메뉴 건너뛰기




Volumn 2, Issue , 2006, Pages

Oscillations and variability in the p53 system

Author keywords

Cancer genetics; Fluorescence microscopy; Quantitative biology; Systems biology

Indexed keywords

FLUORESCENT DYE; PROTEIN MDM2; PROTEIN P53;

EID: 33745451921     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb4100068     Document Type: Article
Times cited : (534)

References (93)
  • 1
    • 0141484562 scopus 로고    scopus 로고
    • Biological networks: The tinkerer as an engineer
    • Alon U (2003) Biological networks: the tinkerer as an engineer. Science 301: 1866-1867
    • (2003) Science , vol.301 , pp. 1866-1867
    • Alon, U.1
  • 3
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421: 499-506
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 5
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 6
    • 0030797355 scopus 로고    scopus 로고
    • Robustness in simple biochemical networks
    • Barkai N, Leibler S (1997) Robustness in simple biochemical networks. Nature 387: 913-917
    • (1997) Nature , vol.387 , pp. 913-917
    • Barkai, N.1    Leibler, S.2
  • 7
    • 0034688220 scopus 로고    scopus 로고
    • Circadian clocks limited by noise
    • Barkai N, Leibler S (2000) Circadian clocks limited by noise. Nature 403: 267-268
    • (2000) Nature , vol.403 , pp. 267-268
    • Barkai, N.1    Leibler, S.2
  • 8
    • 25144450143 scopus 로고    scopus 로고
    • Contributions of low molecule number and chromosomal positioning to stochastic gene expression
    • Becskei A, Kaufmann BB, van Oudenaarden A (2005) Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat Genet 37: 937-944
    • (2005) Nat Genet , vol.37 , pp. 937-944
    • Becskei, A.1    Kaufmann, B.B.2    Van Oudenaarden, A.3
  • 9
    • 0034212551 scopus 로고    scopus 로고
    • Engineering stability in gene networks by autoregulation
    • Becskei A, Serrano L (2000) Engineering stability in gene networks by autoregulation. Nature 405: 590-593
    • (2000) Nature , vol.405 , pp. 590-593
    • Becskei, A.1    Serrano, L.2
  • 10
    • 22744441243 scopus 로고    scopus 로고
    • And the noise played on: Stochastic gene expression and HIV-1 infection
    • Blake WJ, Collins JJ (2005) And the noise played on: stochastic gene expression and HIV-1 infection. Cell 122: 147-149
    • (2005) Cell , vol.122 , pp. 147-149
    • Blake, W.J.1    Collins, J.J.2
  • 12
    • 14644437751 scopus 로고    scopus 로고
    • MDM2 is a central node in the p53 pathway: 12 Years and counting
    • Bond GL, Hu W, Levine AJ (2005) MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets 5: 3-8
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 3-8
    • Bond, G.L.1    Hu, W.2    Levine, A.J.3
  • 13
    • 0037628777 scopus 로고    scopus 로고
    • Low-dose rediation: Thresholds, bystander effects, and adaptive responses
    • Bonner WM (2003) Low-dose rediation: thresholds, bystander effects, and adaptive responses. Proc Natl Acad Sci USA 100: 4973-4975
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4973-4975
    • Bonner, W.M.1
  • 15
    • 0020083107 scopus 로고
    • Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs
    • Brinster RL, Chen HY, Warren R, Sarthy A, Palmiter RD (1982) Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature 296: 39-42
    • (1982) Nature , vol.296 , pp. 39-42
    • Brinster, R.L.1    Chen, H.Y.2    Warren, R.3    Sarthy, A.4    Palmiter, R.D.5
  • 16
    • 27144444111 scopus 로고    scopus 로고
    • ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    • Chen L, Gilkes DM, Pan Y, Lane WS, Chen J (2005) ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J 24: 3411-3422
    • (2005) EMBO J , vol.24 , pp. 3411-3422
    • Chen, L.1    Gilkes, D.M.2    Pan, Y.3    Lane, W.S.4    Chen, J.5
  • 17
    • 25444513462 scopus 로고    scopus 로고
    • Steady states and oscillations in the p53/Mdm2 network
    • Ciliberto A, Novak B, Tyson J (2005) Steady states and oscillations in the p53/Mdm2 network. Cell Cycle 4
