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Volumn 20, Issue 9, 2014, Pages 1409-1417

The role of obesity in cardiomyopathy and nephropathy

Author keywords

Aldosterone; Angiotensin; Cardiomyopathy; Inflammation; Nephropathy; Nuclear factor kappa B; Oxidative stress; Toll like receptor 4

Indexed keywords

ADIPOSE TISSUE; CARDIOMYOPATHY; ENDOTHELIAL DYSFUNCTION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; KIDNEY DISEASE; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; ANIMAL; CARDIOMYOPATHIES; COMPLICATION; KIDNEY DISEASES; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

EID: 84896382372     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990562     Document Type: Review
Times cited : (19)

References (203)
  • 1
    • 55849137212 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome in developing countries
    • Misra A, Khurana L. Obesity and the metabolic syndrome in developing countries. J Clin Endocrinol Metab 2008; 93: S9-30.
    • (2008) J Clin Endocrinol Metab , vol.93
    • Misra, A.1    Khurana, L.2
  • 2
    • 66149137211 scopus 로고    scopus 로고
    • The preventable causes of death in the United States: Comparative risk assessment of dietary, lifestyle, and metabolic risk factors
    • Danaei G, Ding EL, Mozaffarian D, et al. The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med 2009; 6: e1000058.
    • (2009) PLoS Med , vol.6
    • Danaei, G.1    Ding, E.L.2    Mozaffarian, D.3
  • 3
    • 34948842460 scopus 로고    scopus 로고
    • Waist-toheight ratio is the best index of obesity in association with chronic kidney disease
    • Lin CH, Chou CY, Lin CC, Huang CC, Liu CS, Lai SW. Waist-toheight ratio is the best index of obesity in association with chronic kidney disease. Nutrition 2007; 23: 788-93.
    • (2007) Nutrition , vol.23 , pp. 788-793
    • Lin, C.H.1    Chou, C.Y.2    Lin, C.C.3    Huang, C.C.4    Liu, C.S.5    Lai, S.W.6
  • 4
    • 84872352539 scopus 로고    scopus 로고
    • New insights into the true nature of the obesity paradox and the lower cardiovascular risk
    • Chrysant SG, Chrysant GS. New insights into the true nature of the obesity paradox and the lower cardiovascular risk. J Am Soc Hypertens 2013; 7: 85-94.
    • (2013) J Am Soc Hypertens , vol.7 , pp. 85-94
    • Chrysant, S.G.1    Chrysant, G.S.2
  • 6
    • 65449117920 scopus 로고    scopus 로고
    • Obesity and hypertension: Mechanisms, cardiorenal consequences, and therapeutic approaches
    • Reisin E, Jack AV. Obesity and hypertension: mechanisms, cardiorenal consequences, and therapeutic approaches. Med Clin North Am 2009; 93: 733-51.
    • (2009) Med Clin North Am , vol.93 , pp. 733-751
    • Reisin, E.1    Jack, A.V.2
  • 7
    • 79551470814 scopus 로고    scopus 로고
    • Therapeutic approaches to target inflammation in type 2 diabetes
    • Goldfine AB, Fonseca V, Shoelson SE. Therapeutic approaches to target inflammation in type 2 diabetes. Clin Chem 2011; 57: 162-7.
    • (2011) Clin Chem , vol.57 , pp. 162-167
    • Goldfine, A.B.1    Fonseca, V.2    Shoelson, S.E.3
  • 10
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121: 2111-7.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 11
    • 18244370762 scopus 로고    scopus 로고
    • Inflammation, stress, and diabetes
    • Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005; 115: 1111-9.
    • (2005) J Clin Invest , vol.115 , pp. 1111-1119
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 12
    • 82455198885 scopus 로고    scopus 로고
    • Chronic inflammation links cardiovascular, metabolic and renal diseases
    • Manabe I. Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 2011; 75: 2739-48.
    • (2011) Circ J , vol.75 , pp. 2739-2748
    • Manabe, I.1
  • 13
    • 84857501489 scopus 로고    scopus 로고
    • Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: Focus on cardiovascular, lung, neurological and kidney disorders
    • Haines DD, Lekli I, Teissier P, Bak I, Tosaki A. Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders. Acta Physiol (Oxf) 2012; 204: 487-501.
    • (2012) Acta Physiol (Oxf) , vol.204 , pp. 487-501
    • Haines, D.D.1    Lekli, I.2    Teissier, P.3    Bak, I.4    Tosaki, A.5
  • 14
    • 84876569854 scopus 로고    scopus 로고
    • The heme oxygenase system selectively enhances the anti-inflammatory macrophage-m2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in zucker diabetic Fatty rats
    • Jadhav A, Tiwari S, Lee P, Ndisang JF. The heme oxygenase system selectively enhances the anti-inflammatory macrophage-m2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in zucker diabetic Fatty rats. J Pharmacol Exp Ther 2013; 345: 239-49.
    • (2013) J Pharmacol Exp Ther , vol.345 , pp. 239-249
    • Jadhav, A.1    Tiwari, S.2    Lee, P.3    Ndisang, J.F.4
  • 15
    • 84885324545 scopus 로고    scopus 로고
    • Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin resistant type-2 diabetes
    • Ndisang JF, Jadhav A. Hemin therapy suppresses inflammation and retroperitoneal adipocyte hypertrophy to improve glucose metabolism in obese rats co-morbid with insulin resistant type-2 diabetes. Diabetes Obes Metab 2013; 15: 1029-39.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1029-1039
    • Ndisang, J.F.1    Jadhav, A.2
  • 16
    • 45549103859 scopus 로고    scopus 로고
    • JNK-and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro
    • Takahashi K, Yamaguchi S, Shimoyama T, et al. JNK-and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. Am J Physiol Endocrinol Metab 2008; 294: E898-909.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Takahashi, K.1    Yamaguchi, S.2    Shimoyama, T.3
  • 17
    • 77449092780 scopus 로고    scopus 로고
    • Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: Dissociation of adipocyte hypertrophy from inflammation
    • Yeop Han C, Kargi AY, Omer M, et al. Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes: dissociation of adipocyte hypertrophy from inflammation. Diabetes 2010; 59: 386-96.
    • (2010) Diabetes , vol.59 , pp. 386-396
    • Yeop Han, C.1    Kargi, A.Y.2    Omer, M.3
  • 18
    • 77953527349 scopus 로고    scopus 로고
    • Role of heme oxygenase in inflammation, insulinsignalling, diabetes and obesity
    • Ndisang JF. Role of heme oxygenase in inflammation, insulinsignalling, diabetes and obesity. Mediators Inflamm 2010; 2010: 359732.
    • (2010) Mediators Inflamm , vol.2010 , pp. 359732
    • Ndisang, J.F.1
  • 19
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007; 447: 1116-20.
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3
  • 20
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004; 306: 457-61.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 21
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 1996; 271: 665-8.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 22
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 1994; 94: 1543-9.
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 23
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • Klover PJ, Clementi AH, Mooney RA. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005; 146: 3417-27.
    • (2005) Endocrinology , vol.146 , pp. 3417-3427
    • Klover, P.J.1    Clementi, A.H.2    Mooney, R.A.3
  • 24
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003; 52: 2784-9.
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 25
    • 0031596597 scopus 로고    scopus 로고
    • Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulinstimulated glycogen synthesis in rat hepatocytes
    • Kanemaki T, Kitade H, Kaibori M, et al. Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulinstimulated glycogen synthesis in rat hepatocytes. Hepatology 1998; 27: 1296-303.
    • (1998) Hepatology , vol.27 , pp. 1296-1303
    • Kanemaki, T.1    Kitade, H.2    Kaibori, M.3
  • 26
    • 10744228409 scopus 로고    scopus 로고
    • Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    • Ma LJ, Mao SL, Taylor KL, et al. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes 2004; 53: 336-46.
