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Volumn 99, Issue 9, 2004, Pages 1708-1717

Hepatocyte apoptosis, expression of death receptors, and activation of NF-κB in the liver of nonalcoholic and alcoholic steatohepatitis patients

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; UNCOUPLING PROTEIN 2;

EID: 4544335155     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2004.40009.x     Document Type: Article
Times cited : (379)

References (46)
  • 1
    • 0035083842 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Definition and pathology
    • Brunt EM. Nonalcoholic steatohepatitis: Definition and pathology. Semin Liver Dis 2001;21:3-16.
    • (2001) Semin Liver Dis , vol.21 , pp. 3-16
    • Brunt, E.M.1
  • 3
    • 0027363543 scopus 로고
    • Apoptotic bodies in a murine model of alcoholic liver disease: Reversibility of ethanol-induced changes
    • Goldin RD, Hunt NC, Clark J, et al. Apoptotic bodies in a murine model of alcoholic liver disease: Reversibility of ethanol-induced changes. J Pathol 1993;171:73-6.
    • (1993) J Pathol , vol.171 , pp. 73-76
    • Goldin, R.D.1    Hunt, N.C.2    Clark, J.3
  • 4
    • 0028230044 scopus 로고
    • Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver
    • Baroni GS, Marucci L, Benedetti A, et al. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol 1994;20:508-13.
    • (1994) J Hepatol , vol.20 , pp. 508-513
    • Baroni, G.S.1    Marucci, L.2    Benedetti, A.3
  • 5
    • 12644291219 scopus 로고    scopus 로고
    • Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
    • Kurose I, Higuchi H, Miura S, et al. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology 1997;25:368-78.
    • (1997) Hepatology , vol.25 , pp. 368-378
    • Kurose, I.1    Higuchi, H.2    Miura, S.3
  • 6
    • 0035111054 scopus 로고    scopus 로고
    • Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
    • Natori S, Rust C, Stadheim LM, et al. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001;34:248-53.
    • (2001) J Hepatol , vol.34 , pp. 248-253
    • Natori, S.1    Rust, C.2    Stadheim, L.M.3
  • 7
    • 0035113898 scopus 로고    scopus 로고
    • Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis
    • Ziol M, Tepper M, Lohez M, et al. Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis. J Hepatol 2001;34:254-60.
    • (2001) J Hepatol , vol.34 , pp. 254-260
    • Ziol, M.1    Tepper, M.2    Lohez, M.3
  • 8
    • 0036203442 scopus 로고    scopus 로고
    • Apoptosis and apoptosis related proteins in chronic viral liver disease
    • Papakyriakou P, Tzardi M, Valatas V, et al. Apoptosis and apoptosis related proteins in chronic viral liver disease. Apoptosis 2002;7:133-41.
    • (2002) Apoptosis , vol.7 , pp. 133-141
    • Papakyriakou, P.1    Tzardi, M.2    Valatas, V.3
  • 9
    • 0035695238 scopus 로고    scopus 로고
    • Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in nonalcoholic steatohepatitis
    • Susca M, Grassi A, Zauli D, et al. Liver inflammatory cells, apoptosis, regeneration and stellate cell activation in nonalcoholic steatohepatitis. Dig Liver Dis 2001;33:768-77.
    • (2001) Dig Liver Dis , vol.33 , pp. 768-777
    • Susca, M.1    Grassi, A.2    Zauli, D.3
  • 10
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003;125:437-43.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 11
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 12
    • 0032862559 scopus 로고    scopus 로고
    • Activation of nuclear factor κ B and cytokine imbalance in experimental alcoholic liver disease in the rat
    • Nanji AA, Jokelainen K, Rahemtulla A, et al. Activation of nuclear factor κ B and cytokine imbalance in experimental alcoholic liver disease in the rat. Hepatology 1999;30:934-43.
    • (1999) Hepatology , vol.30 , pp. 934-943
    • Nanji, A.A.1    Jokelainen, K.2    Rahemtulla, A.3
  • 13
    • 0032519007 scopus 로고    scopus 로고
    • NF-κB prevents apoptosis and liver dysfunction during liver regeneration
    • Iimuro Y, Nishiura T, Hellerbrand C, et al. NF-κB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998;101:802-11.
    • (1998) J Clin Invest , vol.101 , pp. 802-811
    • Iimuro, Y.1    Nishiura, T.2    Hellerbrand, C.3
  • 14
    • 0034747144 scopus 로고    scopus 로고
    • Delivery of IκB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats
    • Uesugi T, Froh M, Arteel GE, et al. Delivery of IκB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats. Hepatology 2001;34:1149-57.
    • (2001) Hepatology , vol.34 , pp. 1149-1157
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3
  • 15
    • 0036017180 scopus 로고    scopus 로고
    • Ethanol, oxidative stress, and cytokine-induced liver cell injury
    • Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002;27:63-8.
    • (2002) Alcohol , vol.27 , pp. 63-68
    • Hoek, J.B.1    Pastorino, J.G.2
  • 16
    • 18344389339 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism
