A redox-resistant Sirtuin-1 mutant protects against hepatic metabolic and oxidant stress

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7293-7306

  Shao, Di ^a   Fry, Jessica L ^a   Han, Jingyan ^a   Hou, Xiuyun ^a   Pimentel, David R ^a   Matsui, Reiko ^a   Cohen, Richard A ^a   Bachschmid, Markus M ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOELECTRIC POTENTIALS; CELL DEATH; ENZYMES; METABOLISM; OXIDANTS; PEPTIDES;

DEACETYLASE ACTIVITY; GLUTATHIONE ADDUCTS; HISTONE DEACETYLASES; LIPID METABOLISMS; METABOLIC STRESS; METABOLIC SYNDROMES; OXIDATIVE INACTIVATION; POST-TRANSLATIONAL MODIFICATIONS;

CELL SIGNALING;

CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUTAREDOXIN; GLUTATHIONE; HYDROGEN PEROXIDE; PROTEIN P53; S NITROSOCYSTEINE; SIRTUIN;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIPID DIET; LIVER CELL; LIVER DISEASE; LIVER FUNCTION; METABOLIC DISORDER; METABOLIC STRESS; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

GLUTATHIOLATION; GLUTATHIONYLATION; HIGH FAT HIGH SUCROSE DIET; METABOLIC DISEASES; OXIDATIVE STRESS; POLYPHENOLS; REACTIVE OXYGEN AND NITROGEN SPECIES; RESVERATROL;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; GLUTAREDOXINS; GLUTATHIONE; HEK293 CELLS; HEP G2 CELLS; HUMANS; LIVER; LIVER DISEASES; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84896292959     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.520403     Document Type: Article

References (72)

