-
1
-
-
33746750046
-
Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut microflora involved in the development of type 1 diabetes
-
Brugman S, Klatter FA, Visser JTJ, Wildeboer-Veloo ACM, Harmsen HJM, Rozing J, Bos NA (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut microflora involved in the development of type 1 diabetes. Diabetologia 49: 2105-2108
-
(2006)
Diabetologia
, vol.49
, pp. 2105-2108
-
-
Brugman, S.1
Klatter, F.A.2
Visser, J.T.J.3
Wildeboer-Veloo, A.C.M.4
Harmsen, H.J.M.5
Rozing, J.6
Bos, N.A.7
-
2
-
-
0037370384
-
The application of molecular genetic approaches to the study of human evolution
-
Cavalli-Sforza LL, Feldman MW (2003) The application of molecular genetic approaches to the study of human evolution. Nat Genet 33: 266-275
-
(2003)
Nat Genet
, vol.33
, pp. 266-275
-
-
Cavalli-Sforza, L.L.1
Feldman, M.W.2
-
3
-
-
33646198860
-
Pharmaco-metabonomic phenotyping and personalised drug treatment
-
Clayton TA, Lindon JC, Antti H, Charuel C, Hanton G, Provost JP, Le Net JL, Baker D, Walley RJ, Everett JE, Nicholson JK (2006) Pharmaco-metabonomic phenotyping and personalised drug treatment. Nature 440: 1073-1077
-
(2006)
Nature
, vol.440
, pp. 1073-1077
-
-
Clayton, T.A.1
Lindon, J.C.2
Antti, H.3
Charuel, C.4
Hanton, G.5
Provost, J.P.6
Le Net, J.L.7
Baker, D.8
Walley, R.J.9
Everett, J.E.10
Nicholson, J.K.11
-
4
-
-
33747618036
-
Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin resistant mice
-
Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell S, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK (2006a) Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin resistant mice. Proc Natl Acad Sci USA 103: 12511-12516
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 12511-12516
-
-
Dumas, M.E.1
Barton, R.H.2
Toye, A.3
Cloarec, O.4
Blancher, C.5
Rothwell, A.6
Fearnside, J.7
Tatoud, R.8
Blanc, V.9
Lindon, J.C.10
Mitchell, S.11
Holmes, E.12
McCarthy, M.I.13
Scott, J.14
Gauguier, D.15
Nicholson, J.K.16
-
5
-
-
33645671556
-
Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics in large scale epidemiological studies
-
Dumas ME, Maibaum EC, Teague C, Ueshima H, Zhou BF, Lindon JC, Nicholson JK, Stamler J, Elliott P, Chan Q, Holmes E (2006b) Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics in large scale epidemiological studies. Anal Chem 78: 2199-2208
-
(2006)
Anal Chem
, vol.78
, pp. 2199-2208
-
-
Dumas, M.E.1
Maibaum, E.C.2
Teague, C.3
Ueshima, H.4
Zhou, B.F.5
Lindon, J.C.6
Nicholson, J.K.7
Stamler, J.8
Elliott, P.9
Chan, Q.10
Holmes, E.11
-
6
-
-
0035102719
-
CYP3A (2001) genetics in drug metabolism
-
Eichelbaum M, Burk O (2001) CYP3A (2001) genetics in drug metabolism. Nat Med 7: 285-288
-
(2001)
Nat Med
, vol.7
, pp. 285-288
-
-
Eichelbaum, M.1
Burk, O.2
-
7
-
-
0034634448
-
An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk:ApfCD mouse
-
Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK (2000) An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse. FEBS Lett 484: 169-174
-
(2000)
FEBS Lett
, vol.484
, pp. 169-174
-
-
Gavaghan, C.L.1
Holmes, E.2
Lenz, E.3
Wilson, I.D.4
Nicholson, J.K.5
-
8
-
-
32344438563
-
Molecular phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice via metabonomics
-
Gavaghan-McKee CL, Wilson ID, Nicholson JK (2006) Molecular phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice via metabonomics. J Proteome Res 5: 378-384
-
(2006)
J Proteome Res
, vol.5
, pp. 378-384
-
-
Gavaghan-McKee, C.L.1
Wilson, I.D.2
