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Volumn 296, Issue 4, 2009, Pages

Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes

Author keywords

Activating protein 1; Adiponectin; c Jun NH2 terminal kinase; Glucose transporter 4; Insulin resistance; Nuclear factor B; Oxidative stress; Type 1 diabetes

Indexed keywords

8 ISOPROSTANE; ADENYLATE KINASE; ADIPONECTIN; BILIRUBIN; CHROMIUM MESOPORPHYRIN; CYCLIC GMP; FERRITIN; GLUCOSE; HEME OXYGENASE; HEME OXYGENASE 1; HEMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MESOPORPHYRIN; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; SYNAPSIN I; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; STREPTOZOCIN;

EID: 65649110522     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90783.2008     Document Type: Article
Times cited : (77)

References (64)
  • 1
    • 19544370917 scopus 로고    scopus 로고
    • Heme oxygenase and the cardiovascular-renal system
    • DOI 10.1016/j.freeradbiomed.2005.03.010, PII S0891584905001309
    • Abraham NG, Kappas A. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med 39: 1-25, 2005. (Pubitemid 40733115)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.1 , pp. 1-25
    • Abraham, N.G.1    Kappas, A.2
  • 3
    • 0028039868 scopus 로고
    • Isolation and characterization of the mouse heme oxygenase-1 gene: Distal 5′ sequences are required for induction by heme or heavy metals
    • Alam J, Cai J, Smith A. Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals. J Biol Chem 269: 1001-1009, 1994. (Pubitemid 24981976)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.2 , pp. 1001-1009
    • Alam, J.1    Cai, J.2    Smith, A.3
  • 4
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • Anonymous. The Diabetes Control and Complications Trial Research Group
    • Anonymous. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med 329: 977-986, 1993.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 5
    • 24144432114 scopus 로고    scopus 로고
    • Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: The CUPRAC method
    • DOI 10.1080/10715760500210145
    • Apak R, Guclu K, Ozyurek M, Karademir SE, Altun M. Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: the CUPRAC method. Free Radic Res 39: 949-961, 2005. (Pubitemid 41227031)
    • (2005) Free Radical Research , vol.39 , Issue.9 , pp. 949-961
    • Apak, R.1    Guclu, K.2    Ozyurek, M.3    Esin Karademir, S.4    Altun, M.5
  • 8
    • 0041302157 scopus 로고    scopus 로고
    • JNK: A new therapeutic target for diabetes
    • DOI 10.1016/S1471-4892(03)00068-7, PII S1471489203000687
    • Bennett BL, Satoh Y, Lewis AJ. JNK: a new therapeutic target for diabetes. Curr Opin Pharmacol 3: 420-425, 2003. (Pubitemid 36908946)
    • (2003) Current Opinion in Pharmacology , vol.3 , Issue.4 , pp. 420-425
    • Bennett, B.L.1    Satoh, Y.2    Lewis, A.J.3
  • 9
    • 0042822096 scopus 로고    scopus 로고
    • Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism
    • Bruce CR, Carey AL, Hawley JA, Febbraio MA. Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism. Diabetes 52: 2338-2345, 2003.
    • (2003) Diabetes , vol.52 , pp. 2338-2345
    • Bruce, C.R.1    Carey, A.L.2    Hawley, J.A.3    Febbraio, M.A.4
  • 10
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • DOI 10.1038/35065000
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 410: 37-40, 2001. (Pubitemid 32225829)
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 13
    • 0345861893 scopus 로고    scopus 로고
    • Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart
    • DOI 10.1016/j.cardiores.2003.11.021
    • Desrois M, Sidell RJ, Gauguier D, King LM, Radda GK, Clarke K. Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart. Cardiovasc Res 61: 288-296, 2004. (Pubitemid 38091769)
    • (2004) Cardiovascular Research , vol.61 , Issue.2 , pp. 288-296
    • Desrois, M.1    Sidell, R.J.2    Gauguier, D.3    King, L.M.4    Radda, G.K.5    Clarke, K.6
  • 16
    • 33646594112 scopus 로고    scopus 로고
    • Insights from the diabetes control and complications trial/ epidemiology of diabetes interventions and complications study on the use of intensive glycemic treatment to reduce the risk of complications of type 1 diabetes
    • Genuth S. Insights from the diabetes control and complications trial/ epidemiology of diabetes interventions and complications study on the use of intensive glycemic treatment to reduce the risk of complications of type 1 diabetes. Endocr Pract 12, Suppl 1: 34-41, 2006.
