Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity

Biochemical Pharmacology

Volumn 72, Issue 5, 2006, Pages 624-631

  Atherton, Kathryn M ^a   Mutch, Elaine ^b   Ford, Dianne ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cytochrome P450; Daidzein; Genistein; Isoflavone; MCF 7 cells; Phytoestrogen

Indexed keywords

4 METHYLPYRAZOLE; 6,7,4' TRIHYDROXYISOFLAVONE; 7,3',4' TRIHYDROXYISOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; DAIDZEIN; FURAFYLLINE; GENISTEIN; ISOFLAVONE; ISOFLAVONE DERIVATIVE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL COUNT; CELL STRAIN MCF 7; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LIVER METABOLISM; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOYBEAN; STATISTICAL SIGNIFICANCE;

ARYL HYDROCARBON HYDROXYLASES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; GENISTEIN; HUMANS; HYDROXYLATION; ISOFLAVONES; LIVER; SOYBEANS;

EID: 33746690306     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.05.015     Document Type: Article

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