    • (2004) Diabetes , vol.53 , pp. 336-346
    • Ma, L.J.1    Mao, S.L.2    Taylor, K.L.3
  • 27
    • 79551498431 scopus 로고    scopus 로고
    • Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension
    • Li DJ, Evans RG, Yang ZW, et al. Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. Hypertension 2011; 57: 298-307.
    • (2011) Hypertension , vol.57 , pp. 298-307
    • Li, D.J.1    Evans, R.G.2    Yang, Z.W.3
  • 28
    • 79959513002 scopus 로고    scopus 로고
    • Cerium oxide nanoparticles inhibit oxidative stress and nuclear factor-kappaB activation in H9c2 cardiomyocytes exposed to cigarette smoke extract
    • Niu J, Wang K, Kolattukudy PE. Cerium oxide nanoparticles inhibit oxidative stress and nuclear factor-kappaB activation in H9c2 cardiomyocytes exposed to cigarette smoke extract. J Pharmacol Exp Ther 2011; 338: 53-61.
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 53-61
    • Niu, J.1    Wang, K.2    Kolattukudy, P.E.3
  • 29
    • 84883779194 scopus 로고    scopus 로고
    • Severity of left ventricular dysfunction in heart failure patients affects the degree of serum-induced cardiomyocyte apoptosis. Importance of inflammatory response and metabolism
    • Consoli C, Gatta L, Iellamo F, Molinari F, Rosano GM, Marlier LN. Severity of left ventricular dysfunction in heart failure patients affects the degree of serum-induced cardiomyocyte apoptosis. Importance of inflammatory response and metabolism. Int J Cardiol 2012.
    • (2012) Int J Cardiol
    • Consoli, C.1    Gatta, L.2    Iellamo, F.3    Molinari, F.4    Rosano, G.M.5    Marlier, L.N.6
  • 30
    • 84859589503 scopus 로고    scopus 로고
    • Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs
    • Vlahakos D, Arkadopoulos N, Kostopanagiotou G, et al. Deferoxamine attenuates lipid peroxidation, blocks interleukin-6 production, ameliorates sepsis inflammatory response syndrome, and confers renoprotection after acute hepatic ischemia in pigs. Artif Organs 2012; 36: 400-8.
    • (2012) Artif Organs , vol.36 , pp. 400-408
    • Vlahakos, D.1    Arkadopoulos, N.2    Kostopanagiotou, G.3
  • 31
    • 60749095669 scopus 로고    scopus 로고
    • Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes
    • Ascon M, Ascon DB, Liu M, et al. Renal ischemia-reperfusion leads to long term infiltration of activated and effector-memory T lymphocytes. Kidney Int 2009; 75: 526-35.
    • (2009) Kidney Int , vol.75 , pp. 526-535
    • Ascon, M.1    Ascon, D.B.2    Liu, M.3
  • 32
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 2006; 346: 739-45.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 33
    • 82755182706 scopus 로고    scopus 로고
    • Probiotic therapy: Immunomodulating approach toward urinary tract infection
    • Amdekar S, Singh V, Singh DD. Probiotic therapy: immunomodulating approach toward urinary tract infection. Curr Microbiol 2011; 63: 484-90.
    • (2011) Curr Microbiol , vol.63 , pp. 484-490
    • Amdekar, S.1    Singh, V.2    Singh, D.D.3
  • 34
    • 33845476271 scopus 로고    scopus 로고
    • Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat
    • Li X, Meng Y, Wu P, Zhang Z, Yang X. Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat. Regul Pept 2007; 138: 15-25.
    • (2007) Regul Pept , vol.138 , pp. 15-25
    • Li, X.1    Meng, Y.2    Wu, P.3    Zhang, Z.4    Yang, X.5
  • 35
    • 34247854813 scopus 로고    scopus 로고
    • Antagonistic effects of bone morphogenetic protein-4 and-7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation
    • Otani H, Otsuka F, Inagaki K, et al. Antagonistic effects of bone morphogenetic protein-4 and-7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation. Am J Physiol Renal Physiol 2007; 292: F1513-25.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Otani, H.1    Otsuka, F.2    Inagaki, K.3
  • 36
    • 34547602916 scopus 로고    scopus 로고
    • Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, et al. Loss-offunction mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56: 1986-98.
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3
  • 37
    • 84889068833 scopus 로고    scopus 로고
    • Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia
    • Tanguy S, Toufektsian MC, Grauzam S, et al. Cardiac dysfunction in rats with dietary-induced insulin resistance associated with pharmacologically-induced dyslipidemia. Curr Pharm Des 2013.
    • (2013) Curr Pharm Des
    • Tanguy, S.1    Toufektsian, M.C.2    Grauzam, S.3
  • 38
    • 84876273640 scopus 로고    scopus 로고
    • Hyperglycemia-induced Oxidative stress and its Role in Diabetes Mellitus related Cardiovascular Diseases
    • Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced Oxidative stress and its Role in Diabetes Mellitus related Cardiovascular Diseases. Curr Pharm Des 2013.
    • (2013) Curr Pharm Des
    • Fiorentino, T.V.1    Prioletta, A.2    Zuo, P.3    Folli, F.4
  • 39
    • 84876460403 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta protects against obesity-related glomerulopathy through the P38 MAPK pathway
    • Yan Z, Ni Y, Wang P, et al. Peroxisome proliferator-activated receptor delta protects against obesity-related glomerulopathy through the P38 MAPK pathway. Obesity (Silver Spring) 2013; 21: 538-45.
    • (2013) Obesity (Silver Spring) , vol.21 , pp. 538-545
    • Yan, Z.1    Ni, Y.2    Wang, P.3
  • 41
    • 84896368614 scopus 로고    scopus 로고
    • Increased Risk of Cardiovascular Complications in Chronic Kidney Disease: A Possible Role of Leptin
    • Korolczuk A, Dudka J. Increased Risk of Cardiovascular Complications in Chronic Kidney Disease: A Possible Role of Leptin. Curr Pharm Des 2013.
    • (2013) Curr Pharm Des
    • Korolczuk, A.1    Dudka, J.2
  • 42
    • 84861303372 scopus 로고    scopus 로고
    • Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus
    • Kampoli AM, Tousoulis D, Briasoulis A, Latsios G, Papageorgiou N, Stefanadis C. Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus. Curr Pharm Des 2011; 17: 4147-58.
    • (2011) Curr Pharm Des , vol.17 , pp. 4147-4158
    • Kampoli, A.M.1    Tousoulis, D.2    Briasoulis, A.3    Latsios, G.4    Papageorgiou, N.5    Stefanadis, C.6
  • 43
    • 84873336694 scopus 로고    scopus 로고
    • Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    • Xue P, Hou Y, Chen Y, et al. Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome. Diabetes 2013; 62: 845-54.
    • (2013) Diabetes , vol.62 , pp. 845-854
    • Xue, P.1    Hou, Y.2    Chen, Y.3
  • 44
    • 84871620197 scopus 로고    scopus 로고
    • CD36 and Na/K-ATPasealpha1 form a proinflammatory signaling loop in kidney
    • Kennedy DJ, Chen Y, Huang W, et al. CD36 and Na/K-ATPasealpha1 form a proinflammatory signaling loop in kidney. Hypertension 2013; 61: 216-24.
    • (2013) Hypertension , vol.61 , pp. 216-224
    • Kennedy, D.J.1    Chen, Y.2    Huang, W.3
  • 45
    • 67650260800 scopus 로고    scopus 로고
    • Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension
    • Jadhav A, Ndisang JF. Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension. Exp Biol Med (Maywood) 2009; 234: 764-78.