    • (2005) Cell Cycle , vol.4
    • Ciliberto, A.1    Novak, B.2    Tyson, J.3
  • 19
    • 0037136555 scopus 로고    scopus 로고
    • Robustness of the BMP morphogen gradient in Drosophila embryonic patterning
    • Eldar A, Dorfman R, Weiss D, Ashe H, Shilo BZ, Barkai N (2002) Robustness of the BMP morphogen gradient in Drosophila embryonic patterning. Nature 419: 304-308
    • (2002) Nature , vol.419 , pp. 304-308
    • Eldar, A.1    Dorfman, R.2    Weiss, D.3    Ashe, H.4    Shilo, B.Z.5    Barkai, N.6
  • 20
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403: 335-338
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 22
    • 22744432208 scopus 로고    scopus 로고
    • Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria
    • Friedman N, Vardi S, Ronen M, Alon U, Stavans J (2005) Precise temporal modulation in the response of the SOS DNA repair network in individual bacteria. PLoS Biol 3: e238
    • (2005) PLoS Biol , vol.3
    • Friedman, N.1    Vardi, S.2    Ronen, M.3    Alon, U.4    Stavans, J.5
  • 23
    • 0034213619 scopus 로고    scopus 로고
    • Neutralizing noise in gene networks
    • Gardner TS, Collins JJ (2000) Neutralizing noise in gene networks. Nature 405: 520-521
    • (2000) Nature , vol.405 , pp. 520-521
    • Gardner, T.S.1    Collins, J.J.2
  • 24
    • 0037079015 scopus 로고    scopus 로고
    • Computational approaches to cellular rhythms
    • Goldbeter A (2002) Computational approaches to cellular rhythms. Nature 420: 238-245
    • (2002) Nature , vol.420 , pp. 238-245
    • Goldbeter, A.1
  • 25
    • 28944434119 scopus 로고    scopus 로고
    • Real-time kinetics of gene activity in individual bacteria
    • Golding I, Paulsson J, Zawilski SM, Cox EC (2005) Real-time kinetics of gene activity in individual bacteria. Cell 123: 1025-1036
    • (2005) Cell , vol.123 , pp. 1025-1036
    • Golding, I.1    Paulsson, J.2    Zawilski, S.M.3    Cox, E.C.4
  • 26
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL, Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 28
    • 0037041888 scopus 로고    scopus 로고
    • Synthetic gene network for entraining and amplifying cellular oscillations
    • Hasty J, Dolnik M, Rottschafer V, Collins JJ (2002) Synthetic gene network for entraining and amplifying cellular oscillations. Phys Rev Lett 88: 148101
    • (2002) Phys Rev Lett , vol.88 , pp. 148101
    • Hasty, J.1    Dolnik, M.2    Rottschafer, V.3    Collins, J.J.4
  • 29
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M (1997) Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 30
    • 0037044575 scopus 로고    scopus 로고
    • The IκB-NF-κB signaling module: Temporal control and selective gene activation
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002) The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 298: 1241-1245
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 32
    • 0040298568 scopus 로고    scopus 로고
    • Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    • Janicke RU, Sprengart ML, Wati MR, Porter AG (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-9360
    • (1998) J Biol Chem , vol.273 , pp. 9357-9360
    • Janicke, R.U.1    Sprengart, M.L.2    Wati, M.R.3    Porter, A.G.4
  • 33
    • 19544379881 scopus 로고    scopus 로고
    • Stochasticity in gene expression: From theories to phenotypes
    • Kaern M, Elston TC, Blake WJ, Collins JJ (2005) Stochasticity in gene expression: from theories to phenotypes. Nat Rev Genet 6: 451-464
    • (2005) Nat Rev Genet , vol.6 , pp. 451-464
    • Kaern, M.1    Elston, T.C.2    Blake, W.J.3    Collins, J.J.4
  • 34
    • 2942612846 scopus 로고    scopus 로고
    • Using a quantitative blueprint to reprogram the dynamics of the flagella gene network
    • Kalir S, Alon U (2004) Using a quantitative blueprint to reprogram the dynamics of the flagella gene network. Cell 117: 713-720
    • (2004) Cell , vol.117 , pp. 713-720