1. Ribeiro, P. S., Cortez-Pinto, H., Solá, S., Castro, R. E., Ramalho, R. M., Baptista, A., Moura, M. C., Camilo, M. E., and Rodrigues, C. M. (2004) Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am. J. Gastroenterol. 99, 1708-1717 (Pubitemid 39237497)
2. Elliott, P. J., and Jirousek, M. (2008) Sirtuins: novel targets for metabolic disease. Curr. Opin. Investig. Drugs 9, 371-378 (Pubitemid 351507663)
3. Westphal, C. H., Dipp, M. A., and Guarente, L. (2007) A therapeutic role for sirtuins in diseases of aging? Trends Biochem. Sci. 32, 555-560 (Pubitemid 350123051)
4. Potente, M., and Dimmeler, S. (2008) Emerging roles of SIRT1 in vascular endothelial homeostasis. Cell Cycle 7, 2117-2122 (Pubitemid 352036236)
5. Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., and Tschöp, M. H. (2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. U.S.A. 105, 9793-9798 (Pubitemid 352031379)
6. Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., and Li, X. (2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 9, 327-338
7. Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., and Mayo, M. W. (2004) Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380 (Pubitemid 38954844)
8. Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., and Gu, W. (2001) Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (Pubitemid 33035941)
9. Nemoto, S., Fergusson, M. M., and Finkel, T. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α. J. Biol. Chem. 280, 16456-16460 (Pubitemid 40616776)
10. Cheng, H.-L., Mostoslavsky, R., Saito, S., Manis, J. P., Gu, Y., Patel, P., Bronson, R., Appella, E., Alt, F. W., and Chua, K. F. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 100, 10794-10799 (Pubitemid 37140107)
11. Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., and Gores, G. J. (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125, 437-443 (Pubitemid 36929425)
12. Yang, Y., Fu, W., Chen, J., Olashaw, N., Zhang, X., Nicosia, S. V., Bhalla, K., and Bai, W. (2007) SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat. Cell Biol. 9, 1253-1262 (Pubitemid 350042357)
13. Gao, Z., Zhang, J., Kheterpal, I., Kennedy, N., Davis, R. J., and Ye, J. (2011) Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J. Biol. Chem. 286, 22227-22234
14. +. Mol. Cell 44, 851-863
15. Guo, X., Williams, J. G., Schug, T. T., and Li, X. (2010) DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J. Biol. Chem. 285, 13223-13232
16. Nasrin, N., Kaushik, V. K., Fortier, E., Wall, D., Pearson, K. J., de Cabo, R., and Bordone, L. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One 4, e8414
17. Sasaki, T., Maier, B., Koclega, K. D., Chruszcz, M., Gluba, W., Stukenberg, P. T., Minor, W., and Scrable, H. (2008) Phosphorylation regulates SIRT1 function. PLoS One 3, e4020
18. Zschoernig, B., and Mahlknecht, U. (2009) Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochem. Biophys. Res. Commun. 381, 372-377
19. Caito, S., Rajendrasozhan, S., Cook, S., Chung, S., Yao, H., Friedman, A. E., Brookes, P. S., and Rahman, I. (2010) SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J. 24, 3145-3159
20. Kornberg, M. D., Sen, N., Hara, M. R., Juluri, K. R., Nguyen, J. V., Snowman, A. M., Law, L., Hester, L. D., and Snyder, S. H. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat. Cell Biol. 12, 1094-1100
21. Prozorovski, T., Schulze-Topphoff, U., Glumm, R., Baumgart, J., Schröter, F., Ninnemann, O., Siegert, E., Bendix, I., Brüstle, O., Nitsch, R., Zipp, F., and Aktas, O. (2008) Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat. Cell Biol. 10, 385-394
22. Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E., Veech, R. L., and Sartorelli, V. (2003) Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12, 51-62 (Pubitemid 36945036)
23. Zee, R. S., Yoo, C. B., Pimentel, D. R., Perlman, D. H., Burgoyne, J. R., Hou, X., McComb, M. E., Costello, C. E., Cohen, R. A., and Bachschmid, M. M. (2010) Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid. Redox Signal. 13, 1023-1032
24. Zhang, Y., and Hogg, N. (2004) The mechanism of transmembrane S-nitrosothiol transport. Proc. Natl. Acad. Sci. U.S.A. 101, 7891-7896 (Pubitemid 38698024)
25. Haeussler, D. J., Evangelista, A. M., Burgoyne, J. R., Cohen, R. A., Bachschmid, M. M., and Pimental, D. R. (2011) Checkpoints in adenoviral production: cross-contamination and E1A. PLoS One 6, e23160
26. Ruifrok, A. C., and Johnston, D. A. (2001) Quantification of histochemical staining by color deconvolution. Anal. Quant. Cytol. Histol. 23, 291-299 (Pubitemid 32762920)
27. Roy, A., Kucukural, A., and Zhang, Y. (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat. Protoc. 5, 725-738