    • (2009) Exp Biol Med (Maywood) , vol.234 , pp. 764-778
    • Jadhav, A.1    Ndisang, J.F.2
  • 46
    • 84870180860 scopus 로고    scopus 로고
    • Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism
    • Jadhav A, Ndisang JF. Treatment with heme arginate alleviates adipose tissue inflammation and improves insulin sensitivity and glucose metabolism in a rat model of Human primary aldosteronism. Free Radic Biol Med 2012; 53: 2277-2286.
    • (2012) Free Radic Biol Med , vol.53 , pp. 2277-2286
    • Jadhav, A.1    Ndisang, J.F.2
  • 47
    • 55949136575 scopus 로고    scopus 로고
    • Interaction Among Heme Oxygenase, Nuclear Factor-{kappa}B, and Transcription Activating Factors in Cardiac Hypertrophy in Hypertension
    • Jadhav A, Torlakovic E, Ndisang JF. Interaction Among Heme Oxygenase, Nuclear Factor-{kappa}B, and Transcription Activating Factors in Cardiac Hypertrophy in Hypertension. Hypertension 2008; 52: 910-917.
    • (2008) Hypertension , vol.52 , pp. 910-917
    • Jadhav, A.1    Torlakovic, E.2    Ndisang, J.F.3
  • 48
    • 66049154851 scopus 로고    scopus 로고
    • Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats
    • Jadhav A, Torlakovic E, Ndisang JF. Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats. Am J Physiol Renal Physiol 2009; 296: F521-F534.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Jadhav, A.1    Torlakovic, E.2    Ndisang, J.F.3
  • 50
    • 0035019571 scopus 로고    scopus 로고
    • Relaxin generates nitric oxide and provides protection against cardiac anaphylaxis
    • Ndisang JF, Baronti R, Cecere G, Masini E, Bani D, Mannaioni PF. Relaxin generates nitric oxide and provides protection against cardiac anaphylaxis. Inflamm Res 2001; 50 Suppl 2: S122-3.
    • (2001) Inflamm Res , vol.50 , Issue.SUPPL. 2
    • Ndisang, J.F.1    Baronti, R.2    Cecere, G.3    Masini, E.4    Bani, D.5    Mannaioni, P.F.6
  • 51
    • 0032997369 scopus 로고    scopus 로고
    • Modulation of the immunological response of guinea pig mast cells by carbon monoxide
    • Ndisang JF, Gai P, Berni L, et al. Modulation of the immunological response of guinea pig mast cells by carbon monoxide. Immunopharmacology 1999; 43: 65-73.
    • (1999) Immunopharmacology , vol.43 , pp. 65-73
    • Ndisang, J.F.1    Gai, P.2    Berni, L.3
  • 52
    • 66649132533 scopus 로고    scopus 로고
    • Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats
    • Ndisang JF, Jadhav A. Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats. Endocrinology 2009; 150: 2627-36.
    • (2009) Endocrinology , vol.150 , pp. 2627-2636
    • Ndisang, J.F.1    Jadhav, A.2
  • 53
    • 68849093674 scopus 로고    scopus 로고
    • Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months
    • Ndisang JF, Jadhav A. Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months. J Card Fail 2009; 15: 616-28.
    • (2009) J Card Fail , vol.15 , pp. 616-628
    • Ndisang, J.F.1    Jadhav, A.2
  • 54
    • 65649110522 scopus 로고    scopus 로고
    • Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes
    • Ndisang JF, Jadhav A. Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab 2009; 296: E829-41.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Ndisang, J.F.1    Jadhav, A.2
  • 55
    • 73549113296 scopus 로고    scopus 로고
    • The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension
    • Ndisang JF, Jadhav A. The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension. Am J Physiol Regul Integr Comp Physiol 2010; 298: R211-23.
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298
    • Ndisang, J.F.1    Jadhav, A.2
  • 56
    • 77953730770 scopus 로고    scopus 로고
    • Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension
    • Ndisang JF, Jadhav A. Heme arginate therapy enhanced adiponectin and atrial natriuretic peptide, but abated endothelin-1 with attenuation of kidney histopathological lesions in mineralocorticoid-induced hypertension. J Pharmacol Exp Ther 2010; 334: 87-98.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 87-98
    • Ndisang, J.F.1    Jadhav, A.2
  • 57
    • 77950509320 scopus 로고    scopus 로고
    • Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats
    • Ndisang JF, Jadhav A. Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats. Hypertens Res 2010; 33: 338-47.
    • (2010) Hypertens Res , vol.33 , pp. 338-347
    • Ndisang, J.F.1    Jadhav, A.2
  • 58
    • 77953529765 scopus 로고    scopus 로고
    • Interaction between the heme oxygenase system and aldosterone in hypertension
    • Ndisang JF, Jadhav A, Lane N. Interaction between the heme oxygenase system and aldosterone in hypertension. Int J Angiol 2007; 16: 92-97.
    • (2007) Int J Angiol , vol.16 , pp. 92-97
    • Ndisang, J.F.1    Jadhav, A.2    Lane, N.3
  • 59
    • 43949106899 scopus 로고    scopus 로고
    • Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension
    • Ndisang JF, Lane N, Jadhav A. Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension. J Hypertens 2008; 26: 1188-99.
    • (2008) J Hypertens , vol.26 , pp. 1188-1199
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 60
    • 66449100734 scopus 로고    scopus 로고
    • The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulinsensitizing pathways
    • Ndisang JF, Lane N, Jadhav A. The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulinsensitizing pathways. Endocrinology 2009; 150: 2098-108.
    • (2009) Endocrinology , vol.150 , pp. 2098-2108
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 61
    • 66149135526 scopus 로고    scopus 로고
    • Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes
    • Ndisang JF, Lane N, Jadhav A. Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes. Am J Physiol Endocrinol Metab 2009; 296: E1029-41.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 62
    • 74949102157 scopus 로고    scopus 로고
    • Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats
    • Ndisang JF, Lane N, Syed N, Jadhav A. Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 2010; 151: 549-60.
    • (2010) Endocrinology , vol.151 , pp. 549-560
    • Ndisang, J.F.1    Lane, N.2    Syed, N.3    Jadhav, A.4
  • 63
    • 84882445544 scopus 로고    scopus 로고
    • The Heme Oxygenase System Selectively Suppresses the Proinflammatory Macrophage M1 Phenotype and Potentiates Insulin Signaling in Spontaneously Hypertensive Rats
    • Ndisang JF, Mishra M. The Heme Oxygenase System Selectively Suppresses the Proinflammatory Macrophage M1 Phenotype and Potentiates Insulin Signaling in Spontaneously Hypertensive Rats. Am J Hypertens 2013; 26: 1123-31.
    • (2013) Am J Hypertens , vol.26 , pp. 1123-1131
    • Ndisang, J.F.1    Mishra, M.2
  • 64
    • 0034168214 scopus 로고    scopus 로고
    • Induction of heme oxygenase provides protection against cardiac anaphylaxis
    • Ndisang JF, Moncini M, Gai P, et al. Induction of heme oxygenase provides protection against cardiac anaphylaxis. Inflamm Res 2000; 49 Suppl 1: S76-7.
    • (2000) Inflamm Res , vol.49 , Issue.SUPPL. 1
    • Ndisang, J.F.1    Moncini, M.2    Gai, P.3
  • 66
    • 0036679158 scopus 로고    scopus 로고
    • Novel therapeutic strategies for impaired endothelium-dependent vascular relaxation
    • Ndisang JF, Wang R. Novel therapeutic strategies for impaired endothelium-dependent vascular relaxation. Expert Opin Ther Patents 2002; 12: 1237-1247.
