Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype

International Journal of Obesity

Volumn 34, Issue 6, 2010, Pages 1095-1098

  Calvani, R ^a   Miccheli, A ^b   Capuani, G ^b   Tomassini Miccheli, A ^b   Puccetti, C ^b   Delfini, M ^b   Iaconelli, A ^a   Nanni, G ^c   Mingrone, G ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Bariatric surgery; Metabolic profiling; NMR based metabolomics

Indexed keywords

3 HYDROXY 2 METHYLPROPIONIC ACID; HIPPURIC ACID; TRIGONELLINE; XANTHINE;

ARTICLE; BILIOPANCREATIC BYPASS; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISCRIMINANT ANALYSIS; FROZEN SECTION; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INTESTINE; MALE; METABOLITE; METABOLOMICS; MICROBIOME; MORBID OBESITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PHENOTYPE; PILOT STUDY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STOMACH BYPASS; URINALYSIS;

BARIATRIC SURGERY; BLOOD GLUCOSE; BODY MASS INDEX; CASE-CONTROL STUDIES; HUMANS; INSULIN RESISTANCE; INTESTINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; METABOLOMICS; METAGENOME; OBESITY; PILOT PROJECTS;

EID: 77953611756     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.44     Document Type: Article

References (28)

1. McPherson K, Marsh T, Brown M. Modelling Future Trends in Obesity and the Impact on Health. Foresight Tackling Obesities: Future Choices. 2007, (http://www.foresight.gov.uk).
2. Cani PD, Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 2009; 15: 1546-1558.
3. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006; 444: 1027-1031.
4. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 2004; 101: 15718-15723.
5. Goodacre R. Metabolomics of a superorganism. J Nutr 2007; 137: 259S-266S.
6. Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H et al. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA 2008; 105: 2117-2122.
7. Nicholson JK. Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol 2006; 2: 52.
8. Nicholson JK, Wilson ID. Understanding 'global' systems biology: metabonomics and the continuum of metabolism. Nat Rev Drug Discov 2003; 2: 668-676.
9. Bult MJF, van Dalen T, Muller AF. Surgical treatment of obesity. Eur J Endocrinol 2008; 158: 135-145.
10. Schneider BE, Mun EC. Surgical management of morbid obesity. Diabetes Care 2005; 28: 475-480.
11. Engelke UFH, Moolenaar SH, Hoenderop SMGC, Morava E, van der Graaf M, Heerschap A et al. Handbook of 1H-NMR spectro-scopy in inborn errors of metabolism: body fluid NMR spectro-scopy and in vivo MR spectroscopy. Heilbronn: SPS Verlagsgesellschaft, 2006.
12. Miccheli A, Marini F, Capuani G, Miccheli Tomassini A, Delfini M, Di Cocco ME et al. The influence of a sports drink on the post-exercise metabolism of elite athletes as investigated by NMR-based metabolomics. J Am Coll Nutr (in press).
13. Ross A, Schlotterbeck G, Dieterle F, Senn H. NMR spectroscopy techniques for application to metabolomics. In: Lindon JC, Nicholson JK, Holmes E (eds). The Handbook of Metabonomics and Metabolomics. Elsevier BV: Amsterdam, The Netherlands, 2007, pp 55-112.
14. Eriksson L, Johansson E, Kettaneh Wold N, Wold S. Multi and Megavariate Data Analysis. Umetrics AB: Umea?, 2001.
15. Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 2005; 3: 431-438.
16. Waldram A, Holmes E, Wang Y, Rantalainen M, Wilson ID, Tuohy KM et al. Top-down systems biology modeling of host metabo-type-microbiome associations in obese rodents. J Proteome Res 2009; 8: 2361-2375.
17. Salek RM, Maguire ML, Bentley E, Rubtsov DV, Hough T, Cheeseman M et al. A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. Physiol Genomics 2007; 29: 99-108.
18. Williams RE, Lenz EM, Evans JA, Wilson ID, Granger JH, Plumb RS et al. A combined (1)H NMR and HPLC-MS-based metabo-nomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats. J Pharm Biomed Anal 2005; 38: 465-471.
19. Shearer J, Duggan G, Weljie A, Hittel DS, Wasserman DH, Vogel HJ. Metabolomic profiling of dietary-induced insulin resistance in the high fat-fed C57BL/6J mouse. Diabetes Obes Metab 2008; 10: 950-958.
20. Holmes E, Loo RL, Stamler J, Bictash M, Yap IKS, Chan Q et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008; 453: 396-400.
21. Rezzi S, Ramadan Z, Martin FP, Fay LB, van Bladeren P, Lindon JC et al. Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. J Proteome Res 2007; 6: 4469-4477.
22. Sun J, Schnackenberg LK, Holland RD, Schmitt TC, Cantor GH, Dragan YP et al. Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS. J Chromatogr B 2008; 871: 328-340.
23. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE et al. A core gut microbiome in obese and lean twins. Nature 2009; 457: 480-484.
24. Turnbaugh PJ, Gordon JI. The core gut microbiome, energy balance and obesity. J Physiol 2009; 587 (Part 17): 4153-4158.
25. Matsuura F, Yamashita S, Nakamura T, Nishida M, Nozaki S, Funahashi T et al. Effect of visceral fat accumulation on uric acid metabolism in male obese subjects: visceral fat obesity is linked more closely to overproduction of uric acid than subcutaneous fat obesity. Metab Clin Exp 1998; 47: 929-933.
26. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004; 292: 1724-1737.
27. Zhang H, DiBaise JK, Zuccolo A, Kudrna D, Braidotti M, Yu Y et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci USA 2009; 106: 2365-2370.
28. Maggard MA, Shugarman LR, Suttorp M, Maglione M, Sugerman HJ, Livingston EH et al. Meta-analysis: surgical treatment of obesity. Ann Intern Med 2005; 142: 547-559.