    • Minana JB, Gomez-Cambronero L, Lloret A, et al. Mitochondrial oxidative stress and CD95 ligand: A dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology 2002;35:1205-14.
    • (2002) Hepatology , vol.35 , pp. 1205-1214
    • Minana, J.B.1    Gomez-Cambronero, L.2    Lloret, A.3
  • 17
    • 0034468736 scopus 로고    scopus 로고
    • Role of reactive oxygen species (ROS) in apoptosis induction
    • Simon HU, Haj-Yehia A, Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 2000;5:415-8.
    • (2000) Apoptosis , vol.5 , pp. 415-418
    • Simon, H.U.1    Haj-Yehia, A.2    Levi-Schaffer, F.3
  • 18
    • 0033969421 scopus 로고    scopus 로고
    • Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism
    • Boss O, Hagen T, Lowell BB. Uncoupling proteins 2 and 3: Potential regulators of mitochondrial energy metabolism. Diabetes 2000;49:143-56.
    • (2000) Diabetes , vol.49 , pp. 143-156
    • Boss, O.1    Hagen, T.2    Lowell, B.B.3
  • 19
    • 0032898080 scopus 로고    scopus 로고
    • Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver
    • Rashid A, Wu TC, Huang CC, et al. Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 1999;29:1131-38.
    • (1999) Hepatology , vol.29 , pp. 1131-1138
    • Rashid, A.1    Wu, T.C.2    Huang, C.C.3
  • 20
    • 9044219843 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients
    • Pinto HC, Baptista A, Camilo ME, et al. Nonalcoholic steatohepatitis. Clinicopathological comparison with alcoholic hepatitis in ambulatory and hospitalized patients. Dig Dis Sci 1996;41:172-9.
    • (1996) Dig Dis Sci , vol.41 , pp. 172-179
    • Pinto, H.C.1    Baptista, A.2    Camilo, M.E.3
  • 21
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB, et al. Nonalcoholic steatohepatitis: Mayo clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980;5:434-8.
    • (1980) Mayo Clin Proc , vol.5 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3
  • 22
    • 0034093877 scopus 로고    scopus 로고
    • Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats
    • Masson S, Scotte M, Garnier S, et al. Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats. Apoptosis 2000;5:173-9.
    • (2000) Apoptosis , vol.5 , pp. 173-179
    • Masson, S.1    Scotte, M.2    Garnier, S.3
  • 23
    • 0033667705 scopus 로고    scopus 로고
    • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
    • Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000;26:435-9.
    • (2000) Nat Genet , vol.26 , pp. 435-439
    • Arsenijevic, D.1    Onuma, H.2    Pecqueur, C.3
  • 24
    • 0037039366 scopus 로고    scopus 로고
    • A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
    • Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A 2002;99:118-22.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 118-122
    • Krauss, S.1    Zhang, C.Y.2    Lowell, B.B.3
  • 25
    • 0036207189 scopus 로고    scopus 로고
    • Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2
    • Baffy G, Zhang CY, Glickman JN, et al. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology 2002;35:753-61.
    • (2002) Hepatology , vol.35 , pp. 753-761
    • Baffy, G.1    Zhang, C.Y.2    Glickman, J.N.3
  • 26
    • 0033520771 scopus 로고    scopus 로고
    • Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study
    • Cortez-Pinto H, Chatham J, Chacko VP, et al. Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: A pilot study. JAMA 1999;282:1659-64.
    • (1999) JAMA , vol.282 , pp. 1659-1664
    • Cortez-Pinto, H.1    Chatham, J.2    Chacko, V.P.3
  • 27
    • 0035976997 scopus 로고    scopus 로고
    • NF-κB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene
    • Kurland JF, Kodym R, Story MD, et al. NF-κB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene. J Biol Chem 2001;276:45380-6.
    • (2001) J Biol Chem , vol.276 , pp. 45380-45386
    • Kurland, J.F.1    Kodym, R.2    Story, M.D.3
  • 28
    • 0037092949 scopus 로고    scopus 로고
    • Constitutive nuclear factor-κB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins
    • Bureau F, Vanderplasschen A, Jaspar F, et al. Constitutive nuclear factor-κB activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins. Blood 2002;99:3683-91.
    • (2002) Blood , vol.99 , pp. 3683-3691
    • Bureau, F.1    Vanderplasschen, A.2    Jaspar, F.3
  • 29
    • 0037198274 scopus 로고    scopus 로고
    • NF-κB activates Bcl-2 expression in t(14; 18) lymphoma cells
    • Heckman CA, Mehew JW, Boxer LM. NF-κB activates Bcl-2 expression in t(14; 18) lymphoma cells. Oncogene 2002;21:3898-08.
    • (2002) Oncogene , vol.21 , pp. 3898-3808
    • Heckman, C.A.1    Mehew, J.W.2    Boxer, L.M.3
  • 30
    • 0031721754 scopus 로고    scopus 로고
    • Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury
    • Lawson JA, Fisher MA, Simmons CA, et al. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Hepatology 1998;28:761-7.
    • (1998) Hepatology , vol.28 , pp. 761-767
    • Lawson, J.A.1    Fisher, M.A.2    Simmons, C.A.3