    • (2002) Expert Opin Ther Patents , vol.12 , pp. 1237-1247
    • Ndisang, J.F.1    Wang, R.2
  • 67
    • 0037865221 scopus 로고    scopus 로고
    • Age-related alterations in soluble guanylyl cyclase and cGMP pathway in spontaneously hypertensive rats
    • Ndisang JF, Wang R. Age-related alterations in soluble guanylyl cyclase and cGMP pathway in spontaneously hypertensive rats. J Hypertens 2003; 21: 1117-24.
    • (2003) J Hypertens , vol.21 , pp. 1117-1124
    • Ndisang, J.F.1    Wang, R.2
  • 68
    • 0038545203 scopus 로고    scopus 로고
    • Alterations in heme oxygenase/carbon monoxide system in pulmonary arteries in hypertension
    • Ndisang JF, Wang R. Alterations in heme oxygenase/carbon monoxide system in pulmonary arteries in hypertension. Exp Biol Med (Maywood) 2003; 228: 557-63.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 557-563
    • Ndisang, J.F.1    Wang, R.2
  • 70
    • 0038264420 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats
    • Ndisang JF, Wu L, Zhao W, Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 2003; 101: 3893-900.
    • (2003) Blood , vol.101 , pp. 3893-3900
    • Ndisang, J.F.1    Wu, L.2    Zhao, W.3    Wang, R.4
  • 71
    • 0036711791 scopus 로고    scopus 로고
    • Selective regulation of blood pressure by heme oxygenase-1 in hypertension
    • Ndisang JF, Zhao W, Wang R. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 2002; 40: 315-21.
    • (2002) Hypertension , vol.40 , pp. 315-321
    • Ndisang, J.F.1    Zhao, W.2    Wang, R.3
  • 73
    • 84881327164 scopus 로고    scopus 로고
    • Pathophysiology and therapeutics of cardiovascular disease in metabolic syndrome
    • Wang Y, Yu Q, Chen Y, Cao F. Pathophysiology and therapeutics of cardiovascular disease in metabolic syndrome. Curr Pharm Des 2013.
    • (2013) Curr Pharm Des
    • Wang, Y.1    Yu, Q.2    Chen, Y.3    Cao, F.4
  • 75
    • 84876921399 scopus 로고    scopus 로고
    • Biochemistry of adipose tissue: An endocrine organ
    • Coelho M, Oliveira T, Fernandes R. Biochemistry of adipose tissue: an endocrine organ. Arch Med Sci 2013; 9: 191-200.
    • (2013) Arch Med Sci , vol.9 , pp. 191-200
    • Coelho, M.1    Oliveira, T.2    Fernandes, R.3
  • 76
  • 77
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363-74.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 78
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 79
    • 0033073540 scopus 로고    scopus 로고
    • The role of TNF alpha in adipocyte metabolism
    • Sethi JK, Hotamisligil GS. The role of TNF alpha in adipocyte metabolism. Semin Cell Dev Biol 1999; 10: 19-29.
    • (1999) Semin Cell Dev Biol , vol.10 , pp. 19-29
    • Sethi, J.K.1    Hotamisligil, G.S.2
  • 80
    • 84867966112 scopus 로고    scopus 로고
    • Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective
    • Alam I, Ng TP, Larbi A. Does inflammation determine whether obesity is metabolically healthy or unhealthy? The aging perspective. Mediators Inflamm 2012; 2012: 456456.
    • (2012) Mediators Inflamm , vol.2012 , pp. 456456
    • Alam, I.1    Ng, T.P.2    Larbi, A.3
  • 81
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 82
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995; 95: 2111-9.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5    Simsolo, R.B.6
  • 83
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNF alpha by human muscle. Relationship to insulin resistance
    • Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest 1996; 97: 1111-6.
    • (1996) J Clin Invest , vol.97 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 85
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610-4.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 86
    • 84877004146 scopus 로고    scopus 로고
    • Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells
    • Arai S, Maehara N, Iwamura Y, et al. Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells. Cell Rep 2013; 3: 1187-98.
    • (2013) Cell Rep , vol.3 , pp. 1187-1198
    • Arai, S.1    Maehara, N.2    Iwamura, Y.3
  • 87
    • 70350708147 scopus 로고    scopus 로고
    • Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring
    • Sharkey D, Gardner DS, Symonds ME, Budge H. Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring. Am J Physiol Renal Physiol 2009; 297: F1199-207.
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Sharkey, D.1    Gardner, D.S.2    Symonds, M.E.3    Budge, H.4
  • 88
    • 79961151517 scopus 로고    scopus 로고
    • Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis
    • Scholtes VP, Versteeg D, de Vries JP, et al. Toll-like receptor 2 and 4 stimulation elicits an enhanced inflammatory response in human obese patients with atherosclerosis. Clin Sci (Lond) 2011; 121: 205-14.
    • (2011) Clin Sci (Lond) , vol.121 , pp. 205-214
    • Scholtes, V.P.1    Versteeg, D.2    de Vries, J.P.3
  • 89
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007; 132: 2169-80.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 90
    • 31044456529 scopus 로고    scopus 로고
    • CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    • Weisberg SP, Hunter D, Huber R, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 2006; 116: 115-24.
    • (2006) J Clin Invest , vol.116 , pp. 115-124
    • Weisberg, S.P.1    Hunter, D.2    Huber, R.3
  • 91
    • 84872130535 scopus 로고    scopus 로고
    • Anti-inflammatory therapy in chronic disease: Challenges and opportunities
    • Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 2013; 339: 166-72.
    • (2013) Science , vol.339 , pp. 166-172
    • Tabas, I.1    Glass, C.K.2
  • 92
    • 84869084160 scopus 로고    scopus 로고
    • Abdominal obesity and cardiovascular disease: Is inflammation the missing link?
    • Despres JP. Abdominal obesity and cardiovascular disease: is inflammation the missing link? Can J Cardiol 2012; 28: 642-52.
    • (2012) Can J Cardiol , vol.28 , pp. 642-652
    • Despres, J.P.1
  • 93
    • 0033386090 scopus 로고    scopus 로고
    • Inflammation markers and coronary heart disease
    • Tracy RP. Inflammation markers and coronary heart disease. Curr Opin Lipidol 1999; 10: 435-41.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 435-441
    • Tracy, R.P.1
  • 94
    • 2642535951 scopus 로고    scopus 로고
    • Inflammation as a cardiovascular risk factor
    • Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation 2004; 109: II2-10.
    • (2004) Circulation , vol.109
    • Willerson, J.T.1    Ridker, P.M.2
  • 95
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-74.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 96
    • 39649116931 scopus 로고    scopus 로고
    • Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: Implications for longevity
    • Ridker PM. Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity. Nutr Rev 2007; 65: S253-9.
    • (2007) Nutr Rev , vol.65
    • Ridker, P.M.1
  • 97
    • 84866051194 scopus 로고    scopus 로고
    • Heme oxygenase, inflammation, and fibrosis: The good, the bad, and the ugly?
    • Lundvig DM, Immenschuh S, Wagener FA. Heme oxygenase, inflammation, and fibrosis: the good, the bad, and the ugly? Front Pharmacol 2012; 3: 81.
    • (2012) Front Pharmacol , vol.3 , pp. 81
    • Lundvig, D.M.1    Immenschuh, S.2    Wagener, F.A.3
  • 98
    • 84865289995 scopus 로고    scopus 로고
    • Inflammation links excess fat to insulin resistance: The role of the interleukin-1 family
    • Tack CJ, Stienstra R, Joosten LA, Netea MG. Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family. Immunol Rev 2012; 249: 239-52.
