Mitochondrial genome depletion dysregulates bile acid- and paracetamol-induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells

British Journal of Pharmacology

Volumn 162, Issue 8, 2011, Pages 1686-1699

  Perez, M J ^a,b   Gonzalez Sanchez, E ^c   Gonzalez Loyola, A ^c   Gonzalez Buitrago, J M ^a   Marin, J J G ^c  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^b Instituto de Estudios de Ciencias de La Salud de Castilla y Leon   (Spain)

^c UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

ABC proteins; bile acid; cholestasis; drug toxicity; liver; mitochondria; multidrug resistance; paracetamol (acetaminophen); retrograde control; rho cells

Indexed keywords

FAS ANTIGEN; GLYCOCHENODEOXYCHOLIC ACID; GLYCOURSODEOXYCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 4; PARACETAMOL; PROTEIN TYROSINE PHOSPHATASE SHP; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEPATOMA CELL; MITOCHONDRIAL DNA DEPLETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RHO CELL; UPREGULATION; WILD TYPE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; GENOME, MITOCHONDRIAL; GLYCOCHENODEOXYCHOLIC ACID; LIVER; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NF-E2-RELATED FACTOR 2; P-GLYCOPROTEIN; REACTIVE OXYGEN SPECIES; RNA, RIBOSOMAL; URSODEOXYCHOLIC ACID;

EID: 79953049264     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01174.x     Document Type: Article

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