLICATION; TRANSCRIPTION ACTIVITY; ULTRAVIOLET B; UVB IRRADIATION; WESTERN BLOTS;

BIOMOLECULES; DERMATOLOGY; ENZYMES; METABOLISM; METABOLITES; PHOSPHORYLATION;

DISEASES;

7,3',4' TRIHYDROXYISOFLAVONE; CYCLOOXYGENASE 2; DAIDZEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; ONCOPROTEIN; PROTEIN COT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SKIN CANCER; TRANSCRIPTION REGULATION; ULTRAVIOLET B RADIATION;

ANIMALS; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, NEOPLASTIC; ISOFLAVONES; MAP KINASE KINASE 4; MAP KINASE KINASE KINASES; MICE; MICE, INBRED ICR; NEOPLASMS, RADIATION-INDUCED; NF-KAPPA B; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; SOYBEANS; ULTRAVIOLET RAYS;

GLYCINE MAX;

EID: 79954621284     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.147348     Document Type: Article

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