    • (2006) Endocr Pract , vol.12 , Issue.SUPPL. 1 , pp. 34-41
    • Genuth, S.1
  • 17
    • 34548603601 scopus 로고    scopus 로고
    • Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats
    • DOI 10.1016/j.metabol.2007.05.005, PII S0026049507001953
    • Guo Z, Xia Z, Yuen VG, McNeill JH. Cardiac expression of adiponectin and its receptors in streptozotocin-induced diabetic rats. Metabolism 56: 1363-1371, 2007. (Pubitemid 47404598)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.10 , pp. 1363-1371
    • Guo, Z.1    Xia, Z.2    Yuen, V.G.3    McNeill, J.H.4
  • 18
    • 27544513825 scopus 로고    scopus 로고
    • Adiponectin and its potential in the treatment of obesity, diabetes and insulin resistance
    • Haluzik M. Adiponectin and its potential in the treatment of obesity, diabetes and insulin resistance. Curr Opin Investig Drugs 6: 988-993, 2005. (Pubitemid 41535782)
    • (2005) Current Opinion in Investigational Drugs , vol.6 , Issue.10 , pp. 988-993
    • Haluzik, M.1
  • 19
    • 0032961802 scopus 로고    scopus 로고
    • Heme oxygenase and carbon monoxide: Regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study
    • DOI 10.2337/diabetes.48.1.66
    • Henningsson R, Alm P, Ekstrom P, Lundquist I. Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study. Diabetes 48: 66-76, 1999. (Pubitemid 29019354)
    • (1999) Diabetes , vol.48 , Issue.1 , pp. 66-76
    • Henningsson, R.1    Alm, P.2    Ekstrom, P.3    Lundquist, I.4
  • 20
    • 0030833313 scopus 로고    scopus 로고
    • Occurrence and putative hormone regulatory function of a constitutive heme oxygenase in rat pancreatic islets
    • Henningsson R, Alm P, Lundquist I. Occurrence and putative hormone regulatory function of a constitutive heme oxygenase in rat pancreatic islets. Am J Physiol Cell Physiol 273: C703-C709, 1997. (Pubitemid 27396164)
    • (1997) American Journal of Physiology - Cell Physiology , vol.273 , Issue.2
    • Henningsson, R.1    Alm, P.2    Lundquist, I.3
  • 21
    • 27244457379 scopus 로고    scopus 로고
    • DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression
    • Hintze KJ, Theil EC. DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression. Proc Natl Acad Sci USA 102: 15048-15052, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15048-15052
    • Hintze, K.J.1    Theil, E.C.2
  • 22
  • 23
    • 55949136575 scopus 로고    scopus 로고
    • Interaction among heme oxygenase, nuclear factor-kappaB, and transcription activating factors in cardiac hypertrophy in hypertension
    • Jadhav A, Torlakovic E, Ndisang JF. Interaction among heme oxygenase, nuclear factor-kappaB, and transcription activating factors in cardiac hypertrophy in hypertension. Hypertension 52: 910-917, 2008.
