-
1
-
-
0037129380
-
Medical progress: Nonalcoholic fatty liver disease
-
DOI 10.1056/NEJMra011775
-
Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346(16):1221-1231. doi:10.1056/NEJMra011775 (Pubitemid 34984585)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.16
, pp. 1221-1231
-
-
Angulo, P.1
-
2
-
-
0038142845
-
Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
-
DOI 10.1001/jama.289.22.3000
-
Clark JM, Diehl AM (2003) Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289(22):3000-3004. doi:10.1001/jama.289.22.3000 (Pubitemid 37430103)
-
(2003)
Journal of the American Medical Association
, vol.289
, Issue.22
, pp. 3000-3004
-
-
Clark, J.M.1
Diehl, A.M.2
-
3
-
-
34648820054
-
Pathogenesis and management issues for non-alcoholic fatty liver disease
-
Duvnjak M, Lerotic I, Barsic N, Tomasic V, Virovic Jukic L, Velagic V (2007) Pathogenesis and management issues for nonalcoholic fatty liver disease. World J Gastroenterol 13(34):4539-4550 (Pubitemid 47455230)
-
(2007)
World Journal of Gastroenterology
, vol.13
, Issue.34
, pp. 4539-4550
-
-
Duvnjak, M.1
Lerotic, I.2
Barsic, N.3
Tomasic, V.4
Jukic, L.V.5
Velagic, V.6
-
4
-
-
0036718446
-
Nonalcoholic fatty liver disease: Pathogenesis and the role of antioxidants
-
DOI 10.1301/002966402320387224
-
Mehta K, Van Thiel DH, Shah N, Mobarhan S (2002) Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutr Rev 60(9):289-293 (Pubitemid 35025794)
-
(2002)
Nutrition Reviews
, vol.60
, Issue.9
, pp. 289-293
-
-
Mehta, K.1
Van Thiel, D.H.2
Shah, N.3
Mobarhan, S.4
-
5
-
-
12344332455
-
Cytokines and the pathogenesis of non-alcoholic steatohepatitis
-
DOI 10.1136/gut.2003.024935
-
Diehl AM, Li ZP, Lin HZ, Yang SQ (2005) Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 54(2):303-306. doi:10.1136/gut.2003.024935 (Pubitemid 40139250)
-
(2005)
Gut
, vol.54
, Issue.2
, pp. 303-306
-
-
Diehl, A.M.1
Li, Z.P.2
Lin, H.Z.3
Yang, S.Q.4
-
6
-
-
30944451788
-
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
-
DOI 10.1210/en.2005-0570
-
Wang D, Wei Y, Pagliassotti MJ (2006) Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147(2):943-951. doi:10.1210/en. 2005-0570 (Pubitemid 43113013)
-
(2006)
Endocrinology
, vol.147
, Issue.2
, pp. 943-951
-
-
Wang, D.1
Wei, Y.2
Pagliassotti, M.J.3
-
7
-
-
34547889101
-
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells
-
DOI 10.1007/s11010-007-9461-2
-
Wei Y, Wang D, Pagliassotti MJ (2007) Saturated fatty acidmediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Mol Cell Biochem 303(1-2):105-113. doi:10.1007/s11010-007-9461-2 (Pubitemid 47261307)
-
(2007)
Molecular and Cellular Biochemistry
, vol.303
, Issue.1-2
, pp. 105-113
-
-
Wei, Y.1
Wang, D.2
Pagliassotti, M.J.3
-
8
-
-
77950821179
-
Linking endoplasmic reticulum stress to cell death in hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
-
doi:10.1152/ajpendo.00642.2009
-
Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y, Pagliassotti MJ (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab 298(5):E1027-1035. doi:10.1152/ajpendo. 00642.2009
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
, Issue.5
-
-
Pfaffenbach, K.T.1
Gentile, C.L.2
Nivala, A.M.3
Wang, D.4
Wei, Y.5
Pagliassotti, M.J.6
-
9
-
-
33749574062
-
Prion protein helix1 promotes aggregation but is not converted into β-sheet
-
DOI 10.1074/jbc.
