Increased adipose angiotensinogen gene expression in human obesity

Obesity Research

Volumn 8, Issue 4, 2000, Pages 337-341

  Van Harmelen, Vanessa ^a,b   Ariapart, Parisa ^a   Hoffstedt, Johan ^a   Lundkvist, Inger ^a   Bringman, Sven ^a   Arner, Peter ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Lipid Laboratory   (Sweden)

Author keywords

Adipose tissue; Body mass index; RT PCR

Indexed keywords

ANGIOTENSINOGEN; MESSENGER RNA; RNA 18S;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BODY MASS; CHEMISTRY; CHOLECYSTECTOMY; GENE EXPRESSION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; OBESITY; REGRESSION ANALYSIS; STOMACH;

ADIPOSE TISSUE; ADULT; AGED; ANGIOTENSINOGEN; BODY MASS INDEX; CHOLECYSTECTOMY; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; OBESITY; REGRESSION ANALYSIS; RNA, MESSENGER; RNA, RIBOSOMAL, 18S; STOMACH;

EID: 0034218775     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2000.40     Document Type: Article

References (16)

1. Reid IA, Morris BJ, Ganong WF. The renin-angiotensin system. Annu Rev Physiol. 1978;40:377-410.
2. Karlsson C, Lindell K, Ottosson M, Sjöström L, Carlsson B, Carlsson LMS. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab. 1998;83:3925-9.
3. Schling P, Mallow H, Trindl A, Löffler G. Evidence for a local renin angiotensin system in primary cultured human preadipocytes. Int J Obes. 1999;23:336-41.
4. McGrath BP, Matthews PG, Louis W, et al. Double-blind study of dilevalol and captopril, both in combination with hydrochlorothiazide, in patients with moderate to severe hypertension. J Cardiovasc Pharmacol. 1990;16:831-8.
5. Morton JJ, Beattie EC, MacPherson F. Angiotensin II receptor losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: lack of relation to vascular structure. J Vasc Res. 1992;29:264-9.
6. Crandall DL, Herzlinger HE, Saunders BD, Krai JG. Developmental aspects of the adipose tissue renin-angiotensin system: therapeutic implications. Drug Dev Res. 1994;32:117-25.
7. Darimont C, Vassaux G, Ailhaud G, Negrel R. Differentiation of preadipose cells: paracrine role of prostacyclin upon stimulation of adipose cells by angiotensin-II. Endocrinology. 1994;135:2030-6.
8. Jones BH, Standridge MK, Moustaïd N. Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells. Endocrinology. 1997;138:1512-9.
9. Frederich RC, Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension. 1992;19:339-44.
10. Large V, Reynisdotir S, Eleborg L, Van Harmelen V, Strommer L, Arner P. Lipolysis in human fat cells obtained under local and general anesthesia. Int J Obes. 1997; 21:78-82.
11. Liu Q, Arkin S, Biragyn A, et al. Competitive reverse transcriptase-polymerase chain reaction using a synthetic internal RNA standard to quantitate transcripts for leukocyte-derived hormones. Neuroimmunomodulation. 1994;1:33-41.
12. Rodbell M. Metabolism of isolated fat cells. J Biol Chem. 1964;239:375-80.
13. Cooper R, McFarlane-Anderson N, Bennett FI, et al. ACE, angiotensinogen and obesity: a potential pathway leading to hypertension. J Hum Hypertens. 1997;11:107-11.
14. Cooper R, Forrester T, Ogunbiyi O, Muffinda J. Angiotensinogen levels and obesity in four black populations: IC-SHIB investigations. J Hypertens. 1998;16:571-5.
15. Schorr U, Blaschke K, Turan S, Distler A., Sharma AM. Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men. J Hypertens. 1998; 16:1475-80.
16. Umemura S, Nyui N, Tamura K, et al. Plasma angiotensinogen concentrations in obese patients. Am J Hypertens. 1997; 10:629-33.