H1, a derivative of Tetrandrine, exerts anti-MDR activity by initiating intrinsic apoptosis pathway and inhibiting the activation of Erk1/2 and Akt1/2

Biochemical Pharmacology

Volumn 82, Issue 11, 2011, Pages 1593-1603

  Wei, Ning ^a   Liu, Geng Tao ^a   Chen, Xiao Guang ^a   Liu, Qian ^a   Wang, Feng Peng ^b   Sun, Hua ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Anti cancer; Apoptosis; Drug resistance; Survival pathway; Tetrandrine

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; FAS ANTIGEN; FAS LIGAND; H 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE B BETA; REACTIVE OXYGEN METABOLITE; TETRANDRINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYLISOQUINOLINES; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CYTOCHROMES C; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 80255137201     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.08.012     Document Type: Article

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