NF-κB activation and overexpression of regulated genes in human diabetic nephropathy

Nephrology Dialysis Transplantation

Volumn 19, Issue 10, 2004, Pages 2505-2512

  Mezzano, Sergio ^a   Aros, Claudio ^a   Droguett, Alejandra ^a   Burgos, M Eugenia ^a   Ardiles, Leopoldo ^a   Flores, Claudio ^a   Schneider, Herman ^a   Ruiz Ortega, Marta ^b   Egido, Jesús ^b  

^a UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Diabetic nephropathy; MCP 1; NF B; RANTES; Renal disease progression

Indexed keywords

ANGIOTENSIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P50; RANTES; SYNAPTOTAGMIN; BIOLOGICAL MARKER; CCL2 PROTEIN, HUMAN; MESSENGER RNA; TRANSCRIPTION FACTOR RELA;

ADULT; AGED; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETIC NEPHROPATHY; DISEASE COURSE; EPITHELIUM CELL; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GLOMERULUS; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; INFLAMMATION; KIDNEY BIOPSY; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY TUBULE CELL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; PROTEINURIA; TISSUE SECTION; UPREGULATION; GENE EXPRESSION; GENETICS; KIDNEY; METABOLISM; MIDDLE AGED; PATHOLOGY;

ADULT; BIOLOGICAL MARKERS; CHEMOKINE CCL2; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATION; KIDNEY; MALE; MIDDLE AGED; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; RANTES; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; UP-REGULATION;

EID: 5444272878     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh207     Document Type: Article

References (22)

1. Barnes PJ, Karin M. Nuclear factor-κB. A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336: 1066-1071
2. Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol 1997; 9: 240-246
3. Guijarro C, Egido J. Transcription factor κB (NF-κB) in renal disease. Kidney Int 2001; 59: 415-424
4. Wang Y, Rangan GK, Tay Y-C, Wang Y, Harris DC. Induction of monocyte chemoattractant protein-1 by albumin is mediated by nuclear factor κB in proximal tubule cells. J Am Soc Nephrol 1999; 10: 1204-1213
5. Zoja C, Donadelli R, Colleoni S, et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-κB activation. Kidney Int 1998; 53: 1608-1615
6. Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y, Kasai K. Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int 2000; 58: 684-690
7. Gomez-Garre D, Largo R, Tejera N, Fortes J, Manzarbeitia F, Egido J. Activation of nuclear factor κB in tubular epithelial cells of rats with intense proteinuria. Role of angiotensin II and endothelin-1. Hypertension 2001; 37: 1171-1178
8. Mezzano S, Barria M, Droguett A et al. Tubular NF-κB and AP-1 activation in human proteinuric renal disease. Kidney Int 2001; 60: 1366-1377
9. Ruiz-Ortega M, Lorenzo O, Ruperez M, Blanco J, Egido J. Systemic infusion of angiotensin II into normal rats activates nuclear factor κB and AP-1 in the kidney. Role of AT1 and AT2 receptors. Am J Pathol 2001; 158: 1743-1756
10. Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Mezzano S, Egido J. Renin-angiotensin system and renal damage: emerging data on angiotensin II as a proinflammatory mediator Contrib Nephrol 2001; 135: 123-137
11. Cao Z, Cooper ME. Role of angiotensin II in tubulointerstitial injury. Semin Nephrol 2001; 21: 554-562
12. Mezzano S, Droguett MA, Burgos ME et al. Overexpression of chemokines, fibrogenic cytokines, and myofibroblasts in human membranous nephropathy. Kidney Int 2000; 57: 147-158
13. Kato S, Luyckx VA, Ots M et al. Renin -angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int 1999; 56: 1037-1048
14. Iwamoto M, Mizuiri S, Tanimoto H et al. Nuclear factor-κB activation in streptozotocin induced diabetic rats kidneys. J Am Soc Nephrol 2001; 12: 838a.
15. Lal M, Brismar H, Eklof AC, Aperia A. Advanced glycation endproducts induce oxidative stress and activate NF-κB, PKC-β 1, and TGF-β1 in mesangial cells. J Am Soc Nephrol 2001;12: 840a.
16. Hofmann MA, Schiekofer S, Kanitz M et al. Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. Diabetes Care 1998; 21: 1310-1316
17. Mohamed AK, Bierhaus A, Schiekofer S, Tritschler H, Ziegler R, Nawroth PP. The role of oxidative stress and NF-kappa B activation in late diabetic complications. Biofactors 1999; 10: 157-167
18. Duque N, Gomez-Guerrero C, Egido J. Interaction of IgA with Fcα receptors of human mesangial cells activates transcription factor nuclear factor-κ and induces expression and synthesis of monocyte chemoattractant protein-1. IL-8, and IFN-inducible protein-10. J Immunol 1997; 159: 3474-3482
19. Lynn EG, Siow YL, Frohlich J, Cheung GTY, OK. Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-κB. Kidney Int 2001; 60: 520-532
20. Abbate M, Zoja C, Corna D, Capitanio M, Bertani T, Remuzzi G. In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J Am Soc Nephrol 1998; 9: 1213-1224
21. Largo R, Gomez-Garre D, Soto K et al. Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria. Hypertension 1999; 33: 732-739
22. 2 through a PKC-dependent pathway. J Am Soc Nephrol 2002; 13: 1179-1189