    • (2012) Immunol Rev , vol.249 , pp. 239-252
    • Tack, C.J.1    Stienstra, R.2    Joosten, L.A.3    Netea, M.G.4
  • 99
    • 84866164347 scopus 로고    scopus 로고
    • Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: Benefits in type 2 diabetes mellitus
    • de Lemos ET, Oliveira J, Pinheiro JP, Reis F. Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus. Oxid Med Cell Longev 2012; 2012: 741545.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 741545
    • de Lemos, E.T.1    Oliveira, J.2    Pinheiro, J.P.3    Reis, F.4
  • 100
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesityassociated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, et al. Normalization of obesityassociated insulin resistance through immunotherapy. Nat Med 2009; 15: 921-9.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 102
    • 77952503211 scopus 로고    scopus 로고
    • Pathogenesis of insulin resistance in skeletal muscle
    • Abdul-Ghani MA, DeFronzo RA. Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol 2010; 2010: 476279.
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 476279
    • Abdul-Ghani, M.A.1    DeFronzo, R.A.2
  • 104
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008; 454: 428-35.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 105
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 106
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72: 219-46.
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 107
    • 58149102605 scopus 로고    scopus 로고
    • Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue
    • Ito A, Suganami T, Yamauchi A, et al. Role of CC chemokine receptor 2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 2008; 283: 35715-23.
    • (2008) J Biol Chem , vol.283 , pp. 35715-35723
    • Ito, A.1    Suganami, T.2    Yamauchi, A.3
  • 108
    • 72449150103 scopus 로고    scopus 로고
    • The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
    • Kolb H, Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 2010; 53: 10-20.
    • (2010) Diabetologia , vol.53 , pp. 10-20
    • Kolb, H.1    Mandrup-Poulsen, T.2
  • 109
    • 84866753143 scopus 로고    scopus 로고
    • Obesity: Lessons from evolution and the environment
    • Heitmann BL, Westerterp KR, Loos RJ, et al. Obesity: lessons from evolution and the environment. Obes Rev 2012; 13: 910-22.
    • (2012) Obes Rev , vol.13 , pp. 910-922
    • Heitmann, B.L.1    Westerterp, K.R.2    Loos, R.J.3
  • 111
    • 53349102382 scopus 로고    scopus 로고
    • Impaired glucose regulation and type 2 diabetes in children and adolescents
    • Kempf K, Rathmann W, Herder C. Impaired glucose regulation and type 2 diabetes in children and adolescents. Diabetes Metab Res Rev 2008; 24: 427-37.
    • (2008) Diabetes Metab Res Rev , vol.24 , pp. 427-437
    • Kempf, K.1    Rathmann, W.2    Herder, C.3
  • 113
    • 0030705157 scopus 로고    scopus 로고
    • Obesity and heart disease: A statement for healthcare professionals from the Nutrition Committee, American Heart Association
    • Eckel RH. Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1997; 96: 3248-50.
    • (1997) Circulation , vol.96 , pp. 3248-3250
    • Eckel, R.H.1
  • 114
    • 33644850953 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
    • Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2006; 113: 898-918.
    • (2006) Circulation , vol.113 , pp. 898-918
    • Poirier, P.1    Giles, T.D.2    Bray, G.A.3
  • 115
    • 24944563849 scopus 로고    scopus 로고
    • ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure)
    • Hunt SA. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). J Am Coll Cardiol 2005; 46: e1-82.
    • (2005) J Am Coll Cardiol , vol.46
    • Hunt, S.A.1
  • 116
    • 0017348197 scopus 로고
    • Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba Study
    • Rabkin SW, Mathewson FA, Hsu PH. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. Am J Cardiol 1977; 39: 452-8.
    • (1977) Am J Cardiol , vol.39 , pp. 452-458
    • Rabkin, S.W.1    Mathewson, F.A.2    Hsu, P.H.3
  • 117
    • 78650674441 scopus 로고    scopus 로고
    • Obesity is an independent risk factor for heart failure: Zona Franca Cohort study
    • Baena-Diez JM, Byram AO, Grau M, et al. Obesity is an independent risk factor for heart failure: Zona Franca Cohort study. Clin Cardiol 2010; 33: 760-4.
    • (2010) Clin Cardiol , vol.33 , pp. 760-764
    • Baena-Diez, J.M.1    Byram, A.O.2    Grau, M.3
  • 118
    • 68949149092 scopus 로고    scopus 로고
    • Role of obesity in cardiomyopathy and pulmonary hypertension
    • Dela Cruz CS, Matthay RA. Role of obesity in cardiomyopathy and pulmonary hypertension. Clin Chest Med 2009; 30: 509-23, ix.
    • (2009) Clin Chest Med , vol.30
    • Dela Cruz, C.S.1    Matthay, R.A.2
  • 119
    • 0020533259 scopus 로고
    • Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study
    • Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983; 67: 968-77.
    • (1983) Circulation , vol.67 , pp. 968-977
    • Hubert, H.B.1    Feinleib, M.2    McNamara, P.M.3    Castelli, W.P.4
  • 120
    • 0036681988 scopus 로고    scopus 로고
    • Obesity and the risk of heart failure
    • Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305-13.
    • (2002) N Engl J Med , vol.347 , pp. 305-313
    • Kenchaiah, S.1    Evans, J.C.2    Levy, D.3
  • 121
    • 65549109680 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss
    • Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009; 53: 1925-32.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1925-1932
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3
  • 122
    • 35348846641 scopus 로고    scopus 로고
    • Disparate effects of left ventricular geometry and obesity on mortality in patients with preserved left ventricular ejection fraction
    • Lavie CJ, Milani RV, Ventura HO, Cardenas GA, Mehra MR, Messerli FH. Disparate effects of left ventricular geometry and obesity on mortality in patients with preserved left ventricular ejection fraction. Am J Cardiol 2007; 100: 1460-4.
    • (2007) Am J Cardiol , vol.100 , pp. 1460-1464
    • Lavie, C.J.1    Milani, R.V.2    Ventura, H.O.3    Cardenas, G.A.4    Mehra, M.R.5    Messerli, F.H.6
  • 123
    • 0030854233 scopus 로고    scopus 로고
    • Effects of obesity and weight loss on left ventricular mass and relative wall thickness: Survey and intervention study
    • Karason K, Wallentin I, Larsson B, Sjostrom L. Effects of obesity and weight loss on left ventricular mass and relative wall thickness: survey and intervention study. BMJ 1997; 315: 912-6.
    • (1997) BMJ , vol.315 , pp. 912-916
    • Karason, K.1    Wallentin, I.2    Larsson, B.3    Sjostrom, L.4
  • 124
    • 0025084193 scopus 로고
    • Assessment of cardiac function in patients who were morbidly obese
    • discussion 818-20
    • Alaud-din A, Meterissian S, Lisbona R, MacLean LD, Forse RA. Assessment of cardiac function in patients who were morbidly obese. Surgery 1990; 108: 809-18; discussion 818-20.
    • (1990) Surgery , vol.108 , pp. 809-818
    • Alaud-din, A.1    Meterissian, S.2    Lisbona, R.3    McLean, L.D.4    Forse, R.A.5
  • 125
    • 0035064965 scopus 로고    scopus 로고
    • Obesity cardiomyopathy: Pathophysiology and evolution of the clinical syndrome
    • Alpert MA. Obesity cardiomyopathy: pathophysiology and evolution of the clinical syndrome. Am J Med Sci 2001; 321: 225-36.
    • (2001) Am J Med Sci , vol.321 , pp. 225-236
    • Alpert, M.A.1
  • 126
    • 0023584214 scopus 로고
    • Left atrial abnormalities indicating diastolic ventricular dysfunction in cardiopathy of obesity
    • Lavie CJ, Amodeo C, Ventura HO, Messerli FH. Left atrial abnormalities indicating diastolic ventricular dysfunction in cardiopathy of obesity. Chest 1987; 92: 1042-6.
