메뉴 건너뛰기




Volumn 296, Issue 3, 2009, Pages

Hemin therapy attenuates kidney injury in deoxycorticosterone acetate-salt hypertensive rats

Author keywords

AP 1; DOCA salt hypertension; Fibronectin; Glomerulosclerosis; Heme oxygenase; Hypertrophy; Inflammation; Kidney; NF B

Indexed keywords

8 ISOPROSTANE; ANTIOXIDANT; CREATININE; CYCLIC GMP; DEOXYCORTICOSTERONE ACETATE; FERRITIN; FIBRONECTIN; HEME OXYGENASE; HEMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 66049154851     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00510.2007     Document Type: Article
Times cited : (48)

References (57)
  • 1
    • 0028039868 scopus 로고
    • Isolation and characterization of the mouse heme oxygenase-1 gene: Distal 5′ sequences are required for induction by heme or heavy metals
    • Alam J, Cai J, Smith A. Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5′ sequences are required for induction by heme or heavy metals. J Biol Chem 269: 1001-1009, 1994. (Pubitemid 24981976)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.2 , pp. 1001-1009
    • Alam, J.1    Cai, J.2    Smith, A.3
  • 2
    • 24144432114 scopus 로고    scopus 로고
    • Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: The CUPRAC method
    • DOI 10.1080/10715760500210145
    • Apak R, Guclu K, Ozyurek M, Karademir SE, Altun M. Total antioxidant capacity assay of human serum using copper(II)-neocuproine as chromogenic oxidant: the CUPRAC method. Free Radic Res 39: 949-961, 2005. (Pubitemid 41227031)
    • (2005) Free Radical Research , vol.39 , Issue.9 , pp. 949-961
    • Apak, R.1    Guclu, K.2    Ozyurek, M.3    Esin Karademir, S.4    Altun, M.5
  • 6
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331: 1286-1292, 1994.
    • (1994) N Engl J Med , vol.331 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 7
    • 85016142841 scopus 로고
    • Formulary update: Hemin injection (Panhematin) was approved for the treatment of intermittent porphyria
    • edited by Borowitz SM. Charlottesville, VA: University of Virginia Children's Hospital
    • Buck M. Formulary update: hemin injection (Panhematin) was approved for the treatment of intermittent porphyria. In: Vancomycin: Old Controversies and New Issues. Pediatric Pharmacotherapy, edited by Borowitz SM. Charlottesville, VA: University of Virginia Children's Hospital, 1995.
    • (1995) Vancomycin: Old Controversies and New Issues. Pediatric Pharmacotherapy
    • Buck, M.1
  • 8
    • 0026112458 scopus 로고
    • Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse
    • Cowley BD Jr, Chadwick LJ, Grantham JJ, Calvet JP. Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse. J Am Soc Nephrol 1: 1048-1053, 1991.
    • (1991) J Am Soc Nephrol , vol.1 , pp. 1048-1053
    • Cowley Jr., B.D.1    Chadwick, L.J.2    Grantham, J.J.3    Calvet, J.P.4
  • 10
    • 0030022666 scopus 로고    scopus 로고
    • Effects of amlodipine on glomerular filtration, growth, and injury in experimental hypertension
    • Dworkin LD, Tolbert E, Recht PA, Hersch JC, Feiner H, Levin RI. Effects of amlodipine on glomerular filtration, growth, and injury in experimental hypertension. Hypertension 27: 245-250, 1996. (Pubitemid 26045922)
    • (1996) Hypertension , vol.27 , Issue.2 , pp. 245-250
    • Dworkin, L.D.1    Tolbert, E.2    Recht, P.A.3    Hersch, J.C.4    Feiner, H.5    Levin, R.I.6
  • 11
    • 0016637317 scopus 로고
    • Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: Role of renin and sodium in vascular changes
    • Gavras H, Brunner HR, Laragh JH, Vaughan ED Jr, Koss M, Cote LJ, Gavras I. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess: role of renin and sodium in vascular changes. Circ Res 36: 300-309, 1975.