  • 31
    • 0035966059 scopus 로고    scopus 로고
    • Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-κB-independent, caspase-3-dependent pathway
    • Faouzi S, Burckhardt BE, Hanson JC, et al. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-κB-independent, caspase-3-dependent pathway. J Biol Chem 2001;276:49077-82.
    • (2001) J Biol Chem , vol.276 , pp. 49077-49082
    • Faouzi, S.1    Burckhardt, B.E.2    Hanson, J.C.3
  • 32
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • Canbay A, Higuchi H, Bronk SF, et al. Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis. Gastroenterology 2002;123:1323-30.
    • (2002) Gastroenterology , vol.123 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3
  • 33
    • 0028678067 scopus 로고
    • Ethanol-inducible cytochrome P4502E1: Regulation, enzymology and molecular biology
    • Ingelman-Sundberg M, Ronis MJ, Lindros KO, et al. Ethanol-inducible cytochrome P4502E1: Regulation, enzymology and molecular biology. Alcohol Alcohol Suppl 1994;2:131-9.
    • (1994) Alcohol Alcohol Suppl , vol.2 , pp. 131-139
    • Ingelman-Sundberg, M.1    Ronis, M.J.2    Lindros, K.O.3
  • 34
    • 0030935567 scopus 로고    scopus 로고
    • Cytochrome P-4502E1: Its physiological and pathological role
    • Lieber CS. Cytochrome P-4502E1: Its physiological and pathological role. Physiol Rev 1997;77:517-44.
    • (1997) Physiol Rev , vol.77 , pp. 517-544
    • Lieber, C.S.1
  • 35
    • 0032572341 scopus 로고    scopus 로고
    • Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease
    • Taieb J, Mathurin P, Poynard T, et al. Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease. Lancet 1998;351:1930-1.
    • (1998) Lancet , vol.351 , pp. 1930-1931
    • Taieb, J.1    Mathurin, P.2    Poynard, T.3
  • 36
    • 0025363385 scopus 로고
    • Increased plasma tumor necrosis factor in severe alcoholic hepatitis
    • Bird GL, Sheron N, Goka AK, et al. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 1990;112:917-20.
    • (1990) Ann Intern Med , vol.112 , pp. 917-920
    • Bird, G.L.1    Sheron, N.2    Goka, A.K.3
  • 38
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Crespo J, Cayon A, Fernandez-Gil P, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001;34:1158-63.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Crespo, J.1    Cayon, A.2    Fernandez-Gil, P.3
  • 39
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-8.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 40
    • 0036548118 scopus 로고    scopus 로고
    • Inflammation in response to hepatocellular apoptosis
    • Jaeschke H. Inflammation in response to hepatocellular apoptosis. Hepatology 2002;35:964-6.
    • (2002) Hepatology , vol.35 , pp. 964-966
    • Jaeschke, H.1
  • 41
    • 0032055225 scopus 로고    scopus 로고
    • Activation of caspase 3 (CPP32)-like proteases is essential for TNF-α-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model
    • Jaeschke H, Fisher MA, Lawson JA, et al. Activation of caspase 3 (CPP32)-like proteases is essential for TNF-α-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J Immunol 1998;160:3480-6.
    • (1998) J Immunol , vol.160 , pp. 3480-3486
    • Jaeschke, H.1    Fisher, M.A.2    Lawson, J.A.3
  • 42
    • 0037386110 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    • Tilg H, Jalan R, Kaser A, et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol 2003;38:419-25.
    • (2003) J Hepatol , vol.38 , pp. 419-425
    • Tilg, H.1    Jalan, R.2    Kaser, A.3
  • 43
    • 0036784414 scopus 로고    scopus 로고
    • Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study
    • Spahr L, Rubbia-Brandt L, Frossard J, et al. Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study. J Hepatol 2002;37:448-55.
    • (2002) J Hepatol , vol.37 , pp. 448-455
    • Spahr, L.1    Rubbia-Brandt, L.2    Frossard, J.3
  • 44
    • 0032835529 scopus 로고    scopus 로고
    • Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
    • Yin M, Wheeler MD, Kono H, et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 1999;117:942-52.
    • (1999) Gastroenterology , vol.117 , pp. 942-952
    • Yin, M.1    Wheeler, M.D.2    Kono, H.3
  • 45
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • Li Z, Yang S, Lin H, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 2003;37:343-50.
    • (2003) Hepatology , vol.37 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3
  • 46
    • 0034977170 scopus 로고    scopus 로고
    • Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide
    • Deaciuc IV, D'Souza NB, de Villiers WJ, et al. Inhibition of caspases in vivo protects the rat liver against alcohol-induced sensitization to bacterial lipopolysaccharide. Alcohol Clin Exp Res 2001;25:935-43.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 935-943
    • Deaciuc, I.V.1    D'Souza, N.B.2    De Villiers, W.J.3


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