-
Malhi H, Bronk SF, Werneburg NW, Gores GJ (2006) Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J Biol Chem 281(17):12093-12101. doi:10.1074/jbc. M510660200 (Pubitemid 44537031)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.40
, pp. 30242-30250
-
-
Watzlawik, J.1
Skora, L.2
Frense, D.3
Griesinger, C.4
Zweckstetter, M.5
Schulz-Schaeffer, W.J.6
Kramer, M.L.7
-
10
-
-
33644858343
-
The unfolded protein response: A stress signaling pathway critical for health and disease
-
PII 0000611420060124100018
-
Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66(2 Suppl 1):S102-S109. doi:10.1212/01.wnl.00001 92306.98198.ec (Pubitemid 43739994)
-
(2006)
Neurology
, vol.66
, Issue.2 SUPPL. 1
-
-
Zhang, K.1
Kaufman, R.J.2
-
11
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
DOI 10.1038/nrm2199, PII NRM2199
-
Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Natl Rev Mol Cell Biol 8(7):519-529. doi:10.1038/nrm2199 (Pubitemid 46985379)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.7
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
12
-
-
0347285295
-
A trip to the ER: Coping with stress
-
DOI 10.1016/j.tcb.2003.11.001
-
Rutkowski DT, Kaufman RJ (2004) A trip to the ER: coping with stress. Trends Cell Biol 14(1):20-28 (Pubitemid 38076857)
-
(2004)
Trends in Cell Biology
, vol.14
, Issue.1
, pp. 20-28
-
-
Rutkowski, D.T.1
Kaufman, R.J.2
-
13
-
-
26444442450
-
Endoplasmic reticulum stress: Cell life and death decisions
-
DOI 10.1172/JCI26373
-
Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115(10):2656-2664. doi:10.1172/JCI26373 (Pubitemid 41434389)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2656-2664
-
-
Xu, C.1
Bailly-Maitre, B.2
Reed, J.C.3
-
14
-
-
22544444513
-
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
-
DOI 10.1038/nm1259
-
Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ (2005) Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med 11(7):757-764. doi:10.1038/nm1259 (Pubitemid 41021208)
-
(2005)
Nature Medicine
, vol.11
, Issue.7
, pp. 757-764
-
-
Scheuner, D.1
Mierde, D.V.2
Song, B.3
Flamez, D.4
Creemers, J.W.M.5
Tsukamoto, K.6
Ribick, M.7
Schuit, F.C.8
Kaufman, R.J.9
-
15
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306(5695):457-461. doi:10.1126/science.1103160 (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
16
-
-
38649124615
-
Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
-
DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
-
Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ (2008) Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134(2):568-576. doi:10.1053/j.gastro.2007.10.039 (Pubitemid 351173040)
-
(2008)
Gastroenterology
, vol.134
, Issue.2
, pp. 568-576
-
-
Puri, P.1
Mirshahi, F.2
Cheung, O.3
Natarajan, R.4
Maher, J.W.5
Kellum, J.M.6
Sanyal, A.J.7
-
17
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
DOI 10.1172/JCI200523621
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115(5):1343-1351. doi:10.1172/JCI23621 (Pubitemid 40629054)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
18
-
-
0034755341
-
Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
-
DOI 10.1023/A:1012338828418
-
Nehra V, Angulo P, Buchman AL, Lindor KD (2001) Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 46(11):2347-2352 (Pubitemid 33042332)
-
(2001)
Digestive Diseases and Sciences
, vol.46
, Issue.11
, pp. 2347-2352
-
-
Nehra, V.1
Angulo, P.2
Buchman, A.L.3
Lindor, K.D.4
-
19
-
-
34547932066
-
Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers
-
DOI 10.1038/labinvest.3700603, PII 3700603
-
Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM (2007) Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. Lab Invest 87(9):927-937. doi: 10.1038/labinvest.3700603 (Pubitemid 47267812)
-
(2007)
Laboratory Investigation
, vol.87
, Issue.9
, pp. 927-937
-
-
Yang, L.1
Jhaveri, R.2
Huang, J.3
Qi, Y.4
Diehl, A.M.5
-
20
-
-
0033692758
-
Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
-
Hardy S, Langelier Y, Prentki M (2000) Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res 60(22):6353-6358
-
(2000)
Cancer Res
, vol.60
, Issue.22
, pp. 6353-6358
-
-
Hardy, S.1
Langelier, Y.2
Prentki, M.3
-
21
-
-
40449106191
-
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells
-
DOI 10.1152/ajpendo.00478.2007
-
Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A (2008) Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab 294(3):E540-E550. doi:10.1152/ajpendo.00478.2007 (Pubitemid 351355224)
-
(2008)
American Journal of Physiology - Endocrinology and Metabolism
, vol.294
, Issue.3
-
-
Lai, E.1
Bikopoulos, G.2
Wheeler, M.B.3
Rozakis-Adcock, M.4
Volchuk, A.5
-
22
-
-
84863988001
-
Role of endoplasmic reticulum stress in palmitate sodium-induced apoptosis in steatotic L02 hepatocytes
-
Cao J, Yang ZX, Shen W (2011) Role of endoplasmic reticulum stress in palmitate sodium-induced apoptosis in steatotic L02 hepatocytes. J Third Mil Med Univ 33(18):1935-1938
-
(2011)
