Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: Investigation of borate preservation

Analytical Chemistry

Volumn 81, Issue 12, 2009, Pages 4847-4856

  Smith, Leon M ^a   Maher, Anthony D ^a,d   Want, Elizabeth J ^a   Elliott, Paul ^a   Stamler, Jeremiah ^b   Hawkes, Geoffrey E ^c   Holmes, Elaine ^a   Lindon, John C ^a   Nicholson, Jeremy K ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NORTHWESTERN UNIVERSITY   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL VARIATION; BORATE CHEMISTRY; BORATE COMPLEXATION; CARBOXYLATE GROUPS; CHEMICAL EXCHANGE; CLASSIFICATION FEATURES; COMPLEX FORMATIONS; EPIDEMIOLOGICAL STUDIES; H NMR SPECTRA; H NMR SPECTROSCOPY; HUMAN URINE; METABOLIC MAPPING; METABOLIC PROFILING; MULTICOMPONENT; NEW TOOLS; NMR-SPECTROSCOPY; PHENOTYPING; PROTON RELAXATION; RELAXATION RATES; SOLUTION VISCOSITY; TIME POINTS; URINARY METABOLITES; URINE SAMPLE;

BIOMOLECULES; BODY FLUIDS; CARBOXYLATION; METABOLISM; METABOLITES; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTONS;

COMPLEXATION;

2 HYDROXY 2 METHYLPROPIONIC ACID; BIOLOGICAL MARKER; BORIC ACID; CITRIC ACID; ISOBUTYRIC ACID; MANNITOL; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; METABOLITE; MOLECULAR EPIDEMIOLOGY; PHENOTYPE; PRESERVATION; PROTON NUCLEAR MAGNETIC RESONANCE; URINALYSIS;

BORATES; EPIDEMIOLOGY, MOLECULAR; HUMANS; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENOTYPE; PRESERVATION, BIOLOGICAL; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; URINALYSIS;

EID: 67249106875     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac9004875     Document Type: Article

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