Gene regulation in response to graded hypoxia: The non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway

Journal of Theoretical Biology

Volumn 259, Issue 2, 2009, Pages 304-316

  Dayan, Frédéric ^a,b   Monticelli, Marc ^b   Pouysségur, Jacques ^a   Pécou, Elisabeth ^b  

^a CENTRE DE BIOCHIMIE   (France)

^b UNIVERSITÉ DE NICE SOPHIA ANTIPOLIS   (France)

Author keywords

Gene expression; HIF; Mathematical model; Oxygen sensors; Switch like behavior

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

CANCER; ENZYME ACTIVITY; EQUATION; GENE EXPRESSION; HYPOXIA; INHIBITION; NUMERICAL MODEL; OXYGEN; PROTEIN;

ARTICLE; BIOSENSOR; CONTROLLED STUDY; GENE CONTROL; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; MATHEMATICAL ANALYSIS; MOLECULAR MODEL; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; REGULATORY MECHANISM; SIMULATION; STOICHIOMETRY;

CELL HYPOXIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MODELS, BIOLOGICAL; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 67349241646     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.03.009     Document Type: Article

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