    • (1975) Circ Res , vol.36 , pp. 300-309
    • Gavras, H.1    Brunner, H.R.2    Laragh, J.H.3    Vaughan Jr., E.D.4    Koss, M.5    Cote, L.J.6    Gavras, I.7
  • 12
    • 33747428047 scopus 로고    scopus 로고
    • Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney
    • DOI 10.1161/01.HYP.0000230664.32874.52, PII 0000426820060900000023
    • Guo DF, Chenier I, Lavoie JL, Chan JS, Hamet P, Tremblay J, Chen XM, Wang DH, Inagami T. Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney. Hypertension 48: 453-459, 2006. (Pubitemid 44253740)
    • (2006) Hypertension , vol.48 , Issue.3 , pp. 453-459
    • Guo, D.-F.1    Chenier, I.2    Lavoie, J.L.3    Chan, J.S.D.4    Hamet, P.5    Tremblay, J.6    Chen, X.M.7    Wang, D.H.8    Inagami, T.9
  • 13
    • 0033960132 scopus 로고    scopus 로고
    • Chronic activation of glomerular mitogen-activated protein kinases in Dahl salt-sensitive rats
    • Hamaguchi A, Kim S, Izumi Y, Iwao H. Chronic activation of glomerular mitogen-activated protein kinases in Dahl salt-sensitive rats. J Am Soc Nephrol 11: 39-46, 2000. (Pubitemid 30020424)
    • (2000) Journal of the American Society of Nephrology , vol.11 , Issue.1 , pp. 39-46
    • Hamaguchi, A.1    Kim, S.2    Izumi, Y.3    Iwao, H.4
  • 14
    • 0030950540 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-κB activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis
    • Hernandez-Presa M, Bustos C, Ortego M, Tunon J, Renedo G, Ruiz-Ortega M, Egido J. Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis. Circulation 95: 1532-1541, 1997. (Pubitemid 27142812)
    • (1997) Circulation , vol.95 , Issue.6 , pp. 1532-1541
    • Hernandez-Presa, M.1    Bustos, C.2    Ortego, M.3    Tunon, J.4    Renedo, G.5    Ruiz-Ortega, M.6    Egido, J.7
  • 15
    • 27244457379 scopus 로고    scopus 로고
    • DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression
    • Hintze KJ, Theil EC. DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression. Proc Natl Acad Sci USA 102: 15048-15052, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15048-15052
    • Hintze, K.J.1    Theil, E.C.2
  • 16
    • 33947427486 scopus 로고    scopus 로고
    • Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: The possible role of local renin-angiotensin system
    • DOI 10.1210/en.2006-1157
    • Hirono Y, Yoshimoto T, Suzuki N, Sugiyama T, Sakurada M, Takai S, Kobayashi N, Shichiri M, Hirata Y. Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system. Endocrinology 148: 1688-1696, 2007. (Pubitemid 46457130)
    • (2007) Endocrinology , vol.148 , Issue.4 , pp. 1688-1696
    • Hirono, Y.1    Yoshimoto, T.2    Suzuki, N.3    Sugiyama, T.4    Sakurada, M.5    Takai, S.6    Kobayashi, N.7    Shichiri, M.8    Hirata, Y.9
  • 17
    • 3042592232 scopus 로고    scopus 로고
    • Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the renin-angiotensin system
    • Iglarz M, Touyz RM, Viel EC, Amiri F, Schiffrin EL. Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the renin-angiotensin system. Am J Hypertens 17: 597-603, 2004.
    • (2004) Am J Hypertens , vol.17 , pp. 597-603
    • Iglarz, M.1    Touyz, R.M.2    Viel, E.C.3    Amiri, F.4    Schiffrin, E.L.5
  • 18
    • 33645220567 scopus 로고    scopus 로고
    • Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells
    • Iwasaki K, Mackenzie EL, Hailemariam K, Sakamoto K, Tsuji Y. Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells. Mol Cell Biol 26: 2845-2856, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 2845-2856
    • Iwasaki, K.1    Mackenzie, E.L.2    Hailemariam, K.3    Sakamoto, K.4    Tsuji, Y.5
  • 19
    • 55949136575 scopus 로고    scopus 로고
    • Interaction among heme oxygenase, nuclear factor-κB, and transcription activating factors in cardiac hypertrophy in hypertension
    • Jadhav A, Torlakovic E, Ndisang JF. Interaction among heme oxygenase, nuclear factor-κB, and transcription activating factors in cardiac hypertrophy in hypertension. Hypertension 52: 910-917, 2008.