    • (1987) Chest , vol.92 , pp. 1042-1046
    • Lavie, C.J.1    Amodeo, C.2    Ventura, H.O.3    Messerli, F.H.4
  • 127
    • 0034003574 scopus 로고    scopus 로고
    • Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulinresistant prediabetic stage of a type II diabetic rat model
    • Mizushige K, Yao L, Noma T, et al. Alteration in left ventricular diastolic filling and accumulation of myocardial collagen at insulinresistant prediabetic stage of a type II diabetic rat model. Circulation 2000; 101: 899-907.
    • (2000) Circulation , vol.101 , pp. 899-907
    • Mizushige, K.1    Yao, L.2    Noma, T.3
  • 128
    • 0020053498 scopus 로고
    • Cardiovascular effects of obesity and hypertension
    • Messerli FH. Cardiovascular effects of obesity and hypertension. Lancet 1982; 1: 1165-8.
    • (1982) Lancet , vol.1 , pp. 1165-1168
    • Messerli, F.H.1
  • 129
    • 0028799127 scopus 로고
    • Hypertension and left-ventricular hypertrophy
    • Messerli FH, Aepfelbacher FC. Hypertension and left-ventricular hypertrophy. Cardiol Clin 1995; 13: 549-57.
    • (1995) Cardiol Clin , vol.13 , pp. 549-557
    • Messerli, F.H.1    Aepfelbacher, F.C.2
  • 131
    • 34548034881 scopus 로고    scopus 로고
    • Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity
    • Malavazos AE, Ermetici F, Coman C, Corsi MM, Morricone L, Ambrosi B. Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity. Int J Cardiol 2007; 121: 132-4.
    • (2007) Int J Cardiol , vol.121 , pp. 132-134
    • Malavazos, A.E.1    Ermetici, F.2    Coman, C.3    Corsi, M.M.4    Morricone, L.5    Ambrosi, B.6
  • 132
    • 0028827534 scopus 로고
    • Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss
    • Alpert MA, Lambert CR, Panayiotou H, et al. Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss. Am J Cardiol 1995; 76: 1194-7.
    • (1995) Am J Cardiol , vol.76 , pp. 1194-1197
    • Alpert, M.A.1    Lambert, C.R.2    Panayiotou, H.3
  • 133
    • 0026451317 scopus 로고
    • Left ventricular function response to exercise in normotensive obese subjects: Influence of degree and duration of obesity
    • Licata G, Scaglione R, Paterna S, et al. Left ventricular function response to exercise in normotensive obese subjects: influence of degree and duration of obesity. Int J Cardiol 1992; 37: 223-30.
    • (1992) Int J Cardiol , vol.37 , pp. 223-230
    • Licata, G.1    Scaglione, R.2    Paterna, S.3
  • 134
    • 0019976011 scopus 로고
    • Borderline hypertension and obesity: Two prehypertensive states with elevated cardiac output
    • Messerli FH, Ventura HO, Reisin E, et al. Borderline hypertension and obesity: two prehypertensive states with elevated cardiac output. Circulation 1982; 66: 55-60.
    • (1982) Circulation , vol.66 , pp. 55-60
    • Messerli, F.H.1    Ventura, H.O.2    Reisin, E.3
  • 135
    • 77951912134 scopus 로고    scopus 로고
    • Establishment of a concept of visceral fat syndrome and discovery of adiponectin
    • Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci 2010; 86: 131-41.
    • (2010) Proc Jpn Acad Ser B Phys Biol Sci , vol.86 , pp. 131-141
    • Matsuzawa, Y.1
  • 136
    • 52949129178 scopus 로고    scopus 로고
    • Leptin resistance: A possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    • Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008; 52: 1201-10.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1201-1210
    • Martin, S.S.1    Qasim, A.2    Reilly, M.P.3
  • 137
    • 84865297442 scopus 로고    scopus 로고
    • The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
    • Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev 2012; 249: 218-38.
    • (2012) Immunol Rev , vol.249 , pp. 218-238
    • Johnson, A.R.1    Milner, J.J.2    Makowski, L.3
  • 140
    • 46649113125 scopus 로고    scopus 로고
    • Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population
    • Romero-Corral A, Sierra-Johnson J, Lopez-Jimenez F, et al. Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med 2008; 5: 418-25.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 418-425
    • Romero-Corral, A.1    Sierra-Johnson, J.2    Lopez-Jimenez, F.3
  • 141
    • 22944434929 scopus 로고    scopus 로고
    • Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
    • Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005; 436: 356-62.
    • (2005) Nature , vol.436 , pp. 356-362
    • Yang, Q.1    Graham, T.E.2    Mody, N.3
  • 142
    • 84655164778 scopus 로고    scopus 로고
    • Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance
    • Kalupahana NS, Massiera F, Quignard-Boulange A, et al. Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance. Obesity (Silver Spring) 2012; 20: 48-56.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 48-56
    • Kalupahana, N.S.1    Massiera, F.2    Quignard-Boulange, A.3
  • 143
    • 34547828786 scopus 로고    scopus 로고
    • Adiponectin is a novel humoral vasodilator
    • Fesus G, Dubrovska G, Gorzelniak K, et al. Adiponectin is a novel humoral vasodilator. Cardiovasc Res 2007; 75: 719-27.
    • (2007) Cardiovasc Res , vol.75 , pp. 719-727
    • Fesus, G.1    Dubrovska, G.2    Gorzelniak, K.3
  • 144
    • 33947627537 scopus 로고    scopus 로고
    • Adiponectin as an anti-inflammatory factor
    • Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007; 380: 24-30.
    • (2007) Clin Chim Acta , vol.380 , pp. 24-30
    • Ouchi, N.1    Walsh, K.2
  • 145
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941-6.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3
  • 146
    • 74249096153 scopus 로고    scopus 로고
    • Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway
    • Deng G, Long Y, Yu YR, Li MR. Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway. Int J Obes (Lond) 2010; 34: 165-71.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 165-171
    • Deng, G.1    Long, Y.2    Yu, Y.R.3    Li, M.R.4
  • 147
    • 33947220909 scopus 로고    scopus 로고
    • Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome
    • Yilmaz MI, Sonmez A, Caglar K, et al. Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome. Nephrology (Carlton) 2007; 12: 147-53.
    • (2007) Nephrology (Carlton) , vol.12 , pp. 147-153
    • Yilmaz, M.I.1    Sonmez, A.2    Caglar, K.3
  • 148
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 149
    • 24944454234 scopus 로고    scopus 로고
    • Release of Creactive protein in response to inflammatory cytokines by human adipocytes: Linking obesity to vascular inflammation
    • Calabro P, Chang DW, Willerson JT, Yeh ET. Release of Creactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol 2005; 46: 1112-3.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1112-1113
    • Calabro, P.1    Chang, D.W.2    Willerson, J.T.3    Yeh, E.T.4
  • 150
    • 34548402222 scopus 로고    scopus 로고
    • Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
    • Han CY, Subramanian S, Chan CK, et al. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 2007; 56: 2260-73.
    • (2007) Diabetes , vol.56 , pp. 2260-2273
    • Han, C.Y.1    Subramanian, S.2    Chan, C.K.3
  • 151
    • 33746494910 scopus 로고    scopus 로고
    • Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome
    • Mertens I, Verrijken A, Michiels JJ, et al. Among inflammation and coagulation markers, PAI-1 is a true component of the metabolic syndrome. Int J Obes (Lond) 2006; 30: 1308-14.
    • (2006) Int J Obes (Lond) , vol.30 , pp. 1308-1314
    • Mertens, I.1    Verrijken, A.2    Michiels, J.J.3
  • 152
    • 77953501949 scopus 로고    scopus 로고
    • Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: A review
    • Fain JN. Release of inflammatory mediators by human adipose tissue is enhanced in obesity and primarily by the nonfat cells: a review. Mediators Inflamm 2010; 2010: 513948.
