메뉴 건너뛰기




Volumn 364, Issue 1-2, 2012, Pages 115-129

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

Author keywords

Apoptosis; ER stress; Perk expression; Saturated fatty acid

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACTIVATING TRANSCRIPTION FACTOR 4; BINDING IMMUNOGLOBULIN PROTEIN; BINDING PROTEIN; FAT DROPLET; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; PHOSPHOTRANSFERASE; PKR LIKE ER KINASE; SATURATED FATTY ACID; SHORT HAIRPIN RNA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

EID: 84863985147     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1211-9     Document Type: Article
Times cited : (204)

References (36)
  • 1
    • 0037129380 scopus 로고    scopus 로고
    • Medical progress: Nonalcoholic fatty liver disease
    • DOI 10.1056/NEJMra011775
    • Angulo P (2002) Nonalcoholic fatty liver disease. N Engl J Med 346(16):1221-1231. doi:10.1056/NEJMra011775 (Pubitemid 34984585)
    • (2002) New England Journal of Medicine , vol.346 , Issue.16 , pp. 1221-1231
    • Angulo, P.1
  • 2
    • 0038142845 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An underrecognized cause of cryptogenic cirrhosis
    • DOI 10.1001/jama.289.22.3000
    • Clark JM, Diehl AM (2003) Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289(22):3000-3004. doi:10.1001/jama.289.22.3000 (Pubitemid 37430103)
    • (2003) Journal of the American Medical Association , vol.289 , Issue.22 , pp. 3000-3004
    • Clark, J.M.1    Diehl, A.M.2
  • 4
    • 0036718446 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathogenesis and the role of antioxidants
    • DOI 10.1301/002966402320387224
    • Mehta K, Van Thiel DH, Shah N, Mobarhan S (2002) Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants. Nutr Rev 60(9):289-293 (Pubitemid 35025794)
    • (2002) Nutrition Reviews , vol.60 , Issue.9 , pp. 289-293
    • Mehta, K.1    Van Thiel, D.H.2    Shah, N.3    Mobarhan, S.4
  • 5
    • 12344332455 scopus 로고    scopus 로고
    • Cytokines and the pathogenesis of non-alcoholic steatohepatitis
    • DOI 10.1136/gut.2003.024935
    • Diehl AM, Li ZP, Lin HZ, Yang SQ (2005) Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 54(2):303-306. doi:10.1136/gut.2003.024935 (Pubitemid 40139250)
    • (2005) Gut , vol.54 , Issue.2 , pp. 303-306
    • Diehl, A.M.1    Li, Z.P.2    Lin, H.Z.3    Yang, S.Q.4
  • 6
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • DOI 10.1210/en.2005-0570
    • Wang D, Wei Y, Pagliassotti MJ (2006) Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147(2):943-951. doi:10.1210/en. 2005-0570 (Pubitemid 43113013)
    • (2006) Endocrinology , vol.147 , Issue.2 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 7
    • 34547889101 scopus 로고    scopus 로고
    • Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells
    • DOI 10.1007/s11010-007-9461-2
    • Wei Y, Wang D, Pagliassotti MJ (2007) Saturated fatty acidmediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Mol Cell Biochem 303(1-2):105-113. doi:10.1007/s11010-007-9461-2 (Pubitemid 47261307)
    • (2007) Molecular and Cellular Biochemistry , vol.303 , Issue.1-2 , pp. 105-113
    • Wei, Y.1    Wang, D.2    Pagliassotti, M.J.3
  • 8
    • 77950821179 scopus 로고    scopus 로고
    • Linking endoplasmic reticulum stress to cell death in hepatocytes: Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
    • doi:10.1152/ajpendo.00642.2009
    • Pfaffenbach KT, Gentile CL, Nivala AM, Wang D, Wei Y, Pagliassotti MJ (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am J Physiol Endocrinol Metab 298(5):E1027-1035. doi:10.1152/ajpendo. 00642.2009
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.5
    • Pfaffenbach, K.T.1    Gentile, C.L.2    Nivala, A.M.3    Wang, D.4    Wei, Y.5    Pagliassotti, M.J.6
  • 10
    • 33644858343 scopus 로고    scopus 로고
    • The unfolded protein response: A stress signaling pathway critical for health and disease
    • PII 0000611420060124100018
    • Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66(2 Suppl 1):S102-S109. doi:10.1212/01.wnl.00001 92306.98198.ec (Pubitemid 43739994)
    • (2006) Neurology , vol.66 , Issue.2 SUPPL. 1
    • Zhang, K.1    Kaufman, R.J.2
  • 11
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Natl Rev Mol Cell Biol 8(7):519-529. doi:10.1038/nrm2199 (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 12
    • 0347285295 scopus 로고    scopus 로고
