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Volumn 41, Issue 3, 2013, Pages 205-221

Metabolomic fingerprinting: Challenges and opportunities

Author keywords

Bioinformatics; Data analysis; Disease modeling; Metabolomics

Indexed keywords

DATA COLLECTION METHOD; DISEASE MODELING; DYNAMIC INTERACTION; IN-DEPTH UNDERSTANDING; INTEGRATED APPROACH; METABOLIC PROFILES; METABOLOMICS; MULTIVARIATE ANALYSIS TECHNIQUES;

EID: 84896896691     PISSN: 0278940X     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevBiomedEng.2013007736     Document Type: Article
Times cited : (119)

References (103)
  • 1
    • 33750719994 scopus 로고    scopus 로고
    • Global systems biology, personalized medicine and molecular epidemiology
    • Nicholson JK. Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol. 2006;2:52.
    • (2006) Mol Syst Biol. , vol.2 , pp. 52
    • Nicholson, J.K.1
  • 2
    • 50249099816 scopus 로고    scopus 로고
    • Metabolic phenotyping in health and disease
    • Holmes E, Wilson ID, Nicholson JK. Metabolic phenotyping in health and disease. Cell. 2008;134(5):714-7.
    • (2008) Cell. , vol.134 , Issue.5 , pp. 714-717
    • Holmes, E.1    Wilson, I.D.2    Nicholson, J.K.3
  • 5
    • 0043069547 scopus 로고    scopus 로고
    • Opinion: Understanding "global" systems biology: Metabonomics and the continuum of metabolism
    • Nicholson JK, Wilson ID. Opinion: understanding "global" systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov. 2003;2(8):668-76.
    • (2003) Nat Rev Drug Discov. , vol.2 , Issue.8 , pp. 668-676
    • Nicholson, J.K.1    Wilson, I.D.2
  • 7
    • 54549091125 scopus 로고    scopus 로고
    • Systems biology: Metabonomics
    • Nicholson JK, Lindon JC. Systems biology: metabonomics. Nature. 2008;455(7216):1054-6.
    • (2008) Nature. , vol.455 , Issue.7216 , pp. 1054-1056
    • Nicholson, J.K.1    Lindon, J.C.2
  • 12
    • 0032694577 scopus 로고    scopus 로고
    • 'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
    • Nicholson JK, Lindon JC, Holmes E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 1999;29(11):1181-9.
    • (1999) Xenobiotica. , vol.29 , Issue.11 , pp. 1181-1189
    • Nicholson, J.K.1    Lindon, J.C.2    Holmes, E.3
  • 13
    • 0037425743 scopus 로고    scopus 로고
    • Gut flora in health and disease
    • Guarner F, Malagelada JR. Gut flora in health and disease. Lancet. 2003;361(9356):512-9.
    • (2003) Lancet. , vol.361 , Issue.9356 , pp. 512-519
    • Guarner, F.1    Malagelada, J.R.2
  • 19
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-31.
    • (2006) Nature. , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 20
    • 19544374744 scopus 로고    scopus 로고
    • A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats
    • Williams RE, Lenz EM, Evans JA, Wilson ID, Granger JH, Plumb RS, Stumpf CL. A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats. J Pharm Biomed Anal. 2005;38(3):465-71.
    • (2005) J Pharm Biomed Anal. , vol.38 , Issue.3 , pp. 465-471
    • Williams, R.E.1    Lenz, E.M.2    Evans, J.A.3    Wilson, I.D.4    Granger, J.H.5    Plumb, R.S.6    Stumpf, C.L.7
  • 21
    • 0032816821 scopus 로고    scopus 로고
    • Gut origin of sepsis: A prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity
    • MacFie J, O'Boyle C, Mitchell CJ, Buckley PM, Johnstone D, Sudworth P. Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity. Gut. 1999;45(2):223-8.
    • (1999) Gut. , vol.45 , Issue.2 , pp. 223-228
    • McFie, J.1    O'Boyle, C.2    Mitchell, C.J.3    Buckley, P.M.4    Johnstone, D.5    Sudworth, P.6
  • 23
    • 17844404232 scopus 로고    scopus 로고
    • Gut microorganisms, mammalian metabolism and personalized health care
    • Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol. 2005;3(5):431-8.