Nicholson, J.K.3
-
9
-
-
24044545237
-
Gut microbiota strongly influences experimental rodent phenotypes
-
Holmes E, Nicholson JK (2005) Gut microbiota strongly influences experimental rodent phenotypes. Toxicol Lett 87: 1-2
-
(2005)
Toxicol Lett
, vol.87
, pp. 1-2
-
-
Holmes, E.1
Nicholson, J.K.2
-
10
-
-
0034646538
-
Infectious history
-
Lederberg J (2000) Infectious history. Science 288: 287-293
-
(2000)
Science
, vol.288
, pp. 287-293
-
-
Lederberg, J.1
-
11
-
-
33748324506
-
Transgenomic metabolic interactions in a mouse disease model: Interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation
-
Martin FPJ, Verdu EF, Wang Y, Dumas ME, Yap IKS, Cloarec O, Bergonzelli GE, Corthesy-Theulaz I, Kochhar S, Holmes E, Lindon JC, Collins SM, Nicholson JK (2006) Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. J Proteome Res 5: 2185-2193
-
(2006)
J Proteome Res
, vol.5
, pp. 2185-2193
-
-
Martin, F.P.J.1
Verdu, E.F.2
Wang, Y.3
Dumas, M.E.4
Yap, I.K.S.5
Cloarec, O.6
Bergonzelli, G.E.7
Corthesy-Theulaz, I.8
Kochhar, S.9
Holmes, E.10
Lindon, J.C.11
Collins, S.M.12
Nicholson, J.K.13
-
12
-
-
0030995879
-
Molecular mechanisms of genetic polymorphisms of drug metabolism
-
Meyer UA, Zanger UM (1997) Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 37: 269-296
-
(1997)
Annu Rev Pharmacol Toxicol
, vol.37
, pp. 269-296
-
-
Meyer, U.A.1
Zanger, U.M.2
-
13
-
-
0035752835
-
Pharmacogenomics, ethnicity and susceptibility genes
-
Nebert DW, Menon AG (2001) Pharmacogenomics, ethnicity and susceptibility genes. Pharmacogenomics J 1: 541-549
-
(2001)
Pharmacogenomics J
, vol.1
, pp. 541-549
-
-
Nebert, D.W.1
Menon, A.G.2
-
14
-
-
0347185032
-
Pharmacogenomics and 'Individualized Drug Therapy'. High expectations and disappointing results
-
Nebert DW, Nebert J, Vessell ES (2003) Pharmacogenomics and 'Individualized Drug Therapy'. High expectations and disappointing results. Am J Pharmacogenomics 3: 361-370
-
(2003)
Am J Pharmacogenomics
, vol.3
, pp. 361-370
-
-
Nebert, D.W.1
Nebert, J.2
Vessell, E.S.3
-
15
-
-
0028820801
-
Role of cytochrome P4501A in chemical carcinogenesis: Implications for human variability in expression and enzyme activity
-
Nebert DW, Vessell ES (2004) Role of cytochrome P4501A in chemical carcinogenesis: implications for human variability in expression and enzyme activity. Pharmacogenetics 5: 259-274
-
(2004)
Pharmacogenetics
, vol.5
, pp. 259-274
-
-
Nebert, D.W.1
Vessell, E.S.2
-
18
-
-
17844404232
-
Gut microbes, mammalian metabolism and personalized healthcare
-
Nicholson JK, Holmes E, Wilson ID (2005) Gut microbes, mammalian metabolism and personalized healthcare. Nat Rev Microbiol 3: 2-8
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 2-8
-
-
Nicholson, J.K.1
Holmes, E.2
Wilson, I.D.3
-
19
-
-
0032694577
-
'Metabonomics': Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data
-
Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR data. Xenobiotica 29: 1181-1189
-
(1999)
Xenobiotica
, vol.29
, pp. 1181-1189
-
-
Nicholson, J.K.1
Lindon, J.C.2
Holmes, E.3
-
20
-
-
0024946615
-
High resolution proton NMR spectroscopy of biological fluids
-
Nicholson JK, Wilson ID (1989) High resolution proton NMR spectroscopy of biological fluids. Prog NMR Spectrosc 21: 449-501
-
(1989)
Prog NMR Spectrosc
, vol.21
, pp. 449-501
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
21
-
-
0043069547
-
Understanding 'global' systems biology: Metabonomics and the continuum of metabolism
-
