DDTD, an isoflavone derivative, induces cell apoptosis through the reactive oxygen species/apoptosis signal-regulating kinase 1 pathway in human osteosarcoma cells

European Journal of Pharmacology

Volumn 597, Issue 1-3, 2008, Pages 19-26

  Chen, Jung Tsan ^a   Fong, Yi Chin ^a,b   Li, Te Mao ^a   Liu, Ju Fang ^a   Hsu, Che Wei ^a   Chang, Chih Shiang ^a   Tang, Chih Hsin ^c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

ASK1; Isoflavone; Osteosarcoma; ROS

Indexed keywords

3',4' DICHLORO 3 (3,4 DICHLOROPHENYLACETYL) 2,4,6 TRIHYDROXYDEOXYBENZOIN; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 9; ISOFLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; PROTEIN 14 3 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CHEMOTHERAPY; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOSARCOMA CELL; PRIORITY JOURNAL;

14-3-3 PROTEINS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 9; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOFLAVONES; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MAP KINASE KINASE KINASE 5; MITOCHONDRIA; OSTEOSARCOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHYTOESTROGENS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 53449093801     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.08.036     Document Type: Article

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