    • Kalir, S.1    Alon, U.2
  • 35
    • 7644238181 scopus 로고    scopus 로고
    • Biological robustness
    • Kitano H (2004) Biological robustness. Nat Rev Genet 5: 826-837
    • (2004) Nat Rev Genet , vol.5 , pp. 826-837
    • Kitano, H.1
  • 36
  • 37
    • 0031802921 scopus 로고    scopus 로고
    • Keeping an old friend under control: Regulation of p53 stability
    • Kubbutat MH, Vousden KH (1998) Keeping an old friend under control: regulation of p53 stability. Mol Med Today 4: 250-256
    • (1998) Mol Med Today , vol.4 , pp. 250-256
    • Kubbutat, M.H.1    Vousden, K.H.2
  • 38
    • 28744455886 scopus 로고    scopus 로고
    • The strength of indecisiveness: Oscillatory behavior for better cell fate determination
    • Lahav G (2004) The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE 2004: pe55
    • (2004) Sci STKE , vol.2004
    • Lahav, G.1
  • 40
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Larkin ND, Jackson SP (1999) Regulation of p53 in response to DNA damage. Oncogene 18: 7644-7655
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Larkin, N.D.1    Jackson, S.P.2
  • 42
    • 0034633702 scopus 로고    scopus 로고
    • Generation of oscillation by the p53-Mdm2 feedback loop: A theoretical and experimental study
    • Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M (2000) Generation of oscillation by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci USA 97: 11250-11255
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11250-11255
    • Lev Bar-Or, R.1    Maya, R.2    Segel, L.A.3    Alon, U.4    Levine, A.J.5    Oren, M.6
  • 45
    • 0142027814 scopus 로고    scopus 로고
    • Structure and function of the feed-forward loop network motif
    • Mangan S, Alon U (2003) Structure and function of the feed-forward loop network motif. Proc Natl Acad Sci USA 100: 11980-11985
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11980-11985
    • Mangan, S.1    Alon, U.2
  • 46
    • 0031029852 scopus 로고    scopus 로고
    • Stochastic mechanisms in gene expression
    • McAdams HH, Arkin A (1997) Stochastic mechanisms in gene expression. Proc Natl Acad Sci USA 94: 814-819
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 814-819
    • McAdams, H.H.1    Arkin, A.2
  • 47
    • 0033083733 scopus 로고    scopus 로고
    • It's a noisy business! Genetic regulation at the nanomolar scale
    • McAdams HH, Arkin A (1999) It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet 15: 65-69
    • (1999) Trends Genet , vol.15 , pp. 65-69
    • McAdams, H.H.1    Arkin, A.2
  • 48
    • 3242883729 scopus 로고    scopus 로고
    • The p53 response to DNA damage
    • Meek DW (2004) The p53 response to DNA damage. DNA Repair (Amst) 3: 1049-1056
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1049-1056
    • Meek, D.W.1
  • 49
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D, Oren M (2003) The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13: 49-58
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 50
    • 0347304512 scopus 로고    scopus 로고
    • Possible oscillatory behavior in p53-Mdm2 interaction computer simulation
    • Mihalas GI, Simon Z, Balea G, Popa E (2000) Possible oscillatory behavior in p53-Mdm2 interaction computer simulation. J Biol Syst 8: 21-29
    • (2000) J Biol Syst , vol.8 , pp. 21-29
    • Mihalas, G.I.1    Simon, Z.2    Balea, G.3    Popa, E.4
  • 51
    • 3042810019 scopus 로고    scopus 로고
    • Resilient circadian oscillator revealed in individual cyanobacteria
    • Mihalcescu I, Hsing W, Leibler S (2004) Resilient circadian oscillator revealed in individual cyanobacteria. Nature 430: 81-85
    • (2004) Nature , vol.430 , pp. 81-85
    • Mihalcescu, I.1    Hsing, W.2    Leibler, S.3
  • 53
    • 0033959744 scopus 로고    scopus 로고
    • MDM2 - Master regulator of the p53 tumor suppressor protein
    • Momand J, Wu HH, Dasgupta G (2000) MDM2 - master regulator of the p53 tumor suppressor protein. Gene 242: 15-29