J Third Mil Med Univ
, vol.33
, Issue.18
, pp. 1935-1938
-
-
Cao, J.1
Yang, Z.X.2
Shen, W.3
-
23
-
-
33745116619
-
Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
-
DOI 10.1210/en.2005-1494
-
Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A (2006) Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147(7):3398-3407. doi:10.1210/en. 2005-1494 (Pubitemid 43901131)
-
(2006)
Endocrinology
, vol.147
, Issue.7
, pp. 3398-3407
-
-
Karaskov, E.1
Scott, C.2
Zhang, L.3
Teodoro, T.4
Ravazzola, M.5
Volchuk, A.6
-
24
-
-
0033739622
-
PERK mediates cell-cycle exit during the mammalian unfolded protein response
-
doi:10.1073/pnas.220247197
-
Brewer JW, Diehl JA (2000) PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97(23):12625-12630. doi:10.1073/pnas.220247197
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.23
, pp. 12625-12630
-
-
Brewer, J.W.1
Diehl, J.A.2
-
25
-
-
0042165989
-
Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
-
DOI 10.1016/S0016-5085(03)00907-7
-
Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125(2):437-443 (Pubitemid 36929425)
-
(2003)
Gastroenterology
, vol.125
, Issue.2
, pp. 437-443
-
-
Feldstein, A.E.1
Canbay, A.2
Angulo, P.3
Taniai, M.4
Burgart, L.J.5
Lindor, K.D.6
Gores, G.J.7
-
26
-
-
1242291933
-
CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling
-
DOI 10.1002/hep.20067
-
Schattenberg JM, Wang Y, Rigoli RM, Koop DR, Czaja MJ (2004) CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology 39(2):444-455. doi:10.1002/hep. 20067 (Pubitemid 38222185)
-
(2004)
Hepatology
, vol.39
, Issue.2
, pp. 444-455
-
-
Schattenberg, J.M.1
Wang, Y.2
Rigoli, R.M.3
Koop, D.R.4
Czaja, M.J.5
-
27
-
-
70350752060
-
Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response
-
Li Q, Liu Z, Guo J, Chen J, Yang P, Tian J, Sun J, Zong Y, Qu S (2009) Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response. Int J Mol Med 24(4):459-464
-
(2009)
Int J Mol Med
, vol.24
, Issue.4
, pp. 459-464
-
-
Li, Q.1
Liu, Z.2
Guo, J.3
Chen, J.4
Yang, P.5
Tian, J.6
Sun, J.7
Zong, Y.8
Qu, S.9
-
28
-
-
49949089674
-
Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway
-
doi:10.1213/ane.0b013e3181770be9
-
Wang H, Xue Z, Wang Q, Feng X, Shen Z (2008) Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway. Anesth Analg 107(2):534-540. doi:10.1213/ane. 0b013e3181770be9
-
(2008)
Anesth Analg
, vol.107
, Issue.2
, pp. 534-540
-
-
Wang, H.1
Xue, Z.2
Wang, Q.3
Feng, X.4
Shen, Z.5
-
29
-
-
78649450627
-
Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells
-
doi:10.1016/j.lfs.2010.10.012
-
Gu X, Li K, Laybutt DR, He ML, Zhao HL, Chan JC, Xu G (2010) Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells. Life Sci 87(23-26):724-732. doi:10.1016/j.lfs.2010.10.012
-
(2010)
Life Sci
, vol.87
, Issue.23-26
, pp. 724-732
-
-
Gu, X.1
Li, K.2
Laybutt, D.R.3
He, M.L.4
Zhao, H.L.5
Chan, J.C.6
Xu, G.7
-
30
-
-
18344388462
-
Coupling endoplasmic reticulum stress to the cell death program: Role of the ER chaperone GRP78
-
DOI 10.1016/S0014-5793(02)02289-5, PII S0014579302022895
-
Rao RV, Peel A, Logvinova A, Del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM, Bredesen DE (2002) Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78. FEBS Lett 514(2-3):122-128 (Pubitemid 34273925)
-
(2002)
FEBS Letters
, vol.514
, Issue.2-3
, pp. 122-128
-
-
Rao, R.V.1
Peel, A.2
Logvinova, A.3
Del Rio, G.4
Hermel, E.5
Yokota, T.6
Goldsmith, P.C.7
Ellerby, L.M.8
Ellerby H.Michael9
Bredesen, D.E.10
-
31
-
-
67649438633
-
Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stressinduced cell cycle progression and cell death in human hepatocellular carcinoma cells
-
Dai R, Chen R, Li H (2009) Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stressinduced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int J Oncol 34(6):1749-1757
-
(2009)
Int J Oncol
, vol.34
, Issue.6
, pp. 1749-1757
-
-
Dai, R.1
Chen, R.2
Li, H.3
-
34
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
DOI 10.1016/S1097-2765(03)00105-9
-
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D (2003) An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11(3):619-633 (Pubitemid 36385118)
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
Stojdl, D.F.11
Bell, J.C.12
Hettmann, T.13
Leiden, J.M.14
Ron, D.15
-
35
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic- reticulum-resident kinase
-
DOI 10.1038/16729
-
Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397(6716):271-274. doi:10.1038/16729 (Pubitemid 29051178)
-
(1999)
Nature
, vol.397
, Issue.6716
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
36
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
-
DOI 10.1128/MCB.21.4.1249-1259.2001
-
McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21(4):1249-1259. doi:10.1128/MCB.21.4. 1249-1259.2001 (Pubitemid 32114973)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.4
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.-O.3
Aw, T.-Y.4
Holbrook, N.J.5
|