    • (2005) Nat Rev Microbiol. , vol.3 , Issue.5 , pp. 431-438
    • Nicholson, J.K.1    Holmes, E.2    Wilson, I.D.3
  • 24
    • 33746407333 scopus 로고    scopus 로고
    • The emerging science of epigenomics
    • Callinan PA, Feinberg AP. The emerging science of epigenomics. Hum Mol Genet. 2006;15 Spec No 1:R95-101.
    • (2006) Hum Mol Genet. , vol.15 , Issue.SPEC. NO 1
    • Callinan, P.A.1    Feinberg, A.P.2
  • 25
    • 84896900028 scopus 로고    scopus 로고
    • Epigenomics: The new tool in studying complex diseases
    • Bonetta L. Epigenomics: the new tool in studying complex diseases. Nat Educ. 2008;1(1):178.
    • (2008) Nat Educ. , vol.1 , Issue.1 , pp. 178
    • Bonetta, L.1
  • 26
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007;8(4):253-62.
    • (2007) Nat Rev Genet. , vol.8 , Issue.4 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 27
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA. Epigenetics in human disease and prospects for epigenetic therapy. Nature. 2004;429(6990):457-63.
    • (2004) Nature. , vol.429 , Issue.6990 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 28
    • 0036463681 scopus 로고    scopus 로고
    • Metabonomics: A platform for studying drug toxicity and gene function
    • Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov. 2002;1(2):153-61.
    • (2002) Nat Rev Drug Discov. , vol.1 , Issue.2 , pp. 153-161
    • Nicholson, J.K.1    Connelly, J.2    Lindon, J.C.3    Holmes, E.4
  • 29
    • 4644262109 scopus 로고    scopus 로고
    • Metabonomics: Its potential as a tool in toxicology for safety assessment and data integration
    • Griffin JL, Bollard ME. Metabonomics: its potential as a tool in toxicology for safety assessment and data integration. Curr Drug Metab. 2004;5(5):389-98.
    • (2004) Curr Drug Metab. , vol.5 , Issue.5 , pp. 389-398
    • Griffin, J.L.1    Bollard, M.E.2
  • 30
    • 34547190179 scopus 로고    scopus 로고
    • Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies
    • Maher AD, Zirah SF, Holmes E, Nicholson JK. Experimental and analytical variation in human urine in 1H NMR spectroscopy-based metabolic phenotyping studies. Anal Chem. 2007;79(14):5204-11.
    • (2007) Anal Chem. , vol.79 , Issue.14 , pp. 5204-5211
    • Maher, A.D.1    Zirah, S.F.2    Holmes, E.3    Nicholson, J.K.4
  • 32
    • 33947427846 scopus 로고    scopus 로고
    • Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics
    • Lin C, Wu H, Tjeerdema R, Viant M. Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics. 2007;3(1):55-67.
    • (2007) Metabolomics. , vol.3 , Issue.1 , pp. 55-67
    • Lin, C.1    Wu, H.2    Tjeerdema, R.3    Viant, M.4
  • 33
    • 0034368580 scopus 로고    scopus 로고
    • Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids
    • Lindon JC, Nicholson JK, Holmes E, Everett JR. Metabonomics: metabolic processes studied by NMR spectroscopy of biofluids. Concepts Magn Reson. 2000;12(5):289-320.
    • (2000) Concepts Magn Reson. , vol.12 , Issue.5 , pp. 289-320
    • Lindon, J.C.1    Nicholson, J.K.2    Holmes, E.3    Everett, J.R.4
  • 34
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • Beckonert O, Keun HC, Ebbels TM, Bundy J, Holmes E, Lindon JC, Nicholson JK. Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc. 2007;2(11):2692-703.
    • (2007) Nat Protoc. , vol.2 , Issue.11 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.3    Bundy, J.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 37
    • 2942676743 scopus 로고    scopus 로고
    • Metabolomics and systems biology: Making sense of the soup
    • Kell DB. Metabolomics and systems biology: making sense of the soup. Curr Opin Microbiol. 2004;7(3): 296-307.
    • (2004) Curr Opin Microbiol. , vol.7 , Issue.3 , pp. 296-307
    • Kell, D.B.1
  • 38
    • 33847358695 scopus 로고    scopus 로고
    • Analytical strategies in metabonomics
    • Lenz EM, Wilson ID. Analytical strategies in metabonomics. J Proteome Res. 2007;6(2):443-58.
