메뉴 건너뛰기




Volumn 4, Issue , 2010, Pages

Stress-specific response of the p53-Mdm2 feedback loop

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 77954398160     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-4-94     Document Type: Article
Times cited : (41)

References (47)
  • 1
    • 33646807832 scopus 로고    scopus 로고
    • The P53 pathway: what questions remain to be explored?
    • 10.1038/sj.cdd.4401910, 16557269
    • Levine AJ, Hu W, Feng Z. The P53 pathway: what questions remain to be explored?. Cell Death Differ 2006, 13(6):1027-36. 10.1038/sj.cdd.4401910, 16557269.
    • (2006) Cell Death Differ , vol.13 , Issue.6 , pp. 1027-1036
    • Levine, A.J.1    Hu, W.2    Feng, Z.3
  • 2
    • 67349091738 scopus 로고    scopus 로고
    • The ups and downs of p53: understanding protein dynamics in single cells
    • 10.1038/nrc2604, 2892289, 19360021
    • Batchelor E, Loewer A, Lahav G. The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer 2009, 9:371-377. 10.1038/nrc2604, 2892289, 19360021.
    • (2009) Nat Rev Cancer , vol.9 , pp. 371-377
    • Batchelor, E.1    Loewer, A.2    Lahav, G.3
  • 3
    • 0030941458 scopus 로고    scopus 로고
    • P53, the Cellular Gatekeeper for Growth and Division
    • 10.1016/S0092-8674(00)81871-1, 9039259
    • Levine AJ. p53, the Cellular Gatekeeper for Growth and Division. Cell 1997, 88:323-331. 10.1016/S0092-8674(00)81871-1, 9039259.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 4
    • 0035140981 scopus 로고    scopus 로고
    • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
    • 10.1128/MCB.21.4.1297-1310.2001, 99582, 11158315
    • Koumenis C, Alarcon R, Hammond E, Sutphin P, Hoff-man W, Murphy M, Derr J, Taya Y, Lowe SW, Kastan M, Giaccia A. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 2001, 21(4):1297-310. 10.1128/MCB.21.4.1297-1310.2001, 99582, 11158315.
    • (2001) Mol Cell Biol , vol.21 , Issue.4 , pp. 1297-1310
    • Koumenis, C.1    Alarcon, R.2    Hammond, E.3    Sutphin, P.4    Hoff-man, W.5    Murphy, M.6    Derr, J.7    Taya, Y.8    Lowe, S.W.9    Kastan, M.10    Giaccia, A.11
  • 5
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke SP, Clarkin KC, Di Leonardo A, Tsou A, Wahl GM. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes & Development 1996, 10(8):934.
    • (1996) Genes & Development , vol.10 , Issue.8 , pp. 934
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 6
    • 0033230581 scopus 로고    scopus 로고
    • The cellular response to p53: the decision between life and death
    • 10.1038/sj.onc.1203130, 10557106
    • Sionov RV, Haupt Y. The cellular response to p53: the decision between life and death. Oncogene 1999, 18:6145-6157. 10.1038/sj.onc.1203130, 10557106.
    • (1999) Oncogene , vol.18 , pp. 6145-6157
    • Sionov, R.V.1    Haupt, Y.2
  • 7
    • 0037459377 scopus 로고    scopus 로고
    • Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation
    • 10.1016/S0092-8674(03)00193-4, 12654245
    • Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation. Cell 2003, 112:779-791. 10.1016/S0092-8674(03)00193-4, 12654245.
    • (2003) Cell , vol.112 , pp. 779-791
    • Leng, R.P.1    Lin, Y.2    Ma, W.3    Wu, H.4    Lemmers, B.5    Chung, S.6    Parant, J.M.7    Lozano, G.8    Hakem, R.9    Benchimol, S.10
  • 9
    • 50349088876 scopus 로고    scopus 로고
    • Mdm2 and Mdm4 loss regulates distinct p53 activities
    • 10.1158/1541-7786.MCR-07-2079, 2699947, 18567799
    • Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res 2008, 6:947-954. 10.1158/1541-7786.MCR-07-2079, 2699947, 18567799.
    • (2008) Mol Cancer Res , vol.6 , pp. 947-954
    • Barboza, J.A.1    Iwakuma, T.2    Terzian, T.3    El-Naggar, A.K.4    Lozano, G.5
  • 11
    • 0028823020 scopus 로고
    • Rescue of early embrionic lethality in mdm2-deficient mice by deletion of p53
    • 10.1038/378203a0, 7477326
    • Montes de Oca Luna R. Rescue of early embrionic lethality in mdm2-deficient mice by deletion of p53. Nature 1995, 378:203-206. 10.1038/378203a0, 7477326.