    • A trip to the ER: Coping with stress
    • DOI 10.1016/j.tcb.2003.11.001
    • Rutkowski DT, Kaufman RJ (2004) A trip to the ER: coping with stress. Trends Cell Biol 14(1):20-28 (Pubitemid 38076857)
    • (2004) Trends in Cell Biology , vol.14 , Issue.1 , pp. 20-28
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 13
    • 26444442450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Cell life and death decisions
    • DOI 10.1172/JCI26373
    • Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115(10):2656-2664. doi:10.1172/JCI26373 (Pubitemid 41434389)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2656-2664
    • Xu, C.1    Bailly-Maitre, B.2    Reed, J.C.3
  • 14
    • 22544444513 scopus 로고    scopus 로고
    • Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
    • DOI 10.1038/nm1259
    • Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ (2005) Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med 11(7):757-764. doi:10.1038/nm1259 (Pubitemid 41021208)
    • (2005) Nature Medicine , vol.11 , Issue.7 , pp. 757-764
    • Scheuner, D.1    Mierde, D.V.2    Song, B.3    Flamez, D.4    Creemers, J.W.M.5    Tsukamoto, K.6    Ribick, M.7    Schuit, F.C.8    Kaufman, R.J.9
  • 16
    • 38649124615 scopus 로고    scopus 로고
    • Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease
    • DOI 10.1053/j.gastro.2007.10.039, PII S0016508507019191
    • Puri P, Mirshahi F, Cheung O, Natarajan R, Maher JW, Kellum JM, Sanyal AJ (2008) Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. Gastroenterology 134(2):568-576. doi:10.1053/j.gastro.2007.10.039 (Pubitemid 351173040)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 568-576
    • Puri, P.1    Mirshahi, F.2    Cheung, O.3    Natarajan, R.4    Maher, J.W.5    Kellum, J.M.6    Sanyal, A.J.7
  • 17
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200523621
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115(5):1343-1351. doi:10.1172/JCI23621 (Pubitemid 40629054)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 18
    • 0034755341 scopus 로고    scopus 로고
    • Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis
    • DOI 10.1023/A:1012338828418
    • Nehra V, Angulo P, Buchman AL, Lindor KD (2001) Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci 46(11):2347-2352 (Pubitemid 33042332)
    • (2001) Digestive Diseases and Sciences , vol.46 , Issue.11 , pp. 2347-2352
    • Nehra, V.1    Angulo, P.2    Buchman, A.L.3    Lindor, K.D.4
  • 19
    • 34547932066 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers
    • DOI 10.1038/labinvest.3700603, PII 3700603
    • Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM (2007) Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. Lab Invest 87(9):927-937. doi: 10.1038/labinvest.3700603 (Pubitemid 47267812)
    • (2007) Laboratory Investigation , vol.87 , Issue.9 , pp. 927-937
    • Yang, L.1    Jhaveri, R.2    Huang, J.3    Qi, Y.4    Diehl, A.M.5
  • 20
    • 0033692758 scopus 로고    scopus 로고
    • Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
    • Hardy S, Langelier Y, Prentki M (2000) Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects. Cancer Res 60(22):6353-6358
    • (2000) Cancer Res , vol.60 , Issue.22 , pp. 6353-6358
    • Hardy, S.1    Langelier, Y.2    Prentki, M.3
  • 21
    • 40449106191 scopus 로고    scopus 로고
    • Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells
    • DOI 10.1152/ajpendo.00478.2007
    • Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A (2008) Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Am J Physiol Endocrinol Metab 294(3):E540-E550. doi:10.1152/ajpendo.00478.2007 (Pubitemid 351355224)
    • (2008) American Journal of Physiology - Endocrinology and Metabolism , vol.294 , Issue.3
    • Lai, E.1    Bikopoulos, G.2    Wheeler, M.B.3    Rozakis-Adcock, M.4    Volchuk, A.5
  • 22
    • 84863988001 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in palmitate sodium-induced apoptosis in steatotic L02 hepatocytes
    • Cao J, Yang ZX, Shen W (2011) Role of endoplasmic reticulum stress in palmitate sodium-induced apoptosis in steatotic L02 hepatocytes. J Third Mil Med Univ 33(18):1935-1938
    • (2011) J Third Mil Med Univ , vol.33 , Issue.18 , pp. 1935-1938
    • Cao, J.1    Yang, Z.X.2    Shen, W.3
  • 23
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic β-cell apoptosis
    • DOI 10.1210/en.2005-1494