    • (2007) J Proteome Res. , vol.6 , Issue.2 , pp. 443-458
    • Lenz, E.M.1    Wilson, I.D.2
  • 39
    • 0036384102 scopus 로고    scopus 로고
    • NMR-based metabolomics
    • Reo NV. NMR-based metabolomics. Drug Chem Toxicol. 2002;25(4):375-82.
    • (2002) Drug Chem Toxicol. , vol.25 , Issue.4 , pp. 375-382
    • Reo, N.V.1
  • 42
    • 33846233853 scopus 로고    scopus 로고
    • Closed-loop, multiobjective optimization of two-dimensional gas chromatography/ mass spectrometry for serum metabolomics
    • O'Hagan S, Dunn WB, Knowles JD, Broadhurst D, Williams R, Ashworth JJ, Cameron M, Kell DB. Closed-loop, multiobjective optimization of two-dimensional gas chromatography/ mass spectrometry for serum metabolomics. Anal Chem. 2007;79(2):464-76.
    • (2007) Anal Chem. , vol.79 , Issue.2 , pp. 464-476
    • O'Hagan, S.1    Dunn, W.B.2    Knowles, J.D.3    Broadhurst, D.4    Williams, R.5    Ashworth, J.J.6    Cameron, M.7    Kell, D.B.8
  • 43
    • 77955435782 scopus 로고    scopus 로고
    • Integrated ionization approach for RRLCMS/ MS-based metabonomics: Finding potential biomarkers for lung cancer
    • An Z, Chen Y, Zhang R, Song Y, Sun J, He J, Bai J, Dong L, Zhan Q, Abliz Z. Integrated ionization approach for RRLCMS/ MS-based metabonomics: finding potential biomarkers for lung cancer. J Proteome Res. 2010;9(8):4071-81.
    • (2010) J Proteome Res. , vol.9 , Issue.8 , pp. 4071-4081
    • An, Z.1    Chen, Y.2    Zhang, R.3    Song, Y.4    Sun, J.5    He, J.6    Bai, J.7    Dong, L.8    Zhan, Q.9    Abliz, Z.10
  • 44
    • 0242290993 scopus 로고    scopus 로고
    • High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue
    • Rooney OM, Troke J, Nicholson JK, Griffin JL. High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue. Magn Reson Med. 2003;50(5):925-30.
    • (2003) Magn Reson Med. , vol.50 , Issue.5 , pp. 925-930
    • Rooney, O.M.1    Troke, J.2    Nicholson, J.K.3    Griffin, J.L.4
  • 45
    • 0034672533 scopus 로고    scopus 로고
    • The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy
    • Griffin JL, Troke J, Walker LA, Shore RF, Lindon JC, Nicholson JK. The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy. FEBS Lett. 2000;486(3):225-9.
    • (2000) FEBS Lett. , vol.486 , Issue.3 , pp. 225-229
    • Griffin, J.L.1    Troke, J.2    Walker, L.A.3    Shore, R.F.4    Lindon, J.C.5    Nicholson, J.K.6
  • 46
    • 33847372814 scopus 로고    scopus 로고
    • Metabonomics based on NMR spectroscopy
    • Coen M, Kuchel PW. Metabonomics based on NMR spectroscopy. Chem Aust. 2004;71(6):13-17.
    • (2004) Chem Aust. , vol.71 , Issue.6 , pp. 13-17
    • Coen, M.1    Kuchel, P.W.2
  • 47
    • 33646595378 scopus 로고    scopus 로고
    • The Cinderella story of metabolic profiling: Does metabolomics get to go to the functional genomics ball?
    • Griffin JL. The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos Trans R Soc Lond B Biol Sci. 2006;361(1465):147-61.
    • (2006) Philos Trans R Soc Lond B Biol Sci. , vol.361 , Issue.1465 , pp. 147-161
    • Griffin, J.L.1
  • 50
    • 67849106535 scopus 로고    scopus 로고
    • MetaboAnalyst: A web server for metabolomic data analysis and interpretation
    • Xia J, Psychogios N, Young N, Wishart DS. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res. 2009;37(Web Server issue):W652-60.