    • (2008) Hypertension , vol.52 , pp. 910-917
    • Jadhav, A.1    Torlakovic, E.2    Ndisang, J.F.3
  • 25
    • 0033930320 scopus 로고    scopus 로고
    • Atrial natriuretic peptide reduces expression of TNF-α mRNA during reperfusion of the rat liver upon decreased activation of NF-κB and AP-1
    • DOI 10.1016/S0168-8278(00)80364-5
    • Kiemer AK, Vollmar AM, Bilzer M, Gerwig T, Gerbes AL. Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1. J Hepatol 33: 236-246, 2000. (Pubitemid 30485227)
    • (2000) Journal of Hepatology , vol.33 , Issue.2 , pp. 236-246
    • Kiemer, A.K.1    Vollmar, A.M.2    Bilzer, M.3    Gerwig, T.4    Gerbes, A.L.5
  • 26
    • 0028985037 scopus 로고
    • NF-kappa B and rel proteins in innate immunity
    • Kopp EB, Ghosh S. NF-kappa B and rel proteins in innate immunity. Adv Immunol 58: 1-27, 1995.
    • (1995) Adv Immunol , vol.58 , pp. 1-27
    • Kopp, E.B.1    Ghosh, S.2
  • 29
    • 29644441714 scopus 로고    scopus 로고
    • NF-κB and activator protein 1 response elements and the role of histone modifications in IL-1β-induced TGF-β1 gene transcription
    • Lee KY, Ito K, Hayashi R, Jazrawi EP, Barnes PJ, Adcock IM. NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. J Immunol 176: 603-615, 2006. (Pubitemid 43023309)
    • (2006) Journal of Immunology , vol.176 , Issue.1 , pp. 603-615
    • Lee, K.-Y.1    Ito, K.2    Hayashi, R.3    Jazrawi, E.P.I.4    Barnes, P.J.5    Adcock, I.M.6
  • 30
    • 33845476271 scopus 로고    scopus 로고
    • Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat
    • Li X, Meng Y, Wu P, Zhang Z, Yang X. Angiotensin II and Aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat. Regul Pept 138: 15-25, 2007.
    • (2007) Regul Pept , vol.138 , pp. 15-25
    • Li, X.1    Meng, Y.2    Wu, P.3    Zhang, Z.4    Yang, X.5
  • 31
    • 0344873104 scopus 로고    scopus 로고
    • Renal and vascular oxidative stress and salt-sensitivity of arterial pressure
    • DOI 10.1046/j.0001-6772.2003.01204.x
    • Manning RD Jr, Meng S, Tian N. Renal and vascular oxidative stress and salt-sensitivity of arterial pressure. Acta Physiol Scand 179: 243-250, 2003. (Pubitemid 37464109)
    • (2003) Acta Physiologica Scandinavica , vol.179 , Issue.3 , pp. 243-250
    • Manning Jr., R.D.1    Meng, S.2    Tian, N.3
  • 32
    • 27744478015 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cells
    • DOI 10.1170/T638
    • Mark A, Hock T, Kapturczak MH, Agarwal A, Hill-Kapturczak N. Induction of heme oxygenase-1 modulates the profibrotic effects of transforming growth factor-beta in human renal tubular epithelial cells. Cell Mol Biol (Noisy-le-grand) 51: 357-362, 2005. (Pubitemid 41596312)
    • (2005) Cellular and Molecular Biology , vol.51 , Issue.4 , pp. 357-362
    • Mark, A.1    Hock, T.2    Kapturczak, M.H.3    Agarwal, A.4    Hill-Kapturczak, N.5
  • 35
    • 0031914416 scopus 로고    scopus 로고
    • Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease
    • DOI 10.1046/j.1523-1755.1998.00798.x
    • Mosley K, Wembridge DE, Cattell V, Cook HT. Heme oxygenase is induced in nephrotoxic nephritis and hemin, a stimulator of heme oxygenase synthesis, ameliorates disease. Kidney Int 53: 672-678, 1998. (Pubitemid 28124282)
    • (1998) Kidney International , vol.53 , Issue.3 , pp. 672-678
    • Mosley, K.1    Wembridge, D.E.2    Cattell, V.3    Cook, H.T.4
  • 36
    • 0033847184 scopus 로고    scopus 로고
    • The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo
    • Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, Alam J. The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. Am J Pathol 156: 1527-1535, 2000. (Pubitemid 30646692)
    • (2000) American Journal of Pathology , vol.156 , Issue.5 , pp. 1527-1535
    • Nath, K.A.1    Haggard, J.J.2    Croatt, A.J.3    Grande, J.P.4    Poss, K.D.5    Alam, J.6
  • 37
    • 43949106899 scopus 로고    scopus 로고
    • Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension
    • Ndisang JF, Lane N, Jadhav A. Crosstalk between the heme oxygenase system, aldosterone, and phospholipase C in hypertension. J Hypertens 26: 1188-1199, 2008.