28. Ward, J. J., Sodhi, J. S., McGuffin, L. J., Buxton, B. F., and Jones, D. T. (2004) Prediction and functional analysis of native disorder in proteins from the three kingdoms of life. J. Mol. Biol. 337, 635-645 (Pubitemid 38326883)
29. Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L., and Weinberg, R. A. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (Pubitemid 33035942)
30. Langley, E., Pearson, M., Faretta, M., Bauer, U.-M., Frye, R. A., Minucci, S., Pelicci, P. G., and Kouzarides, T. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J. 21, 2383-2396 (Pubitemid 34546711)
31. Chen, W. Y., Wang, D. H., Yen, R. C., Luo, J., Gu, W., and Baylin, S. B. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123, 437-448 (Pubitemid 41546674)
32. Xu, S., Jiang, B., Hou, X., Shi, C., Bachschmid, M. M., Zang, M., Verbeuren, T. J., and Cohen, R. A. (2011) High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. J. Cardiovasc. Pharmacol. 58, 263-271
33. Escande, C., Chini, C. C., Nin, V., Dykhouse, K. M., Novak, C. M., Levine, J., van Deursen, J., Gores, G. J., Chen, J., Lou, Z., and Chini, E. N. (2010) Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J. Clin. Investig. 120, 545-558
34. Joshi-Barve, S., Barve, S. S., Amancherla, K., Gobejishvili, L., Hill, D., Cave, M., Hote, P., and McClain, C. J. (2007) Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes. Hepatology 46, 823-830 (Pubitemid 47436129)
35. Cao, J., Dai, D.-L., Yao, L., Yu, H.-H., Ning, B., Zhang, Q., Chen, J., Cheng, W.-H., Shen, W., and Yang, Z.-X. (2012) Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol. Cell. Biochem. 364, 115-129
36. + depletion. Cell. Physiol. Biochem. 20, 45-54
37. Yu, J., Wang, Z., Kinzler, K. W., Vogelstein, B., and Zhang, L. (2003) PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100, 1931-1936 (Pubitemid 36254551)
38. Ruiz-Ramírez, A., Chávez-Salgado, M., Peñeda-Flores, J. A., Zapata, E., Masso, F., and El-Hafidi, M. (2011) High-sucrose diet increases ROS generation, FFA accumulation, UCP2 level, and proton leak in liver mitochondria. Am. J. Physiol. Endocrinol. Metab. 301, E1198-E1207
39. Mieyal, J. J., Gallogly, M. M., Qanungo, S., Sabens, E. A., and Shelton, M. D. (2008) Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. Antioxid. Redox Signal. 10, 1941-1988
40. Qin, F., Siwik, D. A., Luptak, I., Hou, X., Wang, L., Higuchi, A., Weisbrod, R. M., Ouchi, N., Tu, V. H., Calamaras, T. D., Miller, E. J., Verbeuren, T. J., Walsh, K., Cohen, R. A., and Colucci, W. S. (2012) The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation 125, 1757-1764, S1-S6
41. Deng, X.-Q., Chen, L.-L., and Li, N.-X. (2007) The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats. Liver Int. 27, 708-715 (Pubitemid 47097323)
42. You, M., Cao, Q., Liang, X., Ajmo, J. M., and Ness, G. C. (2008) Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice. J. Nutr. 138, 497-501 (Pubitemid 351355247)
43. Madan, K., Bhardwaj, P., Thareja, S., Gupta, S. D., and Saraya, A. (2006) Oxidant stress and antioxidant status among patients with nonalcoholic fatty liver disease (NAFLD). J. Clin. Gastroenterol. 40, 930-935 (Pubitemid 44690769)
44. Koruk, M., Taysi, S., Savas, M. C., Yilmaz, O., Akcay, F., and Karakok, M. (2004) Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis. Ann. Clin. Lab. Sci. 34, 57-62 (Pubitemid 38280304)
45. Zang, M., Zuccollo, A., Hou, X., Nagata, D., Walsh, K., Herscovitz, H., Brecher, P., Ruderman, N. B., and Cohen, R. A. (2004) AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J. Biol. Chem. 279, 47898-47905 (Pubitemid 39540941)
46. Hou, X., Xu, S., Maitland-Toolan, K. A., Sato, K., Jiang, B., Ido, Y., Lan, F., Walsh, K., Wierzbicki, M., Verbeuren, T. J., Cohen, R. A., and Zang, M. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J. Biol. Chem. 283, 20015-20026
47. Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., and Evans, R. M. (2013) PPARγ signaling and metabolism: the good, the bad and the future. Nat. Med. 19, 557-566
48. Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J. Y., Gao, B., Wierzbicki, M., Verbeuren, T. J., Shaw, R. J., Cohen, R. A., and Zang, M. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13, 376-388
49. Kwon, H.-S., and Ott, M. (2008) The ups and downs of SIRT1. Trends Biochem. Sci. 33, 517-525
50. Nin, V., Escande, C., Chini, C. C., Giri, S., Camacho-Pereira, J., Matalonga, J., Lou, Z., and Chini, E. N. (2012) Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J. Biol. Chem. 287, 23489-23501
51. +-dependent histone deacetylase SIRT1. J. Biol. Chem. 282, 6823-6832