    • (2009) Nucleic Acids Res. , vol.37 , Issue.WEB SERVER ISSUE
    • Xia, J.1    Psychogios, N.2    Young, N.3    Wishart, D.S.4
  • 51
    • 58149341281 scopus 로고    scopus 로고
    • MetaboMinersemi-automated identification of metabolites from 2D NMR spectra of complex biofluids
    • Xia J, Bjorndahl TC, Tang P, Wishart DS. MetaboMinersemi-automated identification of metabolites from 2D NMR spectra of complex biofluids. BMC Bioinformatics. 2008;9:507.
    • (2008) BMC Bioinformatics. , vol.9 , pp. 507
    • Xia, J.1    Bjorndahl, T.C.2    Tang, P.3    Wishart, D.S.4
  • 54
    • 0036174751 scopus 로고    scopus 로고
    • Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data
    • Azmi J, Griffin JL, Antti H, Shore RF, Johansson E, Nicholson JK, Holmes E. Metabolic trajectory characterisation of xenobiotic-induced hepatotoxic lesions using statistical batch processing of NMR data. Analyst. 2002;127(2):271-6.
    • (2002) Analyst. , vol.127 , Issue.2 , pp. 271-276
    • Azmi, J.1    Griffin, J.L.2    Antti, H.3    Shore, R.F.4    Johansson, E.5    Nicholson, J.K.6    Holmes, E.7
  • 56
    • 12244293657 scopus 로고    scopus 로고
    • Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies
    • Cloarec O, Dumas ME, Trygg J, Craig A, Barton RH, Lindon JC, Nicholson JK, Holmes E. Evaluation of the orthogonal projection on latent structure model limitations caused by chemical shift variability and improved visualization of biomarker changes in 1H NMR spectroscopic metabonomic studies. Anal Chem. 2005;77(2):517-26.
    • (2005) Anal Chem. , vol.77 , Issue.2 , pp. 517-526
    • Cloarec, O.1    Dumas, M.E.2    Trygg, J.3    Craig, A.4    Barton, R.H.5    Lindon, J.C.6    Nicholson, J.K.7    Holmes, E.8
  • 57
    • 34249335649 scopus 로고    scopus 로고
    • OPLS discriminant analysis: Combining the strengths of PLS-DA and SIMCA classification
    • Bylesjo M, Rantalainen M, Cloarec O, Nicholson JK, Holmes E, Trygg J. OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification. J Chemom. 2006;20(8-10):341-51.
    • (2006) J Chemom. , vol.20 , Issue.8-10 , pp. 341-351
    • Bylesjo, M.1    Rantalainen, M.2    Cloarec, O.3    Nicholson, J.K.4    Holmes, E.5    Trygg, J.6
  • 58
    • 71549122282 scopus 로고    scopus 로고
    • Systemic metabolic changes of traumatic critically ill patients revealed by an NMR-based metabonomic approach
    • Mao H, Wang H, Wang B, Liu X, Gao H, Xu M, Zhao H, Deng X, Lin D. Systemic metabolic changes of traumatic critically ill patients revealed by an NMR-based metabonomic approach. J Proteome Res. 2009;8(12):5423-30.
    • (2009) J Proteome Res. , vol.8 , Issue.12 , pp. 5423-5430
    • Mao, H.1    Wang, H.2    Wang, B.3    Liu, X.4    Gao, H.5    Xu, M.6    Zhao, H.7    Deng, X.8    Lin, D.9
  • 59
    • 0037163864 scopus 로고    scopus 로고
    • Physiological variation in metabolic phenotyping and functional genomic studies: Use of orthogonal signal correction and PLSDA
    • Gavaghan CL, Wilson ID, Nicholson JK. Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLSDA. FEBS Lett. 2002;530(1-3):191-6.
    • (2002) FEBS Lett. , vol.530 , Issue.1-3 , pp. 191-196
    • Gavaghan, C.L.1    Wilson, I.D.2    Nicholson, J.K.3
  • 61
    • 0027052705 scopus 로고
    • Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine
    • Holmes E, Bonner FW, Sweatman BC, Lindon JC, Beddell CR, Rahr E, Nicholson JK. Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine. Mol Pharmacol. 1992;42(5):922-30.