    • (1995) Nature , vol.378 , pp. 203-206
    • Montes de Oca Luna, R.1
  • 12
    • 0348134742 scopus 로고    scopus 로고
    • Mono-Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
    • 10.1126/science.1091362, 14671306
    • Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W. Mono-Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2. Science 2003, 302:1972-1975. 10.1126/science.1091362, 14671306.
    • (2003) Science , vol.302 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 13
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: positive and negative feedback loops
    • 10.1038/sj.onc.1208615, 15838523
    • Harris SL, Levine AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005, 24(17):2899. 10.1038/sj.onc.1208615, 15838523.
    • (2005) Oncogene , vol.24 , Issue.17 , pp. 2899
    • Harris, S.L.1    Levine, A.J.2
  • 14
    • 0035341041 scopus 로고    scopus 로고
    • Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation
    • 10.1093/nar/29.9.1989, 37263, 11328884
    • Kaku S, Iwahashi Y, Kuraishi A, Albor A, Yamagishi T, Nakaike S, Kulesz-Martin M. Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation. Nucl Acids Res 2001, 29:1989-1993. 10.1093/nar/29.9.1989, 37263, 11328884.
    • (2001) Nucl Acids Res , vol.29 , pp. 1989-1993
    • Kaku, S.1    Iwahashi, Y.2    Kuraishi, A.3    Albor, A.4    Yamagishi, T.5    Nakaike, S.6    Kulesz-Martin, M.7
  • 15
    • 35148847384 scopus 로고    scopus 로고
    • Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    • 10.1016/j.ccr.2007.09.007, 17936560
    • Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lind-strom MS, Bhat KP, Godfrey VL, Evan GI, Zhang Y. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007, 12:355-366. 10.1016/j.ccr.2007.09.007, 17936560.
    • (2007) Cancer Cell , vol.12 , pp. 355-366
    • Itahana, K.1    Mao, H.2    Jin, A.3    Itahana, Y.4    Clegg, H.V.5    Lind-strom, M.S.6    Bhat, K.P.7    Godfrey, V.L.8    Evan, G.I.9    Zhang, Y.10
  • 16
    • 0012907951 scopus 로고    scopus 로고
    • Time delay as a key to apoptosis induction in the p53 network
    • Tiana G, Sneppen K, Jensen MH. Time delay as a key to apoptosis induction in the p53 network. Euro-phys J B 2002, 29:135-140.
    • (2002) Euro-phys J B , vol.29 , pp. 135-140
    • Tiana, G.1    Sneppen, K.2    Jensen, M.H.3
  • 18
    • 27244451471 scopus 로고    scopus 로고
    • P53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback
    • Wagner J, Ma L, Rice JJ, Hu W, Levine AJ, Stolovitzky G. p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback. IEE Proc-Syst Biol 2005, 152:109-118.
    • (2005) IEE Proc-Syst Biol , vol.152 , pp. 109-118
    • Wagner, J.1    Ma, L.2    Rice, J.J.3    Hu, W.4    Levine, A.J.5    Stolovitzky, G.6
  • 19
    • 25444513462 scopus 로고    scopus 로고
    • Steady states and oscillations in the p53/Mdm2 network
    • Ciliberto A, Novak B, Tyson JJ. Steady states and oscillations in the p53/Mdm2 network. Cell Cycle 2005, 4:488-493.
    • (2005) Cell Cycle , vol.4 , pp. 488-493
    • Ciliberto, A.1    Novak, B.2    Tyson, J.J.3
  • 20
    • 42949171936 scopus 로고    scopus 로고
    • Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage
    • 10.1016/j.molcel.2008.03.016, 2579769, 18471974
    • Bacthelor E, Mock CS, Bhan I, Loewer A, Lahav G. Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage. Mol Cell 2008, 30:277-289. 10.1016/j.molcel.2008.03.016, 2579769, 18471974.
    • (2008) Mol Cell , vol.30 , pp. 277-289
    • Bacthelor, E.1    Mock, C.S.2    Bhan, I.3    Loewer, A.4    Lahav, G.5
  • 22
    • 0029802591 scopus 로고    scopus 로고
    • P53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • 10.1101/gad.10.19.2438, 8843196
    • Chen X, Ko LJ, Jayaraman L, Prives C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 1996, 10:2438-2451. 10.1101/gad.10.19.2438, 8843196.
    • (1996) Genes Dev , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 23
    • 0036892060 scopus 로고    scopus 로고
    • Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence
    • 10.1128/MCB.22.24.8612-8625.2002, 139870, 12446780
    • Inga A, Storici F, Darden TA, Resnick MA. Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Mol Cell Biol 2002, 22:8612-8625. 10.1128/MCB.22.24.8612-8625.2002, 139870, 12446780.