Nicholson JK, Wilson ID (2003) Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2: 668-676
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 668-676
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
22
-
-
33745777632
-
UPLC-MSE:a new approach for generating molecular fragment information for biomarker structure elucidation
-
Plumb RS, Johnson KA, Rainville P, Smith BW, Wilson ID, Castro-Perez JM, Nicholson JK (2006) UPLC-MSE:a new approach for generating molecular fragment information for biomarker structure elucidation. Rapid Commun Mass Spectrom 20: 1989-1994
-
(2006)
Rapid Commun Mass Spectrom
, vol.20
, pp. 1989-1994
-
-
Plumb, R.S.1
Johnson, K.A.2
Rainville, P.3
Smith, B.W.4
Wilson, I.D.5
Castro-Perez, J.M.6
Nicholson, J.K.7
-
23
-
-
0035160371
-
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
-
Raamsdonk LM, Teusink B, Broadhurst D, Zhang N, Hayes A, Walsh MC, Berden JA, Brindle KM, Kell DB, Rowland JJ, Westerhoff HV, van Dam K, Oliver SG (2001) A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations. Nat Biotechnol 19: 45-50
-
(2001)
Nat Biotechnol
, vol.19
, pp. 45-50
-
-
Raamsdonk, L.M.1
Teusink, B.2
Broadhurst, D.3
Zhang, N.4
Hayes, A.5
Walsh, M.C.6
Berden, J.A.7
Brindle, K.M.8
Kell, D.B.9
Rowland, J.J.10
Westerhoff, H.V.11
Van Dam, K.12
Oliver, S.G.13
-
24
-
-
33750093232
-
Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice
-
(in press)
-
Rantalainen M, Cloarec O, Trygg J, Beckonert O, Wilson ID, Jackson D, Rowlinson R, Jones S, Rayner S, Nickson J, Tonge R, Wilkinson R, Mills JD, Nicholson JK, Holmes E (2006) Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice. J Proteome Res (in press)
-
(2006)
J Proteome Res
-
-
Rantalainen, M.1
Cloarec, O.2
Trygg, J.3
Beckonert, O.4
Wilson, I.D.5
Jackson, D.6
Rowlinson, R.7
Jones, S.8
Rayner, S.9
Nickson, J.10
Tonge, R.11
Wilkinson, R.12
Mills, J.D.13
Nicholson, J.K.14
Holmes, E.15
-
25
-
-
0037306343
-
Drug metabolism and individualized medicine
-
Srivastava P (2003) Drug metabolism and individualized medicine. Curr Drug Metab 4: 33-44
-
(2003)
Curr Drug Metab
, vol.4
, pp. 33-44
-
-
Srivastava, P.1
-
26
-
-
1542407093
-
1H NMR spectroscopy as a result of metabonomic screening of humans
-
1H NMR spectroscopy as a result of metabonomic screening of humans. Analyst 129: 259-264
-
(2004)
Analyst
, vol.129
, pp. 259-264
-
-
Teague, C.1
Holmes, E.2
Meibaum, E.3
Nicholson, J.K.4
Tang, H.5
Chan, Q.6
Elliot, P.7
Wilson, I.D.8
-
27
-
-
4344670208
-
Metabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identification
-
Wang Y, Holmes E, Nicholson JK, Cloarec O, Chollet J, Tanner M, Singer B H, Utzinger J (2004) Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification. Proc Natl Acad Sci USA 101: 12676-12681
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12676-12681
-
-
Wang, Y.1
Holmes, E.2
Nicholson, J.K.3
Cloarec, O.4
Chollet, J.5
Tanner, M.6
Singer, B.H.7
Utzinger, J.8
-
28
-
-
17444404226
-
High resolution 'ultra performance' liquid chromatography coupled to/oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
-
Wilson ID, Nicholson JK, Castro-Perez J, Grainger JH, Johnson KA, Smith BW, Plumb RS (2005) High resolution 'ultra performance' liquid chromatography coupled to/oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4: 591-598
-
(2005)
J Proteome Res
, vol.4
, pp. 591-598
-
-
Wilson, I.D.1
Nicholson, J.K.2
Castro-Perez, J.3
Grainger, J.H.4
Johnson, K.A.5
Smith, B.W.6
Plumb, R.S.7
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