    • (2008) Hypertension , vol.52 , pp. 910-917
    • Jadhav, A.1    Torlakovic, E.2    Ndisang, J.F.3
  • 25
    • 0141483051 scopus 로고    scopus 로고
    • Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP
    • DOI 10.1007/s00125-003-1174-9
    • Jonas JC, Guiot Y, Rahier J, Henquin JC. Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP. Diabetologia 46: 1234-1244, 2003. (Pubitemid 37214981)
    • (2003) Diabetologia , vol.46 , Issue.9 , pp. 1234-1244
    • Jonas, J.C.1    Guiot, Y.2    Rahier, J.3    Henquin, J.C.4
  • 28
    • 33644845569 scopus 로고    scopus 로고
    • Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic β-cell dysfunction and insulin resistance
    • DOI 10.1016/j.biocel.2006.01.004, PII S1357272506000252, Diabetes: New Research and Novel Therapies
    • Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M, Yamasaki Y. Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. Int J Biochem Cell Biol 38: 782-793, 2006. (Pubitemid 43363411)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.5-6 , pp. 782-793
    • Kaneto, H.1    Nakatani, Y.2    Kawamori, D.3    Miyatsuka, T.4    Matsuoka, T.-A.5    Matsuhisa, M.6    Yamasaki, Y.7
  • 29
    • 0024497521 scopus 로고
    • Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
    • Keyse SM, Tyrrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci USA 86: 99-103, 1989.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 99-103
    • Keyse, S.M.1    Tyrrell, R.M.2
  • 30
    • 44249095590 scopus 로고    scopus 로고
    • Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells
    • Kim DH, Burgess AP, Li M, Tsenovoy PL, Addabbo F, McClung JA, Puri N, Abraham NG. Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther 325: 833-840, 2008.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 833-840
    • Kim, D.H.1    Burgess, A.P.2    Li, M.3    Tsenovoy, P.L.4    Addabbo, F.5    McClung, J.A.6    Puri, N.7    Abraham, N.G.8
  • 34
    • 45249089262 scopus 로고    scopus 로고
    • Oxidative stress: The vulnerable beta-cell
    • Lenzen S. Oxidative stress: the vulnerable beta-cell. Biochem Soc Trans 36: 343-347, 2008.
    • (2008) Biochem Soc Trans , vol.36 , pp. 343-347
    • Lenzen, S.1
  • 35
    • 41149155892 scopus 로고    scopus 로고
    • Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    • Li M, Kim DH, Tsenovoy PL, Peterson SJ, Rezzani R, Rodella LF, Aronow WS, Ikehara S, Abraham NG. Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 57: 1526-1535, 2008.
    • (2008) Diabetes , vol.57 , pp. 1526-1535
    • Li, M.1    Kim, D.H.2    Tsenovoy, P.L.3    Peterson, S.J.4    Rezzani, R.5    Rodella, L.F.6    Aronow, W.S.7    Ikehara, S.8    Abraham, N.G.9
  • 37
    • 51349085477 scopus 로고    scopus 로고
    • Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice
    • Liu Y, Nakagawa Y, Wang Y, Liu L, Du H, Wang W, Ren X, Lutfy K, Friedman T. Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice. J Mol Endocrinol 41: 53-64, 2008.
    • (2008) J Mol Endocrinol , vol.41 , pp. 53-64
    • Liu, Y.1    Nakagawa, Y.2    Wang, Y.3    Liu, L.4    Du, H.5    Wang, W.6    Ren, X.7    Lutfy, K.8    Friedman, T.9
  • 39
    • 4844229186 scopus 로고    scopus 로고
    • The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro
    • Mabley JG, Southan GJ, Salzman AL, Szabo C. The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1beta-induced suppression of islet insulin secretion in vitro. Pancreas 28: E39-E44, 2004.
