Protein tyrosine kinase pathway-derived ROS/NO productions contribute to G2/M cell cycle arrest in evodiamine-treated human cervix carcinoma HeLa cells

Free Radical Research

Volumn 44, Issue 7, 2010, Pages 792-802

  Yang, Jia ^a   Wu, Li Jun ^a   Tashino, Shin Ichi ^b   Onodera, Satoshi ^b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cell cycle arrest; Evodiamine; Genistein; Nitric oxide (NO); Protein tyrosine kinase (PTK); Reactive oxygen species (ROS)

Indexed keywords

CYCLIN B1; EVODIAMINE; NITRIC OXIDE; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RAF PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; GENISTEIN; N(G) NITROARGININE METHYL ESTER; PLANT EXTRACT; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; OXIDATION REDUCTION STATE; SIGNAL TRANSDUCTION; UTERINE CERVIX CARCINOMA; BIOSYNTHESIS; DRUG EFFECTS; FEMALE; HELA CELL LINE; METABOLISM; METAPHASE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

ANTHRACENES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; FEMALE; G2 PHASE; GENISTEIN; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METAPHASE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXIDATION-REDUCTION; PLANT EXTRACTS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; QUINAZOLINES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 77953354020     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2010.481302     Document Type: Article

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