Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1276-1285

  Ham, Young Mi ^a   Lim, Jin Hee ^b   Na, Hye Kyung ^b   Choi, Joon Seok ^b   Park, Byoung Duck ^b   Yim, Hyungshin ^b   Lee, Seung Ki ^b  

^a Korea University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CALCIUM; CATALASE; GINSENOSIDE; GINSENOSIDE RH 2; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DEPOLARIZATION; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CALCIUM; CASPASE 3; CELL LINE, TUMOR; DNA FRAGMENTATION; FLOW CYTOMETRY; GINSENOSIDES; HELA CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; TRANSLOCATION, GENETIC;

EID: 33751183316     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.109926     Document Type: Article

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