    • (1992) Mol Pharmacol. , vol.42 , Issue.5 , pp. 922-930
    • Holmes, E.1    Bonner, F.W.2    Sweatman, B.C.3    Lindon, J.C.4    Beddell, C.R.5    Rahr, E.6    Nicholson, J.K.7
  • 64
    • 34447270785 scopus 로고    scopus 로고
    • A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways
    • Li Z, Srivastava S, Mittal S, Yang X, Sheng L, Chan C. A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways. BMC Bioinformatics. 2007;8:202.
    • (2007) BMC Bioinformatics. , vol.8 , pp. 202
    • Li, Z.1    Srivastava, S.2    Mittal, S.3    Yang, X.4    Sheng, L.5    Chan, C.6
  • 66
    • 77954256613 scopus 로고    scopus 로고
    • MSEA: A web-based tool to identify biologically meaningful patterns in quantitative metabolomic data
    • Xia J, Wishart DS. MSEA: a web-based tool to identify biologically meaningful patterns in quantitative metabolomic data. Nucleic Acids Res. 2010;38(Suppl):W71-7.
    • (2010) Nucleic Acids Res. , vol.38 , Issue.SUPPL.
    • Xia, J.1    Wishart, D.S.2
  • 67
    • 48449106046 scopus 로고    scopus 로고
    • MassTRIX: Mass translator into pathways
    • Suhre K, Schmitt-Kopplin P. MassTRIX: mass translator into pathways. Nucleic Acids Res. 2008;36(Web Server issue):W481-4.
    • (2008) Nucleic Acids Res. , vol.36 , Issue.WEB SERVER ISSUE
    • Suhre, K.1    Schmitt-Kopplin, P.2
  • 69
    • 33749861562 scopus 로고    scopus 로고
    • HiResa tool for comprehensive assessment and interpretation of metabolomic data
    • Zhao Q, Stoyanova R, Du S, Sajda P, Brown TR. HiResa tool for comprehensive assessment and interpretation of metabolomic data. Bioinformatics. 2006;22(20):2562-4.
    • (2006) Bioinformatics. , vol.22 , Issue.20 , pp. 2562-2564
    • Zhao, Q.1    Stoyanova, R.2    Du, S.3    Sajda, P.4    Brown, T.R.5
  • 70
    • 62149124281 scopus 로고    scopus 로고
    • TICL-a web tool for network-based interpretation of compound lists inferred by high-throughput metabolomics
    • Antonov AV, Dietmann S, Wong P, Mewes HW. TICL-a web tool for network-based interpretation of compound lists inferred by high-throughput metabolomics. FEBS J. 2009;276(7):2084-94.
    • (2009) FEBS J. , vol.276 , Issue.7 , pp. 2084-2094
    • Antonov, A.V.1    Dietmann, S.2    Wong, P.3    Mewes, H.W.4
  • 71
    • 26944489574 scopus 로고    scopus 로고
    • The Consortium for Metabonomic Toxicology (COMET): Aims, activities and achievements
    • Lindon J, Keun H, Ebbels T, Pearce J, Holmes E, Nicholson J. The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics. 2005;6(7):691-9.
    • (2005) Pharmacogenomics. , vol.6 , Issue.7 , pp. 691-699
    • Lindon, J.1    Keun, H.2    Ebbels, T.3    Pearce, J.4    Holmes, E.5    Nicholson, J.6
  • 73
    • 0002301232 scopus 로고    scopus 로고
    • Metabonomic applications in toxicity screening and disease diagnosis
    • Shockcor JP, Holmes E. Metabonomic applications in toxicity screening and disease diagnosis. Curr Top Med Chem. 2002;2(1):35-51.
    • (2002) Curr Top Med Chem. , vol.2 , Issue.1 , pp. 35-51
    • Shockcor, J.P.1    Holmes, E.2
  • 74
    • 67249106875 scopus 로고    scopus 로고
    • Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: Investigation of borate preservation
    • Smith LM, Maher AD, Want EJ, Elliott P, Stamler J, Hawkes GE, Holmes E, Lindon JC, Nicholson JK. Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation. Anal Chem. 2009;81(12):4847-56.
