Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Jung, Saet Byel ^a,b   Kim, Cuk Seong ^a,b   Kim, Young Rae ^a   Naqvi, Asma ^a   Yamamori, Tohru ^a,c   Kumar, Santosh ^a   Kumar, Ajay ^a   Irani, Kaikobad ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Chungnam National University   (South Korea)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; NITRIC OXIDE; REDOX EFFECTOR FACTOR 1; SIRTUIN 1; THIOL DERIVATIVE; APEX1 PROTEIN, MOUSE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; NOS3 PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DEACETYLATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PROTEIN DOMAIN; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; VASODILATATION; ACETYLATION; ANIMAL; BIOSYNTHESIS; DIFFUSION CHAMBER; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; METABOLISM; OXIDATION REDUCTION REACTION; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE;

MUS; TETRA;

ACETYLATION; ANIMALS; AORTA; CYSTEINE; DIFFUSION CHAMBERS, CULTURE; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MALE; MICE; MICE, TRANSGENIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION; SIRTUIN 1; TISSUE CULTURE TECHNIQUES; VASODILATION;

EID: 84878661672     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065415     Document Type: Article

References (30)

1. Haigis MC, Sinclair DA, (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5: 253-295.
2. Yang Y, Fu W, Chen J, Olashaw N, Zhang X, et al. (2007) SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol 9: 1253-1262.
3. Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, et al. (2009) JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS One 4: e8414.
4. Zee RS, Yoo CB, Pimentel DR, Perlman DH, Burgoyne JR, et al. (2010) Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal 13: 1023-1032.
5. Kornberg MD, Sen N, Hara MR, Juluri KR, Nguyen JV, et al. (2010) GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol 12: 1094-1100.
6. Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, et al. (2010) SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. Faseb J 24: 3145-3159.
7. Min J, Landry J, Sternglanz R, Xu RM, (2001) Crystal structure of a SIR2 homolog-NAD complex. Cell 105: 269-279.
8. Sherman JM, Stone EM, Freeman-Cook LL, Brachmann CB, Boeke JD, et al. (1999) The conserved core of a human SIR2 homologue functions in yeast silencing. Mol Biol Cell 10: 3045-3059.
9. Chen L, Feng Y, Zhou Y, Zhu W, Shen X, et al. (2010) Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1. J Inorg Biochem 104: 180-185.
10. Tell G, Quadrifoglio F, Tiribelli C, Kelley MR, (2009) The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal 11: 601-620.
11. Sung JS, Demple B, (2006) Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA. FEBS J 273: 1620-1629.
12. Bhakat KK, Mantha AK, Mitra S, (2009) Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal 11: 621-638.
13. Jeon BH, Gupta G, Park YC, Qi B, Haile A, et al. (2004) Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circ Res 95: 902-910.
14. Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, et al. (2010) SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res 38: 832-845.
15. Jaffrey SR, Snyder SH, (2001) The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE 2001: pl1.
16. Walker LJ, Robson CN, Black E, Gillespie D, Hickson ID, (1993) Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol 13: 5370-5376.
17. Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, et al. (2002) Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ 9: 717-725.
18. Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, et al. (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 104: 14855-14860.
19. Stein S, Schafer N, Breitenstein A, Besler C, Winnik S, et al. (2010) SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging (Albany NY) 2: 353-360.
20. Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, et al. (2008) Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 80: 191-199.
21. Chen Z, Peng IC, Cui X, Li YS, Chien S, et al. (2010) Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A 107: 10268-10273.
22. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, et al. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38: 864-878.
23. Zhang R, Chen HZ, Liu JJ, Jia YY, Zhang ZQ, et al. (2010) SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J Biol Chem 285: 7097-7110.
24. Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, et al. (1997) AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A 94: 3633-3638.
25. Xanthoudakis S, Curran T, (1992) Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. Embo J 11: 653-665.
26. Huang LE, Arany Z, Livingston DM, Bunn HF, (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271: 32253-32259.
27. Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, et al. (1997) Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 11: 558-570.
28. Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, et al. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159.
29. Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, et al. (2007) SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev 21: 2644-2658.
30. Jiang A, Gao H, Kelley MR, Qiao X, (2011) Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo. Vision Res 51: 93-100.