    • (2000) Gene , vol.242 , pp. 15-29
    • Momand, J.1    Wu, H.H.2    Dasgupta, G.3
  • 54
    • 0043180477 scopus 로고    scopus 로고
    • Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays
    • Monk NA (2003) Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays. Curr Biol 13: 1409-1413
    • (2003) Curr Biol , vol.13 , pp. 1409-1413
    • Monk, N.A.1
  • 56
    • 8844256589 scopus 로고    scopus 로고
    • Circadian gene expression in individual fibroblasts: Cell-autonomous and self-sustained oscillators pass time to daughter cells
    • Nagoshi E, Saini C, Bauer C, Laroche T, Naef F, Schibler U (2004) Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells. Cell 119: 693-705
    • (2004) Cell , vol.119 , pp. 693-705
    • Nagoshi, E.1    Saini, C.2    Bauer, C.3    Laroche, T.4    Naef, F.5    Schibler, U.6
  • 58
    • 0001389945 scopus 로고
    • Enzyme induction as an all-or-none phenomenon
    • Novick A, Weiner M (1957) Enzyme induction as an all-or-none phenomenon. Proc Natl Acad Sci USA 43: 553-566
    • (1957) Proc Natl Acad Sci USA , vol.43 , pp. 553-566
    • Novick, A.1    Weiner, M.2
  • 60
    • 0033009821 scopus 로고    scopus 로고
    • Low-dose-rate radiation attenuates the response of the tumor suppressor TP53
    • Ohnishi T, Wang X, Takahashi A, Ohnishi K, Ejima Y (1999) Low-dose-rate radiation attenuates the response of the tumor suppressor TP53. Radiat Res 151: 368-372
    • (1999) Radiat Res , vol.151 , pp. 368-372
    • Ohnishi, T.1    Wang, X.2    Takahashi, A.3    Ohnishi, K.4    Ejima, Y.5
  • 61
  • 62
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10: 431-442
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 64
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • Paulsson J (2004) Summing up the noise in gene networks. Nature 427: 415-418
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 65
    • 0030800922 scopus 로고    scopus 로고
    • Mdm2: Keeping p53 under control
    • Piette J, Neel H, Marechal V (1997) Mdm2: keeping p53 under control. Oncogene 15: 1001-1010
    • (1997) Oncogene , vol.15 , pp. 1001-1010
    • Piette, J.1    Neel, H.2    Marechal, V.3
  • 66
    • 0345700833 scopus 로고    scopus 로고
    • Building a cell cycle oscillator: Hysteresis and bistability in the activation of Cdc2
    • Pomerening JR, Sontag ED, Ferrell Jr JE (2003) Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol 5: 346-351
    • (2003) Nat Cell Biol , vol.5 , pp. 346-351
    • Pomerening, J.R.1    Sontag, E.D.2    Ferrell Jr., J.E.3
  • 67
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives C (1998) Signaling to p53: breaking the MDM2-p53 circuit. Cell 95: 5-8
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 68
    • 0032931517 scopus 로고    scopus 로고
    • The p53 pathway
    • Prives C, Hall PA (1999) The p53 pathway. J Pathol 187: 112-126
    • (1999) J Pathol , vol.187 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 70
    • 27644538819 scopus 로고    scopus 로고
    • Tracing the sources of cellular variation
    • Ramanathan S, Swain PS (2005) Tracing the sources of cellular variation. Dev Cell 9: 576-578
    • (2005) Dev Cell , vol.9 , pp. 576-578
    • Ramanathan, S.1    Swain, P.S.2
  • 71
    • 2942718723 scopus 로고    scopus 로고
    • Control of stochasticity in eukaryotic gene expression
    • Raser JM, O'Shea EK (2004) Control of stochasticity in eukaryotic gene expression. Science 304: 1811-1814
    • (2004) Science , vol.304 , pp. 1811-1814
    • Raser, J.M.1    O'Shea, E.K.2
  • 72
    • 25444468618 scopus 로고    scopus 로고
    • Noise in gene expression: Origins, consequences, and control
    • Raser JM, O'Shea EK (2005) Noise in gene expression: origins, consequences, and control. Science 309: 2010-2013
    • (2005) Science , vol.309 , pp. 2010-2013
    • Raser, J.M.1    O'Shea, E.K.2
  • 74
    • 0035370483 scopus 로고    scopus 로고
    • Regulation and function of the p53 tumor suppressor protein