    • (2009) Anal Chem. , vol.81 , Issue.12 , pp. 4847-4856
    • Smith, L.M.1    Maher, A.D.2    Want, E.J.3    Elliott, P.4    Stamler, J.5    Hawkes, G.E.6    Holmes, E.7    Lindon, J.C.8    Nicholson, J.K.9
  • 75
    • 0035881952 scopus 로고    scopus 로고
    • Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition
    • Bollard ME, Holmes E, Lindon JC, Mitchell SC, Branstetter D, Zhang W, Nicholson JK. Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition. Anal Biochem. 2001;295(2):194-202.
    • (2001) Anal Biochem. , vol.295 , Issue.2 , pp. 194-202
    • Bollard, M.E.1    Holmes, E.2    Lindon, J.C.3    Mitchell, S.C.4    Branstetter, D.5    Zhang, W.6    Nicholson, J.K.7
  • 77
    • 41949142066 scopus 로고    scopus 로고
    • Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics
    • Psihogios NG, Gazi IF, Elisaf MS, Seferiadis KI, Bairaktari ET. Gender-related and age-related urinalysis of healthy subjects by NMR-based metabonomics. NMR Biomed. 2008;21(3):195-207.
    • (2008) NMR Biomed. , vol.21 , Issue.3 , pp. 195-207
    • Psihogios, N.G.1    Gazi, I.F.2    Elisaf, M.S.3    Seferiadis, K.I.4    Bairaktari, E.T.5
  • 79
    • 32344438563 scopus 로고    scopus 로고
    • Metabolic phenotyping of nude and normal (Alpk: ApfCD, C57BL10J) mice
    • Gavaghan McKee CL, Wilson ID, Nicholson JK. Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice. J Proteome Res. 2006;5(2):378-84.
    • (2006) J Proteome Res. , vol.5 , Issue.2 , pp. 378-384
    • Gavaghan McKee, C.L.1    Wilson, I.D.2    Nicholson, J.K.3
  • 82
    • 0028083271 scopus 로고
    • Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine
    • Anthony ML, Sweatman BC, Beddell CR, Lindon JC, Nicholson JK. Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine. Mol Pharmacol. 1994;46(1):199-211.
    • (1994) Mol Pharmacol. , vol.46 , Issue.1 , pp. 199-211
    • Anthony, M.L.1    Sweatman, B.C.2    Beddell, C.R.3    Lindon, J.C.4    Nicholson, J.K.5
  • 83
    • 0024580448 scopus 로고
    • Investigations into the biochemical effects of region-specific nephrotoxins
    • Gartland KP, Bonner FW, Nicholson JK. Investigations into the biochemical effects of region-specific nephrotoxins. Mol Pharmacol. 1989;35(2):242-50.
    • (1989) Mol Pharmacol. , vol.35 , Issue.2 , pp. 242-250
    • Gartland, K.P.1    Bonner, F.W.2    Nicholson, J.K.3
  • 86
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
    • Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keun HC. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res. 2009;8(1):352-61.
    • (2009) J Proteome Res. , vol.8 , Issue.1 , pp. 352-361
    • Chan, E.C.1    Koh, P.K.2    Mal, M.3    Cheah, P.Y.4    Eu, K.W.5    Backshall, A.6    Cavill, R.7    Nicholson, J.K.8    Keun, H.C.9
  • 87
    • 33846940552 scopus 로고    scopus 로고
    • Diagnosis of breast cancer using HPLC metabonomics fingerprints coupled with computational methods
    • Fan X, Bai J, Shen P. Diagnosis of breast cancer using HPLC metabonomics fingerprints coupled with computational methods. Conf Proc IEEE Eng Med Biol Soc. 2005;6:6081-4.
    • (2005) Conf Proc IEEE Eng Med Biol Soc. , vol.6 , pp. 6081-6084
    • Fan, X.1    Bai, J.2    Shen, P.3
  • 90
    • 77954715427 scopus 로고    scopus 로고
    • Metabolomic approach for determination of urinary nucleosides as potential tumor markers using electromigration techniques
    • Markuszewski MJ, Struck W, Waszczuk-Jankowska M, Kaliszan R. Metabolomic approach for determination of urinary nucleosides as potential tumor markers using electromigration techniques. Electrophoresis. 2010;31(14):2300-10.