    • Karaskov E, Scott C, Zhang L, Teodoro T, Ravazzola M, Volchuk A (2006) Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis. Endocrinology 147(7):3398-3407. doi:10.1210/en. 2005-1494 (Pubitemid 43901131)
    • (2006) Endocrinology , vol.147 , Issue.7 , pp. 3398-3407
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 24
    • 0033739622 scopus 로고    scopus 로고
    • PERK mediates cell-cycle exit during the mammalian unfolded protein response
    • doi:10.1073/pnas.220247197
    • Brewer JW, Diehl JA (2000) PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci USA 97(23):12625-12630. doi:10.1073/pnas.220247197
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.23 , pp. 12625-12630
    • Brewer, J.W.1    Diehl, J.A.2
  • 25
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
    • DOI 10.1016/S0016-5085(03)00907-7
    • Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ (2003) Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 125(2):437-443 (Pubitemid 36929425)
    • (2003) Gastroenterology , vol.125 , Issue.2 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6    Gores, G.J.7
  • 26
    • 1242291933 scopus 로고    scopus 로고
    • CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling
    • DOI 10.1002/hep.20067
    • Schattenberg JM, Wang Y, Rigoli RM, Koop DR, Czaja MJ (2004) CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling. Hepatology 39(2):444-455. doi:10.1002/hep. 20067 (Pubitemid 38222185)
    • (2004) Hepatology , vol.39 , Issue.2 , pp. 444-455
    • Schattenberg, J.M.1    Wang, Y.2    Rigoli, R.M.3    Koop, D.R.4    Czaja, M.J.5
  • 27
    • 70350752060 scopus 로고    scopus 로고
    • Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response
    • Li Q, Liu Z, Guo J, Chen J, Yang P, Tian J, Sun J, Zong Y, Qu S (2009) Cholesterol overloading leads to hepatic L02 cell damage through activation of the unfolded protein response. Int J Mol Med 24(4):459-464
    • (2009) Int J Mol Med , vol.24 , Issue.4 , pp. 459-464
    • Li, Q.1    Liu, Z.2    Guo, J.3    Chen, J.4    Yang, P.5    Tian, J.6    Sun, J.7    Zong, Y.8    Qu, S.9
  • 28
    • 49949089674 scopus 로고    scopus 로고
    • Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway
    • doi:10.1213/ane.0b013e3181770be9
    • Wang H, Xue Z, Wang Q, Feng X, Shen Z (2008) Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway. Anesth Analg 107(2):534-540. doi:10.1213/ane. 0b013e3181770be9
    • (2008) Anesth Analg , vol.107 , Issue.2 , pp. 534-540
    • Wang, H.1    Xue, Z.2    Wang, Q.3    Feng, X.4    Shen, Z.5
  • 29
    • 78649450627 scopus 로고    scopus 로고
    • Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells
    • doi:10.1016/j.lfs.2010.10.012
    • Gu X, Li K, Laybutt DR, He ML, Zhao HL, Chan JC, Xu G (2010) Bip overexpression, but not CHOP inhibition, attenuates fatty-acid-induced endoplasmic reticulum stress and apoptosis in HepG2 liver cells. Life Sci 87(23-26):724-732. doi:10.1016/j.lfs.2010.10.012
    • (2010) Life Sci , vol.87 , Issue.23-26 , pp. 724-732
    • Gu, X.1    Li, K.2    Laybutt, D.R.3    He, M.L.4    Zhao, H.L.5    Chan, J.C.6    Xu, G.7
  • 31
    • 67649438633 scopus 로고    scopus 로고
    • Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stressinduced cell cycle progression and cell death in human hepatocellular carcinoma cells
    • Dai R, Chen R, Li H (2009) Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stressinduced cell cycle progression and cell death in human hepatocellular carcinoma cells. Int J Oncol 34(6):1749-1757
    • (2009) Int J Oncol , vol.34 , Issue.6 , pp. 1749-1757
    • Dai, R.1    Chen, R.2    Li, H.3
  • 35
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic- reticulum-resident kinase
    • DOI 10.1038/16729
    • Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397(6716):271-274. doi:10.1038/16729 (Pubitemid 29051178)
    • (1999) Nature , vol.397 , Issue.6716 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 36
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
    • DOI 10.1128/MCB.21.4.1249-1259.2001
    • McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ (2001) Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 21(4):1249-1259. doi:10.1128/MCB.21.4. 1249-1259.2001 (Pubitemid 32114973)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.4 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.-O.3    Aw, T.-Y.4    Holbrook, N.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.