    • (2002) Mol Cell Biol , vol.22 , pp. 8612-8625
    • Inga, A.1    Storici, F.2    Darden, T.A.3    Resnick, M.A.4
  • 24
    • 33746095054 scopus 로고    scopus 로고
    • Another turn for p53
    • Tyson JJ. Another turn for p53. Mol Sys Biol 2006, 2:0032.
    • (2006) Mol Sys Biol , vol.2 , pp. 0032
    • Tyson, J.J.1
  • 25
    • 33746605149 scopus 로고    scopus 로고
    • Minimal model of spiky oscillations in NF-kB signalling
    • Krishna S, Jensen MH, Sneppen K. Minimal model of spiky oscillations in NF-kB signalling. Proc Natl Acad Sci (USA) 2006, 103:10840-10845.
    • (2006) Proc Natl Acad Sci (USA) , vol.103 , pp. 10840-10845
    • Krishna, S.1    Jensen, M.H.2    Sneppen, K.3
  • 26
    • 0029788135 scopus 로고    scopus 로고
    • Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation
    • Lu X, Burbidge SA, Griffn S, Smith HM. Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation. Oncogene 1996, 13:413-418.
    • (1996) Oncogene , vol.13 , pp. 413-418
    • Lu, X.1    Burbidge, S.A.2    Griffn, S.3    Smith, H.M.4
  • 27
    • 14644437751 scopus 로고    scopus 로고
    • MDM2 is a Central Node in the p53 Pathway: 12 Years and Counting
    • 10.2174/1568009053332627, 15720184
    • Bond GL, Hu W, Levine AJ. MDM2 is a Central Node in the p53 Pathway: 12 Years and Counting. Current Cancer Drug Targets 2005, 5:3-8. 10.2174/1568009053332627, 15720184.
    • (2005) Current Cancer Drug Targets , vol.5 , pp. 3-8
    • Bond, G.L.1    Hu, W.2    Levine, A.J.3
  • 29
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • 10.1016/S1044-579X(02)00099-8, 12507556
    • Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Seminars in Cancer Biology 2003, 13:49-58. 10.1016/S1044-579X(02)00099-8, 12507556.
    • (2003) Seminars in Cancer Biology , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 30
    • 2342567852 scopus 로고    scopus 로고
    • Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
    • 10.1038/sj.emboj.7600145, 391059, 15029243
    • Stommel JM, Wahl GM. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 2004, 23(7):1547-56. 10.1038/sj.emboj.7600145, 391059, 15029243.
    • (2004) EMBO J , vol.23 , Issue.7 , pp. 1547-1556
    • Stommel, J.M.1    Wahl, G.M.2
  • 31
    • 33747873543 scopus 로고    scopus 로고
    • Real-time Evaluation of p53 Oscillatory Behavior In vivo Using Bioluminescent Imaging
    • 10.1158/0008-5472.CAN-06-1405, 16885345
    • Hamstra DA, Bhojani MS, Griffn LB, Laxman B, Ross BD, Rehemtulla A. Real-time Evaluation of p53 Oscillatory Behavior In vivo Using Bioluminescent Imaging. Cancer Res 2006, 66:7482-7489. 10.1158/0008-5472.CAN-06-1405, 16885345.
    • (2006) Cancer Res , vol.66 , pp. 7482-7489
    • Hamstra, D.A.1    Bhojani, M.S.2    Griffn, L.B.3    Laxman, B.4    Ross, B.D.5    Rehemtulla, A.6
  • 32
    • 18144364375 scopus 로고    scopus 로고
    • The role of p53 in hypoxia-induced apoptosis
    • 10.1016/j.bbrc.2005.03.154, 15865928
    • Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun 2005, 331(3):718-25. 10.1016/j.bbrc.2005.03.154, 15865928.
    • (2005) Biochem Biophys Res Commun , vol.331 , Issue.3 , pp. 718-725
    • Hammond, E.M.1    Giaccia, A.J.2
  • 33
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • 10.1136/jcp.2003.015032, 1770458, 15452150
    • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004, 57(10):1009-14. 10.1136/jcp.2003.015032, 1770458, 15452150.
    • (2004) J Clin Pathol , vol.57 , Issue.10 , pp. 1009-1014
    • Greijer, A.E.1    van der Wall, E.2
  • 35
    • 34047247060 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the Mdm2 gene disrupts the oscillation of p53 and Mdm2 levels in cells
    • 10.1158/0008-5472.CAN-06-2656, 17363597
    • Hu W, Feng Z, Ma L, Wagner J, Rice JJ, Stolovitzky G, Levine AJ. A single nucleotide polymorphism in the Mdm2 gene disrupts the oscillation of p53 and Mdm2 levels in cells. Cancer Res 2007, 67(6):2757-2765. 10.1158/0008-5472.CAN-06-2656, 17363597.