    • (2008) J Hypertens , vol.26 , pp. 1188-1199
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 39
    • 0038264420 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats
    • DOI 10.1182/blood-2002-08-2608
    • Ndisang JF, Wu L, Zhao W, Wang R. Induction of heme oxygenase-1 and stimulation of cGMP production by hemin in aortic tissues from hypertensive rats. Blood 101: 3893-3900, 2003. (Pubitemid 36857864)
    • (2003) Blood , vol.101 , Issue.10 , pp. 3893-3900
    • Ndisang, J.F.1    Wu, L.2    Zhao, W.3    Wang, R.4
  • 40
    • 0035459696 scopus 로고    scopus 로고
    • Intrarenal transport and vasoactive substances in hypertension
    • Ortiz PA, Garvin JL. Intrarenal transport and vasoactive substances in hypertension. Hypertension 38: 621-624, 2001.
    • (2001) Hypertension , vol.38 , pp. 621-624
    • Ortiz, P.A.1    Garvin, J.L.2
  • 41
    • 0033992487 scopus 로고    scopus 로고
    • Chronic treatment with angiotensin II type 1 receptor antagonist suppresses glomerular activator protein-1 activity in salt-sensitive hypertensive rats
    • DOI 10.1159/000025952
    • Otsuka F, Ogura T, Yamauchi T, Sato M, Kataoka H, Kageyama J, Makino H. Chronic treatment with angiotensin II type 1 receptor antagonist suppresses glomerular activator protein-1 activity in salt-sensitive hypertensive rats. Kidney Blood Press Res 23: 35-41, 2000. (Pubitemid 29486338)
    • (2000) Kidney and Blood Pressure Research , vol.23 , Issue.1 , pp. 35-41
    • Otsuka, F.1    Ogura, T.2    Yamauchi, T.3    Sato, M.4    Kataoka, H.5    Kageyama, J.6    Makino, H.7
  • 42
    • 30944437637 scopus 로고    scopus 로고
    • Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage
    • DOI 10.1111/j.1523-1755.2005.00669.x, PII 4494856
    • Rodriguez-Iturbe B, Ferrebuz A, Vanegas V, Quiroz Y, Espinoza F, Pons H, Vaziri ND. Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney Int 68: 2131-2142, 2005. (Pubitemid 43117787)
    • (2005) Kidney International , vol.68 , Issue.5 , pp. 2131-2142
    • Rodriguez-Iturbe, B.1    Ferrebuz, A.2    Vanegas, V.3    Quiroz, Y.4    Espinoza, F.5    Pons, H.6    Vaziri, N.D.7
  • 43
    • 0019832440 scopus 로고
    • DOCA test for aldosteronism: Its usefulness and implications
    • Rodriguez JA, Lopez JM, Biglieri EG. DOCA test for aldosteronism: its usefulness and implications. Hypertension 3: II-102-II-106, 1981.