    • (2004) Pancreas , vol.28
    • Mabley, J.G.1    Southan, G.J.2    Salzman, A.L.3    Szabo, C.4
  • 40
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 41
    • 14244268391 scopus 로고    scopus 로고
    • Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway
    • DOI 10.1210/en.2004-0851
    • Mosen H, Salehi A, Alm P, Henningsson R, Jimenez-Feltstrom J, Ostenson CG, Efendic S, Lundquist I. Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 146: 1553-1558, 2005. (Pubitemid 40289346)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1553-1558
    • Mosen, H.1    Salehi, A.2    Alm, P.3    Henningsson, R.4    Jimenez-Feltstrom, J.5    Ostenson, C.-G.6    Efendic, S.7    Lundquist, I.8
  • 42
    • 33749861323 scopus 로고    scopus 로고
    • Nitric oxide inhibits, and carbon monoxide activates, islets acid α-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion
    • DOI 10.1677/joe.1.06890
    • Mosen H, Salehi A, Henningsson R, Lundquist I. Nitric oxide inhibits, and carbon monoxide activates, islet acid alpha-glucoside hydrolase activities in parallel with glucose-stimulated insulin secretion. J Endocrinol 190: 681-693, 2006. (Pubitemid 44560243)
    • (2006) Journal of Endocrinology , vol.190 , Issue.3 , pp. 681-693
    • Mosen, H.1    Salehi, A.2    Henningsson, R.3    Lundquist, I.4
  • 43
    • 43949106899 scopus 로고    scopus 로고
    • Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension
    • Ndisang JF, Lane N, Jadhav A. Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension. J Hypertens 26: 1188-1199, 2008.
    • (2008) J Hypertens , vol.26 , pp. 1188-1199
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 44
    • 2642537616 scopus 로고    scopus 로고
    • Carbon monoxide and hypertension
    • DOI 10.1097/00004872-200406000-00002
    • Ndisang JF, Tabien HE, Wang R. Carbon monoxide and hypertension. J Hypertens 22: 1057-1074, 2004. (Pubitemid 38720993)
    • (2004) Journal of Hypertension , vol.22 , Issue.6 , pp. 1057-1074
    • Ndisang, J.F.1    Tabien, H.E.N.2    Wang, R.3
  • 45
    • 0038264420 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats
    • DOI 10.1182/blood-2002-08-2608
    • Ndisang JF, Wu L, Zhao W, Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101: 3893-3900, 2003. (Pubitemid 36857864)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3893-3900
    • Ndisang, J.F.1    Wu, L.2    Zhao, W.3    Wang, R.4
  • 46
    • 0036711791 scopus 로고    scopus 로고
    • Selective regulation of blood pressure by heme oxygenase-1 in hypertension
    • Ndisang JF, Zhao W, Wang R. Selective regulation of blood pressure by heme oxygenase-1 in hypertension. Hypertension 40: 315-321, 2002.
    • (2002) Hypertension , vol.40 , pp. 315-321
    • Ndisang, J.F.1    Zhao, W.2    Wang, R.3
  • 47
    • 33646393498 scopus 로고    scopus 로고
    • Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake
    • Nkabyo YS, Gu LH, Jones DP, Ziegler TR. Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr 136: 1242-1248, 2006.