    • (2010) Mediators Inflamm , vol.2010 , pp. 513948
    • Fain, J.N.1
  • 154
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003; 144: 5159-65.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 155
    • 12444318666 scopus 로고    scopus 로고
    • Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
    • Montani JP, Carroll JF, Dwyer TM, et al. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 2004; 28 Suppl 4: S58-65.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.SUPPL. 4
    • Montani, J.P.1    Carroll, J.F.2    Dwyer, T.M.3
  • 156
    • 84868529715 scopus 로고    scopus 로고
    • Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis
    • Yehuda-Shnaidman E, Schwartz B. Mechanisms linking obesity, inflammation and altered metabolism to colon carcinogenesis. Obes Rev 2012; 13: 1083-95.
    • (2012) Obes Rev , vol.13 , pp. 1083-1095
    • Yehuda-Shnaidman, E.1    Schwartz, B.2
  • 158
    • 84861096431 scopus 로고    scopus 로고
    • The link between the reninangiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome
    • Thethi T, Kamiyama M, Kobori H. The link between the reninangiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome. Curr Hypertens Rep 2012; 14: 160-9.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 160-169
    • Thethi, T.1    Kamiyama, M.2    Kobori, H.3
  • 159
    • 0037409237 scopus 로고    scopus 로고
    • The adipose-tissue reninangiotensin-aldosterone system: Role in the metabolic syndrome?
    • Engeli S, Schling P, Gorzelniak K, et al. The adipose-tissue reninangiotensin-aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol 2003; 35: 807-25.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 807-825
    • Engeli, S.1    Schling, P.2    Gorzelniak, K.3
  • 160
    • 0036252233 scopus 로고    scopus 로고
    • Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects
    • Giacchetti G, Faloia E, Mariniello B, et al. Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects. Am J Hypertens 2002; 15: 381-8.
    • (2002) Am J Hypertens , vol.15 , pp. 381-388
    • Giacchetti, G.1    Faloia, E.2    Mariniello, B.3
  • 161
    • 84865657612 scopus 로고    scopus 로고
    • Oxidative stress in the cardiorenal metabolic syndrome
    • Whaley-Connell A, Sowers JR. Oxidative stress in the cardiorenal metabolic syndrome. Curr Hypertens Rep 2012; 14: 360-5.
    • (2012) Curr Hypertens Rep , vol.14 , pp. 360-365
    • Whaley-Connell, A.1    Sowers, J.R.2
  • 163
    • 0026740639 scopus 로고
    • Tissue-specific nutritional regulation of angiotensinogen in adipose tissue
    • Frederich RC, Jr., Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension 1992; 19: 339-44.
    • (1992) Hypertension , vol.19 , pp. 339-344
    • Frederich Jr., R.C.1    Kahn, B.B.2    Peach, M.J.3    Flier, J.S.4
  • 166
    • 59849121325 scopus 로고    scopus 로고
    • Variety of angiotensin receptors in 3T3-L1 preadipose cells and differentiated adipocytes
    • Weiland F, Verspohl EJ. Variety of angiotensin receptors in 3T3-L1 preadipose cells and differentiated adipocytes. Horm Metab Res 2008; 40: 760-6.
    • (2008) Horm Metab Res , vol.40 , pp. 760-766
    • Weiland, F.1    Verspohl, E.J.2
  • 168
    • 17944364171 scopus 로고    scopus 로고
    • Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
    • Massiera F, Seydoux J, Geloen A, et al. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 2001; 142: 5220-5.
    • (2001) Endocrinology , vol.142 , pp. 5220-5225
    • Massiera, F.1    Seydoux, J.2    Geloen, A.3
  • 169
    • 15944377334 scopus 로고    scopus 로고
    • Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    • Yvan-Charvet L, Even P, Bloch-Faure M, et al. Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. Diabetes 2005; 54: 991-9.
    • (2005) Diabetes , vol.54 , pp. 991-999
    • Yvan-Charvet, L.1    Even, P.2    Bloch-Faure, M.3
  • 170
    • 23044505229 scopus 로고    scopus 로고
    • Attenuation of dietinduced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor
    • Kouyama R, Suganami T, Nishida J, et al. Attenuation of dietinduced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor. Endocrinology 2005; 146: 3481-9.
    • (2005) Endocrinology , vol.146 , pp. 3481-3489
    • Kouyama, R.1    Suganami, T.2    Nishida, J.3
  • 171
    • 84862518232 scopus 로고    scopus 로고
    • Obesity-related hypertension: Epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue
    • Aghamohammadzadeh R, Heagerty AM. Obesity-related hypertension: epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Ann Med 2012; 44 Suppl 1: S74-84.
    • (2012) Ann Med , vol.44 , Issue.SUPPL. 1
    • Aghamohammadzadeh, R.1    Heagerty, A.M.2
  • 173
    • 0028922422 scopus 로고
    • Nitric oxide: Pathophysiological mechanisms
    • Gross SS, Wolin MS. Nitric oxide: pathophysiological mechanisms. Annu Rev Physiol 1995; 57: 737-69.
    • (1995) Annu Rev Physiol , vol.57 , pp. 737-769
    • Gross, S.S.1    Wolin, M.S.2
  • 174
    • 19744362790 scopus 로고    scopus 로고
    • "Vasocrine" signalling from perivascular fat: A mechanism linking insulin resistance to vascular disease
    • Yudkin JS, Eringa E, Stehouwer CD. "Vasocrine" signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease. Lancet 2005; 365: 1817-20.
    • (2005) Lancet , vol.365 , pp. 1817-1820
    • Yudkin, J.S.1    Eringa, E.2    Stehouwer, C.D.3
  • 175
    • 84857699742 scopus 로고    scopus 로고
    • Endothelial cells and magnesium: Implications in atherosclerosis
    • Maier JA. Endothelial cells and magnesium: implications in atherosclerosis. Clin Sci (Lond) 2012; 122: 397-407.
    • (2012) Clin Sci (Lond) , vol.122 , pp. 397-407
    • Maier, J.A.1
  • 176
    • 65649110801 scopus 로고    scopus 로고
    • Endothelial dysfunction: The first step toward coronary arteriosclerosis
    • Vanhoutte PM. Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 2009; 73: 595-601.
    • (2009) Circ J , vol.73 , pp. 595-601
    • Vanhoutte, P.M.1
  • 177
    • 84943010192 scopus 로고    scopus 로고
    • Obesity and chronic kidney disease
    • Kopple JD. Obesity and chronic kidney disease. J Ren Nutr 2010; 20: S29-30.
    • (2010) J Ren Nutr , vol.20
    • Kopple, J.D.1
  • 181
    • 0035047374 scopus 로고    scopus 로고
    • Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents
    • Adelman RD, Restaino IG, Alon US, Blowey DL. Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents. J Pediatr 2001; 138: 481-5.
    • (2001) J Pediatr , vol.138 , pp. 481-485
    • Adelman, R.D.1    Restaino, I.G.2    Alon, U.S.3    Blowey, D.L.4
  • 182
    • 5444272878 scopus 로고    scopus 로고
    • NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy
    • Mezzano S, Aros C, Droguett A, et al. NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy. Nephrol Dial Transplant 2004; 19: 2505-12.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 2505-2512
    • Mezzano, S.1    Aros, C.2    Droguett, A.3
  • 183
    • 37349101990 scopus 로고    scopus 로고
    • Obesity, diabetes, and chronic kidney disease
    • Eknoyan G. Obesity, diabetes, and chronic kidney disease. Curr Diab Rep 2007; 7: 449-53.