    • (1981) Hypertension , vol.3
    • Rodriguez, J.A.1    Lopez, J.M.2    Biglieri, E.G.3
  • 44
    • 0031593136 scopus 로고    scopus 로고
    • Suppression of NF-κB and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: Molecular mechanisms of anti- Nephritic action
    • DOI 10.1016/S0925-4439(97)00068-9, PII S0925443997000689
    • Sakurai H, Shigemori N, Hisada Y, Ishizuka T, Kawashima K, Sugita T. Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of antinephritic action. Biochim Biophys Acta 1362: 252-262, 1997. (Pubitemid 28164178)
    • (1997) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1362 , Issue.2-3 , pp. 252-262
    • Sakurai, H.1    Shigemori, N.2    Hisada, Y.3    Ishizuka, T.4    Kawashima, K.5    Sugita, T.6
  • 45
    • 33746138114 scopus 로고    scopus 로고
    • Heme arginate pretreatment attenuates pulmonary NF-κB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction
    • DOI 10.1263/jbb.101.271
    • Sasaki T, Takahashi T, Maeshima K, Shimizu H, Toda Y, Morimatsu H, Takeuchi M, Yokoyama M, Akagi R, Morita K. Heme arginate pretreatment attenuates pulmonary NF-kappaB and AP-1 activation induced by hemorrhagic shock via heme oxygenase-1 induction. Med Chem 2: 271-274, 2006. (Pubitemid 44083145)
    • (2006) Medicinal Chemistry , vol.2 , Issue.3 , pp. 271-274
    • Sasaki, T.1    Takahashi, T.2    Shimizu, H.3    Toda, Y.4    Morimatsu, H.5    Takeuchi, M.6    Yokoyama, M.7    Akagi, R.8    Morita, K.9
  • 46
    • 0023796977 scopus 로고
    • 11-Deoxycorticosterone-induced hypertension, glomerulosclerosis and renal arterial and arteriolar lesions
    • Shimamura T. 11-Deoxycorticosterone-induced hypertension, glomerulosclerosis and renal arterial and arteriolar lesions. Jpn J Exp Med 58: 225-228, 1988. (Pubitemid 18268962)
    • (1988) Japanese Journal of Experimental Medicine , vol.58 , Issue.5 , pp. 225-228
    • Shimamura, T.1
  • 49
    • 0023132858 scopus 로고
    • Bilirubin is an antioxidant of possible physiological importance
    • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 235: 1043-1046, 1987. (Pubitemid 17049750)
    • (1987) Science , vol.235 , Issue.4792 , pp. 1043-1046
    • Stocker, R.1    Yamamoto, Y.2    McDonagh, A.F.3
  • 54
    • 33847419902 scopus 로고    scopus 로고
    • Developmental origins of adult hypertension: New insights into the role of the kidney
    • Vehaskari VM. Developmental origins of adult hypertension: new insights into the role of the kidney. Pediatr Nephrol 22: 490-495, 2007.
    • (2007) Pediatr Nephrol , vol.22 , pp. 490-495
    • Vehaskari, V.M.1
  • 55
    • 33750577971 scopus 로고    scopus 로고
    • Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump
    • Wang R, Shamloul R, Wang X, Meng Q, Wu L. Sustained normalization of high blood pressure in spontaneously hypertensive rats by implanted hemin pump. Hypertension 48: 685-692, 2006.
    • (2006) Hypertension , vol.48 , pp. 685-692
    • Wang, R.1    Shamloul, R.2    Wang, X.3    Meng, Q.4    Wu, L.5
  • 56
    • 24644486790 scopus 로고    scopus 로고
    • Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis
    • DOI 10.1111/j.1523-1755.2005.00380.x, PII 4494563
    • Wang Y, Kramer S, Loof T, Martini S, Kron S, Kawachi H, Shimizu F, Neumayer HH, Peters H. Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis. Kidney Int 68: 47-61, 2005. (Pubitemid 43181363)
    • (2005) Kidney International , vol.68 , Issue.1 , pp. 47-61
    • Wang, Y.1    Kramer, S.2    Loof, T.3    Martini, S.4    Kron, S.5    Kawachi, H.6    Shimizu, F.7    Neumayer, H.-H.8    Peters, H.9
  • 57
    • 23944436597 scopus 로고    scopus 로고
    • Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats
    • DOI 10.1152/ajprenal.00427.2004
    • Xia CF, Bledsoe G, Chao L, Chao J. Kalli1krein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats. Am J Physiol Renal Physiol 289: F622-F631, 2005. (Pubitemid 41208478)
    • (2005) American Journal of Physiology - Renal Physiology , vol.289 , Issue.3
    • Xia, C.-F.1    Bledsoe, G.2    Chao, L.3    Chao, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.