    • (2006) J Nutr , vol.136 , pp. 1242-1248
    • Nkabyo, Y.S.1    Gu, L.H.2    Jones, D.P.3    Ziegler, T.R.4
  • 49
    • 33747051446 scopus 로고    scopus 로고
    • Targeting postprandial hyperglycemia
    • DOI 10.1016/j.metabol.2006.05.012, PII S002604950600179X
    • Rendell MS, Jovanovic L. Targeting postprandial hyperglycemia. Metabolism 55: 1263-1281, 2006. (Pubitemid 44215947)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.9 , pp. 1263-1281
    • Rendell, M.S.1    Jovanovic, L.2
  • 50
    • 0842284799 scopus 로고    scopus 로고
    • β-Cell Glucose Toxicity, Lipotoxicity, and Chronic Oxidative Stress in Type 2 Diabetes
    • Robertson RP, Harmon J, Tran PO, Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53, Suppl 1: S119-S124, 2004. (Pubitemid 38168703)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.T.3    Poitout, V.4
  • 51
    • 33746138114 scopus 로고    scopus 로고
    • Heme arginate pretreatment attenuates pulmonary NF-κB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction
    • DOI 10.1263/jbb.101.271
    • Sasaki T, Takahashi T, Maeshima K, Shimizu H, Toda Y, Morimatsu H, Takeuchi M, Yokoyama M, Akagi R, Morita K. Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction. Med Chem 2: 271-274, 2006. (Pubitemid 44083145)
    • (2006) Medicinal Chemistry , vol.2 , Issue.3 , pp. 271-274
    • Sasaki, T.1    Takahashi, T.2    Shimizu, H.3    Toda, Y.4    Morimatsu, H.5    Takeuchi, M.6    Yokoyama, M.7    Akagi, R.8    Morita, K.9
  • 52
    • 0842277726 scopus 로고    scopus 로고
    • Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats
    • DOI 10.1016/j.expneurol.2003.08.015
    • Shoham S, Bejar C, Kovalev E, Weinstock M. Intracerebroventricular injection of streptozotocin causes neurotoxicity to myelin that contributes to spatial memory deficits in rats. Exp Neurol 184: 1043-1052, 2003. (Pubitemid 38182835)
    • (2003) Experimental Neurology , vol.184 , Issue.2 , pp. 1043-1052
    • Shoham, S.1    Bejar, C.2    Kovalev, E.3    Weinstock, M.4
  • 54
    • 34848892187 scopus 로고    scopus 로고
    • Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    • DOI 10.1161/CIRCULATIONAHA.107.716498
    • Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation 116: 1585-1595, 2007. (Pubitemid 47511422)
    • (2007) Circulation , vol.116 , Issue.14 , pp. 1585-1595
    • Song, P.1    Wu, Y.2    Xu, J.3    Xie, Z.4    Dong, Y.5    Zhang, M.6    Zou, M.-H.7
  • 55
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 235: 1043-1046, 1987. (Pubitemid 17049750)
    • (1987) Science , vol.235 , Issue.4792 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3
  • 56
    • 35748977935 scopus 로고    scopus 로고
    • Evidence for a role of superoxide generation in glucose-induced β-cell dysfunction in vivo
    • DOI 10.2337/db07-0279
    • Tang C, Han P, Oprescu AI, Lee SC, Gyulkhandanyan AV, Chan GN, Wheeler MB, Giacca A. Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes 56: 2722-2731, 2007. (Pubitemid 350044915)
    • (2007) Diabetes , vol.56 , Issue.11 , pp. 2722-2731
    • Tang, C.1    Han, P.2    Oprescu, A.I.3    Lee, S.C.4    Gyulkhandanyan, A.V.5    Chan, G.N.Y.6    Wheeler, M.B.7    Giacca, A.8
  • 60
    • 0027407240 scopus 로고
    • Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity
    • Vreman HJ, Ekstrand BC, Stevenson DK. Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Pediatr Res 33: 195-200, 1993.
    • (1993) Pediatr Res , vol.33 , pp. 195-200
    • Vreman, H.J.1    Ekstrand, B.C.2    Stevenson, D.K.3
  • 61
    • 38949093861 scopus 로고    scopus 로고
    • Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase
    • Wei Y, Sowers JR, Clark SE, Li W, Ferrario CM, Stump CS. Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-kappaB activation via NADPH oxidase. Am J Physiol Endocrinol Metab 294: E345-E351, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Wei, Y.1    Sowers, J.R.2    Clark, S.E.3    Li, W.4    Ferrario, C.M.5    Stump, C.S.6
  • 63
    • 15644379473 scopus 로고    scopus 로고
    • A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1beta
    • Ye J, Laychock SG. A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1beta. Endocrinology 139: 4155-4163, 1998.
    • (1998) Endocrinology , vol.139 , pp. 4155-4163
    • Ye, J.1    Laychock, S.G.2


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