    • (2007) Curr Diab Rep , vol.7 , pp. 449-453
    • Eknoyan, G.1
  • 184
    • 52449100587 scopus 로고    scopus 로고
    • Trends in obesity and abdominal obesity among hypertensive and nonhypertensive adults in the United States
    • Ford ES, Zhao G, Li C, Pearson WS, Mokdad AH. Trends in obesity and abdominal obesity among hypertensive and nonhypertensive adults in the United States. Am J Hypertens 2008; 21: 1124-8.
    • (2008) Am J Hypertens , vol.21 , pp. 1124-1128
    • Ford, E.S.1    Zhao, G.2    Li, C.3    Pearson, W.S.4    Mokdad, A.H.5
  • 185
    • 0030923725 scopus 로고    scopus 로고
    • Mechanisms of abnormal renal sodium handling in obesity hypertension
    • Hall JE. Mechanisms of abnormal renal sodium handling in obesity hypertension. Am J Hypertens 1997; 10: 49S-55S.
    • (1997) Am J Hypertens , vol.10
    • Hall, J.E.1
  • 186
    • 84865593922 scopus 로고    scopus 로고
    • Pathophysiology of obesityrelated renal dysfunction contributes to diabetic nephropathy
    • Bayliss G, Weinrauch LA, D'Elia JA. Pathophysiology of obesityrelated renal dysfunction contributes to diabetic nephropathy. Curr Diab Rep 2012; 12: 440-6.
    • (2012) Curr Diab Rep , vol.12 , pp. 440-446
    • Bayliss, G.1    Weinrauch, L.A.2    D'Elia, J.A.3
  • 187
    • 0036311357 scopus 로고    scopus 로고
    • Prevention of obesity-linked renal disease: Age-dependent effects of dietary food restriction
    • Maddox DA, Alavi FK, Santella RN, Zawada ET, Jr. Prevention of obesity-linked renal disease: age-dependent effects of dietary food restriction. Kidney Int 2002; 62: 208-19.
    • (2002) Kidney Int , vol.62 , pp. 208-219
    • Maddox, D.A.1    Alavi, F.K.2    Santella, R.N.3    Zawada Jr., E.T.4
  • 188
    • 56749183891 scopus 로고    scopus 로고
    • Obesity-induced glomerular hyperfiltration: Its involvement in the pathogenesis of tubular sodium reabsorption
    • Chagnac A, Herman M, Zingerman B, et al. Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption. Nephrol Dial Transplant 2008; 23: 3946-52.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3946-3952
    • Chagnac, A.1    Herman, M.2    Zingerman, B.3
  • 189
    • 14644395574 scopus 로고    scopus 로고
    • Weight loss and the reninangiotensin-aldosterone system
    • Engeli S, Bohnke J, Gorzelniak K, et al. Weight loss and the reninangiotensin-aldosterone system. Hypertension 2005; 45: 356-62.
    • (2005) Hypertension , vol.45 , pp. 356-362
    • Engeli, S.1    Bohnke, J.2    Gorzelniak, K.3
  • 190
    • 0037309569 scopus 로고    scopus 로고
    • Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies
    • Morales E, Valero MA, Leon M, Hernandez E, Praga M. Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis 2003; 41: 319-27.
    • (2003) Am J Kidney Dis , vol.41 , pp. 319-327
    • Morales, E.1    Valero, M.A.2    Leon, M.3    Hernandez, E.4    Praga, M.5
  • 191
    • 0036736073 scopus 로고    scopus 로고
    • Pathways from obesity to hypertension: From the perspective of a vicious triangle
    • Montani JP, Antic V, Yang Z, Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int J Obes Relat Metab Disord 2002; 26 Suppl 2: S28-38.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.SUPPL. 2
    • Montani, J.P.1    Antic, V.2    Yang, Z.3    Dulloo, A.4
  • 192
    • 0842309858 scopus 로고    scopus 로고
    • Is obesity a major cause of chronic kidney disease?
    • Hall JE, Henegar JR, Dwyer TM, et al. Is obesity a major cause of chronic kidney disease? Adv Ren Replace Ther 2004; 11: 41-54.
    • (2004) Adv Ren Replace Ther , vol.11 , pp. 41-54
    • Hall, J.E.1    Henegar, J.R.2    Dwyer, T.M.3
  • 193
    • 33644987045 scopus 로고    scopus 로고
    • Effects of aldosterone on the vasculature
    • Schiffrin EL. Effects of aldosterone on the vasculature. Hypertension 2006; 47: 312-8.
    • (2006) Hypertension , vol.47 , pp. 312-318
    • Schiffrin, E.L.1
  • 194
    • 38549092093 scopus 로고    scopus 로고
    • Aldosterone and vascular inflammation
    • Brown NJ. Aldosterone and vascular inflammation. Hypertension 2008; 51: 161-7.
    • (2008) Hypertension , vol.51 , pp. 161-167
    • Brown, N.J.1
  • 195
    • 59849103396 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation
    • Wei Y, Whaley-Connell AT, Habibi J, et al. Mineralocorticoid receptor antagonism attenuates vascular apoptosis and injury via rescuing protein kinase B activation. Hypertension 2009; 53: 158-65.
    • (2009) Hypertension , vol.53 , pp. 158-165
    • Wei, Y.1    Whaley-Connell, A.T.2    Habibi, J.3
  • 196
    • 34547136451 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade attenuates chronic overexpression of the reninangiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling
    • Stas S, Whaley-Connell A, Habibi J, et al. Mineralocorticoid receptor blockade attenuates chronic overexpression of the reninangiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling. Endocrinology 2007; 148: 3773-80.
    • (2007) Endocrinology , vol.148 , pp. 3773-3780
    • Stas, S.1    Whaley-Connell, A.2    Habibi, J.3
  • 197
    • 66049141708 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat
    • Whaley-Connell A, Habibi J, Wei Y, et al. Mineralocorticoid receptor antagonism attenuates glomerular filtration barrier remodeling in the transgenic Ren2 rat. Am J Physiol Renal Physiol 2009; 296: F1013-22.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Whaley-Connell, A.1    Habibi, J.2    Wei, Y.3
  • 198
    • 18644377454 scopus 로고    scopus 로고
    • Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage
    • Kamijo A, Kimura K, Sugaya T, et al. Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int 2002; 62: 1628-37.
    • (2002) Kidney Int , vol.62 , pp. 1628-1637
    • Kamijo, A.1    Kimura, K.2    Sugaya, T.3
  • 199
    • 33845546137 scopus 로고    scopus 로고
    • Non-esterified fatty acids and blood pressure elevation: A mechanism for hypertension in subjects with obesity/insulin resistance?
    • Sarafidis PA, Bakris GL. Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance? J Hum Hypertens 2007; 21: 12-9.
    • (2007) J Hum Hypertens , vol.21 , pp. 12-19
    • Sarafidis, P.A.1    Bakris, G.L.2
  • 200
    • 56149100684 scopus 로고    scopus 로고
    • Obesity, insulin resistance and kidney disease risk: Insights into the relationship
    • Sarafidis PA. Obesity, insulin resistance and kidney disease risk: insights into the relationship. Curr Opin Nephrol Hypertens 2008; 17: 450-6.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 450-456
    • Sarafidis, P.A.1
  • 201
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003; 112: 1785-8.
    • (2003) J Clin Invest , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 202
    • 84871090162 scopus 로고    scopus 로고
    • Global obesity: Trends, risk factors and policy implications
    • Malik VS, Willett WC, Hu FB. Global obesity: trends, risk factors and policy implications. Nat Rev Endocrinol 2013; 9: 13-27.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 13-27
    • Malik, V.S.1    Willett, W.C.2    Hu, F.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.