    • Ryan KM, Phillips AC, Vousden KH (2001) Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 13: 332-337
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 332-337
    • Ryan, K.M.1    Phillips, A.C.2    Vousden, K.H.3
  • 75
    • 17644427718 scopus 로고    scopus 로고
    • Causal protein-signaling networks derived from multiparameter single-cell data
    • Sachs K, Perez O, Pe'er D, Lauffenburger DA, Nolan GP (2005) Causal protein-signaling networks derived from multiparameter single-cell data. Science 308: 523-529
    • (2005) Science , vol.308 , pp. 523-529
    • Sachs, K.1    Perez, O.2    Pe'er, D.3    Lauffenburger, D.A.4    Nolan, G.P.5
  • 78
    • 0017185026 scopus 로고
    • Non-genetic individuality: Chance in the single cell
    • Spudich JL, Koshland Jr DE (1976) Non-genetic individuality: chance in the single cell. Nature 262: 467-471
    • (1976) Nature , vol.262 , pp. 467-471
    • Spudich, J.L.1    Koshland Jr., D.E.2
  • 79
    • 2342567852 scopus 로고    scopus 로고
    • Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
    • Stommel JM, Wahl GM (2004) Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 23: 1547-1556
    • (2004) EMBO J , vol.23 , pp. 1547-1556
    • Stommel, J.M.1    Wahl, G.M.2
  • 81
    • 0012907951 scopus 로고    scopus 로고
    • Time delay as a key to apoptosis induction in the p53 network
    • Tiana G, Jensen MH, Sneppen K (2002) Time delay as a key to apoptosis induction in the p53 network. Eur Phys J B 29: 135-140
    • (2002) Eur Phys J B , vol.29 , pp. 135-140
    • Tiana, G.1    Jensen, M.H.2    Sneppen, K.3
  • 82
    • 0842332416 scopus 로고    scopus 로고
    • Monitoring p53's pulse
    • Tyson JJ (2004) Monitoring p53's pulse. Nat Genet 36: 113-114
    • (2004) Nat Genet , vol.36 , pp. 113-114
    • Tyson, J.J.1
  • 83
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
    • Tyson JJ, Chen KC, Novak B (2003) Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221-231
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 86
    • 0027246716 scopus 로고
    • Regulation of p53 protein expression in human breast cancer cell lines
    • Vojtesek B, Lane DP (1993) Regulation of p53 protein expression in human breast cancer cell lines. J Cell Sci 105 (Part 3): 607-612
    • (1993) J Cell Sci , vol.105 , Issue.3 PART , pp. 607-612
    • Vojtesek, B.1    Lane, D.P.2
  • 88
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: The cell's response to p53
    • Vousden KH, Lu X (2002) Live or let die: the cell's response to p53. Nat Rev Cancer 2: 594-604
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 89
    • 27244451471 scopus 로고    scopus 로고
    • p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback
    • Wagner J, Ma L, Rice JJ, Hu W, Levine AJ, Stolovitzky GA (2005) p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. IEE Proc Syst Biol 152: 109-118
    • (2005) IEE Proc Syst Biol , vol.152 , pp. 109-118
    • Wagner, J.1    Ma, L.2    Rice, J.J.3    Hu, W.4    Levine, A.J.5    Stolovitzky, G.A.6
  • 90
    • 22744441386 scopus 로고    scopus 로고
    • Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
    • Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV (2005) Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell 122: 169-182
    • (2005) Cell , vol.122 , pp. 169-182
    • Weinberger, L.S.1    Burnett, J.C.2    Toettcher, J.E.3    Arkin, A.P.4    Schaffer, D.V.5
  • 91
    • 21844516029 scopus 로고
    • Smallest chemical-reaction system with Hopf-bifurcation
    • Wilhelm T, Heinrich R (1995) Smallest chemical-reaction system with Hopf-bifurcation. J Math Chem 17: 1-14
    • (1995) J Math Chem , vol.17 , pp. 1-14
    • Wilhelm, T.1    Heinrich, R.2
  • 92
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X, Bayle JH, Olson D, Levine AJ (1993) The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7: 1126-1132
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.