52. Park, S.-J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., Kim, M. K., Beaven, M. A., Burgin, A. B., Manganiello, V., and Chung, J. H. (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-433
53. Abdelmohsen, K., Pullmann, R., Jr., Lal, A., Kim, H. H., Galban, S., Yang, X., Blethrow, J. D., Walker, M., Shubert, J., Gillespie, D. A., Furneaux, H., and Gorospe, M. (2007) Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol. Cell 25, 543-557 (Pubitemid 46274441)
54. Yamazaki, Y., Usui, I., Kanatani, Y., Matsuya, Y., Tsuneyama, K., Fujisaka, S., Bukhari, A., Suzuki, H., Senda, S., Imanishi, S., Hirata, K., Ishiki, M., Hayashi, R., Urakaze, M., Nemoto, H., Kobayashi, M., and Tobe, K. (2009) Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am. J. Physiol. Endocrinol. Metab. 297, E1179-E1186
55. Strum, J. C., Johnson, J. H., Ward, J., Xie, H., Feild, J., Hester, A., Alford, A., and Waters, K. M. (2009) MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol. Endocrinol. 23, 1876-1884
56. Hubbard, B. P., Gomes, A. P., Dai, H., Li, J., Case, A. W., Considine, T., Riera, T. V., Lee, J. E., E, S. Y., Lamming, D. W., Pentelute, B. L., Schuman, E. R., Stevens, L. A., Ling, A. J., Armour, S. M., Michan, S., Zhao, H., Jiang, Y., Sweitzer, S. M., Blum, C. A., Disch, J. S., Ng, P. Y., Howitz, K. T., Rolo, A. P., Hamuro, Y., Moss, J., Perni, R. B., Ellis, J. L., Vlasuk, G. P., and Sinclair, D. A. (2013) Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339, 1216-1219
57. Costantini, S., Sharma, A., Raucci, R., Costantini, M., Autiero, I., and Colonna, G. (2013) Genealogy of an ancient protein family: the Sirtuins, a family of disordered members. BMC Evol. Biol. 13, 60
58. Jung, S.-B., Kim, C.-S., Kim, Y.-R., Naqvi, A., Yamamori, T., Kumar, S., Kumar, A., and Irani, K. (2013) Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One 8, e65415
59. Olmos, Y., Sánchez-Gómez, F. J., Wild, B., García-Quintans, N., Cabezudo, S., Lamas, S., and Monsalve, M. (2013) SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex. Antioxid. Redox Signal. 19, 1507-1521
60. Haigis, M. C., and Sinclair, D. A. (2010) Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295
61. Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horvath, T. L., Sinclair, D. A., Pfluger, P. T., and Tschöp, M. H. (2012) Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 92, 1479-1514
62. Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., and Finkel, T. (2008) A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105, 14447-14452
63. Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L., Watson, P. A., Birdsey, N., Bao, J., Gius, D., Sack, M. N., Jing, E., Kahn, C. R., Friedman, J. E., and Jonscher, K. R. (2011) Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem. J. 433, 505-514
64. Ishikawa, S., Li, G., Takemitsu, H., Fujiwara, M., Mori, N., Yamamoto, I., and Arai, T. (2013) Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. BMC Vet. Res. 9, 187
65. Caton, P. W., Richardson, S. J., Kieswich, J., Bugliani, M., Holland, M. L., Marchetti, P., Morgan, N. G., Yaqoob, M. M., Holness, M. J., and Sugden, M. C. (2013) Sirtuin 3 regulates mouse pancreatic β cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia 56, 1068-1077
66. +-dependent tubulin deacetylase. Mol. Cell 11, 437-444
67. Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W., and Guarente, L. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 126, 941-954 (Pubitemid 44321935)
68. Yu, J., Sadhukhan, S., Noriega, L. G., Moullan, N., He, B., Weiss, R. S., Lin, H., Schoonjans, K., and Auwerx, J. (2013) Metabolic characterization of a Sirt5 deficient mouse model. Sci. Rep. 3, 2806
69. Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., Mills, K. D., Patel, P., Hsu, J. T., Hong, A. L., Ford, E., Cheng, H.-L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M. O., Hursting, S., Barrett, J. C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G. D., and Alt, F. W. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329 (Pubitemid 43121980)
70. Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., Li, P., Cheng, H.-L., Murphy, A. J., Valenzuela, D. M., Luo, H., Kapahi, P., Krauss, R., Mostoslavsky, R., Yancopoulos, G. D., Alt, F. W., Chua, K. F., and Chen, D. (2013) SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Rep. 5, 654-665
71. Peck, B., Chen, C.-Y., Ho, K.-K., Di Fruscia, P., Myatt, S. S., Coombes, R. C., Fuchter, M. J., Hsiao, C.-D., and Lam, E. W. (2010) SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol. Cancer Ther. 9, 844-855
72. Li, S., Banck, M., Mujtaba, S., Zhou, M.-M., Sugrue, M. M., and Walsh, M. J. (2010) p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One 5, e10486