Accumulation of hypoxia-inducible factor-1α is limited by transcription-dependent depletion

Oncogene

Volumn 24, Issue 30, 2005, Pages 4829-4838

  Demidenko, Zoya N ^a   Rapisarda, Anna Maria ^b   Garayoa, Mercedes ^c   Giannakakou, Paraskevi ^d   Melillo, Giovanni ^b   Blagosklonny, Mikhail V ^a,e  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF NAVARRA   (Spain)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ORDWAY RESEARCH INSTITUTE   (United States)

Author keywords

Degradation; HIF 1; Hypoxia; p53; The proteasome

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEASOME; PROTEIN P53; DACTINOMYCIN; DEPSIPEPTIDE; DIOXYGENASE; EGLN3 PROTEIN, HUMAN; FLAVONOID; FLAVOPIRIDOL; FR 901228; HIF1A PROTEIN, HUMAN; IRON; MESSENGER RNA; PIPERIDINE DERIVATIVE; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE; VHL PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

ACETYLATION; ARTICLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; DRUG ACCUMULATION; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; CELL HYPOXIA; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CELL HYPOXIA; CELL LINE, TUMOR; DACTINOMYCIN; DEPSIPEPTIDES; DIOXYGENASES; FLAVONOIDS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; PIPERIDINES; PROCOLLAGEN-PROLINE DIOXYGENASE; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 23044452937     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208636     Document Type: Article

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