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2757-2765
    • Hu, W.1    Feng, Z.2    Ma, L.3    Wagner, J.4    Rice, J.J.5    Stolovitzky, G.6    Levine, A.J.7
  • 36
    • 28044453746 scopus 로고    scopus 로고
    • Detection of functional single-nucleotide polymorphisms that affect apoptosis
    • 10.1073/pnas.0508390102, 1283473, 16260726
    • Harris SL, Gil G, Robins H, Hu W, Hirshfield K, Bond E, Bond G, Levine AJ. Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proc Natl Acad Sci USA 2005, 102(45):16297-302. 10.1073/pnas.0508390102, 1283473, 16260726.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.45 , pp. 16297-16302
    • Harris, S.L.1    Gil, G.2    Robins, H.3    Hu, W.4    Hirshfield, K.5    Bond, E.6    Bond, G.7    Levine, A.J.8
  • 37
    • 34547615407 scopus 로고    scopus 로고
    • Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation
    • Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci (USA) 2007, 104:12365-12370.
    • (2007) Proc Natl Acad Sci (USA) , vol.104 , pp. 12365-12370
    • Wang, Y.V.1    Wade, M.2    Wong, E.3    Li, Y.C.4    Rodewald, L.W.5    Wahl, G.M.6
  • 38
    • 33645429016 scopus 로고
    • Exact Stochastic Simulation of Coupled Chemical Reactions
    • Gillespie DT. Exact Stochastic Simulation of Coupled Chemical Reactions. J Phys Chem 1977, 81:2340-2361.
    • (1977) J Phys Chem , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 39
    • 53149144701 scopus 로고    scopus 로고
    • Explaining oscillations and variability in the p53-Mdm2 system
    • Proctor CJ, Gray DA. Explaining oscillations and variability in the p53-Mdm2 system. BMC Sys Biol 2008, 2:75.
    • (2008) BMC Sys Biol , vol.2 , pp. 75
    • Proctor, C.J.1    Gray, D.A.2
  • 41
    • 0035890265 scopus 로고    scopus 로고
    • Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53
    • 10.1093/emboj/20.22.6297, 125724, 11707401
    • King FW, Wawrzynow A, Höhfeld J, Zylicz M. Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. EMBO J 2001, 20(22):6297-6305. 10.1093/emboj/20.22.6297, 125724, 11707401.
    • (2001) EMBO J , vol.20 , Issue.22 , pp. 6297-6305
    • King, F.W.1    Wawrzynow, A.2    Höhfeld, J.3    Zylicz, M.4
  • 42
    • 0030876484 scopus 로고    scopus 로고
    • Heat shock induces transient p53-dependent cell cycle arrest at G1/S
    • 10.1038/sj.onc.1201210, 9247309
    • Nitta M, Okamura H, Aizawa S, Yamaizumi M. Heat shock induces transient p53-dependent cell cycle arrest at G1/S. Oncogene 1997, 15:561-568. 10.1038/sj.onc.1201210, 9247309.
    • (1997) Oncogene , vol.15 , pp. 561-568
    • Nitta, M.1    Okamura, H.2    Aizawa, S.3    Yamaizumi, M.4
  • 43
    • 0035801391 scopus 로고    scopus 로고
    • Hsp70 interactions with the p53 tumour supporessor protein
    • 10.1093/emboj/20.17.4634, 125613, 11532927
    • Zyclicz M, King FW, Wawrzynow A. Hsp70 interactions with the p53 tumour supporessor protein. EMBO J 2001, 20(17):4634-4638. 10.1093/emboj/20.17.4634, 125613, 11532927.
    • (2001) EMBO J , vol.20 , Issue.17 , pp. 4634-4638
    • Zyclicz, M.1    King, F.W.2    Wawrzynow, A.3
  • 45
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kB transcription factors
    • 10.1038/sj.onc.1203239, 10602461
    • Pahl HL. Activators and target genes of Rel/NF-kB transcription factors. Oncogene 1999, 18:6853-6866. 10.1038/sj.onc.1203239, 10602461.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 46
    • 0037044575 scopus 로고    scopus 로고
    • The IkB-NF-kB signaling module: temporal control and selective gene activation
    • 10.1126/science.1071914, 12424381
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D. The IkB-NF-kB signaling module: temporal control and selective gene activation. Science 2002, 298:1241-1245. 10.1126/science.1071914, 12424381.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 47
    • 7444254365 scopus 로고    scopus 로고
    • Oscillations in NF-kB signaling control the dynamics of gene expression
    • 10.1126/science.1099962, 15499023
    • Nelson DE, et al. Oscillations in NF-kB signaling control the dynamics of gene expression. Science 2004, 306:704-708. 10.1126/science.1099962, 15499023.
    • (2004) Science , vol.306 , pp. 704-708
    • Nelson, D.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.