    • (2010) Electrophoresis. , vol.31 , Issue.14 , pp. 2300-2310
    • Markuszewski, M.J.1    Struck, W.2    Waszczuk-Jankowska, M.3    Kaliszan, R.4
  • 93
    • 0036084536 scopus 로고    scopus 로고
    • Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shock
    • discussion 85
    • Guo W, Magnotti LJ, Ding J, Huang Q, Xu D, Deitch EA. Influence of gut microflora on mesenteric lymph cytokine production in rats with hemorrhagic shock. J Trauma. 2002;52(6):1178-85; discussion 85.
    • (2002) J Trauma. , vol.52 , Issue.6 , pp. 1178-1185
    • Guo, W.1    Magnotti, L.J.2    Ding, J.3    Huang, Q.4    Xu, D.5    Deitch, E.A.6
  • 94
    • 77954197778 scopus 로고    scopus 로고
    • Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
    • Yizhak K, Benyamini T, Liebermeister W, Ruppin E, Shlomi T. Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model. Bioinformatics. 2010;26(12):i255-60.
    • (2010) Bioinformatics. , vol.26 , Issue.12
    • Yizhak, K.1    Benyamini, T.2    Liebermeister, W.3    Ruppin, E.4    Shlomi, T.5
  • 96
    • 33646475134 scopus 로고    scopus 로고
    • Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics
    • Kochhar S, Jacobs DM, Ramadan Z, Berruex F, Fuerholz A, Fay LB. Probing gender-specific metabolism differences in humans by nuclear magnetic resonance-based metabonomics. Anal Biochem. 2006;352(2):274-81.
    • (2006) Anal Biochem. , vol.352 , Issue.2 , pp. 274-281
    • Kochhar, S.1    Jacobs, D.M.2    Ramadan, Z.3    Berruex, F.4    Fuerholz, A.5    Fay, L.B.6
  • 98
    • 19144371287 scopus 로고    scopus 로고
    • NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    • Bollard ME, Stanley EG, Lindon JC, Nicholson JK, Holmes E. NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed. 2005;18(3):143-62.
    • (2005) NMR Biomed. , vol.18 , Issue.3 , pp. 143-162
    • Bollard, M.E.1    Stanley, E.G.2    Lindon, J.C.3    Nicholson, J.K.4    Holmes, E.5
  • 99
    • 34548625266 scopus 로고    scopus 로고
    • Investigation of analytical variation in metabonomic analysis using liquid chromatography/mass spectrometry
    • Sangster TP, Wingate JE, Burton L, Teichert F, Wilson ID. Investigation of analytical variation in metabonomic analysis using liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(18):2965-70.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , Issue.18 , pp. 2965-2970
    • Sangster, T.P.1    Wingate, J.E.2    Burton, L.3    Teichert, F.4    Wilson, I.D.5
  • 100
    • 33745758232 scopus 로고    scopus 로고
    • Application of mass spectrometry for metabolite identification
    • Ma S, Chowdhury SK, Alton KB. Application of mass spectrometry for metabolite identification. Curr Drug Metab. 2006;7(5):503-23.
    • (2006) Curr Drug Metab. , vol.7 , Issue.5 , pp. 503-523
    • Ma, S.1    Chowdhury, S.K.2    Alton, K.B.3
  • 101
    • 0032413197 scopus 로고    scopus 로고
    • A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry
    • Dear GJ, Ayrton J, Plumb R, Sweatman BC, Ismail IM, Fraser IJ, Mutch PJ. A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry. Rapid Commun Mass Spectrom. 1998;12(24):2023-30.
    • (1998) Rapid Commun Mass Spectrom. , vol.12 , Issue.24 , pp. 2023-2030
    • Dear, G.J.1    Ayrton, J.2    Plumb, R.3    Sweatman, B.C.4    Ismail, I.M.5    Fraser, I.J.6    Mutch, P.J.7
  • 103
    • 70349459265 scopus 로고    scopus 로고
    • Review: Microfluidic applications in metabolomics and metabolic profiling
    • Kraly JR, Holcomb RE, Guan Q, Henry CS. Review: microfluidic applications in metabolomics and metabolic profiling. Anal Chim Acta. 2009;653(1):23-35.
    • (2009) Anal Chim Acta. , vol.653 , Issue.1 , pp. 23-35
    • Kraly, J.R.1    Holcomb, R.E.2    Guan, Q.3    Henry, C.S.4


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